{"id":2436,"date":"2013-07-04T00:00:00","date_gmt":"2013-07-04T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/unique-epigenomic-code-identified-during-human-brain-development\/"},"modified":"2019-09-18T12:49:11","modified_gmt":"2019-09-18T19:49:11","slug":"unique-epigenomic-code-identified-during-human-brain-development","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/unique-epigenomic-code-identified-during-human-brain-development\/","title":{"rendered":"\u4eba\u7c7b\u5927\u8111\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u53d1\u73b0\u4e86\u72ec\u7279\u7684\u8868\u89c2\u57fa\u56e0\u7ec4\u7f16\u7801"},"content":{"rendered":"<p>\u52a0\u62c9\u970d\u4e9a\uff0c\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u2014\u2014\u8868\u89c2\u57fa\u56e0\u7ec4\u7684\u53d8\u5316\uff0c\u5305\u62ec DNA \u7684\u5316\u5b66\u4fee\u9970\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u57fa\u56e0\u7ec4\u4e2d\u7684\u989d\u5916\u4fe1\u606f\u5c42\uff0c\u5e76\u88ab\u8ba4\u4e3a\u5728\u5b66\u4e60\u548c\u8bb0\u5fc6\u4ee5\u53ca\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u4e2d\u8d77\u4f5c\u7528\u3002\u7f8e\u56fd\u7d22\u5c14\u514b\u751f\u7269\u5b66\u7814\u7a76\u6240\u79d1\u5b66\u5bb6\u7684\u4e00\u9879\u65b0\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cDNA \u7532\u57fa\u5316\uff08\u4e00\u79cd\u7279\u6b8a\u7684\u8868\u89c2\u57fa\u56e0\u7ec4\u4fee\u9970\uff09\u7684\u666f\u89c2\u5728\u4ece\u51fa\u751f\u5230\u6210\u5e74\u7684\u8fc7\u6e21\u8fc7\u7a0b\u4e2d\uff0c\u5728\u5927\u8111\u7ec6\u80de\u4e2d\u5177\u6709\u9ad8\u5ea6\u52a8\u6001\u6027\uff0c\u6709\u52a9\u4e8e\u7406\u89e3\u5927\u8111\u7ec6\u80de\u57fa\u56e0\u7ec4\u4e2d\u7684\u4fe1\u606f\u662f\u5982\u4f55\u4ece\u80ce\u513f\u53d1\u80b2\u5230\u6210\u5e74\u7684\u3002\u5927\u8111\u6bd4\u8eab\u4f53\u6240\u6709\u5176\u4ed6\u5668\u5b98\u90fd\u8981\u590d\u6742\u5f97\u591a\uff0c\u8fd9\u4e00\u53d1\u73b0\u4e3a\u66f4\u6df1\u5165\u5730\u4e86\u89e3\u5927\u8111\u4e2d\u590d\u6742\u7684\u8fde\u63a5\u6a21\u5f0f\u662f\u5982\u4f55\u5f62\u6210\u7684\u6253\u5f00\u4e86\u5927\u95e8\u3002.\n <\/p>\n<p>\n\u201c\u8fd9\u4e9b\u7ed3\u679c\u6269\u5c55\u4e86\u6211\u4eec\u5bf9 DNA \u7532\u57fa\u5316\u5728\u5927\u8111\u53d1\u80b2\u548c\u529f\u80fd\u4e2d\u72ec\u7279\u4f5c\u7528\u7684\u8ba4\u8bc6\uff0c\u201d\u8d44\u6df1\u4f5c\u8005\u8bf4\u3002 <a href=\"\/zh\/faculty\/ecker.html\/\">\u7ea6\u745f\u592b\u00b7R\u00b7\u827e\u514b<\/a>, \u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u6559\u6388\u517c\u4e3b\u4efb <a href=\"http:\/\/signal.salk.edu\/\">\u57fa\u56e0\u7ec4\u5206\u6790\u5b9e\u9a8c\u5ba4<\/a> \u4ee5\u53ca\u7d22\u5c14\u514b\u56fd\u9645\u9057\u4f20\u5b66\u59d4\u5458\u4f1a\u4e3b\u5e2d\u3002 \u201c\u5b83\u4eec\u4e3a\u6d4b\u8bd5\u8868\u89c2\u57fa\u56e0\u7ec4\u5728\u5065\u5eb7\u529f\u80fd\u548c\u795e\u7ecf\u56de\u8def\u7684\u75c5\u7406\u4e2d\u65ad\u4e2d\u7684\u4f5c\u7528\u63d0\u4f9b\u4e86\u4e00\u4e2a\u65b0\u6846\u67b6\u3002\u201d\n <\/p>\n<div class=\"imageCaption530\"><img decoding=\"async\" alt=\"Marga Behrens, Eran Mukamel, Terry Sejnowski, Joseph Ecker\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2013\/01\/group625ecker.jpg\"><\/p>\n<p>\n\u4ece\u5de6\u8d77\uff1a\u739b\u52a0\u00b7\u8d1d\u4f26\u65af\u3001\u57c3\u5170\u00b7\u7a46\u5361\u6885\u5c14\u3001\u7279\u91cc\u00b7\u585e\u6770\u8bfa\u592b\u65af\u57fa\u3001\u7ea6\u745f\u592b\u00b7\u57c3\u514b\u5c14\n<\/p>\n<p>\u56fe\u7247\uff1a\u7531\u8428\u514b\u751f\u7269\u7814\u7a76\u6240\u63d0\u4f9b<\/p>\n<\/div>\n<p>\n\u5065\u5eb7\u7684\u5927\u8111\u662f\u4e00\u4e2a\u6f2b\u957f\u53d1\u5c55\u8fc7\u7a0b\u7684\u4ea7\u7269\u3002\u6211\u4eec\u5927\u8111\u6700\u524d\u7aef\u7684\u90e8\u5206\uff0c\u79f0\u4e3a\u989d\u53f6\u76ae\u5c42\uff0c\u5728\u6211\u4eec\u601d\u8003\u3001\u51b3\u7b56\u548c\u884c\u52a8\u7684\u80fd\u529b\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u5927\u8111\u901a\u8fc7\u795e\u7ecf\u5143\u548c\u80f6\u8d28\u7ec6\u80de\u7b49\u7279\u6b8a\u7ec6\u80de\u7684\u76f8\u4e92\u4f5c\u7528\u6765\u5b8c\u6210\u6240\u6709\u8fd9\u4e00\u5207\u3002\u6211\u4eec\u77e5\u9053\u8fd9\u4e9b\u7ec6\u80de\u6709\u4e0d\u540c\u7684\u529f\u80fd\uff0c\u4f46\u662f\u4ec0\u4e48\u8d4b\u4e88\u4e86\u8fd9\u4e9b\u7ec6\u80de\u5404\u81ea\u7684\u8eab\u4efd\u5462\uff1f\u7b54\u6848\u5728\u4e8e\u6bcf\u4e2a\u7ec6\u80de\u5982\u4f55\u8868\u8fbe\u5176DNA\u4e2d\u5305\u542b\u7684\u4fe1\u606f\u3002\u8868\u89c2\u57fa\u56e0\u7ec4\u4fee\u9970\uff0c\u5982DNA\u7532\u57fa\u5316\uff0c\u53ef\u4ee5\u5728\u4e0d\u6539\u53d8DNA\u5b57\u6bcd\uff08A-T-C-G\uff09\u7684\u60c5\u51b5\u4e0b\u63a7\u5236\u54ea\u4e9b\u57fa\u56e0\u88ab\u5f00\u542f\u6216\u5173\u95ed\uff0c\u4ece\u800c\u5e2e\u52a9\u533a\u5206\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\u3002.\n <\/p>\n<p>\n\u5728\u8fd9\u9879\u4e8e2013\u5e747\u67084\u65e5\u53d1\u8868\u7684\u65b0\u7814\u7a76\u4e2d\uff0c <em>\u79d1\u5b66<\/em>, \u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u5728\u5c0f\u9f20\u548c\u4eba\u7c7b\u5927\u8111\u989d\u53f6\u76ae\u5c42\u4e2d\uff0cDNA\u7532\u57fa\u5316\u6a21\u5f0f\u4f1a\u7ecf\u5386\u5e7f\u6cdb\u7684\u91cd\u6784\uff0c\u5c24\u5176\u662f\u5728\u7a81\u89e6\uff08\u795e\u7ecf\u5143\u4e4b\u95f4\u7684\u8fde\u63a5\uff09\u5feb\u901f\u751f\u957f\u7684\u53d1\u80b2\u65f6\u671f\u3002\u7814\u7a76\u4eba\u5458\u5728\u4ece\u5a74\u513f\u5230\u6210\u4eba\u7684\u5927\u8111\u57fa\u56e0\u7ec4\u4e2d\u786e\u5b9a\u4e86DNA\u7532\u57fa\u5316\u7684\u7cbe\u786e\u4f4d\u70b9\u3002\u4ed6\u4eec\u53d1\u73b0\u4e00\u79cd\u5f62\u5f0f\u7684DNA\u7532\u57