{"id":17482,"date":"2018-04-19T12:49:10","date_gmt":"2018-04-19T19:49:10","guid":{"rendered":"https:\/\/vermont.salk.edu\/?page_id=17482"},"modified":"2024-09-15T10:27:36","modified_gmt":"2024-09-15T17:27:36","slug":"research-programs","status":"publish","type":"page","link":"https:\/\/www.salk.edu\/zh\/science\/research-centers\/salk-cancer-center\/research-programs\/","title":{"rendered":"Research Programs"},"content":{"rendered":"<h3>The NCI Cancer Center is comprised of two programs:<\/h3>\n<h2>Program 1: Genome Stability, Epigenetics &amp; Aging in Cancer<\/h2>\n<p>The goals of Genome Stability, Epigenetics &#038; Aging in Cancer (GEA) Program are three-fold: 1) to advance cancer research by strengthening ties between Salk Cancer Center researchers studying genomic and epigenetic underpinnings of cancer, while building new points of contact and synergies with researchers studying aging, 2) to continue to foster new technology development and utilization toward understanding tumor heterogeneity (e.g., using spatial transcriptomics to characterize the tumor microenvironment), and 3) to strengthen the translational pipeline so that GEA basic science discoveries can be translated into clinical applications that improve patient outcomes. The goals of the GEA program are represented in the following broad Specific Aims:<\/p>\n<ol style=\"margin-left: 60px;\">\n<li>Therapeutically harness the genetic, epigenetic, and circadian control of tumorigenesis<\/li>\n<li>Examine the contribution of genome stability, stress signaling, and aging to tumorigenesis with the ultimate goal of understanding the tight relationships between DNA repair, DNA-damage response, inter-organelle signaling, inflammation, and cancer initiation<\/li>\n<li>Investigate cancer initiation and heterogeneity by deciphering how cancer cells acquire different differentiation states and trajectories as tumors progress and by developing new single-cell and imaging technologies to visualize the cellular ecosystems of different cancer types.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><strong>The program includes fourteen (14) members:<\/strong><\/p>\n<p><style>.faculty .entries a > div p{line-height: 14px !important;}<\/style><section class=\"faculty\"><div class=\"row entries\"><br \/>\n<div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/diana-hargreaves\/\"><div><p>Diana Hargreaves, PhD<\/p><p><p>Professor<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> BAF chromatin remodeling complex and the role of chromatin regulators in cancer<\/p><p><strong>Disease models:<\/strong> BAF subunit mutant solid tumors such as medulloblastomas <\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Diana_Hargreaves_767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Diana_Hargreaves_767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Diana_Hargreaves_767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Diana_Hargreaves_767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Diana_Hargreaves_767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Diana_Hargreaves_767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Diana_Hargreaves_767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Diana_Hargreaves_767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Diana_Hargreaves_767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Diana_Hargreaves_767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Diana_Hargreaves_767-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Diana Hargreaves, PhD<br><span style='font-size:14px;'><strong>(Program Leader)<\/strong><\/span><\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/jan-karlseder\/\"><div><p>Jan Karlseder, PhD<\/p><p><p>Vice President, Chief Science Officer<\/p>\n<p>Professor<\/p>\n<p>Donald and Darlene Shiley Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> telomere function and dysregulation in cancer cells<\/p><p><strong>Disease models:<\/strong> combined treatment of cancer with mitotic inhibitors (Taxol, Velcade and Vinblastine) and PARP inhibitors<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/karlseder.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/karlseder.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/karlseder-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/karlseder-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/karlseder-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/karlseder-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/karlseder-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/karlseder-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/karlseder-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/karlseder-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/karlseder-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Jan Karlseder, PhD<br><span style='font-size:14px;'><strong>(Program Leader)<\/strong><\/span><\/figcaption><\/figure><\/a><\/div><br \/>\n<\/div><\/section><br \/>\n<style>.faculty .entries a > div p{line-height: 14px !important;}<\/style><section class=\"faculty\"><div class=\"row entries\"><br \/>\n<div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/adam-bowman\/\"><div><p>Adam Bowman, PhD<\/p><p><p>Salk Fellow<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> Biophotonics, Computational Biology, Neurobiology, Systems Biology<\/p><p><strong>Disease models:<\/strong> cancer, neurology<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/11\/Adam-Bowman-767x767-551A0586.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Adam Bowman\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/11\/Adam-Bowman-767x767-551A0586.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/11\/Adam-Bowman-767x767-551A0586-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/11\/Adam-Bowman-767x767-551A0586-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/11\/Adam-Bowman-767x767-551A0586-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/11\/Adam-Bowman-767x767-551A0586-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/11\/Adam-Bowman-767x767-551A0586-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/11\/Adam-Bowman-767x767-551A0586-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/11\/Adam-Bowman-767x767-551A0586-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/11\/Adam-Bowman-767x767-551A0586-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/11\/Adam-Bowman-767x767-551A0586-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Adam Bowman, PhD<\/figcaption><\/figure><\/a><\/div><div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/jesse-dixon\/\"><div><p>Jesse Dixon, MD, PhD<\/p><p><p>Associate Professor<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> 3d genomic control<\/p><p><strong>Disease models:<\/strong> pediatric leukemia, colon cancer<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/11\/Jesse-Dixon-767-1.