{"id":37058,"date":"2022-12-05T09:52:13","date_gmt":"2022-12-05T17:52:13","guid":{"rendered":"https:\/\/vermont.salk.edu\/?page_id=37058"},"modified":"2025-07-23T10:14:47","modified_gmt":"2025-07-23T17:14:47","slug":"program","status":"publish","type":"page","link":"https:\/\/www.salk.edu\/zh\/events\/science-events\/mechanisms-and-models-of-cancer-2025\/program\/","title":{"rendered":"\u7a0b\u5e8f"},"content":{"rendered":"
#MechModels2025<\/strong><\/div>\n

<\/p>\n

*Final program\/schedule will be announced closer to the event.<\/p>\n

Tuesday, July 29<\/strong><\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
12:00 p.m.<\/td>\nMeeting registration opens<\/td>\n<\/tr>\n
4:00 p.m. to
\n8:00 p.m.<\/strong><\/td>\n		Session 1: Metabolic signaling<\/strong><\/td>\n<\/tr>\n
4:00 p.m.<\/td>\nLiron Bar-Peled (Massachusetts General Hospital)
\nIdentification of druggable and redox vulnerabilities in cancer<\/em><\/td>\n<\/tr>\n
4:30 p.m.<\/td>\n*Anna Trimble (Salk Institute)
\nUsing ex vivo tissue slice culture to elucidate the role of the tumor microenvironment in PDAC tumor lipid metabolism<\/em><\/td>\n<\/tr>\n
4:50 p.m.<\/td>\nShruti Naik (Mount Sinai)<\/td>\n<\/tr>\n
5:20 p.m.<\/td>\nRushika Perera (UC San Francisco)
\nUncovering lysosome dependent mechanisms of cellular adaptation in cancer<\/em><\/td>\n<\/tr>\n
5:50 p.m.<\/td>\n*Kamini Singh (Albert Einstein College of Medicine)
\nDecoding immune recognition in pancreatic cancer: Through the lens of the ribosome<\/em><\/td>\n<\/tr>\n
6:00 p.m.<\/em><\/td>\nDinner for registered attendees<\/em><\/td>\n<\/tr>\n
7:10 p.m.<\/td>\n*Krushna Patra (University of Cincinnati)
\nMetabolic remodeling of mitochondrial forms supports GNAS (G\u03b1s<\/sub>) mutant pancreas cancer growth<\/em><\/td>\n<\/tr>\n
7:30 p.m.<\/td>\nReuben Shaw (Salk Institute)<\/td>\n<\/tr>\n
8:00 p.m. to
\n10:00 p.m.<\/em><\/td>\n		Welcome Party in downstairs Foyer at Salk Institute<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

Wednesday, July 30<\/strong><\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
8:00 a.m.<\/td>\nBreakfast<\/td>\n<\/tr>\n
9:00 a.m. to
\n12:20 p.m.<\/strong><\/td>\n		Session 2: Genetics and epigenetics<\/strong><\/td>\n<\/tr>\n
9:00 a.m.<\/td>\n\u591a\u5c3c\u5854\u00b7\u5e03\u96f7\u8fea\uff08\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\uff09
\nUnlocking the chemical space of cancer: A chemoproteomic strategy to map protein function and therapeutic response<\/em><\/td>\n<\/tr>\n
9:30 a.m.<\/td>\n*Shandon Amos (Massachusetts Institute of Technology)
\nEpigenetic reactivation of neutrophil differentiation to target acute leukemia<\/em><\/td>\n<\/tr>\n
9:50 a.m.<\/td>\n*Caterina Bartolacci (University of Cincinnati)
\nThioredoxin reductase 1 inhibition triggers ferroptosis in KRAS-independent lung cancers<\/em><\/td>\n<\/tr>\n
10:10 a.m.<\/td>\nYael David (Memorial Sloan Kettering Cancer Center)
\nTargeting a new metabolism-epigenetic axis towards improved CAR T therapy in multiple myeloma<\/em><\/td>\n<\/tr>\n
10:40 a.m.<\/em><\/td>\nCoffee break<\/em><\/td>\n<\/tr>\n
11:00 a.m.<\/td>\n*Hannah Rasby (Corning Life Sciences)<\/td>\n<\/tr>\n
11:10 a.m.<\/td>\nLiling Wan (University of Pennsylvania)
\nChromatin-associated condensates in gene regulation and cancer<\/em><\/td>\n<\/tr>\n
11:40 a.m.<\/td>\n*Brandon Murphy (University of Utah)
\nElucidating the mechanisms sustaining DTPCs following MAPKi in LUAD<\/em><\/td>\n<\/tr>\n
12:00 p.m.<\/td>\nMallika Singh (Revolution Medicines)
\nTargeting the oncogenic state of RAS with tri-complex inhibitors<\/em><\/td>\n<\/tr>\n
12:30 p.m.<\/em><\/td>\nLunch and Poster Session 1<\/em><\/td>\n<\/tr>\n
2:00 p.m. to
\n4:30 p.m.<\/strong><\/td>\n		Session 3: Tumor evolution<\/strong><\/td>\n<\/tr>\n
2:00 p.m.<\/td>\nKornelia Polyak (Dana-Farber Cancer Institute)
\nBreast tumor evolution<\/em><\/td>\n<\/tr>\n
2:30 p.m.<\/td>\n*Jennifer Loza (Yale University)
\nExploring the impact of neoantigen expression on lung tumor development<\/em><\/td>\n<\/tr>\n
2:50 p.m.<\/td>\n*Pablo Tamayo (UC San Diego)
\nComputational modeling of cancer as an adaptive emergent complex system<\/em><\/td>\n<\/tr>\n
3:10 p.m.<\/td>\nSandra McAllister (Harvard University)
\nOvercoming age-related immune dysfunction and chemoresistance in triple-negative breast cancer<\/em><\/td>\n<\/tr>\n
3:40 p.m.<\/td>\n*Aria Vaishnavi (University of Texas MD Anderson Cancer Center)
\nUnraveling the molecular mechanisms of radon and air pollution-induced lung cancers with novel mouse models<\/em><\/td>\n<\/tr>\n
4:00 p.m.<\/td>\nLudmil Alexandrov (UC San Diego)
\nGeographic and age-related variations in mutational processes in colorectal cancer<\/em><\/td>\n<\/tr>\n
5:00 p.m. to
\n8:00 p.m.<\/em><\/td>\n		Reception\/Dinner at Gravity Heights
\n(RSVP required; shuttle buses available at 4:45 p.m.)<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

