{"id":2452,"date":"2013-09-27T00:00:00","date_gmt":"2013-09-27T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/promising-new-research-earns-salk-scientist-career-development-award\/"},"modified":"2013-09-27T00:00:00","modified_gmt":"2013-09-27T07:00:00","slug":"promising-new-research-earns-salk-scientist-career-development-award","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/promising-new-research-earns-salk-scientist-career-development-award\/","title":{"rendered":"Promising new research earns Salk scientist Career Development Award"},"content":{"rendered":"<p>LA JOLLA, CA\u2014The <a href=\"http:\/\/jdrf.org\/\">Juvenile Diabetes Research Foundation (JDRF)<\/a> has given Salk scientist <a href=\"\/zh\/faculty\/huising.html\/\">Mark Huising<\/a> a five-year, $750,000 Career Development Award for his proposed study on how a novel network of receptors in human islets receives and integrates molecular signals. In pre-clinical models, activation of these receptors has proven to actually prevent diabetes. Career Development Awards are highly competitive and bestowed upon only a handful of people each year.\n<\/p>\n<p>\nThe goal of Huising&#8217;s study, entitled &#8220;Urocortin 3 Marks Mature Beta Cells and Prevents Diabetes,&#8221; is to understand how this protection against diabetes is accomplished. &#8220;Despite years of research,&#8221; he says, &#8220;significant gaps remain in our understanding of the way the islet receives and integrates signals from a wide variety of sources. We envision that among these networks of signaling molecules remain plenty that are unknown and can lead to novel strategies to treat or cure Type 1 diabetes.&#8221;\n<\/p>\n<p>\nType 1 diabetes is a chronic condition in which the pancreas produces little or no insulin. Although the condition, which usually appears during childhood or adolescence, can be managed, it&#8217;s a daily juggling act. Food, exercise and insulin must be carefully balanced with scheduled blood sugar checks and insulin injections. A diagnosis of diabetes is also a major risk factor for such later complications as cardiac failure, kidney problems and lower limb amputations. To date, Type 1 diabetes has no cure, making Huising&#8217;s research all the more exciting. <\/p>\n<p>\nHuising received his doctorate in biology at Radboud University Nijmegen, the Netherlands. Currently working in the <a href=\"\/zh\/faculty\/clayton_foundation_laboratories_for_peptide_biology.html\/\">\u514b\u83b1\u987f\u57fa\u91d1\u4f1a\u80bd\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4<\/a> at the Salk Institute, Huising and his team study the actions of corticotropin-releasing factor (CRF) and urocortins in the pancreas. Urocortin 3, a peptide related to CRF, is abundantly expressed by mature beta cells and makes important contributions to the regulation of insulin secretion and glucose metabolism. <\/p>\n<p>\nThe JDRF is the leading global organization funding Type 1 diabetes research. The foundation currently sponsors $530 million in scientific research in 17 countries and emphasizes seeking researchers &#8220;who will bridge the gap between the bench and bedside.&#8221; The primary purpose of the Career Development Award is to &#8220;attract qualified and promising scientists early in their faculty careers and to give them the opportunity to establish themselves&#8221; in areas pertinent to diabetes research.<\/p>\n<p><strong><br \/>\n\u5173\u4e8e\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\uff1a<\/strong><br \/>\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u662f\u4e16\u754c\u9876\u5c16\u7684\u57fa\u7840\u7814\u7a76\u673a\u6784\u4e4b\u4e00\uff0c\u5176\u56fd\u9645\u77e5\u540d\u7684\u6559\u804c\u4eba\u5458\u5728\u4e00\u4e2a\u72ec\u7279\u3001\u534f\u4f5c\u548c\u5bcc\u6709\u521b\u9020\u6027\u7684\u73af\u5883\u4e2d\uff0c\u6df1\u5165\u63a2\u7a76\u751f\u547d\u79d1\u5b66\u7684\u57fa\u672c\u95ee\u9898\u3002\u7d22\u5c14\u514b\u79d1\u5b66\u5bb6\u4eec\u81f4\u529b\u4e8e\u53d1\u73b0\u548c\u6307\u5bfc\u672a\u6765\u51e0\u4ee3\u7814\u7a76\u4eba\u5458\uff0c\u901a\u8fc7\u7814\u7a76\u795e\u7ecf\u79d1\u5b66\u3001\u9057\u4f20\u5b66\u3001\u7ec6\u80de\u548c\u690d\u7269\u751f\u7269\u5b66\u4ee5\u53ca\u76f8\u5173\u5b66\u79d1\uff0c\u5728\u764c\u75c7\u3001\u8870\u8001\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c7\u3001\u7cd6\u5c3f\u75c5\u548c\u4f20\u67d3\u75c5\u7684\u8ba4\u8bc6\u65b9\u9762\u505a\u51fa\u4e86\u5f00\u521b\u6027\u7684\u8d21\u732e\u3002.<\/p>\n<p>\n\u5b66\u9662\u53d6\u5f97\u4e86\u8bb8\u591a\u6210\u5c31\uff0c\u83b7\u5f97\u4e86\u5305\u62ec\u8bfa\u8d1d\u5c14\u5956\u548c\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\u5728\u5185\u7684\u65e0\u6570\u8363\u8a89\u3002\u8be5\u7814\u7a76\u6240\u7531\u810a\u9ad3\u7070\u8d28\u708e\u75ab\u82d7\u5148\u9a71 Jonas Salk \u535a\u58eb\u4e8e 1960 \u5e74\u521b\u7acb\uff0c\u662f\u4e00\u5bb6\u72ec\u7acb\u7684\u975e\u8425\u5229\u7ec4\u7ec7\u548c\u5efa\u7b51\u5730\u6807\u3002.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[],"disease-research":[173,123,138],"class_list":["post-2452","disclosure","type-disclosure","status-publish","hentry","disease-research-diabetes-type-1","disease-research-metabolism-and-diabetes","disease-research-pre-diabetes"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Promising new research earns Salk scientist Career Development Award - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/promising-new-research-earns-salk-scientist-career-development-award\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Promising new research earns Salk scientist Career Development Award - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA, CA\u2014The Juvenile Diabetes Research Foundation (JDRF) has given Salk scientist Mark Huising a five-year, $750,000 Career Development Award for his proposed study on how a novel network of receptors in human islets receives and integrates molecular signals. 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