{"id":37390,"date":"2023-01-03T00:00:01","date_gmt":"2023-01-03T08:00:01","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=37390"},"modified":"2024-01-30T14:18:47","modified_gmt":"2024-01-30T22:18:47","slug":"microprotein-increases-appetite-in-mice","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/microprotein-increases-appetite-in-mice\/","title":{"rendered":"\u5fae\u86cb\u767d\u589e\u52a0\u5c0f\u9f20\u98df\u6b32"},"content":{"rendered":"

\u62c9\u970d\u4e9a\u2014\u80a5\u80d6\u548c\u4ee3\u8c22\u6027\u75be\u75c5\uff0c\u5982\u7cd6\u5c3f\u75c5\uff0c\u5728\u7f8e\u56fd\u975e\u5e38\u666e\u904d\u3002\u88ab\u79f0\u4e3a\u5fae\u86cb\u767d\u7684\u5fae\u5c0f\u86cb\u767d\u8d28\u5728\u7814\u7a76\u4e2d\u957f\u671f\u88ab\u5ffd\u89c6\uff0c\u4f46\u65b0\u7684\u8bc1\u636e\u8868\u660e\u5b83\u4eec\u5728\u65b0\u9648\u4ee3\u8c22\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u7d22\u5c14\u514b\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u68d5\u8272\u8102\u80aa\u548c\u767d\u8272\u8102\u80aa\u90fd\u5145\u6ee1\u4e86\u6570\u5343\u79cd\u4ee5\u524d\u672a\u77e5\u7684\u5fae\u86cb\u767d\uff0c\u5e76\u8868\u660e\u5176\u4e2d\u4e00\u79cd\u540d\u4e3a Gm8773 \u7684\u5fae\u86cb\u767d\u53ef\u4ee5\u589e\u52a0\u5c0f\u9f20\u7684\u98df\u6b32\u3002.<\/p>\n

\u8fd9\u4e9b\u53d1\u73b0\uff0c\u53d1\u8868\u5728 \u7ec6\u80de\u4ee3\u8c22<\/em><\/a> 2023\u5e741\u67083\u65e5\uff0c\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u5f00\u53d1\u4e00\u79cd\u7597\u6cd5\uff0c\u5e2e\u52a9\u4eba\u4eec\u5728\u67d0\u4e9b\u75be\u75c5\u60c5\u51b5\u4e0b\u589e\u91cd\uff0c\u4f8b\u5982\u764c\u75c7\u5316\u7597\u671f\u95f4\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u786e\u5b9a\u8fd9\u4e9b\u5fae\u86cb\u767d\u7684\u5b58\u5728\uff0c\u8be5\u56e2\u961f\u4e3a\u79d1\u5b66\u754c\u7814\u7a76\u5fae\u86cb\u767d\u63d0\u4f9b\u4e86\u5b9d\u8d35\u7684\u8d44\u6e90\u3002.<\/p>\n

\"From
\u4ece\u5de6\u8d77\uff1a\u827e\u4f26\u00b7\u8428\u52a0\u7279\u91cc\u5b89 (Alan Saghatelian) \u548c\u6258\u9a6c\u65af\u00b7\u9a6c\u4e01\u5185\u65af (Thomas Martinez)
\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.
\u5b66\u5206\uff1a\u4ece\u5de6\u8d77\uff1a\u7d22\u5c14\u514b\u7814\u7a76\u6240\u548c\u52a0\u5dde\u5927\u5b66\u6b27\u6587\u5206\u6821\u7684\u53f2\u8482\u592b\u00b7\u9f50\u67f3\u65af<\/figcaption><\/figure>\n

\u201c\u4e3a\u4e86\u5728\u672a\u6765\u63d0\u4f9b\u66f4\u597d\u7684\u7597\u6cd5\uff0c\u4e86\u89e3\u8c03\u8282\u80a5\u80d6\u548c\u4ee3\u8c22\u5065\u5eb7\u7684\u673a\u5236\u81f3\u5173\u91cd\u8981\uff0c\u201d\u7d22\u5c14\u514b\u6559\u6388\u8bf4\u00a0\u827e\u4f26\u00b7\u8428\u52a0\u7279\u5229\u5b89<\/a>, \uff0c\u8be5\u7814\u7a76\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff0c\u5e76\u62c5\u4efb\u5f17\u96f7\u5fb7\u91cc\u514b\u00b7\u4fdd\u5c14\u68ee\u535a\u58eb\u8bb2\u5e2d\u6559\u6388\u3002\u201c\u62e5\u6709\u8fd9\u4efd\u5fae\u86cb\u767d\u5217\u8868\u5c06\u6709\u52a9\u4e8e\u4ee3\u8c22\u9886\u57df\u8bc6\u522b\u5404\u79cd\u4ee3\u8c22\u75be\u75c5\u4e2d\u7684\u65b0\u53c2\u4e0e\u8005\u3002\u6211\u4eec\u5df2\u7ecf\u5c55\u793a\u4e86\u4e00\u79cd\u4fc3\u8fdb\u8fdb\u98df\u7684\u751f\u7269\u6d3b\u6027\u5fae\u86cb\u767d\uff0c\u4ee5\u53ca\u5176\u4ed6\u53c2\u4e0e\u8102\u80aa\u4ee3\u8c22\u7684\u5fae\u86cb\u767d\u3002\u201d<\/p>\n

