{"id":37123,"date":"2022-12-12T00:00:44","date_gmt":"2022-12-12T08:00:44","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=37123"},"modified":"2024-01-30T14:19:03","modified_gmt":"2024-01-30T22:19:03","slug":"salk-scientists-develop-compound-that-reverses-gut-inflammation-in-mice","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/salk-scientists-develop-compound-that-reverses-gut-inflammation-in-mice\/","title":{"rendered":"\u7d22\u5c14\u514b\u79d1\u5b66\u5bb6\u5f00\u53d1\u51fa\u4e00\u79cd\u80fd\u9006\u8f6c\u5c0f\u9f20\u80a0\u9053\u708e\u75c7\u7684\u5316\u5408\u7269"},"content":{"rendered":"

\u62c9\u8377\u4e9a\u2014\u2014\u65af\u514b\u5c14\u7814\u7a76\u6240\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u7684\u4e00\u79cd\u836f\u7269\uff0c\u80fd\u591f\u50cf\u80a0\u9053\u7684\u603b\u5f00\u5173\u4e00\u6837\u8d77\u4f5c\u7528\u3002\u8fd9\u79cd\u540d\u4e3a FexD \u7684\u5316\u5408\u7269\uff0c\u4e4b\u524d\u5df2\u88ab\u53d1\u73b0\u80fd\u591f\u964d\u4f4e\u5c0f\u9f20\u7684\u80c6\u56fa\u9187\u3001\u71c3\u70e7\u8102\u80aa\u5e76\u62b5\u5fa1\u7ed3\u76f4\u80a0\u764c\u3002\u73b0\u5728\uff0c\u8be5\u56e2\u961f\u5728 \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em><\/a> 2022\u5e7412\u670812\u65e5\uff0c\u5728\u708e\u75c7\u6027\u80a0\u75c5\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cFexD\u4e5f\u80fd\u9884\u9632\u548c\u9006\u8f6c\u80a0\u9053\u708e\u75c7\u3002.<\/p>\n

\"Salk
\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u5316\u5408\u7269 FexD \u53ef\u4ee5\u6cbb\u7597\u5c0f\u9f20\u7684\u80a0\u9053\u708e\u75c7\u3002\u60a3\u6709\u7c7b\u4f3c\u4e8e\u708e\u75c7\u6027\u80a0\u75c5\u7684\u75c7\u72b6\u7684\u5c0f\u9f20\uff0c\u5176\u80a0\u9053\u5185\u58c1\u7ec6\u80de\u53d1\u751f\u4e86\u53d8\u5316\uff08\u5de6\u56fe\uff09\uff0c\u6cbb\u7597\u540e\u6062\u590d\u6b63\u5e38\uff08\u53f3\u56fe\uff09\u3002.
\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.
\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

\u201c\u7d22\u5c14\u514b\u7814\u7a76\u6240\u5f00\u53d1\u7684\u836f\u7269 FexD \u4e3a\u6062\u590d\u6d88\u5316\u7cfb\u7edf\u5e73\u8861\u548c\u6cbb\u7597\u76ee\u524d\u96be\u4ee5\u63a7\u5236\u7684\u708e\u75c7\u6027\u75be\u75c5\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u65b9\u6cd5\uff0c\u201d\u8d44\u6df1\u4f5c\u8005\u517c\u7d22\u5c14\u514b\u7814\u7a76\u6240\u6559\u6388\u8bf4\u3002\u00a0\u7f57\u7eb3\u5fb7\u00b7\u57c3\u6587\u65af<\/a>, \u7d22\u5c14\u514b\u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4\u4e3b\u4efb\uff0c\u4ee5\u53ca\u6bcd\u5a74\u5065\u5eb7\u57fa\u91d1\u4f1a\u5206\u5b50\u4e0e\u53d1\u80b2\u751f\u7269\u5b66\u4e3b\u5e2d\u3002.<\/p>\n

