{"id":2545,"date":"2015-06-17T00:00:00","date_gmt":"2015-06-17T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/protein-plays-unexpected-role-in-embryonic-stem-cells\/"},"modified":"2015-06-17T00:00:00","modified_gmt":"2015-06-17T07:00:00","slug":"protein-plays-unexpected-role-in-embryonic-stem-cells","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/protein-plays-unexpected-role-in-embryonic-stem-cells\/","title":{"rendered":"\u86cb\u767d\u8d28\u5728\u80da\u80ce\u5e72\u7ec6\u80de\u4e2d\u626e\u6f14\u4e86\u610f\u60f3\u4e0d\u5230\u7684\u89d2\u8272"},"content":{"rendered":"<p>\n\u62c9\u970d\u4e9a\u2014\u2014\u5982\u679c\u4f60\u53d1\u73b0\u5bb6\u95e8\u7684\u4e00\u90e8\u5206\u5076\u5c14\u4f1a\u8131\u79bb\u95e8\u6846\uff0c\u5728\u623f\u5b50\u91cc\u4e3a\u4f60\u505a\u5bb6\u52a1\uff0c\u90a3\u4f1a\u662f\u600e\u6837\u7684\u60ca\u5947\uff1f\u8fd9\u6b63\u662f\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u8fd1\u671f\u53d1\u73b0\u6240\u7ecf\u5386\u7684\u60ca\u559c\uff1a\u6838\u5b54\u86cb\u767d\u2014\u2014\u4f5c\u4e3a\u7ec6\u80de\u201c\u95e8\u6237\u201d\uff0c\u5e2e\u52a9\u7ba1\u7406\u7ec6\u80de\u6838\u5185\u5916\u7269\u8d28\u8fdb\u51fa\u7684\u86cb\u767d\u8d28\u2014\u2014\u5b9e\u9645\u4e0a\u5728\u57fa\u56e0\u8868\u8fbe\u65b9\u9762\u626e\u6f14\u7740\u6bd4\u4ee5\u5f80\u8ba4\u4e3a\u7684\u66f4\u91cd\u8981\u7684\u89d2\u8272\u3002.\n<\/p>\n<p>\n\u8be5\u53d1\u73b0\u57282015\u5e746\u670816\u65e5\u53d1\u8868\u4e8e\u300a <a href=\"http:\/\/genesdev.cshlp.org\/content\/early\/2015\/06\/12\/gad.260919.115.abstract\" target=\"_blank\"><em>\u57fa\u56e0\u4e0e\u53d1\u80b2<\/em><\/a>, \uff0c\u8868\u660e\u6838\u5b54\u86cb\u767d\u5728\u80da\u80ce\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u7279\u5b9a\u7ec4\u7ec7\u4e4b\u524d\uff0c\u5728\u7ef4\u6301\u5176\u72b6\u6001\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u8fd9\u4e00\u53d1\u73b0\u4e3a\u7531\u8fd9\u4e9b\u86cb\u767d\u8d28\u7a81\u53d8\u5f15\u8d77\u7684\u9057\u4f20\u6027\u75be\u75c5\u63d0\u4f9b\u4e86\u65b0\u7684\u8ba4\u8bc6\u3002\u5176\u4e2d\u4e00\u79cd\u6838\u5b54\u86cb\u767d\u5728\u5e72\u7ec6\u80de\u5f62\u6210\u795e\u7ecf\u5143\u7684\u8fc7\u7a0b\u4e2d\uff0c\u8d77\u7740\u51fa\u4eba\u610f\u6599\u7684\u5173\u952e\u4f5c\u7528\u3002.