{"id":42162,"date":"2023-08-22T00:00:20","date_gmt":"2023-08-22T07:00:20","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=42162"},"modified":"2023-08-22T20:16:45","modified_gmt":"2023-08-23T03:16:45","slug":"high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/","title":{"rendered":"\u9ad8\u8102\u80aa\u996e\u98df\u6539\u53d8\u80a0\u9053\u7ec6\u83cc\uff0c\u589e\u52a0\u5c0f\u9f20\u7ed3\u76f4\u80a0\u764c\u98ce\u9669"},"content":{"rendered":"
\"The
\u80a0\u9053\u5185\u58c1\u7684\u8936\u76b1\uff08\u7d2b\u8272\uff09\u5728\u5065\u5eb7\u5c0f\u9f20\uff08\u5de6\uff09\u548c\u9ad8\u8102\u80aa\u996e\u98df\u5c0f\u9f20\uff08\u53f3\uff09\u4e4b\u95f4\u5b58\u5728\u5dee\u5f02\u3002\u7d22\u5c14\u514b\u7814\u7a76\u4eba\u5458\u786e\u5b9a\u4e86\u9a71\u52a8\u8fd9\u4e9b\u53d8\u5316\u7684\u7ec6\u83cc\u548c\u80c6\u6c41\u9178\u7684\u53d8\u5316\u3002.
\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.
\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

\u62c9\u970d\u4e9a\u2014\u8fd1\u5e74\u6765\uff0c50\u5c81\u4ee5\u4e0b\u4eba\u7fa4\u7684\u7ed3\u76f4\u80a0\u764c\u53d1\u75c5\u7387\u6709\u6240\u4e0a\u5347\u3002\u4e00\u4e2a\u53ef\u80fd\u7684\u89e3\u91ca\u662f\u80a5\u80d6\u7387\u548c\u9ad8\u8102\u80aa\u996e\u98df\u7684\u589e\u52a0\u3002\u73b0\u5728\uff0c\u7d22\u5c14\u514b\u7814\u7a76\u6240\u548c\u52a0\u5dde\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u9ad8\u8102\u80aa\u996e\u98df\u5982\u4f55\u6539\u53d8\u80a0\u9053\u7ec6\u83cc\uff0c\u5e76\u6539\u53d8\u7531\u8fd9\u4e9b\u7ec6\u83cc\u4fee\u9970\u7684\u79f0\u4e3a\u80c6\u6c41\u9178\u7684\u6d88\u5316\u5206\u5b50\uff0c\u4ece\u800c\u4f7f\u5c0f\u9f20\u6613\u60a3\u7ed3\u76f4\u80a0\u764c\u3002.<\/p>\n

\u5728\u8fd9\u9879\u53d1\u8868\u5728 \u7ec6\u80de\u62a5\u544a<\/em><\/a> 2023\u5e748\u670822\u65e5\uff0c\u7814\u7a76\u56e2\u961f\u5728\u5582\u98df\u9ad8\u8102\u996e\u98df\u7684\u5c0f\u9f20\u4f53\u5185\u53d1\u73b0\u4e86\u7279\u5b9a\u80a0\u9053\u7ec6\u83cc\u6c34\u5e73\u7684\u5347\u9ad8\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u8fd9\u4e9b\u80a0\u9053\u7ec6\u83cc\u4f1a\u6539\u53d8\u80c6\u6c41\u9178\u6c60\u7684\u7ec4\u6210\uff0c\u4ece\u800c\u5f15\u8d77\u708e\u75c7\uff0c\u5e76\u5f71\u54cd\u80a0\u9053\u5e72\u7ec6\u80de\u7684\u66f4\u65b0\u901f\u5ea6\u3002\u80c6\u6c41\u9178\u662f\u7531\u809d\u810f\u4ea7\u751f\u3001\u4f9b\u80a0\u9053\u7528\u4e8e\u5e2e\u52a9\u6d88\u5316\u98df\u7269\u4ee5\u53ca\u5438\u6536\u80c6\u56fa\u9187\u3001\u8102\u80aa\u548c\u8425\u517b\u7269\u8d28\u7684\u5206\u5b50\u3002.<\/p>\n