\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff09\uff0c\u5305\u62ec\u514b\u7f57\u6069\u75c5\u548c\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff0c\u5176\u7279\u5f81\u662f\u80a0\u9053\u4e2d\u514d\u75ab\u7ec6\u80de\u548c\u79f0\u4e3a\u7ec6\u80de\u56e0\u5b50\u7684\u708e\u75c7\u4fe1\u53f7\u5206\u5b50\u8fc7\u91cf\u3002\u73b0\u6709\u7597\u6cd5\uff0c\u5927\u591a\u901a\u8fc7\u6291\u5236\u6574\u4e2a\u514d\u75ab\u7cfb\u7edf\u6216\u9776\u5411\u7279\u5b9a\u7ec6\u80de\u56e0\u5b50\u6765\u8d77\u4f5c\u7528\uff0c\u4f46\u4ec5\u5bf9\u90e8\u5206\u60a3\u8005\u6709\u6548\uff0c\u5e76\u4f34\u6709\u591a\u79cd\u526f\u4f5c\u7528\u3002.<\/p>\n

\u4e8c\u5341\u591a\u5e74\u6765\uff0c\u57c3\u6587\u65af\u7684\u5b9e\u9a8c\u5ba4\u4e00\u76f4\u81f4\u529b\u4e8e\u7814\u7a76\u6cd5\u5c3c\u916fX\u53d7\u4f53\uff08FXR\uff09\u3002FXR\u662f\u4e00\u79cd\u4e3b\u8981\u7684\u8c03\u8282\u86cb\u767d\uff0c\u5b83\u80fd\u611f\u77e5\u8f93\u9001\u5230\u6d88\u5316\u7cfb\u7edf\u7684\u80c6\u6c41\u9178\uff0c\u4ee5\u5e2e\u52a9\u6d88\u5316\u98df\u7269\u548c\u5438\u6536\u8425\u517b\u3002\u5f53FXR\u5728\u8fdb\u9910\u521d\u671f\u68c0\u6d4b\u5230\u80c6\u6c41\u9178\u7684\u53d8\u5316\u65f6\uff0c\u5b83\u4f1a\u901a\u8fc7\u5f00\u542f\u548c\u5173\u95ed\u6570\u5341\u79cd\u4e0e\u6d88\u5316\u3001\u8840\u7cd6\u548c\u8102\u80aa\u4ee3\u8c22\u76f8\u5173\u7684\u7ec6\u80de\u7a0b\u5e8f\uff0c\u4e3a\u8eab\u4f53\u5e94\u5bf9\u98df\u7269\u6d8c\u5165\u505a\u597d\u51c6\u5907\u3002.<\/p>\n

\"From
\u4ece\u5de6\u8d77\uff1aRuth Yu\u3001Ye Zheng\u3001Michael Downes\u3001Ron Evans\u3001Yuwenbin Li \u548c Annette Atkins
\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.
\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

2015\u5e74\uff0c\u57c3\u6587\u65af\u548c\u4ed6\u7684\u540c\u4e8b\u4eec\u7814\u53d1\u51fa\u4e00\u79cd\u540d\u4e3afexaramine\u7684\u836f\u4e38\uff0c\u53ef\u4ee5\u6fc0\u6d3b\u80a0\u9053\u4e2d\u7684FXR\u3002\u4ed6\u4eec\u6700\u521d\u7684\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u79cd\u836f\u4e38\u53ef\u4ee5\u963b\u6b62 \u4f53\u91cd\u589e\u52a0\u548c\u63a7\u5236\u8840\u7cd6<\/a> \u5728\u5c0f\u9f20\u4e2d\u30022019\u5e74\uff0c\u4ed6\u4eec\u53d1\u73b0FexD\u2014\u2014\u4e00\u79cd\u6539\u8fdb\u7248\u7684fexaramine\u2014\u2014\u4e5f \u963b\u6b62\u4e86\u4e0e\u764c\u75c7\u76f8\u5173\u7684\u5e72\u7ec6\u80de\u53d8\u5316<\/a> \u5728\u80a0\u9053\u4e2d\u3002\u4ed6\u4eec\u7684\u5de5\u4f5c\u8868\u660e FXR \u5728\u8c03\u8282\u708e\u75c7\u65b9\u9762\u4e5f\u53d1\u6325\u4e86\u4f5c\u7528\u3002.<\/p>\n

