{"id":33898,"date":"2022-03-09T00:00:57","date_gmt":"2022-03-09T08:00:57","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=33898"},"modified":"2022-03-09T08:55:48","modified_gmt":"2022-03-09T16:55:48","slug":"new-technology-enables-unprecedented-glimpse-inside-single-brain-cells","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/new-technology-enables-unprecedented-glimpse-inside-single-brain-cells\/","title":{"rendered":"\u65b0\u6280\u672f\u4f7f\u5f97\u524d\u6240\u672a\u6709\u5730\u6df1\u5165\u7aa5\u89c6\u5355\u4e2a\u8111\u7ec6\u80de\u6210\u4e3a\u53ef\u80fd"},"content":{"rendered":"

\u62c9\u970d\u4e9a\u2014\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u7684\u57fa\u56e0\u7ec4\u5b66\u6280\u672f\uff0c\u53ef\u4ee5\u540c\u65f6\u5206\u6790\u6765\u81ea\u5355\u4e2a\u7ec6\u80de\u7684 DNA\u3001RNA \u548c\u67d3\u8272\u8d28\uff08DNA \u548c\u86cb\u767d\u8d28\u7684\u7ec4\u5408\uff09\u3002\u8be5\u65b9\u6cd5\u8017\u65f6\u4e94\u5e74\u5f00\u53d1\uff0c\u662f\u5927\u578b\u5408\u4f5c\u9879\u76ee\u7684\u91cd\u8981\u4e00\u6b65\uff0c\u5728\u8fd9\u4e9b\u9879\u76ee\u4e2d\uff0c\u591a\u4e2a\u56e2\u961f\u540c\u65f6\u52aa\u529b\u5bf9\u6570\u5343\u79cd\u65b0\u578b\u7ec6\u80de\u8fdb\u884c\u5206\u7c7b\u3002\u8fd9\u9879\u65b0\u6280\u672f\u53d1\u8868\u5728 \u7ec6\u80de\u57fa\u56e0\u7ec4\u5b66<\/em><\/a> \u5c06\u4e8e2022\u5e743\u67089\u65e5\uff0c\u5c06\u6709\u52a9\u4e8e\u7b80\u5316\u5206\u6790\u3002.<\/p>\n

\"The
\u5c01\u9762\u56fe\u7247\u5c55\u793a\u4e86\u4e00\u9879\u65b0\u6280\u672f\uff0c\u53ef\u4ee5\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u4e86\u89e3\u4eba\u8111\u7684\u5185\u90e8\u8fd0\u4f5c\u3002.
\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.
\u5b66\u5206 \u7ec6\u80de\u57fa\u56e0\u7ec4\u5b66<\/em>, \u7d22\u5c14\u514b\u7814\u7a76\u6240\u548c\u65af\u79d1\u7279\u00b7\u5c3c\u79d1\u5c14\u65af\u3002.<\/figcaption><\/figure>\n

\u201c\u8fd9\u4e2a\u591a\u6a21\u6001\u5e73\u53f0\u5c06\u901a\u8fc7\u63d0\u4f9b\u4e00\u4e2a\u53ef\u4f9b\u8bd5\u56fe\u6574\u5408\u5176\u5355\u4e00\u6a21\u5f0f\u6570\u636e\u7684\u56e2\u961f\u4f7f\u7528\u7684\u7efc\u5408\u6570\u636e\u5e93\u800c\u53d1\u6325\u4f5c\u7528\uff0c\u201d\u4ed6\u8bf4\u3002 \u7ea6\u745f\u592b\u00b7\u57c3\u514b\u5c14<\/a>, \uff0c\u57fa\u56e0\u7ec4\u5206\u6790\u5b9e\u9a8c\u5ba4\u4e3b\u4efb\u3001\u7d22\u5c14\u514b\u56fd\u9645\u9057\u4f20\u5b66\u59d4\u5458\u4f1a\u4e3b\u5e2d\u3001\u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\u3002\u201c\u8fd9\u4e9b\u65b0\u4fe1\u606f\u4e5f\u53ef\u4ee5\u4e3a\u672a\u6765\u7684\u7ec6\u80de\u7c7b\u578b\u5206\u7c7b\u63d0\u4f9b\u4fe1\u606f\u548c\u6307\u5bfc\u3002\u201d<\/p>\n

Ecker \u8ba4\u4e3a\u8fd9\u9879\u6280\u672f\u5bf9\u4e8e\u5927\u89c4\u6a21\u7814\u7a76\u81f3\u5173\u91cd\u8981\uff0c\u4f8b\u5982\u7531\u4ed6\u5171\u540c\u4e3b\u6301\u7684\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7684BRAIN\u8ba1\u5212\u7ec6\u80de\u666e\u67e5\u7f51\u7edc\u3002BRAIN\u8ba1\u5212\u7684\u4e00\u9879\u4e3b\u8981\u5de5\u4f5c\u662f\u5f00\u53d1\u5c0f\u9f20\u548c\u4eba\u7c7b\u5927\u8111\u7ec6\u80de\u7c7b\u578b\u7684\u76ee\u5f55\u3002\u7136\u540e\uff0c\u8fd9\u4e9b\u4fe1\u606f\u53ef\u4ee5\u7528\u6765\u66f4\u597d\u5730\u7406\u89e3\u5927\u8111\u5982\u4f55\u751f\u957f\u548c\u53d1\u80b2\uff0c\u4ee5\u53ca\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u3002.<\/p>\n

