{"id":50829,"date":"2024-09-19T15:36:13","date_gmt":"2024-09-19T22:36:13","guid":{"rendered":"https:\/\/www.salk.edu\/?page_id=50829"},"modified":"2026-06-23T18:30:53","modified_gmt":"2026-06-24T01:30:53","slug":"news","status":"publish","type":"page","link":"https:\/\/www.salk.edu\/zh\/neuroimmunology\/news\/","title":{"rendered":"\u65b0\u95fb"},"content":{"rendered":"<h2>How can scientists visualize cellular life with greater precision?<\/h2>\r\n\r\n<figure class=\"right-align\">\r\n    <img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1.jpg\" alt=\"Mouse brain tissue showing inhibitory neurons labeled with a red fluorescent VIS-Fb that binds to the green calcium biosensor. Neurons are highlighted in blue.\" width=\"300\">\r\n    <figcaption>Mouse brain tissue showing inhibitory neurons labeled with a red fluorescent VIS-Fb that binds to the green calcium biosensor. Neurons are highlighted in blue.<br \/>Credit: Barykina et al., <em>\u81ea\u7136\u65b9\u6cd5<\/em><\/figcaption>\r\n<\/figure>\r\n\r\n<p>LA JOLLA\u2014Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and animals. Using these tools, researchers have watched viruses infect cells in real time, observed cellular trash collection, and tracked the signaling that spurs tumor growth.<\/p>\r\n\r\n<p>Salk scientists and collaborators at Albert Einstein College of Medicine have advanced this visualization technology. The new technology, called visible-spectrum antigen-stabilizable fluorescent nanobodies (VIS-Fbs), was validated in multiple mammalian cell types and provides a powerful tool for a wide range of life science research applications.<\/p>\r\n\r\n<p>The study was published in <a href=\"https:\/\/www.nature.com\/articles\/s41592-026-03056-3\" target=\"_blank\"><em>\u81ea\u7136\u65b9\u6cd5<\/em><\/a> on April 22, 2026.<\/p>\r\n\r\n<p>\u201cThis work establishes a versatile platform for imaging proteins with high specificity and minimal background,\u201d says co-corresponding author <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/axel-nimmerjahn\/\">\u963f\u514b\u585e\u5c14-\u5c3c\u9ed8\u96c5\u6069\uff0c\u535a\u58eb<\/a>, professor and Fran\u00e7oise Gilot-Salk Chair at Salk. \u201cIt opens new opportunities to study how molecular and cellular processes unfold in real time across diverse biological systems.\u201d<\/p>\r\n\r\n<p><a href=\"https:\/\/www.salk.edu\/zh\/news-release\/how-can-scientists-visualize-cellular-life-with-greater-precision\/\" class=\"btn -expand\">Keep Reading &raquo;<\/a><\/p>\r\n\r\n<hr>\r\n\r\n<h2>Beyond Lab Walls Podcast: Nicola Allen on brain inflammation and lifelong cognitive health<\/h2>\r\n\r\n<div class=\"right-align\"><div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-a_q1E1aCiqU\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/a_q1E1aCiqU?