{"id":7338,"date":"2015-11-12T09:32:46","date_gmt":"2015-11-12T17:32:46","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=7338"},"modified":"2024-12-13T12:21:18","modified_gmt":"2024-12-13T20:21:18","slug":"experimental-drug-targeting-alzheimers-disease-shows-anti-aging-effects","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/experimental-drug-targeting-alzheimers-disease-shows-anti-aging-effects\/","title":{"rendered":"\u9776\u5411\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u65b0\u836f\u663e\u793a\u51fa\u6297\u8870\u8001\u529f\u6548"},"content":{"rendered":"

\u62c9\u970d\u4e9a\u2013\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u4e00\u79cd\u65e8\u5728\u5bf9\u6297\u7684\u5b9e\u9a8c\u836f\u7269\u5019\u9009\u7269 \u963f\u5c14\u8328\u6d77\u9ed8\u75c5<\/a> \u75be\u75c5\u5728\u52a8\u7269\u8eab\u4e0a\u5177\u6709\u4e00\u7cfb\u5217\u610f\u60f3\u4e0d\u5230\u7684\u6297\u8870\u8001\u4f5c\u7528\u3002.<\/p>\n

\u8428\u514b\u5c14\u56e2\u961f\u5728\u5176\u5148\u524d\u5f00\u53d1\u7684\u836f\u7269\u5019\u9009\u7269 J147 \u7684\u7814\u7a76\u57fa\u7840\u4e0a\u8fdb\u884c\u4e86\u6269\u5c55\uff0cJ147 \u91c7\u53d6\u4e86\u4e00\u79cd\u4e0d\u540c\u7684\u65b9\u6cd5\uff0c\u9776\u5411\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4e3b\u8981\u98ce\u9669\u56e0\u7d20\u2014\u2014\u8870\u8001\u3002\u5728\u65b0\u7814\u7a76\u4e2d\uff0c\u8be5\u56e2\u961f\u8868\u660e\u8be5\u836f\u7269\u5019\u9009\u7269\u5728\u4e00\u79cd\u901a\u5e38\u4e0d\u7528\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7814\u7a76\u7684\u5c0f\u9f20\u8870\u8001\u6a21\u578b\u4e2d\u6548\u679c\u826f\u597d\u3002\u5f53\u8fd9\u4e9b\u5c0f\u9f20\u63a5\u53d7 J147 \u6cbb\u7597\u65f6\uff0c\u5b83\u4eec\u7684\u8bb0\u5fc6\u529b\u548c\u8ba4\u77e5\u80fd\u529b\u5f97\u5230\u6539\u5584\uff0c\u5927\u8111\u8840\u7ba1\u66f4\u5065\u5eb7\uff0c\u4ee5\u53ca\u5176\u4ed6\u751f\u7406\u7279\u5f81\u4e5f\u5f97\u5230\u6539\u5584\uff0c\u5177\u4f53\u7ec6\u8282\u4e8e 2015 \u5e74 11 \u6708 12 \u65e5\u53d1\u8868\u5728\u8be5\u671f\u520a\u4e0a\u3002 \u8001\u9f84\u5316<\/a><\/em>.<\/p>\n

\u201c\u6700\u521d\u7684\u52a8\u529b\u662f\u60f3\u5728\u4e00\u4e2a\u65b0\u9896\u7684\u52a8\u7269\u6a21\u578b\u4e2d\u6d4b\u8bd5\u8fd9\u79cd\u836f\u7269\uff0c\u8be5\u6a21\u578b\u4e0e99%\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u75c5\u4f8b\u66f4\u4e3a\u76f8\u4f3c\uff0c\u201d\u9996\u5e2d\u4f5c\u8005\u3001\u6559\u6388\u7684\u6210\u5458Antonio Currais\u8bf4\u3002 \u5927\u536b\u00b7\u8212\u4f2f\u7279\u7684<\/a> \u7ec6\u80de\u795e\u7ecf\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4<\/a> \u5728\u7d22\u5c14\u514b\u7814\u7a76\u6240\u3002\u201c\u6211\u4eec\u6ca1\u6709\u9884\u6599\u5230\u4f1a\u770b\u5230\u8fd9\u79cd\u6297\u8870\u8001\u6548\u679c\uff0c\u4f46\u6839\u636e\u8bb8\u591a\u751f\u7406\u6307\u6807\uff0cJ147 \u4f7f\u5e74\u957f\u7684\u8001\u9f20\u770b\u8d77\u6765\u50cf\u5e74\u8f7b\u7684\u3002\u201d<\/p>\n