fa\u5316\u4ece\u51fa\u751f\u8d77\u5c31\u5b58\u5728\u4e8e\u795e\u7ecf\u5143\u548c\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de\u4e2d\u3002\u5f15\u4eba\u6ce8\u76ee\u7684\u662f\uff0c\u7b2c\u4e8c\u79cd\u201c\u975eCG\u201dDNA\u7532\u57fa\u5316\u5f62\u5f0f\u51e0\u4e4e\u4ec5\u5b58\u5728\u4e8e\u795e\u7ecf\u5143\u4e2d\uff0c\u5e76\u4e14\u968f\u7740\u5927\u8111\u7684\u6210\u719f\u800c\u79ef\u7d2f\uff0c\u6700\u7ec8\u6210\u4e3a\u4eba\u7c7b\u795e\u7ecf\u5143\u57fa\u56e0\u7ec4\u4e2d\u4e3b\u8981\u7684\u7532\u57fa\u5316\u5f62\u5f0f\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u6709\u52a9\u4e8e\u6211\u4eec\u7406\u89e3\u5927\u8111\u7ec6\u80de\u590d\u6742\u7684DNA\u666f\u89c2\u5728\u513f\u7ae5\u5173\u952e\u53d1\u80b2\u9636\u6bb5\u662f\u5982\u4f55\u5f62\u6210\u7684\u3002.\n <\/p>\n<div class=\"imageCaption\"><img decoding=\"async\" alt=\"first comprehensive maps of epigenomic changes in the brain known as DNA methylation\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2013\/01\/dnagraphic625.jpg\"><\/p>\n<p>\n\u4e00\u9879\u7531\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u7684\u6700\u65b0\u7814\u7a76\uff0c\u9996\u6b21\u5168\u9762\u7ed8\u5236\u4e86\u5927\u8111\u4e2d\u88ab\u79f0\u4e3a\u201cDNA\u7532\u57fa\u5316\u201d\u7684\u8868\u89c2\u57fa\u56e0\u7ec4\u53d8\u5316\u56fe\u8c31\u3002\"DNA\u7532\u57fa\u5316\"\u662f\u4e00\u79cd\u5316\u5b66\u4fee\u9970\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u57fa\u56e0\u7ec4\u7684\u989d\u5916\u4fe1\u606f\u5c42\u3002.\n <\/p>\n<p>\n\u8fd9\u9879\u7814\u7a76\u4e3a\u6211\u4eec\u63ed\u793a\u4e86\u80ce\u513f\u3001\u5e7c\u5e74\u548c\u6210\u5e74\u8111\u7ec6\u80de\u4e2d\u7279\u5b9a\u57fa\u56e0\u7684\u8c03\u63a7\u65b9\u5f0f\uff0c\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u63a2\u7d22\u7532\u57fa\u5316\u6a21\u5f0f\u7684\u53d8\u5316\u662f\u5426\u4e0e\u5305\u62ec\u7cbe\u795e\u75be\u75c5\u5728\u5185\u7684\u4eba\u7c7b\u75be\u75c5\u76f8\u5173\u8054\u5960\u5b9a\u4e86\u5173\u952e\u57fa\u7840\u3002.\n  <\/p>\n<p>\n\u56fe\u7247\uff1a\u7531\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u7684 Eran Mukamel \u63d0\u4f9b\n<\/p>\n<\/div>\n<p>\nDNA \u4e2d\u7684\u9057\u4f20\u5bc6\u7801\u7531\u56db\u79cd\u5316\u5b66\u78b1\u57fa\u7ec4\u6210\uff1a\u817a\u560c\u5464 (A)\u3001\u9e1f\u560c\u5464 (G)\u3001\u80de\u5627\u5576 (C) \u548c\u80f8\u817a\u5627\u5576 (T)\u3002DNA \u7532\u57fa\u5316\u901a\u5e38\u53d1\u751f\u5728\u6240\u8c13\u7684 CpG \u4f4d\u70b9\uff0c\u5373 DNA \u5b57\u6bcd\u8868\u4e2d C (\u80de\u5627\u5576) \u7d27\u90bb G (\u9e1f\u560c\u5464) \u7684\u5730\u65b9\u3002\u5728\u4eba\u7c7b DNA \u4e2d\uff0c\u5927\u7ea6 80% \u5230 90% \u7684 CpG \u4f4d\u70b9\u88ab\u7532\u57fa\u5316\u3002Salk \u7814\u7a76\u4eba\u5458\u4e4b\u524d\u53d1\u73b0\uff0c\u5728\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u548c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08\u4e00\u79cd\u4eba\u5de5\u884d\u751f\u7684\u5e72\u7ec6\u80de\uff09\u4e2d\uff0c\u5f53 G \u4e0d\u8ddf\u5728 C \u540e\u9762\u65f6\uff0c\u4e5f\u53ef\u80fd\u53d1\u751f DNA \u7532\u57fa\u5316\uff0c\u5373\u201c\u975e CG \u7532\u57fa\u5316\u201d\u3002\u6700\u521d\uff0c\u4ed6\u4eec\u8ba4\u4e3a\u8fd9\u79cd\u7c7b\u578b\u7684\u7532\u57fa\u5316\u5728\u5e72\u7ec6\u80de\u5206\u5316\u4e3a\u7279\u5b9a\u7ec4\u7ec7\u7c7b\u578b\uff08\u5982\u80ba\u6216\u8102\u80aa\u7ec6\u80de\uff09\u65f6\u4f1a\u6d88\u5931\u3002\u76ee\u524d\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u5927\u8111\u4e2d\u5e76\u975e\u5982\u6b64\uff0c\u975e CG \u7532\u57fa\u5316\u5728\u7ec6\u80de\u5206\u5316\u540e\u51fa\u73b0\uff0c\u901a\u5e38\u5728\u5927\u8111\u6210\u719f\u7684\u7ae5\u5e74\u548c\u9752\u5c11\u5e74\u65f6\u671f\u3002.\n <\/p>\n<p>\n\u901a\u8fc7\u5bf9\u5c0f\u9f20\u548c\u4eba\u7c7b\u8111\u7ec4\u7ec7\u4ee5\u53ca\u795e\u7ecf\u5143\u548c\u80f6\u8d28\u7ec6\u80de\uff08\u6765\u81ea\u5927\u8111\u989d\u53f6\u76ae\u5c42\uff09\u5728\u51fa\u751f\u65e9\u671f\u3001\u5e7c\u5e74\u3001\u9752\u5c11\u5e74\u548c\u6210\u5e74\u9636\u6bb5\u7684\u57fa\u56e0\u7ec4\u8fdb\u884c\u6d4b\u5e8f\uff0cSalk\u56e2\u961f\u53d1\u73b0\u975eCG\u7532\u57fa\u5316\u5728\u513f\u7ae5\u65e9\u671f\u548c\u9752\u5c11\u5e74\u65f6\u671f\u5728\u795e\u7ecf\u5143\u4e2d\u79ef\u7d2f\uff0c\u5e76\u6210\u4e3a\u6210\u719f\u4eba\u795e\u7ecf\u5143\u4e2dDNA\u7532\u57fa\u5316\u7684\u4e3b\u8981\u5f62\u5f0f\u3002Ecker\u8868\u793a\uff0c\u201c\u8fd9\u8868\u660e\u5927\u8111\u795e\u7ecf\u56de\u8def\u6210\u719f\u7684\u65f6\u671f\u4f34\u968f\u7740\u5927\u89c4\u6a21\u91cd\u5851\u795e\u7ecf\u8868\u89c2\u57fa\u56e0\u7ec4\u7684\u5e73\u884c\u8fc7\u7a0b\u3002\u201d <a href=\"http:\/\/www.hhmi.org\/\">\u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240<\/a> \u548c <a href=\"http:\/\/www.moore.org\/\">\u6208\u767b\u548c\u8d1d\u8482\u00b7\u6469\u5c14\u57fa\u91d1\u4f1a<\/a> \u8c03\u67e5\u5458.\n <\/p>\n<p>\n\u8fd9\u9879\u7814\u7a76\u9996\u6b21\u63d0\u4f9b\u4e86\u4eba\u7c7b\u548c\u5c0f\u9f20\u5927\u8111\u5728\u53d1\u80b2\u8fc7\u7a0b\u4e2d DNA \u7532\u57fa\u5316\u6a21\u5f0f\u5982\u4f55\u53d8\u5316\u7684\u5168\u9762\u5730\u56fe\uff0c\u8fd9\u4e3a\u63a2\u7d22\u7532\u57fa\u5316\u6a21\u5f0f\u7684\u53d8\u5316\u662f\u5426\u4e0e\u5305\u62ec\u7cbe\u795e\u75be\u75c5\u5728\u5185\u7684\u8bb8\u591a\u4eba\u7c7b\u75be\u75c5\u76f8\u5173\u8054\u5960\u5b9a\u4e86\u5173\u952e\u57fa\u7840\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0cDNA \u7532\u57fa\u5316\u53ef\u80fd\u5728\u7cbe\u795e\u5206\u88c2\u75c7\u3001\u6291\u90c1\u75c7\u3001\u81ea\u6740\u548c\u53cc\u76f8\u60c5\u611f\u969c\u788d\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u201c\u6211\u4eec\u7684\u5de5\u4f5c\u5c06\u4f7f\u6211\u4eec\u80fd\u591f\u5f00\u59cb\u66f4\u8be6\u7ec6\u5730\u63a2\u8ba8\u8868\u89c2\u57fa\u56e0\u7ec4\u7684\u53d8\u5316\u5982\u4f55\u5728\u751f\u547d\u8fc7\u7a0b\u4e2d\u5851\u9020\u5927\u8111\u7ec6\u80de\u7684\u590d\u6742\u8eab\u4efd\uff0c\u201d\u8bba\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u6765\u81ea\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684 Eran Mukamel \u8bf4\u9053\u3002 <a href=\"http:\/\/cnl.salk.edu\/\">\u8ba1\u7b97\u795e\u7ecf\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4<\/a>.\n <\/p>\n<p>\n\u201c\u4eba\u7c7b\u5927\u8111\u88ab\u79f0\u4e3a\u6211\u4eec\u6240\u77e5\u7684\u5b87\u5b99\u4e2d\u6700\u590d\u6742\u7684\u7cfb\u7edf\uff0c\u201d\u65b0\u8bba\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\u745e\u5b89\u00b7\u5229\u65af\u7279\uff08Ryan Lister\uff09\u8bf4\u9053\uff0c\u4ed6\u66fe\u662f\u8428\u514b\u7814\u7a76\u6240\u57c3\u514b\u5c14\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u540e\uff0c\u73b0\u4efb\u4e00\u7814\u7a76\u9879\u76ee\u7684\u8d1f\u8d23\u4eba\u3002 <a href=\"http:\/\/www.uwa.edu.au\/\">\u897f\u6fb3\u5927\u5229\u4e9a\u5927\u5b66<\/a>. \u56e0\u6b64\uff0c\u4e5f\u8bb8\u6211\u4eec\u4e0d\u5e94\u8be5\u5bf9\u8fd9\u79cd\u590d\u6742\u6027\u5ef6\u4f38\u5230\u5927\u8111\u8868\u89c2\u57fa\u56e0\u7ec4\u5c42\u9762\u611f\u5230\u60ca\u8bb6\u3002DNA\u7532\u57fa\u5316\u5728\u5927\u8111\u53d1\u80b2\u7684\u5173\u952e\u9636\u6bb5\u51fa\u73b0\u7684\u8fd9\u4e9b\u72ec\u7279\u7279\u5f81\uff0c\u8868\u660e\u5b58\u5728\u5148\u524d\u672a\u88ab\u8ba4\u8bc6\u7684\u8c03\u63a7\u8fc7\u7a0b\uff0c\u8fd9\u4e9b\u8fc7\u7a0b\u53ef\u80fd\u5bf9\u6b63\u5e38\u5927\u8111\u529f\u80fd\u548c\u5927\u8111\u969c\u788d\u81f3\u5173\u91cd\u8981\u3002\u201c\n <\/p>\n<p>\n\u76ee\u524d\uff0c\u795e\u7ecf\u79d1\u5b66\u5bb6\u666e\u904d\u8ba4\u4e3a\u8bb8\u591a\u7cbe\u795e\u75be\u75c5\u8d77\u6e90\u4e8e\u795e\u7ecf\u53d1\u80b2\uff0c\u662f\u7531\u57fa\u56e0\u6613\u611f\u6027\u548c\u73af\u5883\u5f71\u54cd\uff08\u4f8b\u5982\uff0c\u751f\u547d\u65e9\u671f\u538b\u529b\u6216\u836f\u7269\u6ee5\u7528\uff09\u76f8\u4e92\u4f5c\u7528\u800c\u4ea7\u751f\u7684\uff0c\u5176\u7ed3\u679c\u662f\u5927\u8111\u7f51\u7edc\u6d3b\u52a8\u7684\u6539\u53d8\u3002\u8fd9\u4e9b\u5927\u8111\u7f51\u7edc\u7684\u6784\u5efa\u548c\u5851\u9020\u9700\u8981\u4e00\u4e2a\u6f2b\u957f\u7684\u6210\u719f\u8fc7\u7a0b\uff0c\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7ec6\u80de\u7c7b\u578b\uff08\u795e\u7ecf\u5143\u548c\u80f6\u8d28\u7ec6\u80de\uff09\u9700\u8981\u7cbe\u7ec6\u8c03\u6574\u5b83\u4eec\u8868\u8fbe\u9057\u4f20\u5bc6\u7801\u7684\u65b9\u5f0f\u3002.