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row --><\/div>\r\n\r\n<p>Some of the most important work of protecting the brain may depend on immune and other cell types, which make up a surprising 50% of the human brain. In this special Beyond Lab Walls video podcast episode\u2014part of the <a href=\"https:\/\/www.salk.edu\/zh\/science\/2026-the-salk-institutes-year-of-brain-health-research\/\">Salk Institute\u2019s 2026 Year of Brain Health<\/a>\u2014Salk President <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/gerald-joyce\/\">Gerald Joyce, MD, PhD<\/a>, speaks with <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/nicola-allen\/\">\u5c3c\u53e4\u62c9\u00b7\u827e\u4f26\uff0c\u535a\u58eb<\/a>, a leading neuroscientist whose lab studies how non-neuronal brain cells shape brain function in health, aging, and disease.<\/p>\r\n\r\n<p><a href=\"https:\/\/youtu.be\/a_q1E1aCiqU?si=oICHYakcHpRNXEte\" class=\"btn -expand\" target=\"_blank\">Watch the Podcast &raquo;<\/a><\/p>\r\n\r\n<hr>\r\n\r\n<h2>\u6253\u7834\u795e\u7ecf\u79d1\u5b66\u4e0e\u514d\u75ab\u5b66\u4e4b\u95f4\u7684\u58c1\u5792<\/h2>\r\n\r\n<figure class=\"right-align\">\r\n    <img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/07\/2507-nomis-ni-news.jpg\" alt=\"From left: Nicola Allen, Diana Hargreaves, and Jesse Dixon.\" width=\"300\">\r\n    <figcaption>\u4ece\u5de6\u4e0a\u89d2\u5f00\u59cb\uff1a\u82cf\u73ca\u00b7\u51ef\u5947\u548c\u5c3c\u53e4\u62c9\u00b7\u827e\u4f26\u3002\u4ece\u5de6\u4e0b\u89d2\u5f00\u59cb\uff1a\u9edb\u5b89\u5a1c\u00b7\u54c8\u683c\u91cc\u592b\u65af\u548c\u963f\u514b\u585e\u5c14\u00b7\u5c3c\u9ed8\u8a79\u3002.<br \/>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption>\r\n<\/figure>\r\n\r\n<p>\u9274\u4e8e\u5927\u8111\u548c\u810a\u9ad3\u5728\u7ef4\u6301\u8eab\u4f53\u8fd0\u8f6c\u4e2d\u7684\u6838\u5fc3\u4f5c\u7528\uff0c\u5b83\u4eec\u53d7\u5230\u6781\u5927\u4fdd\u62a4\u4e5f\u5c31\u4e0d\u8db3\u4e3a\u5947\u4e86\u3002\u4f8b\u5982\uff0c\u8d1f\u8d23\u4e3a\u5927\u8111\u4f9b\u6c27\u548c\u6ecb\u517b\u7684\u4e25\u5bc6\u95ed\u5408\u7684\u6bdb\u7ec6\u8840\u7ba1\u7f51\u7edc\uff0c\u4e5f\u5145\u5f53\u4e86\u5173\u952e\u7684\u5c4f\u969c\uff0c\u53ea\u5141\u8bb8\u6781\u5c11\u6570\u751f\u7406\u4e0a\u91cd\u8981\u7684\u5206\u5b50\u901a\u8fc7\uff0c\u800c\u963b\u6b62\u5176\u4f59\u5206\u5b50\u901a\u8fc7\u3002\u4ece\u5386\u53f2\u4e0a\u770b\uff0c\u79d1\u5b66\u754c\u4e00\u76f4\u8ba4\u4e3a\uff0c\u5728\u6211\u4eec\u8840\u6db2\u4e2d\u5faa\u73af\u7684\u514d\u75ab\u7ec6\u80de\u4e5f\u65e0\u6cd5\u8d8a\u8fc7\u201c\u7ed2\u7ef3\u201d\uff0c\u8fdb\u5165\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u8fd9\u4e2a\u201c\u8d35\u5bbe\u5ba4\u201d\u3002.<\/p>\r\n\r\n<p>\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u8fd9\u79cd\u7981\u4ee4\u4f1a\u88ab\u89e3\u9664\uff0c\u4f8b\u5982\u5728\u75c5\u6bd2\u6216\u7ec6\u83cc\u611f\u67d3\u7279\u5b9a\u5f71\u54cd\u5927\u8111\u5e76\u9700\u8981\u514d\u75ab\u7cfb\u7edf\u5feb\u901f\u54cd\u5e94\u7684\u60c5\u51b5\u4e0b\u3002\u201c\u6211\u4eec\u77e5\u9053\u514d\u75ab\u7ec6\u80de\u53ef\u4ee5\u5728\u90a3\u79cd\u60c5\u51b5\u4e0b\u8fdb\u5165\u5927\u8111\uff0c\u201d\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u7684\u514d\u75ab\u5