{"id":50265,"date":"2024-07-23T07:20:00","date_gmt":"2024-07-23T14:20:00","guid":{"rendered":"https:\/\/www.salk.edu\/?post_type=disclosure&p=50265"},"modified":"2024-07-23T08:23:58","modified_gmt":"2024-07-23T15:23:58","slug":"salk-professor-janelle-ayres-named-howard-hughes-medical-institute-investigator","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/salk-professor-janelle-ayres-named-howard-hughes-medical-institute-investigator\/","title":{"rendered":"Salk Professor Janelle Ayres named Howard Hughes Medical Institute Investigator"},"content":{"rendered":"

LA JOLLA\u2014Salk Professor Janelle Ayres<\/a> has been selected as a 2024 Howard Hughes Medical Institute (HHMI) Investigator. The HHMI Investigators program awards established scientists with approximately $9 million in funding over seven years to pursue boundary-breaking research in their field. The honor recognizes her influential work in immunology and microbiology and its applications to the global crisis of antibiotic resistance.\r\n<\/p>

\r\nAyres is among 26 other 2024 selectees, who will join more than 250 standing Investigators\u2014including Salk Professors Joanne Chory<\/a> (1997), \u7ea6\u745f\u592b\u00b7\u57c3\u514b\u5c14<\/a> (2011), and \u51ef\u6cf0<\/a> (2021).\r\n<\/p>\r\n

\"Janelle<\/a>
Janelle Ayres
Click here<\/a> for a high-resolution image.
Credit: Salk Institute<\/figcaption><\/figure>\r\n\r\n

\r\n\u201cJanelle\u2019s research on microbial pathogenesis has greatly enhanced our understanding of host-microbe interactions,\u201d says Salk President Gerald Joyce<\/a>. \u201cReceiving this support from HHMI is a wonderful recognition of her achievements thus far and her potential for continued excellence in the years ahead.\u201d\r\n<\/p>

\r\nAyres is head of the Molecular and Systems Physiology Laboratory, a member of both the Gene Expression Laboratory and the NOMIS Center for Immunobiology and Microbial Pathogenesis, and holder of the Salk Institute Legacy Chair.\r\n<\/p>

\r\nAyres\u2019 discovery of the \u201cCooperative Defense System\u201d has radically shifted scientists\u2019 perspectives on health and disease. Rather than thinking of health as simply the absence of disease, Ayres describes health as an active biological process requiring unique endurance and resilience mechanisms\u2014altogether dubbed the Cooperative Defense System. \r\n<\/p>

\r\nA major principle of this work is the revelation that a person or \u201chost\u201d infected with a pathogen does not need to kill the pathogen to survive. Rather, they can avoid disease by learning to adapt and cooperate with the pathogen.\r\n<\/p>

\r\nAyres\u2019 findings have sweeping therapeutic applications. In 2023, Ayres applied these principles to a study of diarrheal infections, as well as the process of cachexia (losing fat and muscle stores during disease). Her research on diarrheal infections revealed a new potential vaccine strategy for diarrheal diseases<\/a> and other infections, while her research on cachexia revealed that muscle loss surprisingly contributes to the management of disease<\/a>. \r\n<\/p>

\r\nThe clinical implications of Ayres\u2019 work will fuel her future research as an HHMI Investigator. Her new experiments will dig deeper into the factors that make the difference between an infected individual who remains healthy, and one that becomes sick and dies. As these differences and their mechanisms become clearer, she will be able to reveal new strategies to treat infections that can address the global crisis of antibiotic resistance, better ensure patient survival when infected, and better prepare us for the next pandemic when it happens.\r\n<\/p>

\r\nTo maximize the impact of this work, Ayres can now lean on her HHMI community of trusted colleagues for additional scientific support and outreach.\r\n<\/p>

\r\nAyres\u2019 other recent achievements include a $1 million grant from the W. M. Keck Foundation<\/a>, the NIH Director\u2019s Pioneer Award in 2018<\/a>, and induction into the American Academy of Microbiology\u2019s Fellowship Class of 2024<\/a>. She was the 2018 recipient of the Blavatnik National Award for Young Scientists<\/a> for Life Sciences, one of the world\u2019s largest unrestricted prizes for early career scientists.\r\n<\/p>

\r\nAbout the Howard Hughes Medical Institute:<\/strong>
\r\nThe Howard Hughes Medical Institute (HHMI) advances the discovery and sharing of scientific knowledge to benefit us all. Founded in 1953, HHMI is a biomedical research organization and philanthropy with a vibrant community of researchers, educators, students, and professionals. Together, we\u2019re unlocking the fundamentals of biology and building an open, inclusive future for science.\r\n<\/p>

\r\nAbout the Salk Institute for Biological Studies:<\/strong>
\r\nUnlocking the secrets of life itself is the driving force behind the Salk Institute. Our team of world-class, award-winning scientists pushes the boundaries of knowledge in areas such as neuroscience, cancer research, aging, immunobiology, plant biology, computational biology, and more. Founded by Jonas Salk, developer of the first safe and effective polio vaccine, the Institute is an independent, nonprofit research organization and architectural landmark: small by choice, intimate by nature, and fearless in the face of any challenge. Learn more at www.salk.edu.\r\n<\/p>","protected":false},"featured_media":50272,"template":"","faculty":[79],"disease-research":[122],"class_list":["post-50265","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-janelle-ayres","disease-research-immune-system-biology"],"acf":[],"yoast_head":"\nSalk Professor Janelle Ayres named Howard Hughes Medical Institute Investigator - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/salk-professor-janelle-ayres-named-howard-hughes-medical-institute-investigator\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk Professor Janelle Ayres named Howard Hughes Medical Institute Investigator - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Salk Professor Janelle Ayres has been selected as a 2024 Howard Hughes Medical Institute (HHMI) Investigator. 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