\n <\/p>\n<p>\n\u201cDNA\u7532\u57fa\u5316\u5b9e\u73b0\u4e86\u8fd9\u4e00\u4f5c\u7528\uff0c\u201d\u8be5\u7814\u7a76\u7684\u5408\u8457\u8005\u8bf4 <a href=\"\/zh\/faculty\/sejnowski.html\/\">\u7279\u4f26\u65af\u00b7J\u00b7\u585e\u5409\u8bfa\u65af\u57fa<\/a>, \uff0c\uff0c <a href=\"http:\/\/www.hhmi.org\/\">\u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458<\/a>, \u5f17\u6717\u897f\u65af\u00b7\u514b\u91cc\u514b\u4e3b\u5e2d\u3001\u7d22\u5c14\u514b\u7814\u7a76\u6240...\u7684\u6301\u6709\u4eba <a href=\"http:\/\/cnl.salk.edu\/\">\u8ba1\u7b97\u795e\u7ecf\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4<\/a>. \u201c\u6211\u4eec\u53d1\u73b0\uff0c\u7532\u57fa\u5316\u6a21\u5f0f\u5728\u5927\u8111\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u662f\u52a8\u6001\u53d8\u5316\u7684\uff0c\u7279\u522b\u662f\u975eCG\u7532\u57fa\u5316\u5728\u513f\u7ae5\u65e9\u671f\u548c\u9752\u5c11\u5e74\u65f6\u671f\uff0c\u8fd9\u6539\u53d8\u4e86\u6211\u4eec\u5bf9\u6b63\u5e38\u5927\u8111\u529f\u80fd\u548c\u529f\u80fd\u969c\u788d\u7684\u770b\u6cd5\u3002\u201d\n <\/p>\n<p>\n\u901a\u8fc7\u7834\u574f\u795e\u7ecf\u5143\u7684\u8f6c\u5f55\u8868\u8fbe\uff0c\u5171\u540c\u901a\u8baf\u4f5c\u8005 <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/margaritabehrens\/\">\u739b\u683c\u4e3d\u7279\u00b7\u8d1d\u4f26\u65af\u5973\u58eb<\/a>, \u8ba1\u7b97\u795e\u7ecf\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4\u7684\u4e00\u540d\u7814\u7a76\u79d1\u5b66\u5bb6\u8868\u793a\uff0c\u201c\u8fd9\u4e9b\u7532\u57fa\u5316\u6a21\u5f0f\u7684\u6539\u53d8\u5c06\u5f71\u54cd\u7f51\u7edc\u7684\u5f62\u6210\u65b9\u5f0f\uff0c\u8fdb\u800c\u53ef\u80fd\u5bfc\u81f4\u65e5\u540e\u51fa\u73b0\u7cbe\u795e\u75be\u75c5\u3002\u201d\n <\/p>\n<p>\n\u8be5\u7814\u7a76\u7684\u5176\u4ed6\u7814\u7a76\u4eba\u5458\u662f\u6765\u81ea\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684 Joseph R. Nery\u3001Mark Urich\u3001Clare A. Puddifoot\u3001Nicholas D. Johnson\u3001Jacinto Lucero \u548c Matthew D. Schultz\uff1b\u6765\u81ea\u897f\u6fb3\u5927\u5229\u4e9a\u5927\u5b66\u7684 Julian Tonti-Filippini\uff1bYun Huang \u548c Anjana Rao\u3002 <a href=\"http:\/\/www.liai.org\/\">\u62c9\u970d\u4e9a\u8fc7\u654f\u4e0e\u514d\u75ab\u7814\u7a76\u6240<\/a>; \u7f2a\u6e14\u548c\u5ddd\u9e64\u7684 <a href=\"http:\/\/www.uchicago.edu\/\">\u829d\u52a0\u54e5\u5927\u5b66<\/a>; \u5b89\u5fb7\u9c81\u00b7J\u00b7\u5fb7\u6c83\u514b\uff08Andrew J. Dwork\uff09\u548c\u6cd5\u7279\u6885\u00b7G\u00b7\u54c8\u5409\u5409\uff08Fatemeh G. Haghighi\uff09\uff08\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\uff09\uff1b\u970d\u5c14\u683c\u00b7\u6d77\u6069\uff08Holger Heyn\uff09\u548c\u9a6c\u5185\u5c14\u00b7\u57c3\u65af\u7279\u52d2\uff08Manel Esteller\uff09\uff08 <a href=\"http:\/\/www.idibell.cat\/\">\u8d1d\u5c14\u7ef4\u683c\u7279\u751f\u7269\u533b\u5b66\u7814\u7a76\u6240<\/a>; \u4ee5\u53ca\u80e1\u65f6\u541b\uff08Shijun Hu\uff09\u548c\u5434\u5609\uff08Joseph C. Wu\uff09\u7684 <a href=\"http:\/\/med.stanford.edu\/\">\u65af\u5766\u798f\u5927\u5b66\u533b\u5b66\u9662<\/a>.