\u201c\u6bcf\u6b21\u4f60\u8fdb\u98df\u65f6\uff0c\u968f\u7740\u80a0\u9053\u7ec6\u80de\u63a5\u89e6\u5230\u65b0\u7684\u5206\u5b50\uff0c\u4f60\u7684\u80a0\u9053\u90fd\u4f1a\u53d1\u751f\u5c11\u91cf\u708e\u75c7\u3002FXR \u786e\u4fdd\u4e86\u6b63\u5e38\u8fdb\u98df\u671f\u95f4\u708e\u75c7\u5f97\u5230\u63a7\u5236\uff0c\u201d\u8be5\u65b0\u8bba\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3001\u8d44\u6df1\u7814\u7a76\u5458 Michael Downes \u8bf4\u9053\u3002.<\/p>\n

\u5728\u65b0\u5de5\u4f5c\u4e2d\uff0c\u57c3\u6587\u65af\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\u6fc0\u6d3bFXR\u53ef\u7528\u4e8e\u7f13\u89e3\u708e\u75c7\u9a71\u52a8\u6027\u75be\u75c5\u7684\u75c7\u72b6\u3002\u5f53\u7814\u7a76\u4eba\u5458\u7ed9\u60a3\u6709IBD\u7684\u5c0f\u9f20\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21FexD\uff0c\u65e0\u8bba\u662f\u5728\u80a0\u9053\u708e\u75c7\u53d1\u4f5c\u524d\u8fd8\u662f\u53d1\u4f5c\u540e\uff0c\u8be5\u836f\u7269\u90fd\u80fd\u9884\u9632\u6216\u6cbb\u7597\u708e\u75c7\u3002\u901a\u8fc7\u6fc0\u6d3bFXR\uff0cFexD\u51cf\u5c11\u4e86\u4e00\u7c7b\u9ad8\u5ea6\u4fc3\u708e\u514d\u75ab\u7ec6\u80de\uff08\u79f0\u4e3a\u5148\u5929\u6dcb\u5df4\u7ec6\u80de\uff09\u7684\u6d78\u6da6\u3002\u53cd\u8fc7\u6765\uff0c\u5df2\u4e0eIBD\u6709\u5173\u7684\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u4e5f\u964d\u4f4e\u5230\u5065\u5eb7\u5c0f\u9f20\u901a\u5e38\u7684\u6c34\u5e73\u3002.<\/p>\n

\"Ting
\u5ead\u798f
\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.
\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

\u201c\u5f53\u6211\u4eec\u6fc0\u6d3bFXR\u65f6\uff0c\u6211\u4eec\u4f1a\u6062\u590d\u80a0\u9053\u4e2d\u9002\u5f53\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u5c06\u4e8b\u7269\u5e26\u56de\u7a33\u6001\u6c34\u5e73\uff0c\u201d\u8be5\u7814\u7a76\u7684\u5408\u8457\u8005\u3001\u8d44\u6df1\u7814\u7a76\u79d1\u5b66\u5bb6Annette Atkins\u8bf4\u3002.<\/p>\n

\u7531\u4e8eFXR\u66f4\u50cf\u514d\u75ab\u7cfb\u7edf\u7684\u91cd\u7f6e\u6309\u94ae\u800c\u4e0d\u662f\u5173\u95ed\u5f00\u5173\uff0c\u56e0\u6b64FexD\u4e0d\u4f1a\u5b8c\u5168\u963b\u65ad\u7ec6\u80de\u56e0\u5b50\u3002\u8fd9\u610f\u5473\u7740\u5728\u670d\u7528FexD\u540e\uff0c\u514d\u75ab\u7cfb\u7edf\u4f1a\u7ee7\u7eed\u6b63\u5e38\u8fd0\u4f5c\u3002\u8be5\u5316\u5408\u7269\u4ecd\u9700\u9488\u5bf9\u4eba\u7c7b\u4f7f\u7528\u8fdb\u884c\u4f18\u5316\u5e76\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u6d4b\u8bd5\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u4ed6\u4eec\u7684\u53d1\u73b0\u4e3a\u4e86\u89e3\u80a0\u9053\u5065\u5eb7\u4e0e\u708e\u75c7\u4e4b\u95f4\u7684\u590d\u6742\u8054\u7cfb\u63d0\u4f9b\u4e86\u91cd\u8981\u4fe1\u606f\uff0c\u5e76\u53ef\u80fd\u6700\u7ec8\u4e3a\u708e\u75c7\u6027\u80a0\u75c5\u5e26\u6765\u4e00\u79cd\u7597\u6cd5\u3002.<\/p>\n

