{"id":40102,"date":"2023-05-10T00:00:21","date_gmt":"2023-05-10T07:00:21","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=40102"},"modified":"2024-01-30T14:14:50","modified_gmt":"2024-01-30T22:14:50","slug":"how-aggression-promoting-brain-peptide-works-in-fruit-flies","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/how-aggression-promoting-brain-peptide-works-in-fruit-flies\/","title":{"rendered":"\u653b\u51fb\u6027\u4fc3\u8fdb\u8111\u80bd\u5728\u679c\u8747\u4e2d\u7684\u4f5c\u7528\u673a\u5236"},"content":{"rendered":"<p>\u62c9\u970d\u4e9a\u2014\u9664\u4e86\u7528\u795e\u7ecf\u9012\u8d28\u4ea4\u6d41\u5916\uff0c\u5927\u8111\u8fd8\u4f7f\u7528\u4e00\u79cd\u79f0\u4e3a\u795e\u7ecf\u80bd\u7684\u5c0f\u86cb\u767d\u8d28\u3002\u795e\u7ecf\u80bd\u53ef\u5728\u795e\u7ecf\u5143\u4e4b\u95f4\u53d1\u9001\u4fe1\u53f7\uff0c\u5176\u529f\u80fd\u4e0e\u795e\u7ecf\u9012\u8d28\u76f8\u4f3c\uff0c\u4f46\u5b58\u5728\u4e00\u4e9b\u5173\u952e\u5dee\u5f02\uff0c\u4f8b\u5982\u4f53\u79ef\u8f83\u5927\uff0c\u5e76\u4e14\u80fd\u591f\u8fdc\u79bb\u4ea7\u751f\u5b83\u4eec\u7684\u795e\u7ecf\u5143\u4f20\u64ad\u3002\u5c3d\u7ba1\u5b83\u4eec\u7684\u81f3\u5173\u91cd\u8981\u6027\u5df2\u88ab\u5e7f\u6cdb\u8ba4\u8bc6\uff0c\u4f46\u795e\u7ecf\u80bd\u5728\u5927\u8111\u4e2d\u79fb\u52a8\u548c\u5f71\u54cd\u795e\u7ecf\u5143\u7684\u65b9\u5f0f\u4e00\u76f4\u77e5\u4e4b\u751a\u5c11\u2014\u2014\u76f4\u5230\u73b0\u5728\u3002.<\/p>\n<figure id=\"attachment_40344\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"254\" class=\"img-responsive wp-image-40344 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr-458x254.jpg\" alt=\"A fruit fly brain showing male-specific tachykininergic neurons (magenta), which make the neuropeptide tachykinin, and neurons that express TkR86C (green), which receive tachykinin.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr-458x254.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr-300x167.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr-768x427.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr-147x82.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr-585x325.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr-553x307.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr-750x417.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr-767x426.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr-400x222.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr.jpg 936w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><figcaption class=\"wp-caption-text\">\u679c\u8747\u5927\u8111\u663e\u793a\u4e86\u96c4\u6027\u7279\u5f02\u6027\u901f\u6fc0\u80bd\u80fd\u795e\u7ecf\u5143\uff08\u54c1\u7ea2\u8272\uff09\uff0c\u5b83\u4eec\u4ea7\u751f\u795e\u7ecf\u80bd\u901f\u6fc0\u80bd\uff0c\u4ee5\u53ca\u8868\u8fbe TkR86C\uff08\u7eff\u8272\uff09\u7684\u795e\u7ecf\u5143\uff0c\u5b83\u4eec\u63a5\u6536\u901f\u6fc0\u80bd\u3002.