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Jesse Dixon\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/11\/Jesse-Dixon-767-1.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/11\/Jesse-Dixon-767-1-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/11\/Jesse-Dixon-767-1-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/11\/Jesse-Dixon-767-1-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/11\/Jesse-Dixon-767-1-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/11\/Jesse-Dixon-767-1-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/11\/Jesse-Dixon-767-1-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/11\/Jesse-Dixon-767-1-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/11\/Jesse-Dixon-767-1-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/11\/Jesse-Dixon-767-1-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Jesse Dixon, MD, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/joseph-ecker\/\"><div><p>Joseph Ecker, PhD<\/p><p><p>Professor<\/p>\n<p>Salk International Council Chair in Genetics<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> epigenomics of stem cells and cancer cells<\/p><p><strong>Disease models:<\/strong> breast cancer<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/joseph-ecker-salk-institute-767x767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/joseph-ecker-salk-institute-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/joseph-ecker-salk-institute-767x767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/joseph-ecker-salk-institute-767x767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/joseph-ecker-salk-institute-767x767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/joseph-ecker-salk-institute-767x767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/joseph-ecker-salk-institute-767x767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/joseph-ecker-salk-institute-767x767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/joseph-ecker-salk-institute-767x767-750x750.jpg 750w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Joseph Ecker, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/rusty-gage\/\"><div><p>Rusty Gage, PhD<\/p><p><p>Professor<\/p>\n<p>Laboratory of Genetics<\/p>\n<p>Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> neurogenesis, adult stem cells, iPSCs<\/p><p><strong>Disease models:<\/strong> human aging and age-associated diseases<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Gage-Web.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Rusty Gage\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Gage-Web.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Gage-Web-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Gage-Web-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Gage-Web-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Gage-Web-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Gage-Web-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Gage-Web-750x750.jpg 750w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Rusty Gage, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/agnieszka-kendrick\/\"><div><p>Agnieszka Kendrick, PhD<\/p><p>Assistant Professor<\/p><p>Molecular and Cell Biology Laboratory<\/p><p><strong>Areas of interest:<\/strong> Alzheimer's disease, molecular motors<\/p><p><strong>Disease models:<\/strong> colon\/pancreatic cancer<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/07\/Aga-20230831-551A4549-square.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Aga Kendrick\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/07\/Aga-20230831-551A4549-square.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/07\/Aga-20230831-551A4549-square-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/07\/Aga-20230831-551A4549-square-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/07\/Aga-20230831-551A4549-square-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/07\/Aga-20230831-551A4549-square-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/07\/Aga-20230831-551A4549-square-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/07\/Aga-20230831-551A4549-square-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/07\/Aga-20230831-551A4549-square-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/07\/Aga-20230831-551A4549-square-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/07\/Aga-20230831-551A4549-square-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Agnieszka Kendrick, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/pallav-kosuri\/\"><div><p>Pallav Kosuri, PhD<\/p><p>Assistant Professor<\/p><p>Integrative Biology Laboratory<\/p><p><strong>Areas of interest:<\/strong> DNA topography, RNA transcriptomics, chromatin<\/p><p><strong>Disease models:<\/strong> mechanical and cellular architecture<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Pallav Kosuri\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767-600x600.jpg 600w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767-100x100.jpg 100w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Pallav-Kosuri-767-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Pallav Kosuri, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/julie-law\/\"><div><p>Julie Law, PhD<\/p><p>Associate Professor<\/p><p>Plant Molecular and Cellular Biology Laboratory<\/p><p><strong>Areas of interest:<\/strong> DNA methylation; epigenome in both agriculture and human health<\/p><p><strong>Disease models:<\/strong> <em>Arabidopsis thaliana<\/em><\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Law-Web.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Julie Law\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Law-Web.