{"id":2425,"date":"2013-05-07T00:00:00","date_gmt":"2013-05-07T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/salk-scientists-find-potential-therapeutic-target-for-cushings-disease\/"},"modified":"2013-05-07T00:00:00","modified_gmt":"2013-05-07T07:00:00","slug":"salk-scientists-find-potential-therapeutic-target-for-cushings-disease","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/salk-scientists-find-potential-therapeutic-target-for-cushings-disease\/","title":{"rendered":"\u8428\u514b\u7814\u7a76\u6240\u79d1\u5b66\u5bb6\u53d1\u73b0\u5e93\u6b23\u75c5\u6f5c\u5728\u7684\u6cbb\u7597\u9776\u70b9"},"content":{"rendered":"

\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u62c9\u970d\u4e9a\u2014\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\u4e86\u4e00\u79cd\u80fd\u591f\u9a71\u52a8\u5e93\u6b23\u75c5\u4e2d\u5782\u4f53\u7624\u5f62\u6210\u7684\u86cb\u767d\u8d28\uff0c\u8fd9\u4e00\u53d1\u73b0\u53ef\u80fd\u4e3a\u4e34\u5e8a\u533b\u751f\u63d0\u4f9b\u6cbb\u7597\u8fd9\u79cd\u5371\u53ca\u751f\u547d\u7684\u75be\u75c5\u7684\u9776\u70b9\u3002.\n <\/p>\n

\n\u8fd9\u79cd\u540d\u4e3aTR4\uff08\u777e\u4e38\u5b64\u513f\u6838\u53d7\u4f534\uff09\u7684\u86cb\u767d\u8d28\u662f\u4eba\u4f5348\u79cd\u6838\u53d7\u4f53\u4e4b\u4e00\u3002\u6838\u53d7\u4f53\u662f\u4e00\u7c7b\u5b58\u5728\u4e8e\u7ec6\u80de\u5185\u7684\u86cb\u767d\u8d28\uff0c\u8d1f\u8d23\u611f\u77e5\u6fc0\u7d20\u5e76\u4f5c\u51fa\u53cd\u5e94\uff0c\u8c03\u63a7\u7279\u5b9a\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u901a\u8fc7\u57fa\u56e0\u7ec4\u626b\u63cf\uff0cSalk\u56e2\u961f\u53d1\u73b0TR4\u8c03\u63a7\u4e00\u79cd\u4ea7\u751f\u4fc3\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20\uff08ACTH\uff09\u7684\u57fa\u56e0\uff0c\u800c\u5728\u5e93\u6b23\u75c5\uff08CD\uff09\u7684\u5782\u4f53\u80bf\u7624\u4e2d\uff0c\u8fd9\u79cd\u6fc0\u7d20\u4f1a\u8fc7\u91cf\u4ea7\u751f\u3002\u8fd9\u4e9b\u53d1\u73b0\u5df2\u4e8e2013\u5e745\u67086\u65e5\u5728\u300aXXX\u300b\u65e9\u671f\u7f51\u7edc\u7248\u4e0a\u53d1\u8868\u3002 \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>.\n <\/p>\n

\n\u201c\u8fd9\u6b21\u626b\u63cf\u8ba9\u6211\u4eec\u611f\u5230\u60ca\u8bb6\uff0c\u56e0\u4e3a TR4 \u548c ACTH \u4e4b\u95f4\u5e76\u6ca1\u6709\u5df2\u77e5\u7684\u76f8\u5173\u6027\uff0c\u201d\u8d44\u6df1\u4f5c\u8005\u8bf4\u3002 \u7f57\u7eb3\u5fb7\u00b7M\u00b7\u57c3\u6587\u65af<\/a>, \uff0c\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u6559\u6388 \u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4<\/a> \u4ee5\u53ca\u57fa\u56e0\u7ec4\u533b\u5b66\u8d6b\u5c14\u59c6\u65af\u5229\u4e2d\u5fc3\uff08Helmsley Center for Genomic Medicine\uff09\u7684\u9996\u5e2d\u7814\u7a76\u5458\u3002\u201cTR4 \u6b63\u5728\u9a71\u52a8 ACTH \u7684\u751f\u957f\u548c\u8fc7\u8868\u8fbe\u3002\u9776\u5411\u8be5\u901a\u8def\u53ef\u80fd\u5bf9\u5e93\u6b23\u75c5\uff08CD\uff09\u7684\u6cbb\u7597\u6709\u76ca\u3002\u201d\n <\/p>\n