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-1-hr.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<br \/>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u7531\u8428\u5c14\u514b\u79d1\u5b66\u5bb6\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\uff0c\u5176\u53d1\u8868\u5728\u300a <a href=\"https:\/\/www.jneurosci.org\/content\/early\/2023\/03\/27\/JNEUROSCI.1734-22.2023\" target=\"_blank\" rel=\"noopener\"><em>\u795e\u7ecf\u79d1\u5b66\u6742\u5fd7<\/em><\/a> 2023\u5e745\u670810\u65e5\u516c\u5e03\u7684\u7814\u7a76\u7ed3\u679c\u63ed\u793a\u4e86\u795e\u7ecf\u80bd\u5bf9\u5927\u8111\u6d3b\u52a8\u7684\u53ef\u53d8\u5f71\u54cd\uff0c\u9610\u660e\u4e86\u5927\u8111\u5728\u679c\u8747\u4e2d\u7684\u4ea4\u6d41\u65b9\u5f0f\u2014\u2014\u8fd9\u662f\u7406\u89e3\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u6216\u6ce8\u610f\u529b\u7f3a\u9677\u969c\u788d\u7b49\u4eba\u7c7b\u75be\u75c5\u6f5c\u5728\u75c5\u56e0\u7684\u91cd\u8981\u4e00\u6b65\u3002.<\/p>\n<p>\u201c\u7814\u7a76\u66fe\u8ba4\u4e3a\u795e\u7ecf\u80bd\u53ea\u6709\u4e00\u4e2a\u6765\u6e90\u548c\u4e00\u4e2a\u9776\u70b9\uff0c\u80fd\u4ea7\u751f\u5355\u4e00\u7684\u7ed3\u679c\uff0c\u4f46\u5b83\u4eec\u7684\u5b9e\u9645\u5f71\u54cd\u8fdc\u4e0d\u6b62\u4e8e\u6b64\uff0c\u201d\u901a\u8baf\u4f5c\u8005\u8bf4\u3002 <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/kenta-asahina\/\">\u671d\u65e5\u5948 \u5065\u592a<\/a>, \u5206\u5b50\u795e\u7ecf\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4\u7684\u526f\u6559\u6388\u3002\u201c\u795e\u7ecf\u80bd\u53ef\u4ee5 <em>\u8bb8\u591a<\/em> \u4e8b\u7269\uff0c\u5177\u6709\u5404\u79cd\u5148\u524d\u672a\u88ab\u63a2\u7d22\u5230\u7684\u3001\u5bf9\u884c\u4e3a\u4ea7\u751f\u5de8\u5927\u5f71\u54cd\u7684\u6548\u5e94\u3002\u201d<\/p>\n<p>\u795e\u7ecf\u80bd\u53ef\u4ee5\u5f71\u54cd\u4e00\u7cfb\u5217\u884c\u4e3a\uff0c\u5305\u62ec\u8fdb\u98df\u3001\u4ea4\u914d\u548c\u7761\u7720\uff0c\u4ee5\u53ca\u611f\u5230\u6050\u60e7\u6216\u538b\u529b\u3002\u4e00\u4e9b\u795e\u7ecf\u5143\u91ca\u653e\u795e\u7ecf\u80bd\u4f5c\u4e3a\u4fe1\u53f7\u5206\u5b50\uff0c\u800c\u53e6\u4e00\u4e9b\u795e\u7ecf\u5143\u5219\u901a\u8fc7\u4f4d\u4e8e\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\u63a5\u6536\u795e\u7ecf\u80bd\u3002\u5728 Salk \u7814\u7a76\u4e4b\u524d\uff0c\u4eba\u4eec\u4e00\u76f4\u8ba4\u4e3a\u795e\u7ecf\u80bd\u5bf9\u6240\u6709\u8868\u8fbe\u5339\u914d\u53d7\u4f53\u7684\u795e\u7ecf\u5143\u90fd\u5177\u6709\u666e\u904d\u7684\u3001\u7cfb\u7edf\u7684\u5f71\u54cd\u3002\u4f46\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u7279\u5b9a\u7684\u795e\u7ecf\u80bd\u53ef\u80fd\u901a\u8fc7\u4f5c\u7528\u4e8e\u4e0d\u540c\u7684\u8111\u56de\u8def\u6765\u63a7\u5236\u4e0d\u540c\u7684\u884c\u4e3a\uff0c\u5982\u8fdb\u98df\u6216\u653b\u51fb\u884c\u4e3a\u3002.