\n <\/p>\n<p>\n\u8fd9\u9879\u5de5\u4f5c\u5f97\u5230\u4e86...\u7684\u652f\u6301 <a href=\"http:\/\/www.nimh.nih.gov\/\">\u7f8e\u56fd\u56fd\u5bb6\u7cbe\u795e\u536b\u751f\u7814\u7a76\u6240<\/a>, \uff0c \u90a3\u4e2a <a href=\"http:\/\/hhmi.org\">\u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240<\/a>, \uff0c \u90a3\u4e2a <a href=\"http:\/\/www.moore.org\/\">\u6208\u767b\u548c\u8d1d\u8482\u00b7\u6469\u5c14\u57fa\u91d1\u4f1a<\/a>, \uff0c \u90a3\u4e2a <a href=\"http:\/\/www.cirm.ca.gov\/\">\u52a0\u5dde\u518d\u751f\u533b\u5b66\u7814\u7a76\u6240<\/a>, \uff0c \u90a3\u4e2a <a href=\"http:\/\/www.lls.org\/\">\u767d\u8840\u75c5\u548c\u6dcb\u5df4\u7624\u534f\u4f1a<\/a>, \uff0c \u90a3\u4e2a <a href=\"http:\/\/www.arc.gov.au\/\">\u6fb3\u5927\u5229\u4e9a\u7814\u7a76\u7406\u4e8b\u4f1a<\/a>, \uff0c\u548c <a href=\"https:\/\/ctbp.ucsd.edu\/\">\u52a0\u5dde\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\u7406\u8bba\u751f\u7269\u7269\u7406\u4e2d\u5fc3<\/a>.\n<\/p>\n<p><strong><br \/>\n\u5173\u4e8e\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\uff1a<\/strong><br \/>\n\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u662f\u4e16\u754c\u9876\u5c16\u7684\u57fa\u7840\u7814\u7a76\u673a\u6784\u4e4b\u4e00\uff0c\u5176\u56fd\u9645\u77e5\u540d\u7684\u6559\u804c\u4eba\u5458\u5728\u4e00\u4e2a\u72ec\u7279\u3001\u534f\u4f5c\u548c\u5bcc\u6709\u521b\u9020\u6027\u7684\u73af\u5883\u4e2d\uff0c\u6df1\u5165\u63a2\u7a76\u751f\u547d\u79d1\u5b66\u7684\u57fa\u672c\u95ee\u9898\u3002\u7d22\u5c14\u514b\u79d1\u5b66\u5bb6\u4eec\u81f4\u529b\u4e8e\u53d1\u73b0\u548c\u6307\u5bfc\u672a\u6765\u51e0\u4ee3\u7814\u7a76\u4eba\u5458\uff0c\u901a\u8fc7\u7814\u7a76\u795e\u7ecf\u79d1\u5b66\u3001\u9057\u4f20\u5b66\u3001\u7ec6\u80de\u548c\u690d\u7269\u751f\u7269\u5b66\u4ee5\u53ca\u76f8\u5173\u5b66\u79d1\uff0c\u5728\u764c\u75c7\u3001\u8870\u8001\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c7\u3001\u7cd6\u5c3f\u75c5\u548c\u4f20\u67d3\u75c5\u7684\u8ba4\u8bc6\u65b9\u9762\u505a\u51fa\u4e86\u5f00\u521b\u6027\u7684\u8d21\u732e\u3002.\n<\/p>\n<p>\n\u5b66\u9662\u53d6\u5f97\u4e86\u8bb8\u591a\u6210\u5c31\uff0c\u83b7\u5f97\u4e86\u5305\u62ec\u8bfa\u8d1d\u5c14\u5956\u548c\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\u5728\u5185\u7684\u65e0\u6570\u8363\u8a89\u3002\u8be5\u7814\u7a76\u6240\u7531\u810a\u9ad3\u7070\u8d28\u708e\u75ab\u82d7\u5148\u9a71 Jonas Salk \u535a\u58eb\u4e8e 1960 \u5e74\u521b\u7acb\uff0c\u662f\u4e00\u5bb6\u72ec\u7acb\u7684\u975e\u8425\u5229\u7ec4\u7ec7\u548c\u5efa\u7b51\u5730\u6807\u3002.