{"id":54387,"date":"2025-08-29T13:18:29","date_gmt":"2025-08-29T20:18:29","guid":{"rendered":"https:\/\/www.salk.edu\/?post_type=disclosure&#038;p=54387"},"modified":"2025-08-29T14:11:18","modified_gmt":"2025-08-29T21:11:18","slug":"leveraging-microproteins-to-treat-obesity-aging-and-mitochondrial-disorders","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/leveraging-microproteins-to-treat-obesity-aging-and-mitochondrial-disorders\/","title":{"rendered":"\u5229\u7528\u5fae\u91cf\u86cb\u767d\u6cbb\u7597\u80a5\u80d6\u3001\u8870\u8001\u548c\u7ebf\u7c92\u4f53\u75be\u75c5"},"content":{"rendered":"<p>\u62c9\u970d\u4e9a\u2014\u2014\u6b63\u5982\u871c\u8702\u901a\u8fc7\u6388\u7c89\u548c\u4f7f\u82b1\u6735\u7efd\u653e\u6765\u7ed9\u4e88\u82b1\u56ed\u751f\u547d\u4e00\u6837\uff0c\u4e00\u79cd\u540d\u4e3a\u7ebf\u7c92\u4f53\u7684\u5c0f\u578b\u7ec6\u80de\u673a\u5668\u4e5f\u8d4b\u4e88\u6211\u4eec\u7684\u8eab\u4f53\u751f\u547d\uff0c\u5b83\u4eec\u55e1\u55e1\u4f5c\u54cd\u5730\u4ea7\u751f\u80fd\u91cf\uff0c\u4e3a\u6211\u4eec\u7ec6\u80de\u7684\u6bcf\u4e00\u9879\u529f\u80fd\u63d0\u4f9b\u52a8\u529b\u3002\u7ef4\u6301\u7ebf\u7c92\u4f53\u4ee3\u8c22\u9700\u8981\u8bb8\u591a\u5206\u5b50\u548c\u86cb\u767d\u8d28\u7684\u53c2\u4e0e\u2014\u2014\u5176\u4e2d\u4e00\u4e9b\u4ecd\u6709\u5f85\u53d1\u73b0\u3002.<\/p>\n<figure id=\"attachment_54400\"  class=\"wp-caption alignright\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"344\" class=\"img-responsive wp-image-54400 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b-458x344.jpg\" alt=\"From left: Alan Saghatelian and Andr\u00e9a Rocha.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b-458x344.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b-300x225.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b-1024x768.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b-768x576.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b-147x110.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b-585x439.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b-553x415.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b-750x563.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b-767x575.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b-945x709.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b.jpg 1500w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">\u4ece\u5de6\u8d77\uff1aAlan Saghatelian \u548c Andr\u00e9a Rocha\u3002.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-authors-b.