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Law-Web-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Law-Web-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Law-Web-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Law-Web-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Law-Web-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Law-Web-750x750.jpg 750w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Julie Law, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/dmitry-lyumkis\/\"><div><p>Dmitry Lyumkis, PhD<\/p><p><p>Associate Professor<\/p>\n<p>Hearst Foundations Developmental Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> decoding structures of macromolecular assembly using CryoEMDisease models: cancer, inflammation<\/p><p><strong>Disease models:<\/strong> cancer, inflammation<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/11\/Dmitry_Lyumkis_767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/11\/Dmitry_Lyumkis_767.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/11\/Dmitry_Lyumkis_767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/11\/Dmitry_Lyumkis_767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/11\/Dmitry_Lyumkis_767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/11\/Dmitry_Lyumkis_767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/11\/Dmitry_Lyumkis_767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/11\/Dmitry_Lyumkis_767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/11\/Dmitry_Lyumkis_767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/11\/Dmitry_Lyumkis_767-200x200.jpg 200w\" sizes=\"(max-width: 750px) 100vw, 750px\" \/><figcaption>Dmitry Lyumkis, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/graham-mcvicker\/\"><div><p>Graham McVicker, PhD<\/p><p><p>Associate Professor<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> human genetic variation impacting immune system and cancer<\/p><p><strong>Disease models:<\/strong> leukemias, pediatric blood cancers<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Graham-McVicker_767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Graham-McVicker_767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Graham-McVicker_767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Graham-McVicker_767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Graham-McVicker_767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Graham-McVicker_767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Graham-McVicker_767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Graham-McVicker_767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Graham-McVicker_767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Graham-McVicker_767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Graham-McVicker_767-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Graham McVicker, PhD<\/figcaption><\/figure><\/a><\/div>  <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/satchidananda-panda\/\"><div><p>Satchidananda Panda, PhD<\/p><p><p>Professor<\/p>\n<p>Rita and Richard Atkinson Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> circadian rhythms and metabolism<\/p><p><strong>Disease models:<\/strong> colon, endometrial, breast and liver cancer<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Satchin_Panda_767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Satchin_Panda_767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Satchin_Panda_767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Satchin_Panda_767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Satchin_Panda_767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Satchin_Panda_767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Satchin_Panda_767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Satchin_Panda_767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Satchin_Panda_767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Satchin_Panda_767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Satchin_Panda_767-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Satchidananda Panda, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/gerald-shadel\/\"><div><p>Gerald Shadel, PhD<\/p><p><p>Professor<\/p>\n<p>Audrey Geisel Chair in Biomedical Science<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> role of mitochondria in disease, aging, and immune function<\/p><p><strong>Disease models:<\/strong> mitochondrial function in different cancers and neurodegenerative disorders<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Gerald-Shadel-767x767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Gerald Shadel\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Gerald-Shadel-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Gerald-Shadel-767x767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Gerald-Shadel-767x767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Gerald-Shadel-767x767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Gerald-Shadel-767x767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Gerald-Shadel-767x767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Gerald-Shadel-767x767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Gerald-Shadel-767x767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Gerald-Shadel-767x767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Gerald-Shadel-767x767-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Gerald Shadel, PhD<\/figcaption><\/figure><\/a><\/div> <\/p>\n<\/div><\/section>\n<hr \/>\n<h2>Program 2: Tumor Immunology, Metabolism &amp; Therapeutics<\/h2>\n<p>The goals of the Tumor Immunology, Metabolism &#038; Therapeutics (IMT) Program are three-fold: 1) to generate more synergy across labs working on the tumor microenvironment and studying how interactions between cancer cells, fibroblasts, immune cells, and broader metabolic networks work in concert to influence tumor progression, therapeutic responses, and the health of cancer patients, 2) to strengthen collaborations that were naturally forming between many labs in IMT and to stimulate new collaborations with members recently added, and 3) to build innovative solutions and therapeutic strategies to some of the most challenging problems facing cancer today in immuno-oncology, metabolism, metastasis, cachexia, and early detection and prevention. The goals of these studies are represented in the following broad Specific Aims:<\/p>\n<ol style=\"margin-left: 60px;\">\n<li>Dissect how immune cells, the tumor microenvironment, and physiology contribute to cancer progression and health outcomes<\/li>\n<li>Define and target the critical metabolic and signaling networks dysregulated in cancer<\/li>\n<li>Therapeutically target biochemical pathways that sustain tumor progression<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><strong>The program includes seventeen (17) members:<\/strong><\/p>\n<p><style>.faculty .entries a > div p{line-height: 14px !important;}<\/style><section class=\"faculty\"><div class=\"row entries\"><br \/>\n<div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/janelle-ayres\/\"><div><p>Janelle Ayres, PhD<\/p><p><p>Professor<\/p>\n<p>Salk Institute Legacy Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> inflammation and pathobionts in the gut microbiota<\/p><p><strong>Disease models:<\/strong> pathobionts, colorectal cancer<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Janelle-Ayres-767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Janelle-Ayres-767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Janelle-Ayres-767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Janelle-Ayres-767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Janelle-Ayres-767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Janelle-Ayres-767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Janelle-Ayres-767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Janelle-Ayres-767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Janelle-Ayres-767-750x750.jpg 750w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Janelle Ayres, PhD<br><span style='font-size:14px;'><strong>(Program Leader)<\/strong><\/span><\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/christian-metallo\/\"><div><p>Christian Metallo, PhD<\/p><p><p>Professor<\/p>\n<p>Daniel and Martina Lewis Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> systems-based modeling to study metabolic regulation\/flux in cells, tissues, and animals; stable isotope tracers<\/p><p><strong>Disease models:<\/strong> cancer metabolism, metabolic syndrome and obesity, stem cell biology<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/05\/Christian-Metallo-767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Christian Metallo\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/05\/Christian-Metallo-767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/05\/Christian-Metallo-767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/05\/Christian-Metallo-767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/05\/Christian-Metallo-767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/05\/Christian-Metallo-767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/05\/Christian-Metallo-767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/05\/Christian-Metallo-767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/05\/Christian-Metallo-767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/05\/Christian-Metallo-767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2021\/05\/Christian-Metallo-767-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Christian Metallo, PhD<br><span style='font-size:14px;'><strong>(Program Leader)<\/strong><\/span><\/figcaption><\/figure><\/a><\/div><br \/>\n<\/div><\/section><br \/>\n<style>.faculty .entries a > div p{line-height: 14px !important;}<\/style><section class=\"faculty\"><div class=\"row entries\"><br \/>\n<div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/dannielle-engle\/\"><div><p>Dannielle Engle, PhD<\/p><p><p>Assistant Professor<\/p>\n<p>Regulatory Biology Laboratory<\/p>\n<p>Helen McLoraine Developmental Chair in Neurobiology<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> organoid technology, glycosylation in cancer, early detection\/treatment, mouse models<\/p><p><strong>Disease models:<\/strong> pancreatic cancer, pancreatitis<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Dannielle-Engle767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Dannielle Engle\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Dannielle-Engle767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Dannielle-Engle767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Dannielle-Engle767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Dannielle-Engle767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Dannielle-Engle767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Dannielle-Engle767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Dannielle-Engle767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Dannielle-Engle767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Dannielle-Engle767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Dannielle-Engle767-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Dannielle Engle, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/ronald-evans\/\"><div><p>Ronald Evans, PhD<\/p><p><p>Professor and Director<\/p>\n<p>March of Dimes Chair in Molecular and Developmental Biology<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> nuclear receptor function in metabolism and cancer<\/p><p><strong>Disease models:<\/strong> pancreatic cancer, colon cancer, diabetes<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Salk-Ronald-Evans-thumbnail.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Ronald Evans\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Salk-Ronald-Evans-thumbnail.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Salk-Ronald-Evans-thumbnail-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Salk-Ronald-Evans-thumbnail-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Salk-Ronald-Evans-thumbnail-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Salk-Ronald-Evans-thumbnail-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Salk-Ronald-Evans-thumbnail-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Salk-Ronald-Evans-thumbnail-750x750.jpg 750w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Ronald Evans, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/daniel-hollern\/\"><div><p>Daniel Hollern, PhD<\/p><p><p>Assistant Professor<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> triple-negative breast cancer, immune cell dynamics, functional genomics<\/p><p><strong>Disease models:<\/strong> breast cancer<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Daniel Hollern\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767-600x600.jpg 600w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767-100x100.jpg 100w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/09\/Daniel-Hollern-767-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Daniel Hollern, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/tony-hunter\/\"><div><p>Tony Hunter, PhD<\/p><p><p>American Cancer Society Professor<\/p>\n<p>Renato Dulbecco Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> phosphorylation, ubiquitylation and sumoylation in cancer<\/p><p><strong>Disease models:<\/strong> cancer kinome, pancreatic cancer, glioblastoma, prostate cancer<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Hunter-Web.