{"id":24603,"date":"2019-10-17T00:00:18","date_gmt":"2019-10-17T07:00:18","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=24603"},"modified":"2024-01-30T14:47:36","modified_gmt":"2024-01-30T22:47:36","slug":"stem-cell-study-offers-new-way-to-study-early-development-and-pregnancy","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/stem-cell-study-offers-new-way-to-study-early-development-and-pregnancy\/","title":{"rendered":"\u5e72\u7ec6\u80de\u7814\u7a76\u4e3a\u7814\u7a76\u65e9\u671f\u53d1\u80b2\u548c\u6000\u5b55\u63d0\u4f9b\u4e86\u65b0\u65b9\u6cd5"},"content":{"rendered":"<p>\u62c9\u970d\u4e9a\u2014\u5c3d\u7ba1\u6bd5\u4e1a\u3001\u7b2c\u4e00\u4efd\u5de5\u4f5c\u548c\u7ed3\u5a5a\u53ef\u80fd\u662f\u4eba\u751f\u4e2d\u7684\u91cd\u8981\u4e8b\u4ef6\uff0c\u4f46\u4e00\u4e9b\u6700\u91cd\u5927\u7684\u4e8b\u4ef6\u53d1\u751f\u5728\u66f4\u65e9\u7684\u65f6\u5019\uff1a\u5728\u7cbe\u5b50\u4f7f\u5375\u5b50\u53d7\u7cbe\u5e76\u5f00\u59cb\u5206\u88c2\u7684\u6700\u521d\u51e0\u5929\u91cc\u3002.<\/p>\n<p>\u524d100\u4e2a\u7ec6\u80de\uff08\u7edf\u79f0\u4e3a\u80da\u6ce1\uff09\u7684\u7ec4\u7ec7\u65b9\u5f0f\u5bf9\u598a\u5a20\u80fd\u5426\u6210\u529f\u3001\u5668\u5b98\u5982\u4f55\u5f62\u6210\uff0c\u751a\u81f3\u53ef\u80fd\u5bf9\u65e5\u540e\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u75be\u75c5\u90fd\u6709\u6df1\u8fdc\u5f71\u54cd\u3002\u7136\u800c\uff0c\u5728\u6b64\u4e4b\u524d\uff0c\u79d1\u5b66\u5bb6\u4eec\u4e00\u76f4\u6ca1\u6709\u597d\u7684\u65b9\u6cd5\u6765\u6a21\u62df\u80da\u6ce1\u7684\u5f62\u6210\u3002.<\/p>\n<figure id=\"attachment_24614\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"458\" class=\"img-responsive wp-image-24614 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-458x458.jpg\" alt=\"Pictured are blastocyst-like structures (blastoids) from cultured cells immunofluorescently stained for the trophectoderm marker CDX2 (green) and the inner cell mass marker SOX2 (red). The trophoectoderm makes up the outer cells of the blastoid. \" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-768x768.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-945x945.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1-200x200.jpg 200w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1.jpg 1000w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><figcaption class=\"wp-caption-text\">\u56fe\u793a\u4e3a\u57f9\u517b\u7ec6\u80de\u4ea7\u751f\u7684\u7c7b\u80da\u6ce1\u7ed3\u6784\uff08\u7c7b\u80da\u80ce\uff09\uff0c\u4f7f\u7528\u6ecb\u517b\u5916\u80da\u5c42\u6807\u5fd7\u7269CDX2\uff08\u7eff\u8272\uff09\u548c\u5185\u7ec6\u80de\u56e2\u6807\u5fd7\u7269SOX2\uff08\u7ea2\u8272\uff09\u8fdb\u884c\u514d\u75ab\u8367\u5149\u67d3\u8272\u3002\u6ecb\u517b\u5916\u80da\u5c42\u6784\u6210\u7c7b\u80da\u80ce\u7684\u5916\u90e8\u7ec6\u80de\u3002. <\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Picture1.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<\/p>\n<p>\u6765\u6e90\uff1a\u8428\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\/\u97e6\u7279\u5148\u8fdb\u751f\u7269\u5149\u5b50\u6838\u5fc3\u8bbe\u65bd<\/figcaption><\/figure>\n<p>\u7d22\u5c14\u514b\u7814\u7a76\u6240\u548c\u5fb7\u514b\u8428\u65af\u5927\u5b66\u897f\u5357\u533b\u5b66\u4e2d\u5fc3\u7684\u79d1\u5b66\u5bb6\u4eec\u9996\u6b21\u521b\u9020\u4e86\u7531\u5355\u4e2a\u57f9\u517b\u7ec6\u80de\u6784\u6210\u7684\u9f20\u80da\u6ce1\u6837\u7ed3\u6784\uff0c\u4e5f\u79f0\u4e3a\u201c\u7c7b\u80da\u76d8\u201d\uff0c\u4ece\u800c\u65e0\u9700\u5929\u7136\u80da\u80ce\u3002\u4ed6\u4eec\u4e8e2019\u5e7410\u670817\u65e5\u5728\u6b64\u671f\u520a\u4e0a\u62a5\u9053\u4e86\u8fd9\u4e00\u6210\u679c\u3002 <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(19)31080-3\" target=\"_blank\" rel=\"noopener\"><em>\u7ec6\u80de<\/em><\/a>, \u8fd9\u4e9b\u57f9\u517b\u7684\u5375\u88c2\u7403\u5177\u6709\u4e0e\u5929\u7136\u80da\u6ce1\u76f8\u540c\u7684\u7ed3\u6784\uff0c\u751a\u81f3\u53ef\u4ee5\u5728\u5b50\u5bab\u5185\u7740\u5e8a\u2014\u2014\u8fd9\u6709\u52a9\u4e8e\u63a8\u8fdb\u53d1\u80b2\u7814\u7a76\uff0c\u5e76\u53ef\u80fd\u4e3a\u598a\u5a20\u3001\u4e0d\u5b55\u6216\u540e\u4ee3\u65e5\u540e\u5065\u5eb7\u95ee\u9898\u63d0\u4f9b\u4fe1\u606f\u3002.<\/p>\n<p>\u201c\u8fd9\u4e9b\u7814\u7a76\u5c06\u5e2e\u52a9\u6211\u4eec\u66f4\u597d\u5730\u7406\u89e3\u751f\u547d\u7684\u771f\u6b63\u5f00\u7aef\uff1b\u7ec6\u80de\u662f\u5982\u4f55\u5728\u751f\u547d\u65e9\u671f\u4ece\u5355\u4e2a\u7ec6\u80de\u53d1\u80b2\u6210\u6570\u767e\u4e07\u4e2a\u7ec6\u80de\uff0c\u4ee5\u53ca\u5b83\u4eec\u5982\u4f55\u5728\u7a7a\u95f4\u548c\u65f6\u95f4\u4e0a\u7ec4\u88c5\u5728\u4e00\u8d77\uff0c\u5f62\u6210\u4e00\u4e2a\u5b8c\u5168\u53d1\u80b2\u7684\u6709\u673a\u4f53\u3002\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u9879\u5de5\u4f5c\u907f\u514d\u4e86\u4f7f\u7528\u5929\u7136\u80da\u80ce\uff0c\u5e76\u4e14\u662f\u53ef\u6269\u5c55\u7684\uff0c\u201d <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/juan-carlos-izpisua-belmonte\/\">\u80e1\u5b89\u00b7\u5361\u6d1b\u65af\u00b7\u4f0a\u5179\u76ae\u82cf\u4e9a\u00b7\u8d1d\u5c14\u8499\u7279<\/a>, \u7d22\u5c14\u514b\u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4\u7684\u6559\u6388\u3002.<\/p>\n<p>\u5929\u7136\u56ca\u80da\uff0c\u4e00\u65e6\u690d\u5165\u5b50\u5bab\u5373\u53ef\u53d1\u80b2\u6210\u80da\u80ce\uff0c\u4f46\u5b83\u4eec\u4e00\u76f4\u5f88\u96be\u7814\u7a76\u3002\u95ee\u9898\u662f\uff0c\u5c0f\u9f20\u7b49\u52a8\u7269\u6a21\u578b\u4ec5\u80fd\u5c11\u91cf\u4ea7\u751f\u8fd9\u4e9b\u7ed3\u6784\uff0c\u79d1\u5b66\u5bb6\u4eec\u96be\u4ee5\u5728\u8db3\u591f\u6c34\u5e73\u4e0a\u6d4b\u8bd5\u8425\u517b\u4e0d\u826f\u6216\u66b4\u9732\u4e8e\u6bd2\u7d20\u6216\u5404\u79cd\u57fa\u56e0\u7a81\u53d8\u5bf9\u53d1\u80b2\u7684\u5f71\u54cd\u3002.<\/p>\n<p>\u201c\u6211\u4eec\u5bf9\u8fd9\u9879\u5de5\u4f5c\u80fd\u591f\u4fc3\u8fdb\u5bf9\u65e9\u671f\u53d1\u80b2\u7f3a\u9677\u7684\u91cd\u8981\u7814\u7a76\u611f\u5230\u4e50\u89c2\uff0c\u201d\u8be5\u7814\u7a76\u7684\u8054\u5408\u8d1f\u8d23\u4eba\u3001\u5fb7\u514b\u8428\u65af\u5927\u5b66\u897f\u5357\u533b\u5b66\u4e2d\u5fc3\u52a9\u7406\u6559\u6388\u5434\u4fca\uff08Jun Wu\uff09\u8868\u793a\u3002.<\/p>\n<p>\u8428\u514b\u7814\u7a76\u6240\u548c\u5fb7\u514b\u8428\u65af\u5927\u5b66\u897f\u5357\u533b\u5b66\u4e2d\u5fc3\u7684\u56e2\u961f\u4f7f\u7528\u80da\u80ce\u7ec6\u80de\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4f7f\u7528\u6210\u5e74\u5c0f\u9f20\u7ec6\u80de\u5f00\u53d1\u4e86\u7c7b\u80da\u7ec6\u80de\u3002\u6210\u5e74\u7ec6\u80de\u88ab\u7f6e\u4e8e\u4e00\u79cd\u5316\u5b66\u6eb6\u6db2\u4e2d\uff0c\u8be5\u6eb6\u6db2\u4fc3\u4f7f\u5b83\u4eec\u8f6c\u53d8\u4e3a\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff0c\u5373 iPSC\uff0c\u5b83\u53ef\u4ee5\u8f6c\u53d8\u4e3a\u4f53\u5185\u51e0\u4e4e\u4efb\u4f55\u7c7b\u578b\u7684\u7ec4\u7ec7\u3002.<\/p>\n<figure id=\"attachment_24612\"  class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"305\" class=\"img-responsive wp-image-24612 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-458x305.jpg\" alt=\"From left: Ronghui Li, Juan Carlos Izpisua Belmonte and Cuiqing Zhong.