\n<\/p>\n<div class=\"imageCaption\"><img decoding=\"async\" style=\"border-bottom: 1px #006699 solid;\" alt=\"\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/01\/2090-Jacinto_Figure_2.jpg\"><\/p>\n<p>\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\u4e00\u79cd\u540d\u4e3aNup153\uff08\u7eff\u8272\uff09\u7684\u86cb\u767d\u8d28\u53ef\u4ee5\u63a7\u5236\u80da\u80ce\u5e72\u7ec6\u80de\uff08\u84dd\u8272\uff09\u7684\u53d1\u80b2\u3002\u5f53Salk\u79d1\u5b66\u5bb6\u5220\u9664Nup153\uff08\u5de6\uff09\u65f6\uff0c\u7ec6\u80de\u53ef\u4ee5\u81ea\u7531\u5730\u5feb\u901f\u5f00\u59cb\u8f6c\u5316\u4e3a\u795e\u7ecf\u5143\u524d\u4f53\uff08\u7ea2\u8272\u6807\u8bb0\uff09\uff0c\u8fd9\u8868\u660eNup153\u5148\u524d\u672a\u77e5\u7684\u89d2\u8272\u3002.<\/p>\n<p><a target=\"_blank\" href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/02\/2090-Jacinto_Figure_2.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<\/p>\n<p>\n\u56fe\u7247\uff1a\u7531\u8428\u514b\u751f\u7269\u7814\u7a76\u6240\u63d0\u4f9b\n<\/p>\n<\/div>\n<p>\n\u201c\u6211\u4eec\u8ba9\u8fd9\u4e00\u7c7b\u86cb\u767d\u8d28\u7115\u53d1\u4e86\u65b0\u7684\u5149\u5f69\uff0c\u201d <a href=\"https:\/\/www.salk.edu\/zh\/faculty\/hetzer.html\/\">\u9a6c\u4e01\u00b7\u8d6b\u7b56\u5c14<\/a>, \uff0c\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u6559\u6388 <a href=\"https:\/\/www.salk.edu\/zh\/faculty\/molecular_and_cell_biology_laboratory.html\/\">\u5206\u5b50\u4e0e\u7ec6\u80de\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4<\/a> \u4e5f\u662f\u8fd9\u7bc7\u65b0\u8bba\u6587\u7684\u8d44\u6df1\u4f5c\u8005\u3002\u201c\u6211\u5e0c\u671b\u4eba\u4eec\u5f00\u59cb\u63a5\u53d7\u5e76\u8ba4\u8bc6\u5230\uff0c\u6838\u5b54\u86cb\u767d\u4e0d\u4ec5\u4ec5\u662f\u8f6c\u8fd0\u86cb\u767d\u3002\u201d\n<\/p>\n<p>\n\u6838\u5b54\u86cb\u767d\u2014\u2014\u7ea6\u6709 30 \u79cd\u2014\u2014\u901a\u5e38\u662f\u6838\u5b54\u590d\u5408\u4f53\u7684\u7ec4\u6210\u90e8\u5206\uff0c\u6838\u5b54\u590d\u5408\u4f53\u662f\u8fde\u63a5\u7ec6\u80de\u6838\u5185\u90e8\u4e0e\u5916\u90e8\u7ec6\u80de\u8d28\u7684\u5de8\u5927\u7ed3\u6784\u30022010 \u5e74\uff0cHetzer \u7684\u56e2\u961f\u9996\u6b21\u53d1\u73b0\u4e86\u6838\u5b54\u86cb\u767d\u53ef\u80fd\u4e5f\u5728\u7ec6\u80de\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u8c03\u8282\u7ec6\u80de\u6838\u5185\u57fa\u56e0\u8f6c\u5f55\u6210\u86cb\u767d\u8d28\u7684\u65f6\u95f4\u65b9\u9762\u53d1\u6325\u4f5c\u7528\u7684\u7ebf\u7d22\u3002\u4f46\u5176\u5177\u4f53\u4f5c\u7528\u5c1a\u4e0d\u6e05\u695a\u3002.