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Tony Hunter\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Hunter-Web.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Hunter-Web-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Hunter-Web-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Hunter-Web-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Hunter-Web-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Hunter-Web-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Hunter-Web-750x750.jpg 750w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Tony Hunter, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/gerald-joyce\/\"><div><p>Gerald Joyce, MD, PhD<\/p><p><p>President<\/p>\n<p>Professor<\/p>\n<p>Jack H. Skirball Center for Chemical Biology and Proteomics<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> RNA evolution, RNA biology<\/p><p><strong>Disease models:<\/strong> high throughput screening and development of small molecules and biologic therapeutics<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Gerald-Joyce-767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Gerald-Joyce-767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Gerald-Joyce-767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Gerald-Joyce-767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Gerald-Joyce-767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Gerald-Joyce-767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Gerald-Joyce-767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Gerald-Joyce-767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/01\/Gerald-Joyce-767-750x750.jpg 750w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Gerald Joyce, MD, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/susan-kaech\/\"><div><p>Susan Kaech, PhD<\/p><p><p>Professor<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> T cell function, tumor immunology<\/p><p><strong>Disease models:<\/strong> immune checkpoint inhibitors in model systems<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Susan_Kaech_767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Susan Kaech\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Susan_Kaech_767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Susan_Kaech_767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Susan_Kaech_767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Susan_Kaech_767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Susan_Kaech_767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Susan_Kaech_767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Susan_Kaech_767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Susan_Kaech_767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Susan_Kaech_767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/10\/Susan_Kaech_767-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Susan Kaech, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/joseph-noel\/\"><div><p>Joseph Noel, PhD<\/p><p><p>Professor and Director<\/p>\n<p>Arthur and Julie Woodrow Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> biosynthetic enzyme engineering<\/p><p><strong>Disease models:<\/strong> anti-cancer agents<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Noel-Joe_A2A9013c.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Noel-Joe_A2A9013c.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Noel-Joe_A2A9013c-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Noel-Joe_A2A9013c-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Noel-Joe_A2A9013c-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Noel-Joe_A2A9013c-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Noel-Joe_A2A9013c-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Noel-Joe_A2A9013c-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Noel-Joe_A2A9013c-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Noel-Joe_A2A9013c-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Noel-Joe_A2A9013c-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Joseph Noel, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/clodagh-oshea\/\"><div><p>Clodagh O&#8217;Shea, PhD<\/p><p><p>Professor<\/p>\n<p>Wicklow Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> oncolytic adenoviruses, adenovirus genome engineering and E4-ORF3 function<\/p><p><strong>Disease models:<\/strong> tumor-selective oncolytic viral therapy<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/OShea-Web.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/OShea-Web.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/OShea-Web-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/OShea-Web-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/OShea-Web-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/OShea-Web-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/OShea-Web-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/OShea-Web-750x750.jpg 750w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Clodagh O&#8217;Shea, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/talmo-pereira\/\"><div><p>Talmo Pereira, PhD<\/p><p><p>Salk Fellow<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> machine learning, animal behavior<\/p><p><strong>Disease models:<\/strong> motor control, single cell states throughout development and disease<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/05\/Talmo-Pereira-767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Talmo Pereira\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/05\/Talmo-Pereira-767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/05\/Talmo-Pereira-767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/05\/Talmo-Pereira-767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/05\/Talmo-Pereira-767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/05\/Talmo-Pereira-767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/05\/Talmo-Pereira-767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/05\/Talmo-Pereira-767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/05\/Talmo-Pereira-767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/05\/Talmo-Pereira-767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/05\/Talmo-Pereira-767-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Talmo Pereira, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/samuel-pfaff\/\"><div><p>Samuel Pfaff, PhD<\/p><p><p>Professor<\/p>\n<p>Benjamin H. Lewis Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> signaling principles that control specification\/connectivity of spinal neurons in locomotion<\/p><p><strong>Disease models:<\/strong> post-polio syndrome<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Pfaff-Web.