<\/p>\n<figure id=\"attachment_40351\"  class=\"wp-caption alignleft\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" class=\"img-responsive wp-image-40351 size-medium\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1-300x300.jpg\" alt=\"A male fly (left) with an excess amount of tachykinin attacking a female fly (right)\u2014a behavior unlikely when tachykinin levels are normal.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1-200x200.jpg 200w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1.jpg 767w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption class=\"wp-caption-text\">\u4e00\u53ea\u96c4\u8747\uff08\u5de6\uff09\u56e0\u8fc7\u91cf\u7684\u7f13\u6fc0\u80bd\u800c\u653b\u51fb\u4e00\u53ea\u96cc\u8747\uff08\u53f3\uff09\u2014\u2014\u5f53\u7f13\u6fc0\u80bd\u6c34\u5e73\u6b63\u5e38\u65f6\uff0c\u8fd9\u79cd\u884c\u4e3a\u4e0d\u592a\u53ef\u80fd\u53d1\u751f\u3002.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/AsahinaMay2023-2r-767-1.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<br \/>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u671d\u9633 (Asahina) \u7684\u56e2\u961f\u5e0c\u671b\u7814\u7a76\u795e\u7ecf\u80bd\u901f\u6fc0\u80bd\uff0c\u5df2\u77e5\u901f\u6fc0\u80bd\u4f1a\u589e\u52a0\u8bb8\u591a\u52a8\u7269\u7269\u79cd\u7684\u653b\u51fb\u6027\uff0c\u5305\u62ec\u679c\u8747\u3001\u5c0f\u9f20\u751a\u81f3\u4eba\u7c7b\u3002\u4ed6\u4eec\u60f3\u77e5\u9053\u901f\u6fc0\u80bd\u5982\u4f55\u5f71\u54cd\u795e\u7ecf\u5143\u901a\u8baf\u548c\u52a8\u7269\u884c\u4e3a\u3002.<\/p>\n<p>\u4e3a\u4e86\u8ffd\u8e2a\u901f\u6fc0\u80bd\uff0c\u8be5\u56e2\u961f\u521b\u9020\u4e86\u4e00\u4e2a\u5206\u5b50\u6807\u8bb0\uff0c\u7528\u4e8e\u6807\u8bb0\u679c\u8747\u4e2d\u5e26\u6709\u901f\u6fc0\u80bd\u53d7\u4f53\u7684\u795e\u7ecf\u5143\u3002\u5229\u7528\u8be5\u6807\u8bb0\uff0c\u8be5\u56e2\u961f\u80fd\u591f\u53ef\u89c6\u5316\u901f\u6fc0\u80bd\u5982\u4f55\u6fc0\u6d3b\u67d0\u4e9b\u795e\u7ecf\u5143\uff0c\u8fd9\u4e9b\u795e\u7ecf\u5143\u53ef\u4ee5\u4ea7\u751f\u679c\u8747\u7279\u6709\u7684\u884c\u4e3a\u3002\u8868\u8fbe\u7684\u53d7\u4f53\u5dee\u5f02\u4ee5\u53ca\u7279\u5b9a\u7684\u884c\u4e3a\uff0c\u4ee3\u8868\u4e86\u4e00\u79cd\u4f7f\u7528\u795e\u7ecf\u80bd\u8fdb\u884c\u795e\u7ecf\u5143\u4ea4\u6d41\u7684\u65b0\u673a\u5236\u3002.<\/p>\n<p>\u8868\u8fbe\u7684\u53d7\u4f53\u5dee\u5f02\u4ee3\u8868\u4e86\u4e00\u79cd\u5e38\u88ab\u5ffd\u89c6\u7684\u795e\u7ecf\u80bd\u795e\u7ecf\u901a\u8baf\u673a\u5236\uff0c\u56e0\u4e3a\u4e00\u79cd\u795e\u7ecf\u80bd\u53ef\u4ee5\u5728\u4e0d\u540c\u6d53\u5ea6\u4e0b\u6fc0\u6d3b\u4e0d\u540c\u7684\u53d7\u4f53\u3002.