\u201c\u80a0\u9053\u5fae\u751f\u7269\u7684\u5e73\u8861\u53d7\u996e\u98df\u5f71\u54cd\uff0c\u6211\u4eec\u6b63\u5728\u53d1\u73b0\u80a0\u9053\u5fae\u751f\u7269\u79cd\u7fa4\uff08\u80a0\u9053\u5fae\u751f\u7269\u7ec4\uff09\u7684\u53d8\u5316\u5982\u4f55\u5bfc\u81f4\u764c\u75c7\u95ee\u9898\uff0c\u201d\u8054\u5408\u901a\u8baf\u4f5c\u8005\u3001\u6559\u6388\u8bf4\u9053\u3002 \u7f57\u7eb3\u5fb7\u00b7\u57c3\u6587\u65af<\/a>, \u7d22\u5c14\u514b\u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4\u4e3b\u4efb\u3002\u201c\u8fd9\u4e3a\u964d\u4f4e\u764c\u75c7\u98ce\u9669\u7684\u5e72\u9884\u63aa\u65bd\u94fa\u5e73\u4e86\u9053\u8def\u3002\u201d<\/p>\n

2019\u5e74\uff0c\u57c3\u6587\u65af\u53ca\u5176\u540c\u4e8b\u5728\u5c0f\u9f20\u8eab\u4e0a\u5c55\u793a\u4e86 \u9ad8\u8102\u80aa\u996e\u98df\u63d0\u9ad8\u4e86\u6574\u4f53\u80c6\u6c41\u9178\u6c34\u5e73<\/a>. \u4ed6\u4eec\u53d1\u73b0\uff0c\u80c6\u6c41\u9178\u7684\u8fd9\u79cd\u53d8\u5316\u5173\u95ed\u4e86\u80a0\u9053\u4e2d\u7684\u4e00\u4e2a\u5173\u952e\u86cb\u767d\u2014\u2014\u6cd5\u5c3c\u7d22\u7c7bX\u53d7\u4f53\uff08FXR\uff09\uff0c\u5e76\u589e\u52a0\u4e86\u764c\u75c7\u7684\u53d1\u751f\u7387\u3002.<\/p>\n

\u7136\u800c\uff0c\u6545\u4e8b\u4e2d\u4ecd\u7136\u5b58\u5728\u4e00\u4e9b\u7f3a\u5931\u7684\u73af\u8282\uff0c\u5305\u62ec\u9ad8\u8102\u80aa\u996e\u98df\u5982\u4f55\u6539\u53d8\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u548c\u80c6\u6c41\u9178\u3002.<\/p>\n

\u5728\u65b0\u7814\u7a76\u4e2d\uff0c\u57c3\u6587\u65af\u7684\u7814\u7a76\u5c0f\u7ec4\u4e0e\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684\u7f57\u5e03\u00b7\u5948\u7279\u548c\u76ae\u7279\u00b7\u591a\u96f7\u65af\u5766\u7684\u5b9e\u9a8c\u5ba4\u5408\u4f5c\uff0c\u7814\u7a76\u4e86\u9ad8\u8102\u80aa\u996e\u98df\u52a8\u7269\u6d88\u5316\u9053\u4e2d\u7684\u5fae\u751f\u7269\u7ec4\u548c\u4ee3\u8c22\u7ec4\u2014\u2014\u81b3\u98df\u548c\u5fae\u751f\u7269\u884d\u751f\u7684\u5316\u5408\u7269\u96c6\u5408\u3002\u4ed6\u4eec\u7814\u7a76\u4e86\u60a3\u6709\u6613\u60a3\u7ed3\u76f4\u80a0\u80bf\u7624\u9057\u4f20\u7a81\u53d8\u7684\u5c0f\u9f20\u3002.<\/p>\n