\"Antonio
\u5b89\u4e1c\u5c3c\u5965\u00b7\u5e93\u62c9\u4f0a\u65af\u548c\u5927\u536b\u00b7\u8212\u4f2f\u7279
\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.
\u56fe\u7247\uff1a\u7531\u8428\u514b\u751f\u7269\u7814\u7a76\u6240\u63d0\u4f9b<\/figcaption><\/figure>\n

\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u662f\u4e00\u79cd\u8fdb\u884c\u6027\u8111\u90e8\u75be\u75c5\uff0c\u6700\u8fd1\u5728\u7f8e\u56fd\u5df2\u6210\u4e3a\u7b2c\u4e09\u5927\u6b7b\u4ea1\u539f\u56e0\uff0c\u5f71\u54cd\u7740\u4e94\u767e\u591a\u4e07\u7f8e\u56fd\u4eba\u3002\u636e \u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662<\/a>. \u5c3d\u7ba1\u8fc7\u53bb 20 \u5e74\u5f00\u53d1\u7684\u5927\u591a\u6570\u836f\u7269\u90fd\u4ee5\u5927\u8111\u4e2d\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u6c89\u79ef\uff08\u8fd9\u662f\u8be5\u75be\u75c5\u7684\u4e00\u4e2a\u6807\u5fd7\uff09\u4e3a\u76ee\u6807\uff0c\u4f46\u5f88\u5c11\u6709\u836f\u7269\u5728\u4e34\u5e8a\u4e0a\u88ab\u8bc1\u660e\u6709\u6548\u3002.<\/p>\n

\u201c\u5c3d\u7ba1\u8fc7\u53bb20\u5e74\u5f00\u53d1\u7684\u5927\u591a\u6570\u836f\u7269\u90fd\u4ee5\u5927\u8111\u4e2d\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u6c89\u79ef\u4e3a\u76ee\u6807\uff08\u8fd9\u662f\u8be5\u75be\u75c5\u7684\u4e00\u4e2a\u6807\u5fd7\uff09\uff0c\u4f46\u6ca1\u6709\u4e00\u79cd\u5728\u4e34\u5e8a\u4e0a\u88ab\u8bc1\u660e\u6709\u6548\uff0c\u201d\u8be5\u7814\u7a76\u7684\u8d44\u6df1\u4f5c\u8005Schubert\u8bf4\u3002.<\/p>\n

\u51e0\u5e74\u524d\uff0c\u8212\u4f2f\u7279\u548c\u4ed6\u7684\u540c\u4e8b\u4eec\u5f00\u59cb\u4ece\u4e00\u4e2a\u65b0\u7684\u89d2\u5ea6\u7740\u624b\u6cbb\u7597\u8fd9\u79cd\u75be\u75c5\u3002\u4e0e\u5176\u9488\u5bf9\u6dc0\u7c89\u6837\u86cb\u767d\uff0c\u8be5\u5b9e\u9a8c\u5ba4\u51b3\u5b9a\u5c06\u91cd\u70b9\u653e\u5728\u8be5\u75be\u75c5\u7684\u4e3b\u8981\u98ce\u9669\u56e0\u7d20\u2014\u2014\u8870\u8001\u4e0a\u3002\u4ed6\u4eec\u5229\u7528\u9488\u5bf9\u4e0e\u8870\u8001\u76f8\u5173\u7684\u8111\u6bd2\u6027\u8fdb\u884c\u7684\u7ec6\u80de\u7b5b\u9009\uff0c\u5408\u6210\u4e86 J147\u3002.<\/p>\n