\u8102\u80aa\u7ec4\u7ec7\u5206\u6ccc\u8bb8\u591a\u4e0d\u540c\u7684\u86cb\u767d\u8d28\u6765\u8c03\u8282\u8fdb\u98df\u3001\u80fd\u91cf\u5e73\u8861\u548c\u4ea7\u70ed\u3002\u767d\u8272\u8102\u80aa\uff0c\u88ab\u79f0\u4e3a\u201c\u574f\u8102\u80aa\u201d\uff0c\u901a\u5e38\u4f4d\u4e8e\u76ae\u80a4\u4e0b\u65b9\u548c\u8179\u90e8\u533a\u57df\u3002\u8fd9\u79cd\u8102\u80aa\u4f5c\u4e3a\u80fd\u91cf\u50a8\u5b58\u5e93\uff0c\u4e0e\u80a5\u80d6\u548c\u5176\u4ed6\u8d85\u91cd\u5f15\u8d77\u7684\u75be\u75c5\u6709\u5173\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u68d5\u8272\u8102\u80aa\u6216\u201c\u597d\u8102\u80aa\u201d\u4f4d\u4e8e\u80a9\u90e8\u548c\u810a\u9ad3\u6cbf\u7ebf\u3002\u68d5\u8272\u8102\u80aa\u4e0e\u9002\u5f53\u7684\u8425\u517b\u3001\u8fd0\u52a8\u548c\u5065\u5eb7\u6709\u5173\u3002.<\/p>\n

\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u5229\u7528\u521b\u65b0\u7684\u57fa\u56e0\u7ec4\u6280\u672f\uff0c\u5bf9\u5c0f\u9f20\u7ec6\u80de\u4e2d\u7684\u68d5\u8272\u8102\u80aa\u3001\u767d\u8272\u8102\u80aa\u548c\u7c73\u8272\u8102\u80aa\uff08\u4e00\u79cd\u517c\u5177\u767d\u8272\u8102\u80aa\u548c\u68d5\u8272\u8102\u80aa\u7279\u6027\u7684\u8102\u80aa\uff09\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u4ed6\u4eec\u53d1\u73b0\u4e863877\u4e2a\u5728\u767d\u8272\u8102\u80aa\u548c\u68d5\u8272\u8102\u80aa\u4e2d\u5747\u4ea7\u751f\u5fae\u86cb\u767d\u7684\u57fa\u56e0\u3002\u6b64\u5916\uff0c\u4ed6\u4eec\u8fd8\u63a2\u7d22\u4e86\u5728\u5582\u98df\u9ad8\u8102\u80aa\u897f\u65b9\u996e\u98df\u7684\u5c0f\u9f20\u4e2d\u8fd9\u4e9b\u57fa\u56e0\u7684\u6c34\u5e73\uff0c\u5e76\u5c06\u6570\u767e\u79cd\u5fae\u86cb\u767d\u4e0e\u8102\u80aa\u7ec4\u7ec7\u4ee3\u8c22\u7684\u53d8\u5316\u8054\u7cfb\u8d77\u6765\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u9879\u5206\u6790\u9996\u6b21\u63ed\u793a\u4e86\u8bb8\u591a\u53ef\u80fd\u4e0e\u4ee3\u8c22\u76f8\u5173\u7684\u5fae\u86cb\u767d\u3002.<\/p>\n

\u201c\u6211\u4eec\u63d0\u4f9b\u4e86\u4e00\u4efd\u8def\u7ebf\u56fe\uff0c\u4ecb\u7ecd\u4e86\u5982\u4f55\u6700\u597d\u5730\u5229\u7528\u6211\u4eec\u7684\u6570\u636e\u6765\u8fde\u63a5\u5e76\u6700\u7ec8\u786e\u5b9a\u5fae\u86cb\u767d\u5728\u57fa\u672c\u4ee3\u8c22\u9014\u5f84\u4e2d\u7684\u4f5c\u7528\uff0c\u201d\u7b2c\u4e00\u4f5c\u8005 Thomas Martinez \u8bf4\uff0c\u4ed6\u66fe\u662f Saghatelian \u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u540e\u7814\u7a76\u5458\uff0c\u73b0\u4efb\u52a0\u5dde\u5927\u5b66\u6b27\u6587\u5206\u6821\u52a9\u7406\u6559\u6388\u3002.<\/p>\n

