{"id":34989,"date":"2022-06-23T00:00:51","date_gmt":"2022-06-23T07:00:51","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=34989"},"modified":"2022-06-23T08:32:49","modified_gmt":"2022-06-23T15:32:49","slug":"hair-raising-research-salk-scientists-find-surprising-link-between-immune-system-hair-growth","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/hair-raising-research-salk-scientists-find-surprising-link-between-immune-system-hair-growth\/","title":{"rendered":"Hair-raising research: Salk scientists find surprising link between immune system, hair growth"},"content":{"rendered":"

LA JOLLA\u2014Salk scientists have uncovered an unexpected molecular target of a common treatment for alopecia, a condition in which a person\u2019s immune system attacks their own hair follicles, causing hair loss. The findings, published in Nature Immunology<\/em><\/a> on June 23, 2022, describe how immune cells called regulatory T cells interact with skin cells using a hormone as a messenger to generate new hair follicles and hair growth.<\/p>\n

\u201cFor the longest time, regulatory T cells have been studied for how they decrease excessive immune reactions in autoimmune diseases,\u201d says corresponding author Ye Zheng<\/a>, associate professor in Salk\u2019s NOMIS Center for Immunobiology and Microbial Pathogenesis. \u201cNow we\u2019ve identified the upstream hormonal signal and downstream growth factor that actually promote hair growth and regeneration completely separate from suppressing immune response.\u201d<\/p>\n

\"
Glucocorticoid hormone signal in regulatory T cells promotes hair follicle stem cell activation and new hair growth. Left: After hair loss, skin cells (blue) from a normal mouse can activate hair follicle stem cells (red). Right: Cells from mice without glucocorticoid receptors in their regulatory T cells cannot activate hair follicle stem cells.
Click here<\/a> for a high-resolution image.
Credit: Salk Institute<\/figcaption><\/figure>\n

The scientists didn\u2019t begin by studying hair loss. They were interested in researching the roles of regulatory T cells and glucocorticoid hormones in autoimmune diseases. (Glucocorticoid hormones are cholesterol-derived steroid hormones produced by the adrenal gland and other tissues.) They first investigated how these immune components functioned in multiple sclerosis, Crohn\u2019s disease and asthma.<\/p>\n

They found that glucocorticoids and regulatory T cells did not function together to play a significant role in any of these conditions. So, they thought they\u2019d have more luck looking at environments where regulatory T cells expressed particularly high levels of glucocorticoid receptors (which respond to glucocorticoid hormones), such as in skin tissue. The scientists induced hair loss in normal mice and mice lacking glucocorticoid receptors in their regulatory T cells.<\/p>\n

\u201cAfter two weeks, we saw a noticeable difference between the mice\u2014the normal mice grew back their hair, but the mice without glucocorticoid receptors barely could,\u201d says first author Zhi Liu, a postdoctoral fellow in the Zheng lab. \u201cIt was very striking, and it showed us the right direction for moving forward.\u201d<\/p>\n

The findings suggested that some sort of communication must be occurring between regulatory T cells and hair follicle stem cells to allow for hair regeneration.<\/p>\n

Using a variety of techniques for monitoring multicellular communication, the scientists then investigated how the regulatory T cells and glucocorticoid receptors behaved in skin tissue samples. They found that glucocorticoids instruct the regulatory T cells to activate hair follicle stem cells, which leads to hair growth. This crosstalk between the T cells and the stem cells depends on a mechanism whereby glucocorticoid receptors induce production of the protein TGF-beta3, all within the regulatory T cells. TGF-beta3 then activates the hair follicle stem cells to differentiate into new hair follicles, promoting hair growth. Additional analysis confirmed that this pathway was completely independent of regulatory T cells\u2019 ability to maintain immune balance.<\/p>\n

\"From
From left: Ye Zheng and Zhi Liu.
Click here<\/a> for a high-resolution image.
Credit: Salk Institute<\/figcaption><\/figure>\n

However, regulatory T cells don\u2019t normally produce TGF-beta3, as they did here. When the scientists scanned databases, they found that this phenomenon occurs in injured muscle and heart tissue, similar to how hair removal simulated a skin tissue injury in this study.<\/p>\n

\u201cIn acute cases of alopecia, immune cells attack the skin tissue, causing hair loss. The usual remedy is to use glucocorticoids to inhibit the immune reaction in the skin, so they don’t keep attacking the hair follicles,\u201d says Zheng. \u201cApplying glucocorticoids has the double benefit of triggering the regulatory T cells in the skin to produce TGF-beta3, stimulating the activation of the hair follicle stem cells.\u201d<\/p>\n

This study revealed that regulatory T cells and glucocorticoid hormones are not just immunosuppressants but also have a regenerative function. Next,\u00a0the scientists will look at other injury models and isolate regulatory T cells from injured tissues to monitor increased levels of TGF-beta3 and other growth factors.<\/p>\n

This work was supported by a NOMIS fellowship and the NOMIS Foundation, the National Institute of Health (NCI CCSG P30-014195, NIA P01- 454 AG073084, NIA-NMG RF1-AG064049, NIA P30-AG068635, R01-AI107027, R01-AI1511123, R21-AI154919, and S10-OD023689), the Leona M. and Harry B. Helmsley Charitable Trust, the Crohn\u2019s and Colitis Foundation, the National Cancer Institute, and Salk\u2019s Cancer Center Core Facilities (P30-CA014195).<\/p>\n

Other authors included Xianting Hu, Yuqiong Liang, Jingting Yu, and Maxim N. Shokhirev of Salk; and Huabin Li of Fudan University in Shanghai.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[56],"disease-research":[122,335],"class_list":["post-34989","disclosure","type-disclosure","status-publish","hentry","faculty-ye-zheng","disease-research-immune-system-biology","disease-research-regeneration"],"acf":[],"yoast_head":"\nHair-raising research: Salk scientists find surprising link between immune system, hair growth - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/hair-raising-research-salk-scientists-find-surprising-link-between-immune-system-hair-growth\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hair-raising research: Salk scientists find surprising link between immune system, hair growth - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Salk scientists have uncovered an unexpected molecular target of a common treatment for alopecia, a condition in which a person\u2019s immune system attacks their own hair follicles, causing hair loss. 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