<\/p>\n<p>\u795e\u7ecf\u5143\u4f1a\u50cf\u4e00\u8fde\u4e32\u5012\u4e0b\u7684\u591a\u7c73\u8bfa\u9aa8\u724c\u4e00\u6837\u76f8\u4e92\u89e6\u53d1\u653e\u7535\uff0c\u800c\u795e\u7ecf\u80bd\u5219\u80fd\u52a0\u901f\u8fd9\u4e00\u8fc7\u7a0b\u2014\u2014\u5c31\u50cf\u7ed9\u6bcf\u4e00\u5f20\u591a\u7c73\u8bfa\u9aa8\u724c\u90fd\u591a\u63a8\u4e00\u628a\u4e00\u6837\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u6765\u81ea\u4e00\u79cd\u96c4\u6027\u7279\u5f02\u6027\u795e\u7ecf\u5143\uff08\u82cd\u8747\u6709\u6027\u522b\u7279\u5f02\u6027\u795e\u7ecf\u5143\uff09\u7684\u901f\u6fc0\u80bd\u4f1a\u5f71\u54cd\u4e24\u4e2a\u72ec\u7acb\u7684\u4e0b\u6e38\u795e\u7ecf\u5143\u7fa4\uff0c\u8fd9\u4e24\u4e2a\u795e\u7ecf\u5143\u7fa4\u2014\u2014\u5c31\u50cf\u7b2c\u4e00\u5f20\u591a\u7c73\u8bfa\u9aa8\u724c\u4e4b\u540e\u7684\u6240\u6709\u9aa8\u724c\u4e00\u6837\u2014\u2014\u4f9d\u8d56\u4e8e\u795e\u7ecf\u80bd\u4fe1\u53f7\u6765\u4ea7\u751f\u4f5c\u7528\u3002\u7b2c\u4e00\u7ec4\u795e\u7ecf\u5143\u8868\u8fbe\u4e00\u79cd\u7279\u5b9a\u7684\u901f\u6fc0\u80bd\u53d7\u4f53\uff08TkR86C\uff09\uff0c\u5e76\u4e14\u662f\u4fc3\u8fdb\u653b\u51fb\u6027\u884c\u4e3a\u6240\u5fc5\u9700\u7684\u3002\u7b2c\u4e8c\u7ec4\u795e\u7ecf\u5143\u8868\u8fbe\u53e6\u4e00\u79cd\u901f\u6fc0\u80bd\u53d7\u4f53\uff08TkR99D\uff09\uff0c\u5e76\u4e14\u4ec5\u5728\u901f\u6fc0\u80bd\u8fc7\u91cf\u4ea7\u751f\u65f6\u88ab\u6fc0\u6d3b\u3002\u901f\u6fc0\u80bd\u5f71\u54cd\u5927\u8111\u4e0d\u540c\u90e8\u4f4d\u7684\u795e\u7ecf\u5143\uff0c\u5e76\u4e14\u795e\u7ecf\u5143\u5bf9\u4e0d\u540c\u6d53\u5ea6\u7684\u901f\u6fc0\u80bd\u4ea7\u751f\u4e0d\u540c\u7684\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u8fd9\u4e24\u7ec4\u795e\u7ecf\u5143\u7684\u6d3b\u52a8\u6a21\u5f0f\u4e0e\u679c\u8747\u96c4\u6027\u7684\u653b\u51fb\u6c34\u5e73\u76f8\u5173\u3002.<\/p>\n<figure id=\"attachment_40346\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"225\" class=\"img-responsive wp-image-40346 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-458x225.jpg\" alt=\"From left: Kenta Asahina and Margot Wohl.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-458x225.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-300x148.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-1024x504.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-768x378.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-147x72.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-585x288.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-553x272.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-750x369.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-767x377.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-945x465.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-1250x615.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500-400x197.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/05\/PR-Asahina-JNeuro3-1500.jpg 1500w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><figcaption class=\"wp-caption-text\">\u4ece\u5de6\u8d77\uff1a\u671d\u65e5\u5948\u5065\u592a\u548c\u739b\u683c\u7279\u00b7\u6c83\u200b\u200b\u5c14\u3002.<br \/><a 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