Thursday, July 31<\/strong><\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
8:00 a.m.<\/em><\/td>\nBreakfast<\/em><\/td>\n<\/tr>\n
9:00 a.m. to
\n12:10 p.m.<\/strong><\/td>\n		Session 4: Tumor macroenvironment<\/strong><\/td>\n<\/tr>\n
9:00 a.m.<\/td>\nJulio Aguirre-Ghiso (Albert Einstein College of Medicine)
\nDisseminated cancer cell dormancy: Molecular triggers of entry and exit<\/em><\/td>\n<\/tr>\n
9:30 a.m.<\/td>\n*Shi Li (Fred Hutchinson Cancer Center)
\nDiscovery of astrocytic checkpoints regulating disseminated tumor cell survival<\/em><\/td>\n<\/tr>\n
9:50 a.m.<\/td>\n*Bharti Garg (UC San Diego)
\nActin cytoskeleton dynamics in tumor cells mediate Immune-suppressive microenvironment and sensitize pancreas tumors to PD-1 blockade therapy<\/em><\/td>\n<\/tr>\n
10:10 a.m.<\/td>\nCyrus Ghajar (Fred Hutch Cancer Center)
\nUnderstanding and overcoming the numbers game that underlies disseminated tumor cell immune evasion<\/em><\/td>\n<\/tr>\n
10:40 a.m.<\/em><\/td>\nCoffee break<\/em><\/td>\n<\/tr>\n
11:00 a.m.<\/td>\nSheila Stewart (Washington University School of Medicine in St. Louis)
\nSenescent stromal changes drive breast tumorigenesis and contribute to therapy-induced bone loss<\/em><\/td>\n<\/tr>\n
11:30 a.m.<\/td>\n*Nesli Dolcen (Stanford University)
\nGenetic dissection of metabolic tumor suppression in vivo<\/em><\/td>\n<\/tr>\n
11:50 a.m.<\/td>\n*Florian Karreth (H. Lee Moffitt Cancer Center)
\nNon-canonical RNA binding of the MYBL2 transcription factor nucleates transcriptional condensates and promotes melanoma<\/em><\/td>\n<\/tr>\n
12:10 p.m.<\/em><\/td>\nLunch and Poster Session 2<\/em><\/td>\n<\/tr>\n
2:00 p.m. to
\n4:50 p.m.<\/strong><\/td>\n		Session 5: Plasticity of cancer cells and their niche<\/strong><\/td>\n<\/tr>\n
2:00 p.m.<\/td>\nTuomas Tammela (Memorial Sloan Kettering Cancer Center)
\nFunctional and molecular interrogation of a malignant high-plasticity cell state in carcinomas<\/em><\/td>\n<\/tr>\n
2:30 p.m.<\/td>\n*Henry Arnold (University of Utah)
\nOpposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma<\/em><\/td>\n<\/tr>\n
2:50 p.m.<\/td>\n*Debadrita Bhattacharya (Stanford University)
\nInvestigating transcriptional regulators of intratumoral heterogeneity in small cell lung cancer<\/em><\/td>\n<\/tr>\n
3:10 p.m.<\/td>\nCosimo Commisso (Sanford Burnham Prebys)
\nReprogramming the stroma: Metabolic plasticity and aging in pancreatic tumor evolution<\/em><\/td>\n<\/tr>\n
3:40 p.m.<\/em><\/td>\nCoffee break<\/em><\/td>\n<\/tr>\n
4:00 p.m.<\/td>\n*Peter Westcott (Cold Spring Harbor Laboratory)
\nTumor cell state and niche remodeling during benign-to-malignant transition in the colon<\/em><\/td>\n<\/tr>\n
4:20 p.m.<\/td>\nShiri Gur-Cohen (UC San Diego)
\nLymphovascular niches as hubs of cancer plasticity and evolution<\/em><\/td>\n<\/tr>\n
5:30 p.m. to
\n8:30 p.m.<\/em><\/td>\n		Reception and Dinner Il Fornaio
\n(RSVP required; shuttle buses available at 5:00 p.m.)<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