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Pfaff-Web.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Pfaff-Web-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Pfaff-Web-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Pfaff-Web-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Pfaff-Web-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Pfaff-Web-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Pfaff-Web-750x750.jpg 750w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Samuel Pfaff, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/deepshika-ramanan\/\"><div><p>Deepshika Ramanan, PhD<\/p><p>Assistant Professor<\/p><p>NOMIS Center for Immunobiology and Microbial Pathogenesis<\/p><p><strong>Areas of interest:<\/strong> mammary-entero axis; host-microbe interactions; multigenerational immune transfer<\/p><p><strong>Disease models:<\/strong> human tissue samples, breast milk, mouse models<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/10\/Shika-767.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Deepshika Ramanan\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/10\/Shika-767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/10\/Shika-767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/10\/Shika-767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/10\/Shika-767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/10\/Shika-767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/10\/Shika-767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/10\/Shika-767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/10\/Shika-767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/10\/Shika-767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/10\/Shika-767-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Deepshika Ramanan, PhD<\/figcaption><\/figure><\/a><\/div><div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/alan-saghatelian\/\"><div><p>Alan Saghatelian, PhD<\/p><p><p>Professor<\/p>\n<p>Dr. Frederik Paulsen Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> mass spectrometry strategies for detection of metabolites and peptides <\/p><p><strong>Disease models:<\/strong> global lipid and peptide profiling of cancer (colon, lung cancer) and metabolic diseases<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Alan_Saghatelian_767x767lr.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Alan_Saghatelian_767x767lr.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Alan_Saghatelian_767x767lr-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Alan_Saghatelian_767x767lr-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Alan_Saghatelian_767x767lr-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Alan_Saghatelian_767x767lr-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Alan_Saghatelian_767x767lr-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Alan_Saghatelian_767x767lr-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Alan_Saghatelian_767x767lr-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Alan_Saghatelian_767x767lr-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Alan_Saghatelian_767x767lr-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Alan Saghatelian, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/reuben-shaw\/\"><div><p>Reuben Shaw, PhD<\/p><p><p>Professor<\/p>\n<p>William R. Brody Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> metabolic changes and vulnerabilities in cancer, autophagy, starvation signaling<\/p><p><strong>Disease models:<\/strong> lung cancer, pancreatic cancer, hamartoma syndromes<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Reuben-Shaw-2023-767x767-2.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Reuben-Shaw-2023-767x767-2.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Reuben-Shaw-2023-767x767-2-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Reuben-Shaw-2023-767x767-2-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Reuben-Shaw-2023-767x767-2-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Reuben-Shaw-2023-767x767-2-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Reuben-Shaw-2023-767x767-2-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Reuben-Shaw-2023-767x767-2-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Reuben-Shaw-2023-767x767-2-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Reuben-Shaw-2023-767x767-2-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/09\/Reuben-Shaw-2023-767x767-2-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Reuben Shaw, PhD<\/figcaption><\/figure><\/a><\/div> <!-- [faculty id=\"11819\" template=\"7\"] --> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/christina-towers\/\"><div><p>Christina Towers, PhD<\/p><p><p>Assistant Professor<\/p>\n<p>Richard Heyman and Anne Daigle Endowed Developmental Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> cellular homeostasis in cancer via canonical and non-canonical autophagy pathways pathways; mitophagy<\/p><p><strong>Disease models:<\/strong> cancer, neurodegeneration, infection<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/12\/Christina-Towers-767-1.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"Christina Towers\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/12\/Christina-Towers-767-1.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/12\/Christina-Towers-767-1-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/12\/Christina-Towers-767-1-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/12\/Christina-Towers-767-1-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/12\/Christina-Towers-767-1-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/12\/Christina-Towers-767-1-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/12\/Christina-Towers-767-1-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/12\/Christina-Towers-767-1-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/12\/Christina-Towers-767-1-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2020\/12\/Christina-Towers-767-1-200x200.jpg 200w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Christina Towers, PhD<\/figcaption><\/figure><\/a><\/div> <div class=\"col-xs-6 col-sm-4 col-md-3\"><div style=\"display:none;\">page link: <\/div><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/ye-zheng\/\"><div><p>Ye Zheng, PhD<\/p><p><p>Professor<\/p>\n<p>NOMIS Center for Immunobiology and Microbial Pathogenesis<\/p>\n<p>Becky and Ralph S. O'Connor Chair<\/p>\n<\/p><p><strong>Areas of interest:<\/strong> molecular mechanisms of regulatory and effector T cells function<\/p><p><strong>Disease models:<\/strong> autoimmune and metabolic diseases, tumors<\/p><\/div><figure><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Zheng-Web.jpg\" class=\"img-responsive center-block wp-post-image\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Zheng-Web.