\n<\/p>\n<p>\n\u5728\u65b0\u5de5\u4f5c\u4e2d\uff0cHetzer \u548c\u4ed6\u7684\u540c\u4e8b\u4eec\u4e13\u6ce8\u4e8e\u4e00\u79cd\u7279\u5b9a\u7684\u6838\u5b54\u86cb\u767d Nup153\uff0c\u8fd9\u79cd\u86cb\u767d\u5df2\u77e5\u4f1a\u5feb\u901f\u5730\u5728\u6838\u5b54\u590d\u5408\u4f53\u4e0a\u79fb\u52a8\u8fdb\u51fa\uff0c\u8fd9\u8868\u660e\u5b83\u53ef\u80fd\u5728\u8fdb\u884c\u4e00\u4e9b\u9664\u4e86\u4e3a\u6838\u5b54\u63d0\u4f9b\u7ed3\u6784\u652f\u6491\u4e4b\u5916\u7684\u5de5\u4f5c\u3002.\n<\/p>\n<p>\n\u7814\u7a76\u4eba\u5458\u8f6c\u5411\u4e86\u5c0f\u9f20\u80da\u80ce\u5e72\u7ec6\u80de\u2014\u2014\u8fd9\u79cd\u7ec6\u80de\u6709\u6f5c\u529b\u5206\u5316\u6210\u8eab\u4f53\u4e2d\u7684\u4efb\u4f55\u4e00\u79cd\u7ec6\u80de\u7c7b\u578b\u2014\u2014\u5e76\u5220\u9664\u4e86 Nup153\u3002\u4ed6\u4eec\u66fe\u9884\u8ba1\uff0c\u5982\u679c Nup153 \u5728\u7ec6\u80de\u5206\u5316\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\uff0c\u90a3\u4e48\u4ece\u5e72\u7ec6\u80de\u4e2d\u53bb\u9664\u5b83\u5c06\u963b\u6b62\u5b83\u4eec\u5206\u5316\u3002\u7136\u800c\uff0c\u7ed3\u679c\u6070\u6070\u76f8\u53cd\u3002.\n<\/p>\n<p>\n\u201c\u6700\u5927\u7684\u60ca\u559c\u662f\uff0c\u5f53\u6211\u4eec\u79fb\u9664\u8fd9\u4e2a\u57fa\u56e0\u65f6\uff0c\u5e72\u7ec6\u80de\u5f00\u59cb\u5206\u5316\u4e86\uff0c\u201d\u8d6b\u7b56\u5c14\u8bf4\u9053\u3002\u201c\u800c\u4e14\u5b83\u4eec\u4e0d\u4ec5\u5f00\u59cb\u5206\u5316\uff0c\u8fd8\u5f00\u59cb\u5206\u5316\u6210\u795e\u7ecf\u5143\u3002\u201d\n<\/p>\n<div class=\"imageCaption530\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/01\/2090_Martin-Hetzer_Filipe-Jacinto.jpg\"><\/p>\n<p>\n\u9a6c\u4e01\u00b7\u8d6b\u7b56\u5c14\uff08Martin Hetzer\uff09\u548c\u83f2\u5229\u4f69\u00b7\u8d3e\u8f9b\u6258\uff08Filipe Jacinto\uff09\u6765\u81ea\u5206\u5b50\u4e0e\u7ec6\u80de\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4 <\/p>\n<p><a target=\"_blank\" href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/02\/2090_Martin-Hetzer_Filipe-Jacinto.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<\/p>\n<p>\n\u56fe\u7247\uff1a\u7531\u8428\u514b\u751f\u7269\u7814\u7a76\u6240\u63d0\u4f9b\n<\/p>\n<\/div>\n<p>\n\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0cNup153 \u4f1a\u5239\u4f4f\u67d0\u4e9b\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u8111\u7ec6\u80de\u6240\u9700\u7684\u57fa\u56e0\u3002\u5f53\u5239\u8f66\u88ab\u89e3\u9664\u65f6\uff0c\u5e72\u7ec6\u80de\u5f00\u59cb\u5206\u5316\u3002.