\"Microproteins
\u5fae\u86cb\u767d\u548c\u79f0\u4e3a smORFs \u7684\u5c0f\u86cb\u767d\u662f\u672a\u8868\u5f81\u7684\u4ee3\u8c22\u8c03\u63a7\u56e0\u5b50\u7684\u4e00\u4e2a\u6f5c\u5728\u4e30\u5bcc\u6765\u6e90\u3002.
\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.
\u5b66\u5206\uff1a\u7d22\u5c14\u514b\u7814\u7a76\u6240\u548c \u7ec6\u80de\u4ee3\u8c22<\/em><\/figcaption><\/figure>\n

\u8be5\u56e2\u961f\u8fd8\u91cd\u70b9\u7814\u7a76\u4e86\u4e00\u79cd\u540d\u4e3aGm8773\u7684\u5fae\u86cb\u767d\uff0c\u5b83\u4f4d\u4e8e\u5927\u8111\u7684\u6442\u98df\u4e2d\u5fc3\u2014\u2014\u4e0b\u4e18\u8111\u3002\u8be5\u5fae\u86cb\u767d\u5728\u5927\u8111\u4e2d\u7684\u4f4d\u7f6e\u8868\u660e\u5b83\u53ef\u80fd\u5728\u98df\u6b32\u4e2d\u8d77\u4f5c\u7528\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5f53\u79d1\u5b66\u5bb6\u4eec\u5c06Gm8773\u65bd\u7528\u4e8e\u80a5\u80d6\u5c0f\u9f20\u65f6\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u6444\u5165\u4e86\u66f4\u591a\u7684\u98df\u7269\u3002\u8fd8\u6709\u4e00\u79cd\u540d\u4e3aFAM237B\u7684\u4eba\u7c7b\u57fa\u56e0\u4e0eGm8773\u76f8\u4f3c\uff0c\u8fd9\u79cd\u57fa\u56e0\u53ef\u80fd\u5728\u4eba\u7c7b\u4e2d\u8d77\u5230\u7c7b\u4f3c\u7684\u4f5c\u7528\uff0c\u4fc3\u8fdb\u8fdb\u98df\u3002\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u8fd9\u79cd\u5fae\u86cb\u767d\u6700\u7ec8\u53ef\u4ee5\u88ab\u5f00\u53d1\u6210\u4e00\u79cd\u7597\u6cd5\uff0c\u4ee5\u4fc3\u8fdb\u90a3\u4e9b\u7ecf\u5386\u6781\u7aef\u4f53\u91cd\u51cf\u8f7b\u8005\u7684\u4f53\u91cd\u589e\u957f\u3002.<\/p>\n

\u201c\u6211\u4eec\u7814\u7a76\u4e2d\u4ecb\u7ecd\u7684\u65b0\u578b\u5fae\u86cb\u767d\u662f\u4ee3\u8c22\u9886\u57df\u548c\u8102\u80aa\u751f\u7269\u5b66\u7814\u7a76\u7684\u4ee4\u4eba\u5174\u594b\u7684\u53d1\u73b0\uff0c\u201d\u5171\u540c\u901a\u8baf\u4f5c\u8005 Chris Barnes \u8bf4\uff0c\u4ed6\u66fe\u4efb\u804c\u4e8e\u8bfa\u548c\u8bfa\u5fb7\u897f\u96c5\u56fe\u7814\u7a76\u9662\uff0c\u73b0\u4efb Velia Therapeutics \u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u8d1f\u8d23\u4eba\u3002\u201c\u6211\u4eec\u5e0c\u671b\u8fd9\u4e2a\u8d44\u6e90\u80fd\u591f\u4e3a\u79d1\u5b66\u754c\u5728\u81ea\u5df1\u7684\u5b9e\u9a8c\u5ba4\u4e2d\u63d0\u51fa\u5927\u91cf\u65b0\u7684\u5b9e\u9a8c\u5047\u8bbe\uff0c\u5e76\u5e0c\u671b\u8fd9\u9879\u5de5\u4f5c\u80fd\u591f\u53d1\u73b0\u65b0\u7684\u751f\u7269\u5b66\u673a\u5236\u3002\u201d<\/p>\n

\u672a\u6765\uff0c\u79d1\u5b66\u5bb6\u4eec\u8ba1\u5212\u5f00\u53d1\u5de5\u5177\u6765\u7814\u7a76 Gm8773 \u548c FAM237B \u7684\u4f5c\u7528\uff0c\u6700\u7ec8\u76ee\u6807\u662f\u5f00\u53d1\u4e00\u79cd\u80fd\u591f\u589e\u52a0\u4eba\u7c7b\u98df\u6b32\u7684\u7597\u6cd5\u3002.<\/p>\n