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<br \/>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u6b63\u5728\u4ed4\u7ec6\u7814\u7a76\u7ebf\u7c92\u4f53\u662f\u5426\u4f9d\u8d56\u5fae\u86cb\u767d\u2014\u2014\u8fd9\u4e9b\u5fae\u86cb\u767d\u5f88\u5c0f\uff0c\u96be\u4ee5\u53d1\u73b0\uff0c\u56e0\u6b64\u5b83\u4eec\u5728\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u88ab\u4f4e\u4f30\u4e86\u3002\u5728\u4ed6\u4eec\u7684\u65b0\u7814\u7a76\u4e2d\uff0c\u53bb\u5e74\u5728\u7d22\u5c14\u514b\u65b0\u53d1\u73b0\u7684\u4e00\u79cd\u540d\u4e3a SLC35A4-MP \u7684\u5fae\u86cb\u767d\uff0c\u88ab\u53d1\u73b0\u5bf9\u7ef4\u6301\u7ebf\u7c92\u4f53\u7ed3\u6784\u548c\u8c03\u8282\u5c0f\u9f20\u8102\u80aa\u7ec6\u80de\u7684\u4ee3\u8c22\u5e94\u6fc0\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u672a\u6765\u57fa\u4e8e\u5fae\u86cb\u767d\u7684\u6cbb\u7597\u80a5\u80d6\u3001\u8870\u8001\u548c\u5176\u4ed6\u7ebf\u7c92\u4f53\u75be\u75c5\u7684\u7814\u7a76\u57cb\u4e0b\u4e86\u4f0f\u7b14\u3002.<\/p>\n<p>\u8be5\u7814\u7a76\u53d1\u8868\u5728 <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.ads7381\" target=\"_blank\" rel=\"noopener\"><em>\u79d1\u5b66\u8fdb\u5c55<\/em><\/a> 2025\u5e748\u670829\u65e5\uff0c\u662f\u2026\u2026\u7684\u4e00\u90e8\u5206 <a href=\"https:\/\/www.salk.edu\/zh\/news-release\/new-ai-tool-illuminates-dark-side-of-the-human-genome\/\" target=\"_blank\" rel=\"noopener\">\u8fd1\u671f\u4e00\u7cfb\u5217\u7684\u53d1\u73b0<\/a> \u5728\u8428\u5c14\u514b\u7814\u7a76\u6240\uff0c\u8fd9\u9879\u7814\u7a76\u5c55\u793a\u4e86\u5fae\u86cb\u767d\u5728\u7ec6\u80de\u751f\u7269\u5b66\u4e2d\u7684\u529f\u80fd\u91cd\u8981\u6027\uff0c, <a href=\"https:\/\/www.salk.edu\/zh\/news-release\/finding-microproteins-to-treat-obesity-and-metabolic-disorders\/\" target=\"_blank\" rel=\"noopener\">\u65b0\u9648\u4ee3\u8c22<\/a>, \uff0c\u4ee5\u53ca\u538b\u529b\u3002.<\/p>\n<p>\u201c\u5fae\u86cb\u767d\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u88ab\u8ba4\u4e3a\u662f\u968f\u673a\u7684\u57fa\u56e0\u5783\u573e\uff0c\u4f46\u6211\u4eec\u7684\u5de5\u4f5c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u8bb8\u591a\u5fae\u86cb\u767d\u5b9e\u9645\u4e0a\u662f\u7ec6\u80de\u751f\u7406\u5b66\u7684\u5173\u952e\u8c03\u8282\u56e0\u5b50\uff0c\u201d\u8d44\u6df1\u4f5c\u8005\u8bf4 <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/alan-saghatelian\/\" target=\"_blank\" rel=\"noopener\">\u827e\u4f26\u00b7\u8428\u52a0\u7279\u5229\u5b89<\/a>, \u201c\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u63ed\u793a\u4e86\u4e00\u79cd\u5fae\u86cb\u767d\u8d1f\u8d23\u7ef4\u6301\u68d5\u8272\u8102\u80aa\u7ec4\u7ec7\u4e2d\u7684\u7ebf\u7c92\u4f53\u7ed3\u6784\u548c\u529f\u80fd\uff0c\u800c\u68d5\u8272\u8102\u80aa\u7ec4\u7ec7\u5219\u8c03\u8282\u4f53\u6e29\u548c\u80fd\u91cf\u5e73\u8861\u3002\u201d<\/p>\n<p>2024\u5e74\u665a\u6625\uff0cSaghatelian\u7684\u5b9e\u9a8c\u5ba4\u53d1\u73b0\u4e86\u2026\u2026\u7684\u57fa\u56e0\u5bc6\u7801 