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-458x305.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-300x200.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-768x512.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-1024x683.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-147x98.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-585x390.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-553x369.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-750x500.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-767x511.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-945x630.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-1250x833.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500-400x267.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500.jpg 1500w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><figcaption class=\"wp-caption-text\">\u4ece\u5de6\u8d77\uff1a\u674e\u8363\u8f89\u3001\u80e1\u5b89\u00b7\u5361\u6d1b\u65af\u00b7\u4f0a\u5179\u76ae\u82cf\u4e9a\u00b7\u8d1d\u5c14\u8499\u7279\u548c\u949f\u7fe0\u9752\u3002.<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/10\/Belmonte_Li_Zhong_PR_1500.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<\/p>\n<p>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u4e3a\u4e86\u9f13\u52b1 iPS \u7ec6\u80de\u5f62\u6210\u7c7b\u56ca\u80da\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u5b83\u4eec\u5206\u6210\u5c0f\u7ec4\uff0c\u653e\u5728\u4e00\u79cd\u7279\u6b8a\u7684\u57f9\u517b\u57fa\u4e2d\uff0c\u4e0d\u4e45\u5b83\u4eec\u5c31\u5f7c\u6b64\u8fde\u63a5\u8d77\u6765\u3002\u8fd9\u6b63\u662f\u7814\u7a76\u4eba\u5458\u5e0c\u671b\u770b\u5230\u7684\u2014\u2014\u8fd9\u4e9b\u7ec6\u80de\u5f00\u59cb\u5f62\u6210\u4e0e\u53d7\u7cbe\u5375\u53d1\u80b2\u6210\u56ca\u80da\u4e4b\u524d\u7684\u53d1\u80b2\u9636\u6bb5\u76f8\u4f3c\u7684\u7ed3\u6784\u3002.<\/p>\n<p>\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u8fde\u63a5\u7740\u7684\u7ec6\u80de\u5f00\u59cb\u5f62\u6210\u4e00\u4e2a\u7403\u4f53\uff0c\u5177\u6709\u5185\u5c42\u548c\u5916\u5c42\u3002\u671d\u5411\u5185\u90e8\u7684\u7ec6\u80de\u79ef\u7d2f\u4e86\u4f7f\u5b83\u4eec\u533a\u522b\u4e8e\u5916\u90e8\u7ec6\u80de\u7684\u86cb\u767d\u8d28\u3002\u671d\u5411\u5916\u90e8\u7684\u7ec6\u80de\u4e5f\u5f00\u59cb\u6fc0\u6d3b\u4e00\u79cd\u79f0\u4e3a YAP 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Li\u8bf4\u3002.<\/p>\n<p>\u7206\u88c2\u4f53\u5305\u542b\u4e0e\u5929\u7136\u56ca\u80da\u76f8\u540c\u7684\u4e09\u79cd\u539f\u59cb\u7ec6\u80de\u7c7b\u578b\uff08\u6210\u5e74\u751f\u7269\u4f53\u4e2d\u7684\u6240\u6709\u7ec6\u80de\u90fd\u6765\u81ea\u8fd9\u4e09\u79cd\u7ec6\u80de\uff09\u3002\u5b83\u4eec\u7684\u5927\u5c0f\u4e5f\u4e0e\u5929\u7136\u56ca\u80da\u76f8\u4f3c\uff0c\u5e76\u663e\u793a\u51fa\u76f8\u4f3c\u7684\u57fa\u56e0\u7279\u5f81\u3002\u8fdb\u4e00\u6b65\u7684\u5b9e\u9a8c\u8868\u660e\uff0c\u7206\u88c2\u4f53\u53ef\u4ee5\u8fdb\u4e00\u6b65\u53d1\u80b2\u6210\u7c7b\u4f3c\u65e9\u671f\u7740\u5e8a\u540e\u80da\u80ce\u7684\u7ed3\u6784\u3002.<\/p>\n<p>\u201c\u6211\u8ba4\u4e3a\u8fd9\u7c7b\u8d44\u6e90\u5bf9\u4e8e\u7814\u7a76\u54fa\u4e73\u52a8\u7269\u7684\u65e9\u671f\u53d1\u80b2\u5c06\u975e\u5e38\u5f3a\u5927\uff0c\u201d\u8be5\u7814\u7a76\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3001Izpisua 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