\n<\/p>\n<p>\n\u201c\u8fd9\u9879\u7814\u7a76\u4e0d\u4ec5\u63ed\u793a\u4e86\u6838\u5b54\u86cb\u767d\u5728\u901a\u8fc7\u6c89\u9ed8\u795e\u7ecf\u57fa\u56e0\u4ecb\u5bfc\u80da\u80ce\u5e72\u7ec6\u80de\u7684\u672a\u5206\u5316\u72b6\u6001\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u800c\u4e14\u8fd8\u4e3a\u9610\u660e\u8fd9\u4e9b\u86cb\u767d\u8d28\u5728\u54fa\u4e73\u52a8\u7269\u53d1\u80b2\u4e2d\u7684\u4f5c\u7528\u5f15\u5165\u4e86\u65b0\u7684\u673a\u5236\u65b9\u5411\uff0c\u201d\u901a\u8baf\u4f5c\u8005\u3001Hetzer\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u540e\u7814\u7a76\u5458Filipe Jacinto\u8bf4\u3002.\n<\/p>\n<p>\n\u8d6b\u7b56\u5c14\u6000\u7591\u5176\u4ed6\u6838\u5b54\u86cb\u767d\u5728\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u4e2d\u4e5f\u8d77\u7740\u4f5c\u7528\uff0c\u4f46\u4ed6\u8c28\u614e\u5730\u6307\u51fa\uff0c\u8fd9\u4e9b\u4f5c\u7528\u53ef\u80fd\u5927\u4e0d\u76f8\u540c\u2014\u2014\u4ed6\u8bf4\uff0c\u6bcf\u79cd\u6838\u5b54\u86cb\u767d\u53ef\u80fd\u9776\u5411\u4e0d\u540c\u7684\u4e00\u7ec4\u57fa\u56e0\uff0c\u6709\u4e9b\u53ef\u80fd\u6fc0\u6d3b\u57fa\u56e0\u800c\u975e\u6291\u5236\u57fa\u56e0\u3002.\n<\/p>\n<p>\n\u8bb8\u591a\u6838\u5b54\u86cb\u767d\u57fa\u56e0\u7684\u7a81\u53d8\u4e0e\u4eba\u7c7b\u75be\u75c5\u548c\u53d1\u80b2\u969c\u788d\u6709\u5173\uff0c\u5305\u62ec\u67d0\u4e9b\u7c7b\u578b\u7684\u767d\u8840\u75c5\u548c\u9057\u4f20\u6027\u5fc3\u810f\u75c5\u3002\u8d6b\u7b56\u5c14\u8bf4\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u7814\u7a76\u4eba\u5458\u4e00\u76f4\u8ba4\u4e3a\u8fd9\u4e9b\u7a81\u53d8\u901a\u8fc7\u6539\u53d8\u86cb\u767d\u8d28\u8fdb\u51fa\u7ec6\u80de\u6838\u7684\u8fd0\u8f93\u6765\u5bfc\u81f4\u75be\u75c5\u3002\u201c\u73b0\u5728\uff0c\u6211\u4eec\u610f\u8bc6\u5230\u8fd9\u53ef\u80fd\u4e0d\u662f\u552f\u4e00\u7684\u89e3\u91ca\uff0c\u201d\u4ed6\u8bf4\u3002\u201c\u8bb8\u591a\u8fd9\u4e9b\u75be\u75c5\u548c\u53d1\u80b2\u969c\u788d\u5b9e\u9645\u4e0a\u53ef\u80fd\u662f\u7531\u8fd9\u4e9b\u57fa\u56e0\u8c03\u63a7\u57fa\u56e0\u8868\u8fbe\u7a0b\u5e8f\u7684\u80fd\u529b\u5f15\u8d77\u7684\u3002\u201d\n<\/p>\n<p>\n\u4ed6\u7684\u5b9e\u9a8c\u5ba4\u6b63\u8ba1\u5212\u5bf9Nup153\u8fdb\u884c\u540e\u7eed\u7814\u7a76\uff0c\u5305\u62ec\u5b83\u5982\u4f55\u88ab\u52df\u96c6\u5230\u57fa\u56e0\u4e0a\uff0c\u4ee5\u53ca\u7814\u7a76\u5176\u4ed6\u6838\u5b54\u86cb\u767d\u7684\u53d1\u80b2\u4f5c\u7528\u3002.\n<\/p>\n<p>\n\u514b\u91cc\u65af\u00b7\u672c\u7eb3\uff0c\u4e3b\u4efb <a href=\"http:\/\/igc.salk.edu\/\">\u6574\u5408\u57fa\u56e0\u7ec4\u5b66\u4e0e\u751f\u7269\u4fe1\u606f\u5b66\u6838\u5fc3<\/a> \u5728\u7d22\u5c14\u514b\u7814\u7a76\u6240\uff0c\u4e5f\u4e3a\u8fd9\u9879\u5de5\u4f5c\u505a\u51fa\u4e86\u8d21\u732e\u3002.