{"id":34014,"date":"2022-03-11T00:00:50","date_gmt":"2022-03-11T08:00:50","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=34014"},"modified":"2022-03-11T13:33:49","modified_gmt":"2022-03-11T21:33:49","slug":"salk-scientists-receive-2022-mark-foundation-endeavor-award-to-study-lung-cancer","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/salk-scientists-receive-2022-mark-foundation-endeavor-award-to-study-lung-cancer\/","title":{"rendered":"\u7d22\u5c14\u514b\u79d1\u5b66\u5bb6\u8363\u83b7 2022 \u5e74\u9a6c\u514b\u57fa\u91d1\u4f1a\u7814\u7a76\u80ba\u764c\u52aa\u529b\u5956"},"content":{"rendered":"

LA JOLLA\u2014Professors \u9c81\u672c-\u8096<\/a>, Susan Kaech<\/a>, \u514b\u91cc\u65af\u8482\u5b89\u00b7\u6885\u5854\u6d1b<\/a> \u548c Alan Saghatelian<\/a> have received a 2022 Mark Foundation for Cancer Research Endeavor Award to support their research exploring the metabolic changes that help lung cancers develop. The $3 million Endeavor Award promotes collaborative science to tackle some of the toughest challenges in cancer research. The Salk team\u2014one of four teams chosen out of nearly 200 applications submitted by institutions around the world\u2014hopes their work will lead to the development of more effective lung cancer treatments.<\/p>\n

\u201cNew therapies for difficult-to-treat solid tumors like lung cancer are urgently needed,\u201d says Shaw, head investigator on the project, who is also William R. Brody Chair and director of the Salk\u2019s National Cancer Institute-designated Cancer Center. \u201cThis Endeavor award will accelerate our efforts to identify novel metabolic targets and develop precision drugs for specific genetic subsets of non-small cell lung cancer.\u201d<\/p>\n

\"From
From left: Alan Saghatelian, Susan Kaech, Christian Metallo and Reuben Shaw
Click here<\/a> for a high-resolution image.
Credit: Salk Institute<\/figcaption><\/figure>\n

In recognition of how The Mark Foundation Endeavor Awards foster the formation of strong, multi-disciplinary teams in cancer research, the MacMillan Family Foundation is supporting the Endeavor program by fully funding the work of the Salk Endeavor team. The MacMillan family\u2019s generous gift reflects their commitment to directly supporting scientists who think creatively to address the needs of cancer patients.<\/p>\n

\u201cWe are very grateful to The Mark Foundation and MacMillan family\u2014this exciting project brings together four labs that are each deep experts in different aspects of tumor biology,\u201d says Shaw. \u201cWith this funding, we can define a comprehensive set of metabolic targets and fuel our plan to develop several new therapies for the more than 100,000 patients diagnosed with lung cancer every year.\u201d<\/p>\n

Most deadly lung cancer cases (85 percent) are non-small-cell lung carcinomas (NSCLCs). In order to grow, cancer cells undergo unique metabolic changes to sustain their growth demands, including changes in glucose and fat metabolism. The Salk team previously defined one fat metabolism change in a subset of NSCLCs and pioneered new therapeutics based on the finding. Now, The Mark Foundation Endeavor Award will enable the team to comprehensively study and define the metabolic changes occurring in all NSCLCs, which will dramatically expand therapeutic possibilities.<\/p>\n

\u201cCollaboration is critical to success in science,\u201d said Raymond DuBois, executive chairman of the board of The Mark Foundation. \u201cWe\u2019re confident that the incredible projects selected for Endeavor Awards will have a direct and substantial impact on the lives of cancer patients.\u201d<\/p>","protected":false},"featured_media":0,"template":"","faculty":[111,407,45,311],"disease-research":[46,164],"class_list":["post-34014","disclosure","type-disclosure","status-publish","hentry","faculty-alan-saghatelian","faculty-christian-metallo","faculty-reuben-shaw","faculty-susan-kaech","disease-research-cancer-biology","disease-research-lung-cancer"],"acf":[],"yoast_head":"\nSalk scientists receive 2022 Mark Foundation Endeavor Award to study lung cancer - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/salk-scientists-receive-2022-mark-foundation-endeavor-award-to-study-lung-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk scientists receive 2022 Mark Foundation Endeavor Award to study lung cancer - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Professors Reuben Shaw, Susan Kaech, Christian Metallo and Alan Saghatelian have received a 2022 Mark Foundation for Cancer Research Endeavor Award to support their research exploring the metabolic changes that help lung cancers develop. 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