\"From
\u4ece\u5de6\u8d77\uff1a\u7f57\u7eb3\u5fb7\u00b7\u57c3\u6587\u65af\u3001\u6797\u6653\u5b87\u3001\u5b89\u59ae\u7279\u00b7\u963f\u7279\u91d1\u65af\u548c\u8fc8\u514b\u5c14\u00b7\u5510\u65af\u3002.
\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.
\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u5c3d\u7ba1\u9ad8\u8102\u80aa\u996e\u98df\u5582\u517b\u7684\u5c0f\u9f20\u80a0\u9053\u5185\u80c6\u6c41\u9178\u542b\u91cf\u66f4\u591a\uff0c\u4f46\u5176\u79cd\u7c7b\u591a\u6837\u6027\u5374\u8f83\u4f4e\uff0c\u67d0\u4e9b\u7ecf\u80a0\u9053\u7ec6\u83cc\u6539\u53d8\u7684\u80c6\u6c41\u9178\u7684\u6bd4\u4f8b\u8f83\u9ad8\u3002\u4ed6\u4eec\u8fd8\u8868\u660e\uff0c\u8fd9\u4e9b\u6539\u53d8\u7684\u80c6\u6c41\u9178\u4f1a\u5f71\u54cd\u80a0\u9053\u5e72\u7ec6\u80de\u7684\u589e\u6b96\u3002\u5f53\u8fd9\u4e9b\u7ec6\u80de\u4e0d\u7ecf\u5e38\u66f4\u65b0\u65f6\uff0c\u5b83\u4eec\u4f1a\u7d2f\u79ef\u7a81\u53d8\u2014\u2014\u8fd9\u662f\u4fc3\u8fdb\u764c\u75c7\u751f\u957f\u7684\u5173\u952e\u4e00\u6b65\uff0c\u800c\u764c\u75c7\u901a\u5e38\u8d77\u6e90\u4e8e\u8fd9\u4e9b\u5e72\u7ec6\u80de\u3002.<\/p>\n

\u201c\u6211\u4eec\u624d\u521a\u521a\u5f00\u59cb\u4e86\u89e3\u8fd9\u4e9b\u7ec6\u83cc\u5076\u8054\u7684\u80c6\u6c41\u9178\u53ca\u5176\u5728\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\uff0c\u201d\u8be5\u7814\u7a76\u7684\u5408\u8457\u8005\u3001\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u79d1\u5b66\u7814\u7a76\u5458\u8fc8\u514b\u5c14\u00b7\u5510\u65af\u8bf4\u3002.<\/p>\n

\u9ad8\u8102\u996e\u98df\u5c0f\u9f20\u7684\u5fae\u751f\u7269\u7ec4\u4e5f\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff1a\u8fd9\u4e9b\u5c0f\u9f20\u6d88\u5316\u9053\u5185\u7684\u80a0\u9053\u7ec6\u83cc\u7fa4\u843d\u591a\u6837\u6027\u8f83\u4f4e\uff0c\u5e76\u4e14\u5305\u542b\u7684\u7ec6\u83cc\u4e0e\u672a\u6444\u53d6\u9ad8\u8102\u996e\u98df\u5c0f\u9f20\u7684\u5fae\u751f\u7269\u7ec4\u4e0d\u540c\u3002\u5176\u4e2d\u4e24\u79cd\u7ec6\u83cc\u2014\u2014\u4f0a\u6c0f\u6746\u83cc<\/em> \u548c \u7f57\u7ea6\u6c0f\u83cc<\/em>\u2014\u80fd\u591f\u751f\u6210\u8fd9\u4e9b\u7ecf\u8fc7\u4fee\u9970\u7684\u80c6\u6c41\u9178\u3002.<\/p>\n

\u79d1\u5b66\u5bb6\u4eec\u60ca\u8bb6\u5730\u53d1\u73b0\uff0c\u9ad8\u8102\u80aa\u996e\u98df\u5bf9\u5fae\u751f\u7269\u7ec4\u548c\u80c6\u6c41\u9178\u7684\u5f71\u54cd\u6bd4\u589e\u52a0\u764c\u75c7\u6613\u611f\u6027\u7684\u57fa\u56e0\u7a81\u53d8\u66f4\u5927\u3002.<\/p>\n

\u201c\u6211\u4eec\u5df2\u7ecf\u67e5\u660e\u9ad8\u8102\u80aa\u996e\u98df\u5982\u4f55\u5f71\u54cd\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u5e76\u91cd\u5851\u80c6\u6c41\u9178\u5e93\uff0c\u4f7f\u80a0\u9053\u8fdb\u5165\u4e00\u79cd\u53d1\u708e\u7684\u3001\u4e0e\u75be\u75c5\u76f8\u5173\u7684\u72b6\u6001\uff0c\u201d\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3001Evans\u5b9e\u9a8c\u5ba4\u524d\u535a\u58eb\u540e\u7814\u7a76\u5458Ting Fu\u8bf4\u9053\u3002.<\/p>\n

