{"id":30647,"date":"2021-04-30T00:00:45","date_gmt":"2021-04-30T07:00:45","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=30647"},"modified":"2023-12-11T12:37:22","modified_gmt":"2023-12-11T20:37:22","slug":"the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness\/","title":{"rendered":"\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u523a\u7a81\u86cb\u767d\u5728\u75be\u75c5\u4e2d\u8d77\u7740\u91cd\u8981\u7684\u9644\u52a0\u4f5c\u7528"},"content":{"rendered":"

LA JOLLA\u2014Scientists have known for a while that SARS-CoV-2’s distinctive \u201cspike\u201d proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself. <\/p>\n

The paper, published on April 30, 2021, in Circulation Research<\/em><\/a>, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. The findings help explain COVID-19\u2019s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies.<\/p>\n

\"\"
Representative images of vascular endothelial control cells (left) and cells treated with the SARS-CoV-2 Spike protein (right) show that the spike protein causes increased mitochondrial fragmentation in vascular cells.
Click here<\/a> for a high-resolution image.
Credit: Salk Institute<\/figcaption><\/figure>\n

\u201cA lot of people think of it as a respiratory disease, but it\u2019s really a vascular disease,\u201d says Assistant Research Professor Uri Manor<\/a>, who is co-senior author of the study. \u201cThat could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings.\u201d<\/p>\n

Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy, among others.<\/p>\n

While the findings themselves aren\u2019t entirely a surprise, the paper provides clear confirmation and a detailed explanation of the mechanism through which the protein damages vascular cells for the first time. There\u2019s been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented.<\/p>\n

In the new study, the researchers created a \u201cpseudovirus\u201d that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal model\u2014proving that the spike protein alone was enough to cause disease. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls.<\/p>\n

The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. They showed that the spike protein damaged the cells by binding ACE2. This binding disrupted ACE2\u2019s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented.<\/p>\n

Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own.<\/p>\n

\u201cIf you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,\u201d Manor explains. \u201cFurther studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.\u201d<\/p>\n

The researchers next hope to take a closer look at the mechanism by which the disrupted ACE2 protein damages mitochondria and causes them to change shape.<\/p>\n

Other authors on the study are Yuyang Lei and Zu-Yi Yuan of Jiaotong University in Xi\u2019an, China; Cara R. Schiavon, Leonardo Andrade, and Gerald S. Shadel of Salk; Ming He, Hui Shen, Yichi Zhang, Yoshitake Cho, Mark Hepokoski, Jason X.-J. Yuan, Atul Malhotra, Jin Zhang of the University of California San Diego; Lili Chen, Qian Yin, Ting Lei, Hongliang Wang and Shengpeng Wang of Xi\u2019an Jiatong University Health Science Center in Xi\u2019an, China.<\/p>\n

The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xi\u2019an Jiaotong University; and Xi\u2019an Jiaotong University.<\/p>","protected":false},"featured_media":30667,"template":"","faculty":[405],"disease-research":[366,462],"class_list":["post-30647","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-uri-manor","disease-research-infectious-disease","disease-research-stroke"],"acf":[],"yoast_head":"\nThe novel coronavirus\u2019 spike protein plays additional key role in illness - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The novel coronavirus\u2019 spike protein plays additional key role in illness - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Scientists have known for a while that SARS-CoV-2’s distinctive \u201cspike\u201d proteins help the virus infect its host by latching on to healthy cells. 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