{"id":33789,"date":"2022-03-07T00:00:52","date_gmt":"2022-03-07T08:00:52","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=33789"},"modified":"2023-01-05T10:37:37","modified_gmt":"2023-01-05T18:37:37","slug":"cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice\/","title":{"rendered":"\u7ec6\u80de\u91cd\u7f16\u7a0b\u7597\u6cd5\u53ef\u5b89\u5168\u9006\u8f6c\u5c0f\u9f20\u7684\u8870\u8001\u8ff9\u8c61"},"content":{"rendered":"<p>\u62c9\u970d\u4e9a\u2014\u5e74\u9f84\u53ea\u662f\u4e00\u4e2a\u6570\u5b57\uff0c\u4f46\u5b83\u5e38\u5e38\u4f1a\u5e26\u6765\u4e0d\u53d7\u6b22\u8fce\u7684\u526f\u4f5c\u7528\uff0c\u4ece\u9aa8\u9abc\u8106\u5f31\u3001\u808c\u8089\u65e0\u529b\u5230\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u764c\u75c7\u98ce\u9669\u589e\u52a0\u3002\u73b0\u5728\uff0c\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u4e0e\u7f57\u6c0f\u96c6\u56e2\u6210\u5458\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u5408\u4f5c\uff0c\u5df2\u7ecf\u8bc1\u660e\u4ed6\u4eec\u53ef\u4ee5\u5728\u4e2d\u5e74\u548c\u8001\u5e74\u5c0f\u9f20\u8eab\u4e0a\u5b89\u5168\u6709\u6548\u5730\u9006\u8f6c\u8870\u8001\u8fc7\u7a0b\uff0c\u65b9\u6cd5\u662f\u5c06\u5b83\u4eec\u7684\u7ec6\u80de\u90e8\u5206\u91cd\u7f6e\u5230\u66f4\u5e74\u8f7b\u7684\u72b6\u6001\u3002\u8fd9\u9879\u7814\u7a76\u53d1\u8868\u5728 <a href=\"https:\/\/www.nature.com\/articles\/s43587-022-00183-2\" target=\"_blank\" rel=\"noopener\"><em>\u81ea\u7136\u8870\u8001<\/em><\/a> 2022\u5e743\u67087\u65e5.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-XryS6SnGTho\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/XryS6SnGTho?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u6211\u4eec\u53ef\u4ee5\u5728\u6574\u4e2a\u751f\u547d\u5468\u671f\u4e2d\u4f7f\u7528\u8fd9\u79cd\u65b9\u6cd5\u6765\u5ef6\u7f13\u6b63\u5e38\u52a8\u7269\u7684\u8870\u8001\u3002\u8fd9\u9879\u6280\u672f\u5728\u5c0f\u9f20\u8eab\u4e0a\u65e2\u5b89\u5168\u53c8\u6709\u6548\uff0c\u201d\u8054\u5408\u901a\u8baf\u4f5c\u8005\u8bf4\u3002 <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/juan-carlos-izpisua-belmonte\/\">\u80e1\u5b89\u00b7\u5361\u6d1b\u65af\u00b7\u4f0a\u5179\u76ae\u82cf\u4e9a\u00b7\u8d1d\u5c14\u8499\u7279<\/a><u>,<\/u> \u7d22\u5c14\u514b\u7814\u7a76\u6240\u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4\u6559\u6388\u3001\u7f57\u6770\u00b7\u5409\u5217\u654f\u8bb2\u5e2d\u7684\u6301\u6709\u8005\u3002\u201c\u9664\u4e86\u5e94\u5bf9\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\uff0c\u8fd9\u79cd\u65b9\u6cd5\u8fd8\u6709\u53ef\u80fd\u4e3a\u751f\u7269\u533b\u5b66\u754c\u63d0\u4f9b\u4e00\u79cd\u65b0\u5de5\u5177\uff0c\u901a\u8fc7\u6539\u5584\u7ec6\u80de\u529f\u80fd\u548c\u5f39\u6027\u6765\u6062\u590d\u7ec4\u7ec7\u548c\u6709\u673a\u4f53\u7684\u5065\u5eb7\uff0c\u4ee5\u5e94\u5bf9\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7b49\u4e0d\u540c\u75be\u75c5\u72b6\u51b5\u3002\u201d<\/p>\n<figure id=\"attachment_33881\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" class=\"img-responsive wp-image-33881 size-medium\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-300x300.jpg\" alt=\"Cellular rejuvenation therapy safely reverses signs of aging in mice \" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-1024x1024.