\"Ting
\u5ead\u798f
\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.
\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u9ad8\u8102\u80aa\u996e\u98df\u4f1a\u6539\u53d8\u5fae\u751f\u7269\u7ec4\u7684\u6784\u6210\uff0c\u4fc3\u8fdb\u7c7b\u4f3c\u4ee5\u4e0b\u7ec6\u83cc\u7684\u751f\u957f \u74e6\u4f26\u65af <\/em>\u548c R. \u8179\u90e8\u9c8e<\/em>. \u53cd\u8fc7\u6765\uff0c\u8fd9\u4f1a\u63d0\u9ad8\u4fee\u9970\u8fc7\u7684\u80c6\u6c41\u9178\u7684\u6c34\u5e73\u3002\u5728\u4e00\u4e2a\u6076\u6027\u5faa\u73af\u4e2d\uff0c\u8fd9\u4e9b\u80c6\u6c41\u9178\u4f1a\u521b\u9020\u4e00\u4e2a\u66f4\u5177\u708e\u75c7\u7684\u73af\u5883\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u6539\u53d8\u80a0\u9053\u7ec6\u83cc\u7684\u6784\u6210\u3002.<\/p>\n

\u201c\u6211\u4eec\u5df2\u7ecf\u5206\u6790\u4e86\u9ad8\u8102\u80aa\u996e\u98df\u4e3a\u4f55\u5bf9\u60a8\u4e0d\u5229\uff0c\u5e76\u786e\u5b9a\u4e86\u4e0e\u9ad8\u8102\u80aa\u996e\u98df\u76f8\u5173\u7684\u7279\u5b9a\u5fae\u751f\u7269\u83cc\u682a\uff0c\u201dMarch of Dimes \u5206\u5b50\u4e0e\u53d1\u80b2\u751f\u7269\u5b66\u4e3b\u5e2d\u57c3\u6587\u65af\u8bf4\u9053\u3002\u201c\u901a\u8fc7\u4e86\u89e3\u95ee\u9898\u6240\u5728\uff0c\u6211\u4eec\u5c31\u80fd\u66f4\u597d\u5730\u77e5\u9053\u5982\u4f55\u9884\u9632\u548c\u9006\u8f6c\u5b83\u3002\u201d<\/p>\n

\u672a\u6765\uff0c\u8be5\u56e2\u961f\u5c06\u7814\u7a76\u5728\u52a8\u7269\u5f00\u59cb\u6444\u5165\u9ad8\u8102\u80aa\u996e\u98df\u540e\uff0c\u5fae\u751f\u7269\u7ec4\u548c\u80c6\u6c41\u9178\u7684\u53d8\u5316\u901f\u5ea6\u3002\u4ed6\u4eec\u8fd8\u8ba1\u5212\u7814\u7a76\u901a\u8fc7\u9776\u5411FXR\u6765\u9006\u8f6c\u9ad8\u8102\u80aa\u996e\u98df\u4e0e\u764c\u75c7\u76f8\u5173\u7684\u5f71\u54cd\uff0cFXR\u662f\u4ed6\u4eec\u5148\u524d\u53d1\u73b0\u4e0e\u80c6\u6c41\u9178\u53d8\u5316\u76f8\u5173\u7684\u86cb\u767d\u8d28\u3002.<\/p>\n

\u8be5\u8bba\u6587\u7684\u5176\u4ed6\u4f5c\u8005\u662f\uff1aSalk\u7814\u7a76\u6240\u7684Tae Gyu Oh\u3001Justin L McCarville\u3001Fritz Cayabyab\u3001Mingxiao He\u3001Ruth T. Yu\u3001Annette Atkins\u548cJanelle Ayres\uff1b\u52a0\u5dde\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\u7684Gibraan Rahman\u3001Hui Zhi\u3001Zhenjiang Xu\u3001Anupriya Tripathi\u3001Cameron Martino\u3001Qiyun Zhu\u3001Fernando Vargas\u548cManuela Raffatellu\uff1b\u4e0d\u5217\u98a0\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u7684Tao Huan\u3001Jian Guo\u3001Brian Low\u548cShipei Xing\uff1b\u4ee5\u53ca\u6089\u5c3c\u5927\u5b66\u7684Sally Coulter\u548cChristopher Liddle\u3002.<\/p>\n