\u5176\u4ed6\u4f5c\u8005\u5305\u62ec\uff1a\u6765\u81ea\u8428\u514b\u7814\u7a76\u6240\u7684\u8f9b\u897f\u5a05\u00b7\u5510\u7eb3\u68ee\uff08Cynthia Donaldson\uff09\u3001\u743c\u00b7M\u00b7\u6c83\u6069\uff08Joan M. Vaughan\uff09\u3001\u52a0\u5c14\u6587\u00b7\u5218\uff08Calvin Lau\uff09\u548c\u9a6c\u514b\u897f\u59c6\u00b7N\u00b7\u8096\u5e0c\u5217\u592b\uff08Maxim N. Shokhirev\uff09\uff1b\u4fc4\u4ea5\u4fc4\u5dde\u7acb\u5927\u5b66\u7684\u5e03\u83b1\u6069\u00b7C\u00b7\u585e\u5c14\uff08Brian C. Searle\uff09\uff1b\u534e\u76db\u987f\u5927\u5b66\u7684\u6797\u8d5b\u00b7K\u00b7\u76ae\u8bfa\uff08Lindsay K. Pino\uff09\u548c\u8fc8\u514b\u5c14\u00b7J\u00b7\u9ea6\u8003\u65af\uff08Michael J. MacCoss\uff09\uff1b\u6765\u81ea\u5df4\u897f\u7684\u5357\u91cc\u5965\u683c\u5170\u5fb7\u5929\u4e3b\u6559\u5927\u5b66\u7684\u7231\u5fb7\u534e\u591a\u00b7V\u00b7\u5fb7\u7d22\u8428\uff08Eduardo V. De Souza\uff09\u548c\u514b\u91cc\u65af\u8482\u4e9a\u8bfa\u00b7V\u00b7\u6bd4\u624e\u7f57\uff08Cristiano V. Bizarro\uff09\uff1b\u4ee5\u53ca\u8bfa\u548c\u8bfa\u5fb7\u897f\u96c5\u56fe\u7814\u7a76\u4e2d\u5fc3\u6709\u9650\u516c\u53f8\u7684\u838e\u8389\u00b7\u83b1\u6602\u65af-\u963f\u4f2f\u7279\uff08Sally Lyons-Abbott\uff09\u3001\u5b89\u5409\u00b7L\u00b7\u5e03\u514b\u7279\uff08Angie L. Bookout\uff09\u3001\u963f\u91cc\u5c14\u00b7\u963f\u5e03\u62c9\u83ab\u592b\uff08Ariel Abramov\uff09\u3001\u963f\u91cc\u5b89\u00b7F\u00b7\u5df4\u514b\u7f57\uff08Arian F. Baquero\uff09\u3001\u5361\u62c9\u5229\u00b7\u5df4\u514b\u7f57\uff08Karalee Baquero\uff09\u3001\u6234\u592b\u00b7\u5f17\u91cc\u5fb7\u91cc\u5e0c\uff08Dave Friedrich\uff09\u3001\u8d3e\u65af\u6c40\u00b7\u80e1\u963f\u5fb7\uff08Justin Huard\uff09\u3001\u96f7\u00b7\u6234\u7ef4\u65af\uff08Ray Davis\uff09\u3001 Bong Kim\u3001\u6cf0\u00b7\u79d1\u8d6b\uff08Ty Koch\uff09\u3001\u827e\u4f26\u00b7J\u00b7\u9ed8\u745f\uff08Aaron J. Mercer\uff09\u3001\u827e\u838e\u00b7\u7c73\u65af\u594e\u65af\uff08Ayesha Misquith\uff09\u3001\u8428\u62c9\u00b7A\u00b7\u9ed8\u91cc\uff08Sara A. Murray\uff09\u3001\u8428\u5361\u62c9\u00b7\u4f69\u91cc\uff08Sakara Perry\uff09\u3001\u514b\u91cc\u65af\u8482\u5a1c\u00b7\u6851\u798f\u5fb7\uff08Christina Sanford\uff09\u3001\u4e9a\u5386\u514b\u65af\u00b7\u897f\u8499\uff08Alex Simon\uff09\u3001\u5f20\u5b87\uff08Yu Zhang\uff09\u3001\u52a0\u52d2\u7279\u00b7\u9f50\u666e\uff08Garrett Zipp\uff09\u548c\u5b89\u5fb7\u9c81\u00b7J\u00b7\u60e0\u7279\u5c14\uff08Andrew J. Whittle\uff09\u3002.<\/p>\n

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