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-768x768.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-945x945.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-1250x1250.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500-200x200.jpg 200w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500.jpg 1500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-caption-text\">\u7ec6\u80de\u91cd\u7f16\u7a0b\u7597\u6cd5\u53ef\u5b89\u5168\u5730\u9006\u8f6c\u5c0f\u9f20\u8870\u8001\u8ff9\u8c61\u3002.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/ScienceImage-1500.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<br \/>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u968f\u7740\u751f\u7269\u4f53\u8870\u8001\uff0c\u4e0d\u4ec5\u662f\u5916\u8868\u548c\u5065\u5eb7\u4f1a\u53d1\u751f\u53d8\u5316\uff1b\u5b83\u4eec\u4f53\u5185\u6bcf\u4e00\u4e2a\u7ec6\u80de\u90fd\u643a\u5e26\u4e00\u4e2a\u8bb0\u5f55\u65f6\u95f4\u6d41\u901d\u7684\u5206\u5b50\u65f6\u949f\u3002\u4e0e\u5e74\u8f7b\u7684\u4e2a\u4f53\u6216\u52a8\u7269\u76f8\u6bd4\uff0c\u4ece\u5e74\u957f\u8005\u6216\u52a8\u7269\u8eab\u4e0a\u5206\u79bb\u51fa\u7684\u7ec6\u80de\u7684 DNA \u4e0a\u5177\u6709\u4e0d\u540c\u7684\u5316\u5b66\u7269\u8d28\u6a21\u5f0f\u2014\u2014\u79f0\u4e3a\u8868\u89c2\u9057\u4f20\u6807\u8bb0\u3002\u79d1\u5b66\u5bb6\u77e5\u9053\uff0c\u5728\u7ec6\u80de\u4e2d\u6dfb\u52a0\u56db\u79cd\u91cd\u7f16\u7a0b\u5206\u5b50\u2014\u2014Oct4\u3001Sox2\u3001Klf4 \u548c cMyc\uff0c\u4e5f\u79f0\u4e3a\u201c\u5c71\u4e2d\u56e0\u5b50\u201d\u2014\u2014\u7684\u6df7\u5408\u7269\uff0c\u53ef\u4ee5\u5c06\u8fd9\u4e9b\u8868\u89c2\u9057\u4f20\u6807\u8bb0\u91cd\u7f6e\u4e3a\u5176\u539f\u59cb\u6a21\u5f0f\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u4ece\u53d1\u80b2\u89d2\u5ea6\u6765\u770b\uff0c\u5c06\u6210\u5e74\u7ec6\u80de\u56de\u62e8\u6210\u5e72\u7ec6\u80de\u3002.<\/p>\n<p>2016\u5e74\uff0cIzpisua Belmonte\u5b9e\u9a8c\u5ba4\u9996\u6b21\u62a5\u9053\uff0c\u4ed6\u4eec\u53ef\u4ee5\u4f7f\u7528\u5c71\u4e2d\u56e0\u5b50\u6765 <a href=\"https:\/\/www.salk.edu\/zh\/news-release\/turning-back-time-salk-scientists-reverse-signs-aging\/\">\u5bf9\u6297\u8870\u8001\u8ff9\u8c61\uff0c\u5ef6\u957f\u5bff\u547d<\/a> \u5728\u60a3\u6709\u65e9\u8870\u75c7\u7684\u5c0f\u9f20\u4e2d\u3002\u6700\u8fd1\uff0c\u8be5\u56e2\u961f\u53d1\u73b0\uff0c\u5373\u4f7f\u5728\u5e74\u8f7b\u5c0f\u9f20\u4e2d\uff0c\u5c71\u4e2d\u56e0\u5b50\u4e5f\u80fd <a href=\"https:\/\/www.salk.edu\/zh\/news-release\/new-study-shows-how-to-boost-muscle-regeneration-and-rebuild-tissue\/\">\u52a0\u901f\u808c\u8089\u518d\u751f<\/a>. \u5728\u8fd9\u4e9b\u521d\u6b65\u89c2\u5bdf\u4e4b\u540e\uff0c\u5176\u4ed6\u79d1\u5b66\u5bb6\u4e5f\u91c7\u7528\u4e86\u540c\u6837\u7684\u65b9\u6cd5\u6765\u6539\u5584\u5fc3\u810f\u3001\u5927\u8111\u548c\u53c2\u4e0e\u89c6\u89c9\u7684\u89c6\u795e\u7ecf\u7b49\u5176\u4ed6\u7ec4\u7ec7\u7684\u673a\u80fd\u3002.