\u76ee\u524d\uff0c\u5355\u7ec6\u80de\u6280\u672f\u901a\u8fc7\u4ece\u7ec6\u80de\u6838\u4e2d\u63d0\u53d6 DNA\u3001RNA \u6216\u67d3\u8272\u8d28\uff0c\u7136\u540e\u5206\u6790\u5176\u5206\u5b50\u7ed3\u6784\u4ee5\u5bfb\u627e\u6a21\u5f0f\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u65b9\u6cd5\u4f1a\u7834\u574f\u7ec6\u80de\uff0c\u4f7f\u5f97\u7814\u7a76\u4eba\u5458\u9700\u8981\u4f9d\u8d56\u8ba1\u7b97\u7b97\u6cd5\u6765\u5206\u6790\u5355\u4e2a\u7ec6\u80de\u7684\u591a\u4e2a\u7ec4\u4ef6\u6216\u6bd4\u8f83\u7ed3\u679c\u3002.<\/p>\n

\u5bf9\u4e8e\u4e00\u79cd\u540d\u4e3asnmCAT-seq\u7684\u65b0\u65b9\u6cd5\uff0c\u79d1\u5b66\u5bb6\u4eec\u4f7f\u7528\u751f\u7269\u6807\u8bb0\u7269\u5bf9\u7ec6\u80de\u5185\u7684DNA\u3001RNA\u548c\u67d3\u8272\u8d28\u8fdb\u884c\u6807\u8bb0\uff0c\u800c\u65e0\u9700\u5c06\u5176\u4ece\u7ec6\u80de\u4e2d\u79fb\u9664\u3002\u8fd9\u4f7f\u5f97\u7814\u7a76\u4eba\u5458\u80fd\u591f\u5728\u540c\u4e00\u7ec6\u80de\u4e2d\u6d4b\u91cf\u8fd9\u4e09\u79cd\u7c7b\u578b\u7684\u5206\u5b50\u4fe1\u606f\u3002\u968f\u540e\uff0c\u79d1\u5b66\u5bb6\u4eec\u5229\u7528\u8be5\u65b9\u6cd5\u786e\u5b9a\u4e86\u4eba\u8111\u989d\u53f6\u76ae\u5c42\u533a\u57df\u768463\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u5e76\u5bf9\u6574\u5408\u591a\u79cd\u5355\u7ec6\u80de\u6280\u672f\u7684\u8ba1\u7b97\u65b9\u6cd5\u7684\u6709\u6548\u6027\u8fdb\u884c\u4e86\u57fa\u51c6\u6d4b\u8bd5\u3002\u7814\u7a76\u56e2\u961f\u53d1\u73b0\uff0c\u8ba1\u7b97\u65b9\u6cd5\u5728\u8868\u5f81\u5e7f\u6cdb\u5b9a\u4e49\u7684\u8111\u7ec6\u80de\u7fa4\u4f53\u65b9\u9762\u5177\u6709\u5f88\u9ad8\u7684\u51c6\u786e\u6027\uff0c\u4f46\u5728\u5206\u6790\u7cbe\u7ec6\u5b9a\u4e49\u7684\u7ec6\u80de\u7c7b\u578b\u65f6\u5374\u8868\u73b0\u51fa\u663e\u8457\u7684\u6b67\u4e49\uff0c\u8fd9\u8868\u660e\u9700\u8981\u901a\u8fc7\u591a\u6837\u5316\u7684\u6d4b\u91cf\u6765\u5b9a\u4e49\u7ec6\u80de\u7c7b\u578b\uff0c\u4ee5\u5b9e\u73b0\u66f4\u51c6\u786e\u7684\u5206\u7c7b\u3002.<\/p>\n

\"From<\/a>
\u4ece\u5de6\u8d77\uff1a\u7ea6\u745f\u592b\u00b7\u57c3\u514b\u5c14 (Joseph Ecker) \u548c\u7f57\u5d07\u6e90 (Chongyuan Luo)
\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.
\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

\u8fd9\u9879\u6280\u672f\u8fd8\u53ef\u4ee5\u7528\u4e8e\u66f4\u597d\u5730\u7406\u89e3\u57fa\u56e0\u548c\u7ec6\u80de\u5982\u4f55\u76f8\u4e92\u4f5c\u7528\u5bfc\u81f4\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002.<\/p>\n