\u6b64\u524d\uff0c\u8be5\u56e2\u961f\u53d1\u73b0 J147 \u80fd\u591f\u963b\u6b62\u751a\u81f3\u9006\u8f6c\u60a3\u6709\u9057\u4f20\u6027\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08\u6700\u5e38\u7528\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5c0f\u9f20\u6a21\u578b\uff09\u7684\u5c0f\u9f20\u7684\u8bb0\u5fc6\u4e27\u5931\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u75c5\u7406\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u5f62\u5f0f\u7684\u75be\u75c5\u4ec5\u5360\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u75c5\u4f8b\u7684\u7ea6 1%\u3002\u8212\u4f2f\u7279\u8bf4\uff0c\u5bf9\u4e8e\u5176\u4ed6\u4eba\u6765\u8bf4\uff0c\u5e74\u8001\u662f\u4e3b\u8981\u7684\u98ce\u9669\u56e0\u7d20\u3002\u8be5\u56e2\u961f\u5e0c\u671b\u63a2\u8ba8\u8be5\u5019\u9009\u836f\u7269\u5bf9\u4e00\u79cd\u5feb\u901f\u8870\u8001\u5e76\u7ecf\u5386\u66f4\u63a5\u8fd1\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u7c7b\u4eba\u969c\u788d\u7684\u5c0f\u9f20\u54c1\u79cd\u7684\u5f71\u54cd\u3002.<\/p>\n

\u5728\u8fd9\u9879\u6700\u65b0\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86\u4e00\u6574\u5957\u7efc\u5408\u6027\u68c0\u6d4b\u65b9\u6cd5\uff0c\u6765\u6d4b\u91cf\u4e09\u7ec4\u52a0\u901f\u8870\u8001\u5c0f\u9f20\u5927\u8111\u4e2d\u6240\u6709\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u4ee5\u53ca\u5927\u8111\u548c\u8840\u6db2\u4e2d\u7684 500 \u591a\u79cd\u53c2\u4e0e\u4ee3\u8c22\u7684\u5c0f\u5206\u5b50\u3002\u8fd9\u4e09\u7ec4\u52a0\u901f\u8870\u8001\u7684\u5c0f\u9f20\u5305\u62ec\u4e00\u7ec4\u5e74\u8f7b\u7684\u3001\u4e00\u7ec4\u5e74\u8001\u7684\uff0c\u4ee5\u53ca\u4e00\u7ec4\u5e74\u8001\u4f46\u968f\u7740\u8870\u8001\u8fc7\u7a0b\u5582\u98df\u4e86 J147 \u7684\u5c0f\u9f20\u3002.<\/p>\n

\u63a5\u53d7J147\u6cbb\u7597\u7684\u8001\u5e74\u5c0f\u9f20\u5728\u8bb0\u5fc6\u548c\u5176\u4ed6\u8ba4\u77e5\u6d4b\u8bd5\u4e2d\u8868\u73b0\u66f4\u597d\uff0c\u5e76\u4e14\u8fd0\u52a8\u80fd\u529b\u4e5f\u66f4\u5f3a\u3002\u63a5\u53d7J147\u6cbb\u7597\u7684\u5c0f\u9f20\u5927\u8111\u4e2d\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u75c5\u7406\u8ff9\u8c61\u4e5f\u66f4\u5c11\u3002\u91cd\u8981\u7684\u662f\uff0c\u7531\u4e8e\u6536\u96c6\u4e86\u4e09\u4e2a\u5c0f\u9f20\u7ec4\u7684\u5927\u91cf\u6570\u636e\uff0c\u56e0\u6b64\u53ef\u4ee5\u8bc1\u660e\uff0c\u63a5\u53d7J147\u5582\u517b\u7684\u8001\u5e74\u5c0f\u9f20\u5728\u57fa\u56e0\u8868\u8fbe\u548c\u65b0\u9648\u4ee3\u8c22\u7684\u8bb8\u591a\u65b9\u9762\u4e0e\u5e74\u8f7b\u52a8\u7269\u975e\u5e38\u76f8\u4f3c\u3002\u8fd9\u5305\u62ec\u4fc3\u8fdb\u80fd\u91cf\u4ee3\u8c22\u3001\u51cf\u8f7b\u5927\u8111\u708e\u75c7\u4ee5\u53ca\u964d\u4f4e\u5927\u8111\u4e2d\u6c27\u5316\u8102\u80aa\u9178\u6c34\u5e73\u7684\u6807\u8bb0\u7269\u3002.<\/p>\n