\u672c\u7814\u7a76\u5f97\u5230\u4e86\u4ee5\u4e0b\u673a\u6784\u7684\u8d44\u52a9\uff1a\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08CA014195\uff09\u3001\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08CA265762-01\uff0cDP1 AT010885\uff0cAI126277\uff0cAI145325\uff0cAI154644\uff0cAI114625\uff0cP01HL147835\uff0cR01DK057978\uff09\u3001\u5fae\u751f\u7269\u4ee3\u8c22\u7269\u534f\u4f5c\u4e2d\u5fc3\uff081U24DK133658-54701\uff09\u3001\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u535a\u58eb\u540e\u5fae\u751f\u7269\u7ec4\u4e2d\u5fc3\u79cd\u5b50\u8bd5\u70b9\u57fa\u91d1\u3001\u4f11\u4f0a\u7279\u533b\u5b66\u57fa\u91d1\u4f1a\u5956\u5b66\u91d1\u3001\u7d22\u5c14\u514b\u6821\u53cb\u5956\u5b66\u91d1\u3001\u514b\u7f57\u6069\u75c5\u4e0e\u7ed3\u80a0\u708e\u57fa\u91d1\u4f1a\uff08CCFA\uff09\u708e\u75c7\u6027\u80a0\u75c5\u7814\u7a76\u8bbf\u95ee\u5956\u5b66\u91d1\u3001\u5362\u65af\u7279\u52a0\u767b\u57fa\u91d1\u4f1a\uff08122215393-02\uff09\u3001\u8bfa\u7c73\u65af\u57fa\u91d1\u4f1a\u3001SWCRF\u7814\u7a76\u5458\u5956\u3001\u79d1\u5c14\u666e\u5229\u57fa\u91d1\u4f1a\uff08David C. Copley Foundation\uff09\u3001\u74e6\u897f\u91cc\u5bb6\u65cf\u57fa\u91d1\u4f1a\uff08Wasily Family Foundation\uff09\u3001\u5510\u548c\u6d1b\u6797\u00b7\u5f17\u91cc\u4f2f\u683c\u57fa\u91d1\u4f1a\uff08Don and Lorraine Freeberg Foundation\uff09\u548c\u4f2f\u52d2\u65af\u00b7\u97e6\u5c14\u79d1\u59c6\u57fa\u91d1\u4f1a\uff08Burroughs Wellcome Fund\uff09\u3002.<\/p>","protected":false},"featured_media":42199,"template":"","faculty":[91],"disease-research":[46,123],"class_list":["post-42162","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-ronald-evans","disease-research-cancer-biology","disease-research-metabolism-and-diabetes"],"acf":[],"yoast_head":"\nHigh-fat diets alter gut bacteria, boosting colorectal cancer risk in mice - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-fat diets alter gut bacteria, boosting colorectal cancer risk in mice - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"The inner folds of the intestines (purple) are different in healthy mice (left) compared to mice fed a high-fat diet (right). Salk researchers identified changes in bacteria and bile acids that drive these changes.Click here for a high-resolution image.Credit: Salk Institute LA JOLLA\u2014The prevalence of colorectal cancer in people under the age of 50 has risen in recent decades. One suspected reason: the increasing rate of obesity and high-fat diets. Now, researchers at the Salk Institute and UC San Diego have discovered how high-fat diets can change gut bacteria and alter digestive molecules called bile acids that are modified by those bacteria, predisposing mice to colorectal cancer.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/zh\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2023-08-23T03:16:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/08\/ScienceImage.png\" \/>\n\t<meta property=\"og:image:width\" content=\"250\" \/>\n\t<meta property=\"og:image:height\" content=\"240\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\\\/\",\"name\":\"High-fat diets alter gut bacteria, boosting colorectal cancer risk in mice - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/ScienceImage.png\",\"datePublished\":\"2023-08-22T07:00:20+00:00\",\"dateModified\":\"2023-08-23T03:16:45+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\\\/#breadcrumb\"},\"inLanguage\":\"zh-CN\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-CN\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/ScienceImage.png\",\"contentUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/ScienceImage.png\",\"width\":250,\"height\":240,\"caption\":\"The inner folds of the intestines (purple) are different in healthy mice (left) compared to mice fed a high-fat diet (right). Salk researchers identified changes in bacteria and bile acids that drive these changes.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"High-fat diets alter gut bacteria, boosting colorectal cancer risk in mice\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-CN\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-CN\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"High-fat diets alter gut bacteria, boosting colorectal cancer risk in mice - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/zh\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/","og_locale":"zh_CN","og_type":"article","og_title":"High-fat diets alter gut bacteria, boosting colorectal cancer risk in mice - Salk Institute for Biological Studies","og_description":"The inner folds of the intestines (purple) are different in healthy mice (left) compared to mice fed a high-fat