\n<\/p>\n<p>\n\u8fd9\u9879\u5de5\u4f5c\u4ee5\u53ca\u53c2\u4e0e\u7814\u7a76\u7684\u5b66\u8005\u5f97\u5230\u4e86\u4ee5\u4e0b\u673a\u6784\u8d44\u52a9\uff1a <a href=\"http:\/\/nih.gov\/\" target=\"_blank\">\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662<\/a> \u548c <a href=\"http:\/\/www.cancer.gov\/\" target=\"_blank\">\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240<\/a>.\n<\/p>\n<p>\n<strong>\u5173\u4e8e\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\uff1a<\/strong><br \/>\n\u7d22\u5c14\u514b\u751f\u7269\u5b66\u7814\u7a76\u6240\u662f\u4e16\u754c\u9876\u5c16\u7684\u57fa\u7840\u7814\u7a76\u673a\u6784\u4e4b\u4e00\uff0c\u5176\u56fd\u9645\u77e5\u540d\u7684\u6559\u804c\u5458\u5de5\u5728\u4e00\u4e2a\u72ec\u7279\u7684\u3001\u5408\u4f5c\u548c\u5bcc\u6709\u521b\u9020\u529b\u7684\u73af\u5883\u4e2d\uff0c\u63a2\u7d22\u751f\u547d\u79d1\u5b66\u7684\u57fa\u672c\u95ee\u9898\u3002\u7d22\u5c14\u514b\u79d1\u5b66\u5bb6\u81f4\u529b\u4e8e\u79d1\u5b66\u53d1\u73b0\u548c\u57f9\u517b\u4e0b\u4e00\u4ee3\u7814\u7a76\u4eba\u5458\uff0c\u901a\u8fc7\u5bf9\u795e\u7ecf\u79d1\u5b66\u3001\u9057\u4f20\u5b66\u3001\u7ec6\u80de\u548c\u690d\u7269\u751f\u7269\u5b66\u4ee5\u53ca\u76f8\u5173\u5b66\u79d1\u7684\u7814\u7a76\uff0c\u5728\u764c\u75c7\u3001\u8870\u8001\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u7cd6\u5c3f\u75c5\u548c\u4f20\u67d3\u75c5\u7b49\u9886\u57df\u53d6\u5f97\u4e86\u5f00\u521b\u6027\u7684\u8d21\u732e\uff0c\u52a0\u6df1\u4e86\u6211\u4eec\u5bf9\u8fd9\u4e9b\u75be\u75c5\u7684\u7406\u89e3\u3002.<\/p>\n<p>\u6559\u804c\u5458\u5de5\u7684\u6210\u5c31\u83b7\u5f97\u4e86\u65e0\u6570\u8363\u8a89\uff0c\u5305\u62ec\u8bfa\u8d1d\u5c14\u5956\u548c\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\u8d44\u683c\u3002\u8be5\u7814\u7a76\u6240\u7531\u810a\u9ad3\u7070\u8d28\u708e\u75ab\u82d7\u5148\u9a71 Jonas Salk \u533b\u751f\u4e8e 1960 \u5e74\u521b\u7acb\uff0c\u662f\u4e00\u5bb6\u72ec\u7acb\u7684\u975e\u8425\u5229\u7ec4\u7ec7\u548c\u5efa\u7b51\u5730\u6807\u3002.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[86],"disease-research":[],"class_list":["post-2545","disclosure","type-disclosure","status-publish","hentry","faculty-martin-hetzer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Protein plays unexpected role in embryonic stem cells - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/protein-plays-unexpected-role-in-embryonic-stem-cells\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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