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38580077\/\" target=\"_blank\" rel=\"noopener\">SLC35A4-MP<\/a> \u9690\u85cf\u5728\u4fe1\u4f7fRNA\uff08mRNA\uff09\u94fe\u4e0a\u7684\u4e0a\u6e38\u5f00\u653e\u9605\u8bfb\u6846\u4e2d\u3002\u957f\u671f\u4ee5\u6765\u7684\u4fe1\u5ff5\u662f\uff0c\u6bcf\u6761mRNA\u94fe\u53ea\u7f16\u7801\u4e00\u79cd\u86cb\u767d\u8d28\u2014\u2014mRNA\u4e0e\u86cb\u767d\u8d28\u4e4b\u95f4\u603b\u662f\u4fdd\u6301\u4e00\u5bf9\u4e00\u7684\u6bd4\u4f8b\u3002\u56e0\u6b64\uff0c\u5f53\u79d1\u5b66\u5bb6\u4eec\u5728mRNA\u94fe\u4e0a\u53d1\u73b0\u989d\u5916\u7684\u9057\u4f20\u7269\u8d28\u2014\u2014\u4e0a\u6e38\u5f00\u653e\u9605\u8bfb\u6846\u2014\u2014\u65f6\uff0c\u4ed6\u4eec\u8ba4\u4e3a\u8fd9\u4e9b\u8981\u4e48\u662f 1) \u968f\u673a\u7684\u975e\u7f16\u7801\u5783\u573e\uff0c\u8981\u4e48\u662f 2) \u5f71\u54cd\u8be5mRNA\u7ffb\u8bd1\u7684\u8c03\u63a7\u4ee3\u7801\u3002.<\/p>\n<figure id=\"attachment_54389\"  class=\"wp-caption alignleft\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" class=\"img-responsive wp-image-54389 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-300x300.jpg\" alt=\"Mitochondria in the fat tissue of mice unable to produce SLC35A4-MP, causing the mitochondria to be structurally compromised and dysfunctional.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-1024x1024.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-768x768.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1-945x945.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1.jpg 1500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption class=\"wp-caption-text\">\u65e0\u6cd5\u4ea7\u751fSLC35A4-MP\u7684\u5c0f\u9f20\u8102\u80aa\u7ec4\u7ec7\u4e2d\u7684\u7ebf\u7c92\u4f53\uff0c\u5bfc\u81f4\u7ebf\u7c92\u4f53\u7ed3\u6784\u53d7\u635f\u4e14\u529f\u80fd\u969c\u788d\u3002.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-1.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<br \/>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u4f46\u968f\u7740\u57fa\u56e0\u63a2\u9488\u548c\u6d4b\u5e8f\u6280\u672f\u7684\u65e5\u76ca\u6210\u719f\uff0c\u7814\u7a76\u4eba\u5458\u5f88\u5feb\u610f\u8bc6\u5230\uff0c\u5176\u4e2d\u4e00\u4e9b\u4e0a\u6e38\u5f00\u653e\u9605\u8bfb\u6846\u7f16\u7801\u4e86\u529f\u80fd\u6027\u7684\u5fae\u86cb\u767d\u3002\u8fd9\u4e00\u53d1\u73b0\u4e3a\u7ec6\u80de\u751f\u547d\u5e26\u6765\u4e86\u5168\u65b0\u7684\u7ef4\u5ea6\uff0c\u56e0\u4e3a\u957f\u671f\u9690\u85cf\u5728\u88ab\u5ffd\u89c6\u7684\u4e0a\u6e38\u5f00\u653e\u9605\u8bfb\u6846\u4e2d\u7684\u5fae\u86cb\u767d\u73b0\u5728\u5df2\u7ecf\u5927\u653e\u5f02\u5f69\u2014\u2014\u968f\u65f6\u53ef\u4ee5\u88ab\u91c7\u6458\u548c\u7814\u7a76\u3002.