b66\u5bb6\u82cf\u73ca\u00b7\u51ef\u5947\u8bf4\u3002\u201c\u4f46\u5728\u5065\u5eb7\u7a33\u5b9a\u72b6\u6001\u4e0b\uff0c\u5b83\u786e\u5b9e\u88ab\u8ba4\u4e3a\u662f\u4e00\u4e2a\u514d\u75ab\u7279\u6743\u5668\u5b98\u3002\u201d<\/p>\r\n\r\n<p>\u7136\u800c\uff0c\u8fc7\u53bb\u5341\u591a\u5e74\u7684\u4e00\u4e9b\u7814\u7a76\u5df2\u7ecf\u98a0\u8986\u4e86\u8fd9\u4e00\u6559\u6761\u3002Kaeche\u5c06\u8fd9\u4e00\u8f6c\u53d8\u5f88\u5927\u7a0b\u5ea6\u4e0a\u5f52\u529f\u4e8e\u5f00\u521b\u6027\u7684\u5de5\u4f5c\uff0c\u8fd9\u4e9b\u5de5\u4f5c\u63ed\u793a\u4e86\u5148\u524d\u88ab\u5ffd\u89c6\u7684\u6dcb\u5df4\u7ed3\u6784\u7f51\u7edc\uff0c\u8fd9\u4e9b\u7f51\u7edc\u5141\u8bb8\u514d\u75ab\u7cfb\u7edf\u7684\u7ec6\u80de\u5373\u4f7f\u5728\u6ca1\u6709\u611f\u67d3\u7684\u60c5\u51b5\u4e0b\u4e5f\u80fd\u5bc6\u5207\u76d1\u89c6\u5927\u8111\u3002\u5176\u4ed6\u8fd1\u671f\u7814\u7a76\u4e5f\u786e\u7acb\u4e86\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e0e\u5faa\u73af\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u7684\u4ea4\u6d41\u5728\u4ece\u6162\u6027\u75bc\u75db\u5230\u764c\u75c7\u3001\u518d\u5230\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u75be\u75c5\u72b6\u6001\u4e2d\u7684\u4f5c\u7528\u3002.<\/p>\r\n\r\n<p><a href=\"https:\/\/www.science.org\/content\/article\/breaking-barrier-between-neuroscience-and-immunology\" class=\"btn -expand\" target=\"_blank\">\u7ee7\u7eed\u9605\u8bfb \u00bb<\/a><\/p>\r\n\r\n<hr>\r\n\r\n<h2>\u7d22\u5c14\u514b\u7814\u7a76\u6240\u664b\u5347\u4e09\u540d\u795e\u7ecf\u79d1\u5b66\u3001\u514d\u75ab\u5b66\u548c\u764c\u75c7\u7814\u7a76\u9886\u57df\u7684\u6559\u804c\u5458\u5de5<\/h2>\r\n\r\n<figure class=\"right-align\">\r\n    <img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/04\/250421-pr-promotions-allen-hargreaves-dixon-458x149.jpg\" alt=\"From left: Nicola Allen, Diana Hargreaves, and Jesse Dixon.\" width=\"300\">\r\n    <figcaption>\u4ece\u5de6\u8d77\uff1a\u59ae\u53ef\u62c9\u00b7\u827e\u4f26\u3001\u9edb\u5b89\u5a1c\u00b7\u54c8\u683c\u91cc\u592b\u65af\u548c\u6770\u897f\u00b7\u8fea\u514b\u68ee\u3002.<br \/>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption>\r\n<\/figure>\r\n\r\n<p>\u62c9\u970d\u4e9a\u2014\u4e09\u4f4d\u8428\u514b\u7814\u7a76\u6240\u7684\u6559\u804c\u5458\u5de5\u56e0\u5176\u5bf9\u79d1\u5b66\u7684\u6770\u51fa\u3001\u521b\u65b0\u8d21\u732e\u800c\u83b7\u5f97\u664b\u5347\u3002\u526f\u6559\u6388 <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/nicola-allen\/\">\u5c3c\u53e4\u62c9\u00b7\u827e\u4f26<\/a> \u548c <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/diana-hargreaves\/\">\u6234\u5b89\u5a1c\u00b7\u54c8\u683c\u91cc\u592b\u65af<\/a> \u664b\u5347\u4e3a\u6b63\u6559\u6388\uff0c\u4ee5\u53ca\u52a9\u7406\u6559\u6388 <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/jesse-dixon\/\">\u6770\u897f\u00b7\u8fea\u514b\u68ee<\/a> \u664b\u5347\u4e3a\u526f\u6559\u6388\u3002\u6b64\u6b21\u664b\u5347\u57fa\u4e8e\u7d22\u5c14\u514b\u5b66\u9662\u6559\u804c\u5458\u5de5\u548c\u975e\u5c45\u6c11\u7814\u7a76\u5458\u7684\u63a8\u8350\uff0c\u5e76\u4e8e2025\u5e744\u67084\u65e5\u83b7\u5f97\u7d22\u5c14\u514b\u5b66\u9662\u9662\u957f\u548c\u8463\u4e8b\u4f1a\u6279\u51c6\u3002.