\n\u5728\u5176\u7814\u7a76\u4e2d\uff0c\u57c3\u6587\u65af\u53ca\u5176\u540c\u4e8b\u53d1\u73b0\uff0c\u5728\u4eba\u7c7b\u548c\u5c0f\u9f20\u7ec6\u80de\u4e2d\u5f3a\u5236\u8fc7\u8868\u8fbeTR4\u4f1a\u589e\u52a0ACTH\u7684\u4ea7\u751f\u3001\u7ec6\u80de\u589e\u6b96\u548c\u80bf\u7624\u4fb5\u88ad\u7387\u3002\u5f53TR4\u8868\u8fbe\u964d\u4f4e\u65f6\uff0c\u6240\u6709\u8fd9\u4e9b\u4e8b\u4ef6\u90fd\u4f1a\u9006\u8f6c\u3002.\n <\/p>\n

\n\u5e93\u6b23\u75c5\u572880\u591a\u5e74\u524d\u9996\u6b21\u88ab\u63cf\u8ff0\uff0c\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u75be\u75c5\uff0c\u7531\u4f4d\u4e8e\u5927\u8111\u57fa\u5e95\u90e8\u7684\u5782\u4f53\u80bf\u7624\u6216\u5782\u4f53\u817a\u8fc7\u5ea6\u751f\u957f\u5f15\u8d77\u3002\u60a3\u6709\u5e93\u6b23\u75c5\u7684\u60a3\u8005\u4f53\u5185\u4fc3\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20\uff08ACTH\uff09\u8fc7\u591a\uff0c\u8fd9\u4f1a\u523a\u6fc0\u76ae\u8d28\u9187\u7684\u4ea7\u751f\u548c\u91ca\u653e\u3002\u76ae\u8d28\u9187\u662f\u4e00\u79cd\u5728\u5e94\u6fc0\u60c5\u51b5\u4e0b\u6b63\u5e38\u4ea7\u751f\u7684\u6fc0\u7d20\u3002.\n <\/p>\n

\n\u867d\u7136\u8fd9\u4e9b\u5782\u4f53\u7624\u51e0\u4e4e\u603b\u662f\u826f\u6027\u7684\uff0c\u4f46\u5b83\u4eec\u4f1a\u5bfc\u81f4ACTH\u548c\u76ae\u8d28\u9187\u5206\u6ccc\u8fc7\u91cf\uff0c\u4ece\u800c\u53ef\u80fd\u5bfc\u81f4\u5404\u79cd\u4f7f\u4eba\u8870\u5f31\u7684\u75c7\u72b6\uff0c\u5305\u62ec\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u538b\u3001\u9aa8\u8d28\u758f\u677e\u75c7\u3001\u80a5\u80d6\u75c7\u548c\u5fc3\u7406\u969c\u788d\u3002\u624b\u672f\u5207\u9664\u80bf\u7624\u662f\u4e00\u7ebf\u7597\u6cd5\uff0c\u7f13\u89e3\u7387\u7ea6\u4e3a80%\uff1b\u7136\u800c\uff0c\u9ad8\u8fbe25%\u7684\u75c5\u4f8b\u4f1a\u590d\u53d1\u3002.\n <\/p>\n

\n\u8bf8\u5982\u5361\u9ea6\u89d2\u7684\u7b49\u836f\u7269\uff0c\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u67d0\u4e9b\u5782\u4f53\u80bf\u7624\u7684\u836f\u7269\uff0c\u5355\u72ec\u6216\u4e0e\u916e\u5eb7\u5511\u8054\u5408\u4f7f\u7528\uff0c\u916e\u5eb7\u5511\u662f\u4e00\u79cd\u901a\u5e38\u7528\u4e8e\u6cbb\u7597\u771f\u83cc\u611f\u67d3\u7684\u836f\u7269\uff0c\u5df2\u88ab\u8bc1\u660e\u5bf9\u67d0\u4e9b\u5e93\u6b23\u75c5\u7684\u60a3\u8005\u6709\u6548\u3002\u6700\u8fd1\uff0c\u7c73\u975e\u53f8\u916e\u2014\u2014\u88ab\u8a89\u4e3a\u5815\u80ce\u836fRU-486\u2014\u2014\u5df2\u88abFDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597CD\u3002\u5c3d\u7ba1\u533b\u5b66\u7597\u6cd5\u53d6\u5f97\u4e86\u8fd9\u4e9b\u8fdb\u5c55\uff0c\u4f46\u7d22\u5c14\u514b\u79d1\u5b66\u5bb6\u8868\u793a\uff0cCD\u8fd8\u9700\u8981\u5176\u4ed6\u6cbb\u7597\u65b9\u6cd5\u3002.\n <\/p>\n