<\/p>\n<p>\u6700\u65e9\u88ab\u63cf\u8ff0\u7684\u4e00\u4e9b\u529f\u80fd\u6027\u5fae\u86cb\u767d\u4e0e\u4ee3\u8c22\u548c\u7ebf\u7c92\u4f53\u8c03\u63a7\u6709\u5173\u3002\u8fd9\u5305\u62ec Saghatelian \u5728 2024 \u5e74\u7684\u4e00\u9879\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u4e2d\u7684\u5b9e\u9a8c\u5ba4\u9996\u6b21\u5728\u7ebf\u7c92\u4f53\u58c1\u4e2d\u53d1\u73b0\u4e86 SLC35A4-MP\u3002\u8fdb\u4e00\u6b65\u7684\u6d4b\u8bd5\u8868\u660e\uff0c\u8fd9\u79cd\u5fae\u86cb\u767d\u53ef\u80fd\u6709\u52a9\u4e8e\u7ef4\u6301\u5065\u5eb7\u7684\u7ec6\u80de\u4ee3\u8c22\u3002.<\/p>\n<p>\u4f46\u8fd9\u4e9b\u53d1\u73b0\u662f\u57fa\u4e8e\u5728\u8bd5\u7ba1\u548c\u57f9\u517b\u76bf\u7ec6\u80de\u4e2d\u8fdb\u884c\u7684\u751f\u7269\u5316\u5b66\u6d4b\u5b9a\u6536\u96c6\u7684\u6570\u636e\u3002\u8981\u5168\u9762\u8bc1\u5b9e\u548c\u63cf\u8ff0 SLC35A4-MP \u7684\u751f\u7406\u4f5c\u7528\uff0c\u8fd8\u9700\u8981\u5728\u6d3b\u4f53\u7cfb\u7edf\u4e2d\u6d4b\u8bd5\u5176\u529f\u80fd\u3002.<\/p>\n<p>\u201cSLC35A4-MP\u662f\u9996\u6279\u5728\u5c0f\u9f20\u4e2d\u529f\u80fd\u5f97\u5230\u8868\u5f81\u7684\u5fae\u86cb\u767d\u4e4b\u4e00\uff0c\u201d\u6587\u7ae0\u7b2c\u4e00\u4f5c\u8005\u3001Saghatelian\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u540e\u7814\u7a76\u5458Andr\u00e9a Rocha\u8bf4\u3002\u201c\u4e8b\u5b9e\u4e0a\uff0c\u6211\u4eec\u53d1\u73b0SLC35A4-MP\u5728\u5c0f\u9f20\u4e2d\u8c03\u8282\u7ebf\u7c92\u4f53\u529f\u80fd\u548c\u8102\u8d28\u4ee3\u8c22\uff0c\u8fd9\u786e\u5b9e\u8868\u660e\uff0c\u5728\u6211\u4eec\u5bfb\u627e\u8c03\u8282\u5065\u5eb7\u7684\u751f\u7269\u5b66\u56e0\u7d20\u65f6\uff0c\u4e0d\u80fd\u5ffd\u89c6\u5fae\u86cb\u767d\u3002\u201d<\/p>\n<p>\u4e3a\u4e86\u5bf9SLC35A4-MP\u8fdb\u884c\u5206\u7c7b\uff0c\u7814\u7a76\u4eba\u5458\u89c2\u5bdf\u4e86\u4e00\u79cd\u4ee3\u8c22\u7ec4\u7ec7\uff0c\u8fd9\u79cd\u7ec4\u7ec7\u4ee5\u5176\u9ad8\u6548\u8fd0\u4f5c\u7684\u7ebf\u7c92\u4f53\u800c\u95fb\u540d\uff1a\u68d5\u8272\u8102\u80aa\u3002\u68d5\u8272\u8102\u80aa\u7ec6\u80de\u4ee3\u8c22\u9700\u6c42\u5f88\u9ad8\uff0c\u56e0\u4e3a\u5b83\u4eec\u8d1f\u8d23\u8c03\u8282\u80fd\u91cf\u5e73\u8861\u548c\u4f53\u6e29\u3002\u7814\u7a76\u4eba\u5458\u4ece\u5c0f\u9f20\u68d5\u8272\u8102\u80aa\u7ec6\u80de\u4e2d\u5b8c\u5168\u53bb\u9664\u4e86SLC35A4-MP\uff0c\u7136\u540e\u8bf1\u53d1\u4e86\u4ee3\u8c22\u5e94\u6fc0\u4e8b\u4ef6\uff0c\u5982\u5bd2\u51b7\u66b4\u9732\u6216\u9ad8\u8102\u80aa\u996e\u98df\u3002.<\/p>\n<figure id=\"attachment_54392\"  class=\"wp-caption alignright\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" class=\"img-responsive wp-image-54392 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-300x300.jpg\" alt=\"Mature brown fat cells in mice show SLC34A4-MP (red), DNA (blue), and mitochondria (green).