{"id":56750,"date":"2026-05-07T10:05:55","date_gmt":"2026-05-07T17:05:55","guid":{"rendered":"https:\/\/www.salk.edu\/?post_type=disclosure&#038;p=56750"},"modified":"2026-05-07T10:06:55","modified_gmt":"2026-05-07T17:06:55","slug":"ian-guldner-joins-salk-institute-to-advance-foundational-research-on-brain-aging-and-alzheimers-disease","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/ian-guldner-joins-salk-institute-to-advance-foundational-research-on-brain-aging-and-alzheimers-disease\/","title":{"rendered":"Ian Guldner joins Salk Institute to advance foundational research  on brain aging and Alzheimer\u2019s disease"},"content":{"rendered":"<ul style=\"margin-bottom: 30px;\">\n<li style=\"list-style: none; padding-left: -20px !important; margin-left: -20px !important;\"><strong>Highlights<\/strong><\/li>\n<li>Salk has recruited Ian Guldner as a new assistant professor, bringing fresh momentum to foundational research on Alzheimer\u2019s disease and related dementias<\/li>\n<li>Guldner\u2019s lab will identify cellular communication mechanisms that regulate brain aging and disease, and target those interactions to preserve brain health<\/li>\n<li>His recruitment was enabled by a gift from the Ray and Dagmar Dolby Family Fund and will create new opportunities for collaboration across Salk in neurodegeneration, immunobiology, and aging<\/li>\n<\/ul>\n<p>LA JOLLA\u2014The Salk Institute has recruited Ian Guldner, PhD, as a new assistant professor with foundational research expertise in brain aging and Alzheimer\u2019s disease. Guldner\u2019s goal is to identify cellular communication mechanisms that regulate brain aging and disease, and target those interactions to preserve brain health. He will launch his new lab at Salk in late 2026.<\/p>\n<figure id=\"attachment_56751\"  class=\"wp-caption alignright\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"327\" class=\"img-responsive wp-image-56751 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner-458x327.jpg\" alt=\"Neurodegenerative disease researcher Ian Guldner, PhD, joins the Salk Institute.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner-458x327.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner-300x214.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner-768x548.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner-18x12.jpg 18w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner-147x105.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner-585x418.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner-553x395.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner-750x535.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner-767x548.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/05\/260507-pr-guldner.jpg 818w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">Neurodegenerative disease researcher Ian Guldner, PhD, joins the Salk Institute.<br \/>Credit: Luci Valentine Photography<\/figcaption><\/figure>\n<p>This faculty recruitment was made possible by a donation from the Ray and Dagmar Dolby Family Fund, led by David Dolby, Salk Trustee and CEO of Dolby Family Ventures.<\/p>\n<p>\u201cAt Salk, we believe the most meaningful advances in medicine begin with fundamental questions about how life works,\u201d says Salk President <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/gerald-joyce\/\" target=\"_blank\" rel=\"noopener\">\u6770\u62c9\u5c14\u5fb7\u00b7\u4e54\u4f0a\u65af<\/a>. \u201cWe are grateful to David Dolby and the Dolby Family Fund for sharing this belief and for enabling Ian to join our collaborative community, bringing an inventive approach to understanding how our brains change as we age. By revealing the earliest cellular shifts that precede disease, his work will help build the scientific foundation for future strategies to protect cognitive health.\u201d<\/p>\n<p>Guldner\u2019s research centers on proteostasis, the cellular processes that build, fold, recycle, and dispose of proteins. These processes are essential for keeping neurons healthy over decades. His lab will also investigate immune surveillance in the brain, including how microglia, the brain\u2019s resident immune cells, interact with neurons and respond to age-related molecular stress.<\/p>\n<p>Earlier this year, Guldner published a first-author <a href=\"https:\/\/www.nature.com\/articles\/s41586-025-09987-9\">study in <em>\u81ea\u7136<\/em><\/a> describing how aging promotes the accumulation of certain neuron-derived synaptic proteins inside microglia. These findings point to a new way to think about how proteins move between brain cells over time, and how that exchange may intersect with cognitive decline and neurodegeneration. In addition to his work on brain aging, he has published research examining how immune responses shape cancer brain metastases, giving him a broad perspective on how the immune system influences brain health across diseases.<\/p>\n<p>\u201cSalk is a place where big, fundamental questions are taken seriously, and where collaboration is part of the daily rhythm,\u201d says Guldner. \u201cI\u2019m excited to join a community that values curiosity and creativity, and to work with colleagues across the Institute to understand how brain cells change with age and what that means for Alzheimer\u2019s disease and related disorders.\u201d<\/p>\n<p>At Salk, Guldner\u2019s research program will open new opportunities for collaboration across the Institute, including with scientists studying neurodegeneration, immunobiology, cancer, and the cellular mechanisms of aging. By developing and applying new tools to track protein dynamics and cell-to-cell communication in the brain, his lab aims to uncover the systems that regulate brain aging and disease and to target these interactions to preserve brain health.<\/p>\n<p>\u201cThe complexity of Alzheimer\u2019s disease and related dementias requires new tools that let scientists see biology with greater precision,\u201d Dolby says. \u201cWe need even more early-stage research to discover the next generation of therapies. My family and I are proud to support Salk\u2019s foundational approach to discovery, and to help make it possible to recruit Ian Guldner to the faculty, accelerating the kind of work that can ultimately improve lives.\u201d<\/p>\n<p>Guldner earned his BS in biology at Moravian College and his PhD in biology from the University of Notre Dame, and then completed his postdoctoral studies at Stanford University. In 2024, he was awarded a K99\/R00 Pathway to Independence Award from the National Institute on Aging, part of the National Institutes of Health.<\/p>","protected":false},"featured_media":56754,"template":"","faculty":[],"disease-research":[],"class_list":["post-56750","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ian Guldner joins Salk Institute to advance foundational research on brain aging and Alzheimer\u2019s disease - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/ian-guldner-joins-salk-institute-to-advance-foundational-research-on-brain-aging-and-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ian Guldner joins Salk Institute to advance foundational research on brain aging and Alzheimer\u2019s disease - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"Highlights Salk has recruited Ian Guldner as a new assistant professor, bringing fresh momentum to foundational research on Alzheimer\u2019s disease and related dementias Guldner\u2019s lab will identify cellular communication mechanisms that regulate brain aging and disease, and target those interactions to preserve brain health His recruitment was enabled by a gift from the Ray and Dagmar Dolby Family Fund and will create new opportunities for collaboration across Salk in neurodegeneration, immunobiology, and aging LA JOLLA\u2014The Salk Institute has recruited Ian Guldner, PhD, as a new assistant professor with foundational research expertise in brain aging and Alzheimer\u2019s disease. Guldner\u2019s goal is to identify cellular communication mechanisms that regulate brain aging and disease, and target those interactions to preserve brain health. 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