Friday, August 1<\/strong><\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
8:00 a.m.<\/em><\/td>\nBreakfast<\/em><\/td>\n<\/tr>\n
9:00 a.m. to
\n12:40 p.m.<\/strong><\/td>\n		Session 6: Immunity, inflammation, and cancer<\/strong><\/td>\n<\/tr>\n
9:00 a.m.<\/td>\nChristine Moussion (Genentech)<\/td>\n<\/tr>\n
9:30 a.m.<\/td>\n*Melissa Reeves (University of Utah)
\nTumor cells drive the spatial organization of intratumoral immune cells and chemokine landscapes in heterogeneous tumors<\/em><\/td>\n<\/tr>\n
9:50 a.m.<\/td>\n*Alex Jaeger (Moffitt Cancer Center)
\nKP\/RiboMHC: A novel mouse model for proteogenomic analysis of tumor-specific antigen presentation in vivo<\/em><\/td>\n<\/tr>\n
10:10 a.m.<\/td>\nMichel DuPage (UC Berkley)<\/td>\n<\/tr>\n
10:40 a.m.<\/em><\/td>\nCoffee break<\/em><\/td>\n<\/tr>\n
11:00 a.m.<\/td>\nYvonne Chen (UC Los Angeles)
\nEngineering multi-pronged CAR-T cells for cancer therapy<\/em><\/td>\n<\/tr>\n
11:30 a.m.<\/td>\n*Zeda Zhang (Memorial Sloan Kettering Cancer Center)
\nTargeting dysregulated wound healing programs in cancer and fibrosis with immune engineering<\/em><\/td>\n<\/tr>\n
11:50 a.m.<\/td>\n*Helen McRae (Salk Institute)
\nEpigenetic control of tumor associated macrophages \u2013 targeting the BAF nucleosome remodeling complex<\/em><\/td>\n<\/tr>\n
12:10 p.m.<\/td>\nMikala Egeblad (Johns Hopkins University)
\nNeutrophils drive vascular occlusion, pleomorphic tumor necrosis, and metastasis<\/em><\/td>\n<\/tr>\n
12:40 p.m.<\/em><\/td>\nLunch<\/em><\/td>\n<\/tr>\n
1:40 p.m. to
\n3:30 p.m.<\/strong><\/td>\n		Session 7: Last Hurrah!<\/strong><\/td>\n<\/tr>\n
1:40 p.m.<\/td>\n*Kailash Chandra Mangalhara (Salk Institute)
\nMitochondrial complex II inhibition promotes tumor inflammation<\/em><\/td>\n<\/tr>\n
2:00 p.m.<\/td>\n*Yuwenbin Li (Salk Institute)
\nStromal education of pancreatic cancer cells drives an NF\u03baB-mediated immune evasion program<\/em><\/td>\n<\/tr>\n
2:20 p.m.<\/td>\n*Suzanne Dufresne (Salk Institute)
\nLeveraging autophagy and pyrimidine metabolism to target pancreatic cancer<\/em><\/td>\n<\/tr>\n
2:40 p.m.<\/td>\n*Jasper Hsu (Salk Institute)
\nCA19-9 induces microenvironment remodeling and promotes immunosuppression in pancreatic ductal adenocarcinoma<\/em><\/td>\n<\/tr>\n
3:00 p.m.<\/td>\nSilvio Gutkind (UC San Diego)
\nUnderstanding precancer to cancer transition at single-cell resolution: The Hippo in the room<\/em><\/td>\n<\/tr>\n
3:30 p.m. to
\n5:30 p.m.<\/em><\/td>\n		Reception on Red Brick Courtyard<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

*Short talks<\/em><\/p>\n

 <\/p>","protected":false},"excerpt":{"rendered":"

#MechModels2025<\/strong><\/div>\n

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