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[42,114],"disease-research":[171,161,146,124,167],"class_list":["post-2436","disclosure","type-disclosure","status-publish","hentry","faculty-joseph-ecker","faculty-terrence-sejnowski","disease-research-bipolar-disorder","disease-research-depression","disease-research-aging-and-regenerative-medicine","disease-research-neuroscience-and-neurological-disorders","disease-research-schizophrenia"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Unique epigenomic code identified during human brain development - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/unique-epigenomic-code-identified-during-human-brain-development\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Unique epigenomic code identified during human brain development - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA,CA\u2014Changes in the epigenome, including chemical modifications of DNA, can act as an extra layer of information in the genome, and are thought to play a role in learning and memory, as well as in age-related cognitive decline. The results of a new study by scientists at the Salk Institute for Biological Studies show that the landscape of DNA methylation, a particular type of epigenomic modification, is highly dynamic in brain cells during the transition from birth to adulthood, helping to understand how information in the genomes of cells in the brain is controlled from fetal development to adulthood. The brain is much more complex than all other organs in the body and this discovery opens the door to a deeper understanding of how the intricate patterns of connectivity in the brain are formed.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/zh\/news-release\/unique-epigenomic-code-identified-during-human-brain-development\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2019-09-18T19:49:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/unique-epigenomic-code-identified-during-human-brain-development\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/unique-epigenomic-code-identified-during-human-brain-development\\\/\",\"name\":\"Unique epigenomic code identified during human brain development - 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The results of a new study by scientists at the Salk Institute for Biological Studies show that the landscape of DNA methylation, a particular type of epigenomic modification, is highly dynamic in brain cells during the transition from birth to adulthood, helping to understand how information in the genomes of cells in the brain is controlled from fetal development to adulthood. 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