<\/p>\r\n\r\n<p>\u201c\u5c3c\u53e4\u62c9\u3001\u9edb\u5b89\u5a1c\u548c\u6770\u897f\u90fd\u5728\u5404\u81ea\u9886\u57df\u4e0d\u65ad\u7a81\u7834\u5df2\u77e5\u548c\u53ef\u80fd\u6027\u7684\u754c\u9650\uff0c\u201d\u7d22\u5c14\u514b\u7814\u7a76\u6240\u6240\u957f\u8bf4\u9053\u3002 <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/gerald-joyce\/\">\u6770\u62c9\u5c14\u5fb7\u00b7\u4e54\u4f0a\u65af<\/a>. \u5c3c\u53e4\u62c9\u5728\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u795e\u7ecf\u514d\u75ab\u5b66\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u9879\u76ee\u4e5f\u505a\u51fa\u4e86\u5173\u952e\u8d21\u732e\uff0c\u6234\u5b89\u5a1c\u548c\u6770\u897f\u90fd\u5728\u764c\u75c7\u7814\u7a76\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u8981\u8fdb\u5c55\u3002\u6211\u4eec\u5f88\u671f\u5f85\u770b\u5230\u4ed6\u4eec\u7684\u9886\u5bfc\u80fd\u529b\u548c\u521b\u65b0\u7cbe\u795e\u5c06\u5982\u4f55\u7ee7\u7eed\u5851\u9020\u7814\u7a76\u6240\u7684\u6210\u529f\u3002\u201c<\/p>\r\n\r\n<p><a href=\"https:\/\/www.salk.edu\/zh\/news-release\/salk-institute-promotes-three-faculty-members-in-neuroscience-immunology-and-cancer-research\/\" class=\"btn -expand\">\u7ee7\u7eed\u9605\u8bfb \u00bb<\/a><\/p>\r\n\r\n<hr>\r\n\r\n<h2>Salk Institute launches Neuroimmunology Initiative with $20 million gift from\r\nNOMIS Foundation<\/h2>\r\n<p><strong>Scientists will explore the understudied crosstalk between the immune and nervous systems,\r\nand the role it plays in health and disease<\/strong><\/p>\r\n\r\n<figure class=\"right-align\">\r\n    <img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2024\/06\/NOMIS-PR-300x300.jpg\" alt=\"From top left:  Susan Kaech and Nicola Allen. From bottom left: Axel Nimmerjahn and Diana Hargreaves.\" width=\"300\">\r\n    <figcaption>\u4ece\u5de6\u4e0a\u8d77\uff1a\u82cf\u73ca\u00b7\u51ef\u5947\uff08Susan Kaech\uff09\u548c\u59ae\u53ef\u62c9\u00b7\u827e\u4f26\uff08Nicola Allen\uff09\u3002\u4ece\u5de6\u4e0b\u8d77\uff1a\u963f\u514b\u585e\u5c14\u00b7\u5c3c\u9ed8\u7ea6\u7ff0\uff08Axel Nimmerjahn\uff09\u548c\u9edb\u5b89\u5a1c\u00b7\u54c8\u683c\u91cc\u592b\u65af\uff08Diana Hargreaves\uff09\u3002.<br \/>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption>\r\n<\/figure>\r\n\r\n\r\n<p>LA JOLLA\u2014The Salk Institute will receive $20 million over four years from the NOMIS\r\nFoundation to launch a new Neuroimmunology Initiative within the Institute\u2019s <a href=\"https:\/\/www.salk.edu\/zh\/science\/research-centers\/nomis-center\/\">NOMIS\u514d\u75ab\u751f\u7269\u5b66\u548c\u5fae\u751f\u7269\u81f4\u75c5\u4e2d\u5fc3<\/a>. By funding research programs, faculty\r\nrecruitment, and pilot grants, the generous gift will enable Salk scientists to develop a deep\r\nunderstanding of the crosstalk between the immune and nervous systems and the role it plays\r\nin health and disease.