diet (right). Salk researchers identified changes in bacteria and bile acids that drive these changes.Click here for a high-resolution image.Credit: Salk Institute LA JOLLA\u2014The prevalence of colorectal cancer in people under the age of 50 has risen in recent decades. One suspected reason: the increasing rate of obesity and high-fat diets. Now, researchers at the Salk Institute and UC San Diego have discovered how high-fat diets can change gut bacteria and alter digestive molecules called bile acids that are modified by those bacteria, predisposing mice to colorectal cancer.","og_url":"https:\/\/www.salk.edu\/zh\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/","og_site_name":"Salk Institute for Biological Studies","article_modified_time":"2023-08-23T03:16:45+00:00","og_image":[{"width":250,"height":240,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/08\/ScienceImage.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/","url":"https:\/\/www.salk.edu\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/","name":"High-fat diets alter gut bacteria, boosting colorectal cancer risk in mice - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/#primaryimage"},"thumbnailUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/08\/ScienceImage.png","datePublished":"2023-08-22T07:00:20+00:00","dateModified":"2023-08-23T03:16:45+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/#breadcrumb"},"inLanguage":"zh-CN","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/"]}]},{"@type":"ImageObject","inLanguage":"zh-CN","@id":"https:\/\/www.salk.edu\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/#primaryimage","url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/08\/ScienceImage.png","contentUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/08\/ScienceImage.png","width":250,"height":240,"caption":"The inner folds of the intestines (purple) are different in healthy mice (left) compared to mice fed a high-fat diet (right). Salk researchers identified changes in bacteria and bile acids that drive these changes."},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/high-fat-diets-alter-gut-bacteria-to-boost-colorectal-cancer-risk-in-mice\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"High-fat diets alter gut bacteria, boosting colorectal cancer risk in mice"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240","description":"\u79d1\u5b66\u7684\u529b\u91cf","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-CN"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"zh-CN","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"paper_url":"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(23)01008-2","journal_title":"Cell Reports","paper_author_list":"Ting Fu, Tao Huan, Gibraan Rahman, Hui Zhi, Zhenjiang Xu, Tae Gyu Oh, Jian Guo, Sally Coulter, Anupriya Tripathi, Cameron Martino, Justin L McCarville, Qiyun Zhu, Fritz Cayabyab, Brian Low, Mingxiao He, Shipei Xing, Fernando Vargas, Ruth T. Yu, Annette Atkins, Christopher Liddle, Janelle Ayres, Manuela Raffatellu, Pieter C. Dorrestein, Michael Downes, Rob Knight, Ronald M. Evans","doi":"10.1016\/j.celrep.2023.112997","paper_title":"Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression","subhead":"Salk scientists pinpointed specific microbes and bile acids that become more prevalent in the guts of mice fed high-fat diets","home_photo":"","listing_photo":"","legacy_boilerplate":[],"hide_boilerplate":[],"disable_date":false,"listing_excerpt":"<p>LA JOLLA\u2014The prevalence of colorectal cancer in people under the age of 50 has risen in recent decades. One suspected reason: the increasing rate of obesity and high-fat diets. Now, researchers at the Salk Institute and UC San Diego have discovered how high-fat diets can change gut bacteria and alter digestive molecules called bile acids that are modified by those bacteria, predisposing mice to colorectal cancer.<\/p>\n","descriptive_blurb":"","has_journal_cover":false,"og_image_override":false,"gallery":false},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/42162","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":12,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/42162\/revisions"}],"predecessor-version":[{"id":42224,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/42162\/revisions\/42224"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/media\/42199"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/media?parent=42162"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/faculty?post=42162"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disease-research?post=42162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}