\u201c\u7b2c\u4e00\u4f5c\u8005 Ting Fu \u66fe\u662f\u7d22\u5c14\u514b\u5927\u5b66\u7684\u535a\u58eb\u540e\u7814\u7a76\u5458\uff0c\u73b0\u5728\u662f\u5a01\u65af\u5eb7\u661f\u5927\u5b66\u9ea6\u8fea\u900a\u5206\u6821\u7684\u52a9\u7406\u6559\u6388\u3002.<\/p>\n

\u8be5\u8bba\u6587\u7684\u5176\u4ed6\u4f5c\u8005\u5305\u62ec\u6765\u81ea\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u674e\u5b87\u6587\u5bbe\u3001\u5434\u6cf0\u73ea\u3001\u5f17\u91cc\u8328\u00b7\u5361\u4e9a\u5df4\u5e03\u3001\u4f55\u5357\u6d77\u3001\u5510\u7434\u3001\u6469\u6839\u00b7\u7279\u9c81\u4f0a\u7279\u3001\u4fdd\u7f57\u00b7\u6885\u8fea\u7eb3\u3001\u4f55\u660e\u6653\u3001\u4fde\u6da6\u601d\u548c\u90d1\u70e8\uff0c\u4ee5\u53ca\u6765\u81ea\u6089\u5c3c\u5927\u5b66\u7684\u8428\u8389\u00b7\u5e93\u5c14\u7279\u548c\u514b\u91cc\u65af\u6258\u5f17\u00b7\u5229\u5fb7\u5c14\u3002.<\/p>\n

\u672c\u7814\u7a76\u90e8\u5206\u7531\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08DK057978\u3001HL105278 \u548c HL088093\uff09\u3001\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08CA014195\uff09\u3001\u6fb3\u5927\u5229\u4e9a\u56fd\u5bb6\u5065\u5eb7\u4e0e\u533b\u5b66\u7814\u7a76\u59d4\u5458\u4f1a\uff081087297 \u53f7\u62e8\u6b3e\uff09\u3001Leona M. \u548c Harry B. Helmsley \u6148\u5584\u4fe1\u6258\u57fa\u91d1\uff082017PG-MED001\uff09\u3001SWCRF \u7814\u7a76\u5458\u5956\u3001Hewitt \u533b\u5b66\u57fa\u91d1\u4f1a\u5956\u5b66\u91d1\u3001Salk \u6821\u53cb\u5956\u5b66\u91d1\u3001\u514b\u7f57\u6069\u75c5\u4e0e\u7ed3\u80a0\u708e\u57fa\u91d1\u4f1a\uff08CCFA\uff09\u708e\u75c7\u6027\u80a0\u75c5\u7814\u7a76\u8bbf\u95ee\u5956\u5b66\u91d1\u3001Stand Up To Cancer-Cancer Research UK-Lustgarten \u57fa\u91d1\u4f1a\u80f0\u817a\u764c\u68a6\u60f3\u56e2\u961f\u7814\u7a76\u57fa\u91d1\uff08SU2C-AACR-DT-20-16\uff09\u3001\u970d\u534e\u5fb7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u3001NOMIS \u57fa\u91d1\u4f1a\u4ee5\u53ca\u7f8e\u56fd\u56fd\u5bb6\u73af\u5883\u5065\u5eb7\u79d1\u5b66\u7814\u7a76\u6240\uff08P42ES010337\uff09\u8d44\u52a9\u3002.<\/p>","protected":false},"featured_media":37143,"template":"","faculty":[91,56],"disease-research":[447,122],"class_list":["post-37123","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-ronald-evans","faculty-ye-zheng","disease-research-colorectal-cancer","disease-research-immune-system-biology"],"acf":[],"yoast_head":"\nSalk scientists develop compound that reverses gut inflammation in mice - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/salk-scientists-develop-compound-that-reverses-gut-inflammation-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk scientists develop compound that reverses gut inflammation in mice - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014A drug developed by Salk Institute researchers acts like a master reset switch in the intestines. The compound, called FexD, has previously been found to lower cholesterol, burn fat, and ward off colorectal cancer in mice. 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