\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-1024x1024.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-768x768.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2-945x945.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2.jpg 1500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption class=\"wp-caption-text\">\u5c0f\u9f20\u6210\u719f\u7684\u68d5\u8272\u8102\u80aa\u7ec6\u80de\u663e\u793a SLC34A4-MP\uff08\u7ea2\u8272\uff09\u3001DNA\uff08\u84dd\u8272\uff09\u548c\u7ebf\u7c92\u4f53\uff08\u7eff\u8272\uff09\u3002.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/08\/250829-saghatelian-microscopy-2.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<br \/>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u6ca1\u6709SLC35A4-MP\uff0c\u5c0f\u9f20\u5728\u5bd2\u51b7\u66b4\u9732\u4e0b\u65e0\u6cd5\u63d0\u9ad8\u65b0\u9648\u4ee3\u8c22\u3002\u5b83\u4eec\u7ebf\u7c92\u4f53\u7ed3\u6784\u53d7\u635f\u3001\u589e\u5927\u3001\u529f\u80fd\u5931\u8c03\u5e76\u53d1\u708e\u3002\u5728\u7ebf\u7c92\u4f53\u4e4b\u5916\uff0c\u68d5\u8272\u8102\u80aa\u7ec6\u80de\u7684\u5176\u4ed6\u90e8\u5206\u4e5f\u53d7\u5230\u5f71\u54cd\u3002\u7814\u7a76\u4eba\u5458\u89c2\u5bdf\u5230\u7ec6\u80de\u5185\u90e8\u91cd\u5851\u548c\u8fdb\u4e00\u6b65\u708e\u75c7\u7684\u8ff9\u8c61\u2014\u2014\u8fd9\u662f\u80a5\u80d6\u76f8\u5173\u75be\u75c5\u4e2d\u65b0\u9648\u4ee3\u8c22\u4e0b\u964d\u7684\u6807\u5fd7\u3002.<\/p>\n<p>\u7814\u7a76\u7ed3\u679c\u8bc1\u660e\u4e86SLC35A4-MP\u5728\u8c03\u8282\u68d5\u8272\u8102\u80aa\u7ec6\u80de\u529f\u80fd\u548c\u5bf9\u4ee3\u8c22\u538b\u529b\u7684\u53cd\u5e94\u65b9\u9762\u8d77\u7740\u57fa\u672c\u4f5c\u7528\u3002\u800c\u4e14\uff0c\u7531\u4e8e\u7ebf\u7c92\u4f53\uff0c\u6211\u4eec\u7ec6\u80de\u5185\u5fd9\u788c\u7684\u201c\u871c\u8702\u201d\uff0c\u5b58\u5728\u4e8e\u4f53\u5185\u6240\u6709\u7ec6\u80de\u7c7b\u578b\u4e2d\uff0c\u56e0\u6b64\u8fd9\u4e9b\u53d1\u73b0\u4e5f\u5ef6\u4f38\u5230\u4e86\u5168\u8eab\u3002SLC35A4-MP\u53ef\u80fd\u6210\u4e3a\u6cbb\u7597\u5f71\u54cd\u4ee3\u8c22\u548c\u7ebf\u7c92\u4f53\u529f\u80fd\u7684\u4efb\u4f55\u75be\u75c5\u6216\u7d0a\u4e71\u7684\u6709\u529b\u9776\u70b9\uff0c\u4ece\u80a5\u80d6\u75c7\u5230\u8870\u8001\uff0c\u4e43\u81f3\u66f4\u5e7f\u6cdb\u7684\u9886\u57df\u3002.<\/p>\n<p>\u5fae\u86cb\u767d\u7814\u7a76\u7ec8\u4e8e\u5f00\u59cb\u84ec\u52c3\u53d1\u5c55\uff0c\u8be5\u56e2\u961f\u5728\u5bfb\u627e\u66f4\u591a\u529f\u80fd\u6027\u5fae\u86cb\u767d\u7684\u9053\u8def\u4e0a\u770b\u5230\u4e86\u5149\u660e\u7684\u524d\u666f\u3002.