<\/p>\n<p>\u5728\u65b0\u7684\u7814\u7a76\u4e2d\uff0cIzpisua Belmonte \u548c\u4ed6\u7684\u540c\u4e8b\u4eec\u5728\u5065\u5eb7\u52a8\u7269\u8870\u8001\u8fc7\u7a0b\u4e2d\u6d4b\u8bd5\u4e86\u7ec6\u80de\u590d\u539f\u65b9\u6cd5\u7684\u4e0d\u540c\u53d8\u4f53\u3002\u5176\u4e2d\u4e00\u7ec4\u5c0f\u9f20\u4ece 15 \u4e2a\u6708\u5927\u5230 22 \u4e2a\u6708\u5927\u63a5\u53d7\u5b9a\u671f\u5242\u91cf\u7684 Yamanaka \u56e0\u5b50\uff0c\u8fd9\u5927\u7ea6\u76f8\u5f53\u4e8e\u4eba\u7c7b\u7684 50 \u5c81\u5230 70 \u5c81\u3002\u53e6\u4e00\u7ec4\u5219\u4ece 12 \u4e2a\u6708\u5927\u5230 22 \u4e2a\u6708\u5927\u63a5\u53d7\u6cbb\u7597\uff0c\u5927\u7ea6\u76f8\u5f53\u4e8e\u4eba\u7c7b\u7684 35 \u5c81\u5230 70 \u5c81\u3002\u7b2c\u4e09\u7ec4\u5219\u5728 25 \u4e2a\u6708\u5927\u65f6\u4ec5\u63a5\u53d7\u4e86\u4e00\u4e2a\u6708\u7684\u6cbb\u7597\uff0c\u7c7b\u4f3c\u4e8e\u4eba\u7c7b\u7684 80 \u5c81\u3002.<\/p>\n<p>\u201c\u6211\u4eec\u771f\u6b63\u60f3\u786e\u5b9a\u7684\u662f\uff0c\u957f\u671f\u91c7\u7528\u8fd9\u79cd\u65b9\u6cd5\u662f\u5b89\u5168\u7684\uff0c\u201d\u8be5\u65b0\u8bba\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3001\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u79d1\u7814\u4eba\u5458\u666e\u62c9\u8fea\u666e\u00b7\u96f7\u8fea\u8bf4\u9053\uff0c\u201c\u4e8b\u5b9e\u4e0a\uff0c\u6211\u4eec\u6ca1\u6709\u53d1\u73b0\u4efb\u4f55\u5bf9\u8fd9\u4e9b\u52a8\u7269\u7684\u5065\u5eb7\u3001\u884c\u4e3a\u6216\u4f53\u91cd\u4ea7\u751f\u8d1f\u9762\u5f71\u54cd\u3002\u201d<\/p>\n<p>\u4e0e\u5bf9\u7167\u52a8\u7269\u76f8\u6bd4\uff0c\u63a5\u53d7\u5c71\u4e2d\u56e0\u5b50\u7684\u5c0f\u9f20\u6ca1\u6709\u51fa\u73b0\u8840\u7ec6\u80de\u6539\u53d8\u6216\u795e\u7ecf\u7cfb\u7edf\u53d8\u5316\u3002\u6b64\u5916\uff0c\u7814\u7a76\u5c0f\u7ec4\u5728\u6240\u6709\u52a8\u7269\u7ec4\u4e2d\u5747\u672a\u53d1\u73b0\u764c\u75c7\u3002.<\/p>\n<figure id=\"attachment_33879\"  class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" class=\"img-responsive wp-image-33879 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-300x300.jpg\" alt=\"Juan Carlos Izpisua Belmonte and Pradeep Reddy\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-1024x1024.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-768x768.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-1536x1536.jpg 1536w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-945x945.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-1250x1250.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr-200x200.jpg 200w, https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr.jpg 1568w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-caption-text\">\u4ece\u5de6\u8d77\uff1a\u80e1\u5b89\u00b7\u5361\u6d1b\u65af\u00b7\u4f0a\u5179\u76ae\u82cf\u4e9a\u00b7\u8d1d\u5c14\u8499\u7279\u548c\u666e\u62c9\u8fea\u666e\u00b7\u96f7\u8fea\u3002.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2022\/02\/Juan-Carlos-Pradeep-Reddy-hr.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<br 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