\u53e6\u4e00\u4e2a\u663e\u8457\u6548\u679c\u662f J147 \u963b\u6b62\u4e86\u8001\u5e74\u5c0f\u9f20\u5927\u8111\u5fae\u8840\u7ba1\u7684\u8840\u6db2\u6cc4\u6f0f\u3002\u201c\u53d7\u635f\u7684\u8840\u7ba1\u662f\u8870\u8001\u7684\u4e00\u4e2a\u666e\u904d\u7279\u5f81\uff0c\u800c\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e2d\uff0c\u8fd9\u79cd\u60c5\u51b5\u901a\u5e38\u4f1a\u66f4\u7cdf\uff0c\u201dCurrais \u8bf4\u3002.<\/p>\n

Currais\u548cSchubert\u6307\u51fa\uff0c\u5c3d\u7ba1\u8fd9\u4e9b\u7814\u7a76\u4ee3\u8868\u4e86\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u836f\u7269\u53d1\u73b0\u548c\u8870\u8001\u80cc\u666f\u4e0b\u52a8\u7269\u6d4b\u8bd5\u7684\u4e00\u79cd\u4ee4\u4eba\u5174\u594b\u7684\u65b0\u65b9\u6cd5\uff0c\u4f46\u8981\u8bc1\u660e\u8fd9\u9879\u5de5\u4f5c\u7684\u4e34\u5e8a\u76f8\u5173\u6027\uff0c\u552f\u4e00\u7684\u65b9\u6cd5\u662f\u5c06J147\u63a8\u8fdb\u5230\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u3002.<\/p>\n

\u201c\u5982\u679c J147 \u88ab\u8bc1\u660e\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5b89\u5168\u6709\u6548\uff0c\u5176\u660e\u663e\u7684\u6297\u8870\u8001\u6548\u679c\u5c06\u662f\u4e00\u4e2a\u53d7\u6b22\u8fce\u7684\u597d\u5904\uff0c\u201d\u8212\u4f2f\u7279\u8865\u5145\u9053\u3002\u8be5\u56e2\u961f\u8ba1\u5212\u660e\u5e74\u5f00\u59cb\u4eba\u4f53\u8bd5\u9a8c\u3002.<\/p>\n

\u8be5\u8bba\u6587\u7684\u5176\u4ed6\u4f5c\u8005\u5305\u62ec\u6765\u81ea\u5965\u65af\u74e6\u5c14\u5fb7\u00b7\u594e\u4ea8\u8d1d\u683c\u7684 \u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821<\/a>; \u4ee5\u53ca\u6765\u81ea\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u7ea6\u4e66\u4e9a\u00b7\u6208\u5fb7\u5821\u3001\u51ef\u745f\u7433\u00b7\u6cd5\u7f57\u5e0c\u3001\u9a6c\u514b\u65af\u00b7\u5f20\u3001\u739b\u683c\u4e3d\u7279\u00b7\u666e\u8d56\u5c14\u3001\u7406\u67e5\u5fb7\u00b7\u8fbe\u53e4\u4ec0\u3001\u4e39\u5c3c\u5c14\u00b7\u591a\u5c14\u8482\u548c\u5e15\u6885\u62c9\u00b7\u9a6c\u8d6b\u3002.<\/p>\n

\u672c\u7814\u7a76\u5f97\u5230\u4e86Salk\u7814\u7a76\u6240Pioneer\u57fa\u91d1\u535a\u58eb\u540e\u5956\u5b66\u91d1\u548cSalk Nomis\u7814\u7a76\u5458\u5956\u5b66\u91d1\u3001Hewitt\u57fa\u91d1\u4f1a\u548cBundy\u57fa\u91d1\u4f1a\u7684\u5956\u5b66\u91d1\uff0c\u4ee5\u53caBurns\u57fa\u91d1\u4f1a\u548cNIH\u7684\u8d44\u52a9\u3002.<\/p>\n

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