<\/p><p>\r\n\u201cWe are deeply grateful to the NOMIS Foundation for investing in neuroimmunology and in\r\nSalk,\u201d says Salk President <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/gerald-joyce\/\">\u6770\u62c9\u5c14\u5fb7\u00b7\u4e54\u4f0a\u65af<\/a>. \u201cThis funding will allow us to tackle currently\r\nunaddressed scientific questions, opening fundamentally new areas of scientific inquiry across\r\nhuman health and disease, and paving the way toward innovative therapeutic interventions for\r\na wide range of disorders that have both a neurological and immunological component, such as\r\nAlzheimer\u2019s disease, ALS, long COVID, and some forms of cancer.\"<\/p>\r\n<p><a href=\"https:\/\/www.salk.edu\/zh\/news-release\/salk-institute-launches-neuroimmunology-initiative-with-20-million-gift-from-nomis-foundation\/\" class=\"btn -expand\">\u7ee7\u7eed\u9605\u8bfb \u00bb<\/a><\/p>","protected":false},"excerpt":{"rendered":"<h2>How can scientists visualize cellular life with greater precision?<\/h2>\r\n\r\n<figure class=\"right-align\">\r\n    <img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1.jpg\" alt=\"Mouse brain tissue showing inhibitory neurons labeled with a red fluorescent VIS-Fb that binds to the green calcium biosensor. Neurons are highlighted in blue.\" width=\"300\">\r\n    <figcaption>Mouse brain tissue showing inhibitory neurons labeled with a red fluorescent VIS-Fb that binds to the green calcium biosensor. Neurons are highlighted in blue.<br \/>Credit: Barykina et al., <em>\u81ea\u7136\u65b9\u6cd5<\/em><\/figcaption>\r\n<\/figure>\r\n\r\n<p>LA JOLLA\u2014Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and animals. Using these tools, researchers have watched viruses infect cells in real time, observed cellular trash collection, and tracked the signaling that spurs tumor growth.<\/p>","protected":false},"author":3,"featured_media":0,"parent":50819,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"folder":[],"class_list":["post-50829","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>News - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/neuroimmunology\/news\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"News - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"How can scientists visualize cellular life with greater precision?        Mouse brain tissue showing inhibitory neurons labeled with a red fluorescent VIS-Fb that binds to the green calcium biosensor. Neurons are highlighted in blue.Credit: Barykina et al., Nature Methods   LA JOLLA\u2014Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and animals. 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Mouse brain tissue showing inhibitory neurons labeled with a red fluorescent VIS-Fb that binds to the green calcium biosensor. Neurons are highlighted in blue.Credit: Barykina et al., Nature Methods   LA JOLLA\u2014Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and animals. 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