<\/p>\n<p>\u201c\u968f\u7740\u79d1\u5b66\u5bb6\u4eec\u80fd\u591f\u5728\u6211\u4eec\u7684\u86cb\u767d\u8d28\u6570\u636e\u5e93\u4e2d\u6dfb\u52a0\u66f4\u591a\u5fae\u86cb\u767d\uff0c\u4e00\u4e2a\u6301\u7eed\u5b58\u5728\u7684\u95ee\u9898\u662f\uff0c\u8fd9\u4e9b\u5fae\u86cb\u767d\u662f\u5426\u5177\u6709\u4efb\u4f55\u751f\u7406\u610f\u4e49\uff1f\u201dSaghatelian \u8bf4\u3002\u201c\u6211\u4eec\u7684\u7814\u7a76\u8868\u660e\uff0c\u662f\u7684\uff0c\u5b83\u4eec\u662f\u91cd\u8981\u7684\u751f\u7406\u8c03\u8282\u56e0\u5b50\u3002\u6211\u5e0c\u671b\u8fd9\u80fd\u4e3a\u672a\u6765\u5fae\u86cb\u767d\u7684\u7814\u7a76\u589e\u6dfb\u66f4\u591a\u52a8\u529b\u3002\u201d<\/p>\n<p>\u5176\u4ed6\u4f5c\u8005\u5305\u62ec\u6765\u81ea\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684Antonio Pinto\u3001Jolene Diedrich\u3001Huanqi Shan\u3001Eduardo Vieira de Souza\u3001Joan Vaughan\u548cMark Foster\uff1b\u6765\u81ea\u8bfa\u534e\u7814\u7a76\u6240\u548cIntegrate Bioscience\u7684Christian Schmedt\uff1b\u6765\u81ea\u52a0\u5dde\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\u7684Guy Perksin\u548cMark Ellisman\uff1b\u6765\u81ea\u6d1b\u514b\u83f2\u52d2\u5927\u5b66\u7684Kaja Pluci\u0144ska\u548cPaul Cohen\uff1b\u4ee5\u53ca\u6765\u81ea\u8bfa\u534e\u7814\u7a76\u6240\u548c\u52a0\u5dde\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\u7684Srinath Sampath\u3002.<\/p>\n<p>\u8fd9\u9879\u5de5\u4f5c\u5f97\u5230\u4e86\u4ee5\u4e0b\u673a\u6784\u7684\u8d44\u52a9\uff1a\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08P30 CA014195\u3001R01 GM102491\u3001U24 NS120055\u3001R01 NS108934\u3001R01 GM138780\u3001R01 AG065549\u3001S10 OD021784\u3001RC2 DK129961\u3001NIA R01 AG081037\u3001NIA R01 AG062479\u3001NIMH RF1 MH129261\u3001NIH-NCI CCSG P30 CA014195\u3001NIH-NIA \u5723\u5730\u4e9a\u54e5\u5185\u68ee\u4f11\u514b\u4e2d\u5fc3 P30 AG068635\u3001NIH-NIA \u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7814\u7a76\u4e2d\u5fc3 P30 AG062429\uff09\u3001\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u57fa\u91d1\u4f1a\uff082014862\uff09\u3001\u7f8e\u56fd\u5fc3\u810f\u534f\u4f1a\u827e\u4f26\u5021\u8bae\u3001\u52a0\u5dde\u518d\u751f\u533b\u5b66\u7814\u7a76\u6240\u3001\u4ea8\u5229\u00b7L\u00b7\u6839\u745f\u57fa\u91d1\u4f1a\u3001\u8d6b\u5c14\u59c6\u65af\u5229\u6148\u5584\u4fe1\u6258\u57fa\u91d1\u4ee5\u53ca\u4e54\u6cbb\u00b7E\u00b7\u4f11\u4f0a\u7279\u533b\u5b66\u7814\u7a76\u6240\u3002.<\/p>","protected":false},"featured_media":54394,"template":"","faculty":[111],"disease-research":[146,123,176,166],"class_list":["post-54387","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-alan-saghatelian","disease-research-aging-and-regenerative-medicine","disease-research-metabolism-and-diabetes","disease-research-mitochondrial-disease","disease-research-obesity"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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