\u201c\u8fd9\u4e9b\u75be\u75c5\u5e7f\u6cdb\u5730\u5f71\u54cd\u8bb8\u591a\u7ec6\u80de\u7c7b\u578b\u3002\u4f46\u53ef\u80fd\u5b58\u5728\u67d0\u4e9b\u7279\u522b\u6613\u611f\u7684\u7ec6\u80de\u7fa4\u4f53\uff0c\u201d\u8054\u5408\u7b2c\u4e00\u4f5c\u8005\u8bf4\u9053\u3002\u00a0\u7f57\u5d07\u8fdc<\/a>, \u4eba\u7c7b\u9057\u4f20\u5b66\u52a9\u7406\u6559\u6388\uff0c\u00a0\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u5927\u536b\u00b7\u683c\u82ac\u533b\u5b66\u9662<\/a>. \u57fa\u56e0\u7814\u7a76\u5df2\u7ecf\u7cbe\u786e\u5b9a\u4f4d\u4e86\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u75be\u75c5\u76f8\u5173\u7684\u57fa\u56e0\u7ec4\u533a\u57df\u3002\u6211\u4eec\u63d0\u4f9b\u53e6\u4e00\u4e2a\u6570\u636e\u7ef4\u5ea6\uff0c\u5e76\u8bc6\u522b\u53d7\u8fd9\u4e9b\u57fa\u56e0\u7ec4\u533a\u57df\u5f71\u54cd\u7684\u7ec6\u80de\u7c7b\u578b\u3002\u201c<\/p>\n

\u4e0b\u4e00\u6b65\uff0c\u8be5\u56e2\u961f\u8ba1\u5212\u5229\u7528\u65b0\u5e73\u53f0\u5bf9\u5927\u8111\u7684\u5176\u4ed6\u533a\u57df\u8fdb\u884c\u6d4b\u5e8f\uff0c\u5e76\u5c06\u5065\u5eb7\u4eba\u8111\u7ec6\u80de\u4e0e\u53d7\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5176\u4ed6\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u5f71\u54cd\u7684\u5927\u8111\u7ec6\u80de\u8fdb\u884c\u6bd4\u8f83\u3002.<\/p>\n

\u5176\u4ed6\u4f5c\u8005\u5305\u62ec\u6765\u81ea\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u5218\u6c49\u5e86\u3001\u738b\u90a6\u5b89\u3001\u5f20\u7af9\u7af9\u3001\u674e\u4e1c\u5347\u3001\u5468\u9759\u5929\u3001\u725b\u5347\u52c7\u3001Rosa Castanon\u3001Anna Bartlett\u3001Angeline Rivkin\u3001Jacinta Lucero\u3001Joseph R. Nery\u3001Jesse R. Dixon \u548c M. Margarita Behrens\uff1b\u6765\u81ea\u52a0\u5dde\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\u7684\u8c22\u65b9\u660e\u3001Ethan J. Armand\u3001Wayne I. Doyle\u3001Sebastian Preissl \u548c Eran A. Mukamel\uff1b\u6765\u81ea\u745e\u5178\u5361\u7f57\u6797\u65af\u5361\u7814\u7a76\u6240\u7684 Kimberly Siletti\u3001\u80e1\u4e3d\u5a1f\u548c Sten Linnarsson\uff1b\u6765\u81ea\u897f\u96c5\u56fe\u827e\u4f26\u8111\u79d1\u5b66\u7814\u7a76\u6240\u7684 Trygve E. Bakken\u3001Rebecca D. Hodge \u548c Ed Lein\uff1b\u6765\u81ea\u52a0\u5dde\u62c9\u970d\u4e9a\u8def\u5fb7\u7ef4\u5e0c\u764c\u75c7\u7814\u7a76\u6240\u7684\u623f\u8363\u6b23\u3001\u738b\u946b\u946b\u548c\u4efb\u5175\uff1b\u6765\u81ea\u7ebd\u7ea6\u57fa\u56e0\u7ec4\u4e2d\u5fc3\u7684 Tim Stuart \u548c Rahul Satija\uff1b\u4ee5\u53ca\u6765\u81ea\u8fc8\u963f\u5bc6\u5927\u5b66\u7684 David A. Davis \u548c Deborah C. Mash\u3002.<\/p>\n

\u8be5\u7814\u7a76\u5f97\u5230\u4e86\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff085R21HG009274\u30015R21MH112161\u30015U19MH11483\u3001R01MH125252\u3001U01HG012079\u30015T32MH020002\u3001R01HG010634 \u548c U01MH114812\uff09\u3001\u970d\u534e\u5fb7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u548c\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u533b\u5b66\u9662\u7684\u652f\u6301\u3002.<\/p>","protected":false},"featured_media":33972,"template":"","faculty":[42],"disease-research":[124],"class_list":["post-33898","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-joseph-ecker","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nNew technology enables unprecedented glimpse inside single brain cells - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/new-technology-enables-unprecedented-glimpse-inside-single-brain-cells\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New technology enables unprecedented glimpse inside single brain cells - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Salk Institute researchers have developed a new genomic technology to simultaneously analyze the DNA, RNA and chromatin\u2014a combination of DNA and protein\u2014from a single cell. The method, which took five years to develop, is an important step forward for large collaborations where multiple teams are working simultaneously to classify thousands of new cell types. 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