{"id":28220,"date":"2020-09-24T13:44:11","date_gmt":"2020-09-24T20:44:11","guid":{"rendered":"https:\/\/vermont.salk.edu\/?page_id=28220"},"modified":"2022-01-20T09:43:42","modified_gmt":"2022-01-20T17:43:42","slug":"profiles-corina-antal","status":"publish","type":"page","link":"https:\/\/www.salk.edu\/zh\/engage\/women-science\/profiles-corina-antal\/","title":{"rendered":"\u4e2a\u4eba\u8d44\u6599"},"content":{"rendered":"

From wrangling bull sharks to climbing mountains to seeking a cure for pancreatic cancer, Antal follows her passions, and she is redefining what it means to be a scientist.<\/h2>\n
\"Corina
Corina Antal
Postdoctoral Fellow, Evans Lab<\/figcaption><\/figure>\n

Antal grew up in Chicago, with a keen interest in marine biology; she frequented the nearby world-renowned Shedd Aquarium because the underwater world captivated her imagination. After graduating from high school, Antal moved to Florida to pursue a degree in marine biology at the University of Miami.<\/p>\n

In Miami, Antal wanted to understand the population dynamics, diet and genetic differences of sharks in order to aid in global conservation efforts to maintain healthy oceans. Antal would take a boat into Biscayne Bay, hop into the water and then attempt to hold a shark while another student tagged it and took a biopsy.<\/p>\n

Although her research was invigorating, Antal wondered what it would be like to conduct research that had a more direct impact on humans. The summer of her junior year, she stumbled across an opportunity to study a chronic bladder condition called interstitial cystitis.<\/p>\n

\u201cI wanted to have a bigger impact on human health and disease,\u201d says Antal. That desire led her to pursue a PhD in biomedical sciences at UC San Diego. There she examined the role of protein kinase C (PKC) in tumors by trying to identify how cancer-associated mutations affected this enzyme at the molecular level.<\/p>\n

\u201cWe expected that the PKC mutations would cause tumors. Surprisingly, we found the opposite,\u201d says Antal. \u201cPKC was acting as a tumor suppressor, so our research suggested a shift in therapeutic strategies targeting PKC.\u201d<\/p>\n

Antal\u2019s graduate work became nationally recognized for its potential to point to new treatments; she made the 2016 Forbes \u201c30 Under 30\u201d list in the science category for her discovery.<\/p>\n

\u201cWhile I was in graduate school, my mother was diagnosed with triple-negative breast cancer, an aggressive and difficult-to-treat cancer,\u201d says Antal. \u201cThis inspired another change in my career trajectory as I decided that I wanted to tackle the deadliest cancers.\u201d<\/p>\n

Upon graduating, she joined the lab of \u7f57\u7eb3\u5fb7\u00b7\u57c3\u6587\u65af<\/a> at Salk, where Antal chose to focus on pancreatic cancer<\/a>, which is difficult to treat and has a poor prognosis. Research in the Evans lab focuses on foundational and translational discoveries, such as figuring out that a chemically modified form of vitamin D can break down the barrier that protects pancreatic tumors, allowing for better drug delivery and immune cell support.<\/p>\n

During one of her recent research projects at Salk, Antal identified RNA-binding proteins that seem to play a role in pancreatic cancer. Serendipitously, one of the country\u2019s leading experts in RNA-binding proteins was located across the street, at UC San Diego, and he happens to be Antal\u2019s husband. As it turns out, Professor Gene Yeo was in the process of writing a paper about the exact protein Antal was interested in. They are now starting an academic collaboration to examine how these RNA-binding proteins affect pancreatic cancer development.<\/p>\n

Despite the fact that their work happens to overlap, Antal did not meet Yeo through academic pursuits. They met while training for the Coeur d\u2019Alene Ironman Triathlon (a 2.4-mile swim and a 112-mile bike ride, followed by a 26.2-mile marathon) when she was in graduate school. These days, Antal and Yeo have less time for Ironman training, but they still manage to dash outside to go rock climbing. Two of their favorite spots are Red Rock Canyon and Holcomb Valley Pinnacles.<\/p>\n

\u201cThere are so many scientists who climb. I\u2019ll be climbing my route, and all of a sudden I hear someone talking about CRISPR or DNA sequencing. It\u2019s a great community,\u201d says Antal.<\/p>\n

She also recently became involved with the Pancreatic Cancer Action Network and started a Salk team to participate in the PurpleStride Walk and Run event. Through these experiences, she has met a lot of pancreatic cancer patients, and these relationships drive her to keep searching for a cure.<\/p>\n

\u201cI feel like my career has been a series of haphazard opportunities,\u201d says Antal with a laugh. \u201cBut I\u2019m very happy where I ended up.\u201d<\/p>\n

\n
\n

\u4ea7\u751f\u5f71\u54cd.<\/h2>\n

\u7acb\u5373\u6350\u6b3e<\/a><\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

From wrangling bull sharks to climbing mountains to seeking a cure for pancreatic cancer, Antal follows her passions, and she is redefining what it means to be a scientist.<\/h2>\n
\"Corina
Corina Antal
Postdoctoral Fellow, Evans Lab<\/figcaption><\/figure>\n

Antal grew up in Chicago, with a keen interest in marine biology; she frequented the nearby world-renowned Shedd Aquarium because the underwater world captivated her imagination. After graduating from high school, Antal moved to Florida to pursue a degree in marine biology at the University of Miami.<\/p>","protected":false},"author":91,"featured_media":0,"parent":2906,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"folder":[527],"class_list":["post-28220","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nProfiles - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/engage\/women-science\/profiles-corina-antal\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Profiles - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"From wrangling bull sharks to climbing mountains to seeking a cure for pancreatic cancer, Antal follows her passions, and she is redefining what it means to be a scientist. 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