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Zheng-Web-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Zheng-Web-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Zheng-Web-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Zheng-Web-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Zheng-Web-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/10\/Zheng-Web-750x750.jpg 750w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><figcaption>Ye Zheng, PhD<\/figcaption><\/figure><\/a><\/div><\/p>\n<div class=\"col-xs-6 col-sm-4 col-md-3\"><\/div><\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<h3>The NCI Cancer Center is comprised of two programs:<\/h3>\n<h2>Program 1: Genome Stability, Epigenetics &amp; Aging in Cancer<\/h2>\n<p>The goals of Genome Stability, Epigenetics &#038; Aging in Cancer (GEA) Program are three-fold: 1) to advance cancer research by strengthening ties between Salk Cancer Center researchers studying genomic and epigenetic underpinnings of cancer, while building new points of contact and synergies with researchers studying aging, 2) to continue to foster new technology development and utilization toward understanding tumor heterogeneity (e.g., using spatial transcriptomics to characterize the tumor microenvironment), and 3) to strengthen the translational pipeline so that GEA basic science discoveries can be translated into clinical applications that improve patient outcomes. The goals of the GEA program are represented in the following broad Specific Aims:<\/p>","protected":false},"author":91,"featured_media":0,"parent":17510,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-no-margin.php","meta":{"_acf_changed":false,"footnotes":""},"folder":[551],"class_list":["post-17482","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research Programs - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/science\/research-centers\/salk-cancer-center\/research-programs\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Programs - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"The NCI Cancer Center is comprised of two programs: Program 1: Genome Stability, Epigenetics &amp; Aging in Cancer The goals of Genome Stability, Epigenetics &#038; Aging in Cancer (GEA) Program are three-fold: 1) to advance cancer research by strengthening ties between Salk Cancer Center researchers studying genomic and epigenetic underpinnings of cancer, while building new points of contact and synergies with researchers studying aging, 2) to continue to foster new technology development and utilization toward understanding tumor heterogeneity (e.g., using spatial transcriptomics to characterize the tumor microenvironment), and 3) to strengthen the translational pipeline so that GEA basic science discoveries can be translated into clinical applications that improve patient outcomes. The goals of the GEA program are represented in the following broad Specific Aims:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/zh\/science\/research-centers\/salk-cancer-center\/research-programs\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-15T17:27:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/science\\\/research-centers\\\/salk-cancer-center\\\/research-programs\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/science\\\/research-centers\\\/salk-cancer-center\\\/research-programs\\\/\",\"name\":\"Research Programs - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"datePublished\":\"2018-04-19T19:49:10+00:00\",\"dateModified\":\"2024-09-15T17:27:36+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/science\\\/research-centers\\\/salk-cancer-center\\\/research-programs\\\/#breadcrumb\"},\"inLanguage\":\"zh-CN\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/science\\\/research-centers\\\/salk-cancer-center\\\/research-programs\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/science\\\/research-centers\\\/salk-cancer-center\\\/research-programs\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Science\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/science\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Research Centers\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/science\\\/research-centers\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Salk&#8217;s Cancer Center\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/science\\\/research-centers\\\/salk-cancer-center\\\/\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Research Programs\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-CN\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-CN\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Research Programs - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/zh\/science\/research-centers\/salk-cancer-center\/research-programs\/","og_locale":"zh_CN","og_type":"article","og_title":"Research Programs - Salk Institute for Biological Studies","og_description":"The NCI Cancer Center is comprised of two programs: Program 1: Genome Stability, Epigenetics &amp; Aging in Cancer The goals of Genome Stability, Epigenetics &#038; Aging in Cancer (GEA) Program are three-fold: 1) to advance cancer research by strengthening ties between Salk Cancer Center researchers studying genomic and epigenetic underpinnings of cancer, while building new points of contact and synergies with researchers studying aging, 2) to continue to foster new technology development and utilization toward understanding tumor heterogeneity (e.g., using spatial transcriptomics to characterize the tumor microenvironment), and 3) to strengthen the translational pipeline so that GEA basic science discoveries can be translated into clinical applications that improve patient outcomes. 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