\n\u201c\u5782\u4f53\u7624\u6781\u96be\u63a7\u5236\uff0c\u201d\u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4\u8d44\u6df1\u79d1\u5b66\u5bb6\u3001\u8be5\u7814\u7a76\u7684\u5408\u8457\u8005\u8fc8\u514b\u5c14\u00b7\u5510\u65af\u8bf4\u3002\u201c\u8981\u60f3\u63a7\u5236\u5b83\u4eec\uff0c\u5c31\u5fc5\u987b\u6740\u6b7b\u5782\u4f53\u4e2d\u6b63\u5728\u589e\u6b96\u7684\u7ec6\u80de\uff0c\u800c\u8fd9\u4e9b\u7ec6\u80de\u53ef\u80fd\u5728\u4ea7\u751f\u4e00\u79cd\u91cd\u8981\u7684\u6fc0\u7d20\u3002\u201d\n <\/p>\n

\n\u5148\u524d\u7684\u7814\u7a76\u53d1\u73b0\uff0cTR4 \u672c\u8eab\u5c31\u662f\u5782\u4f53\u4e2d\u5176\u4ed6\u4fe1\u53f7\u5206\u5b50\u7684\u5929\u7136\u9776\u70b9\u3002\u4e3a\u6cbb\u7597\u5176\u4ed6\u764c\u75c7\u800c\u5f00\u53d1\u7684\u9776\u5411\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u6709\u53ef\u80fd\u88ab\u7528\u4e8e\u7834\u574f\u8fd9\u4e00\u4fe1\u53f7\u7ea7\u8054\u53cd\u5e94\u3002\u970d\u534e\u5fb7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\u3001\u6bcd\u5a74\u5065\u5eb7\u7814\u7a76\u57fa\u91d1\u4f1a\uff08March of Dimes\uff09\u5206\u5b50\u4e0e\u53d1\u80b2\u751f\u7269\u5b66\u4e3b\u5e2d\u4f0a\u4e07\u65af\uff08Evans\uff09\u8868\u793a\uff1a\u201c\u6211\u4eec\u7684\u53d1\u73b0\u53ef\u80fd\u4f1a\u4e3a\u4e34\u5e8a\u533b\u751f\u63d0\u4f9b\u4e00\u79cd\u73b0\u6709\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u5e93\u6b23\u75c5\u3002\u201d\n <\/p>\n

\n\u53c2\u4e0e\u8be5\u7814\u7a76\u7684\u5176\u4ed6\u7814\u7a76\u4eba\u5458\u5305\u62ec\u6765\u81ea\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u5927\u536b\u00b7\u76d6\u82ac\u533b\u5b66\u9662\u7684\u674e\u6e21\uff08Li Du\uff09\u3001\u9a6c\u6587\u00b7\u4f2f\u683c\u65af\u5948\u5fb7\uff08Marvin Bergsneider\uff09\u3001\u83b1\u5229\u00b7\u7c73\u5c14\u8428\u5fb7\u96f7\uff08Leili Mirsadraei\uff09\u3001\u65af\u8482\u82ac\u00b7H\u00b7\u6768\uff08Stephen H. Young\uff09\u3001\u5a01\u5ec9\u00b7H\u00b7\u6c38\uff08William H. Yong\uff09\u548c\u5b89\u4e1c\u5c3c\u00b7P\u00b7\u5e0c\u5c3c\uff08Anthony P. Heaney\uff09\uff0c\u4ee5\u53ca\u6765\u81ea\u683c\u7f57\u5b81\u6839\u5927\u5b66\u7684\u7ea6\u7ff0\u00b7W\u00b7\u743c\u514b\uff08Johan W. Jonker\uff09\u3002.\n<\/p>\n

\n\u8fd9\u9879\u7814\u7a76\u5f97\u5230\u4e86...\u7684\u652f\u6301 \u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662<\/a>, \uff0c \u90a3\u4e2a Leona M. \u548c Harry B. Helmsley \u6148\u5584\u4fe1\u6258\u57fa\u91d1<\/a>, \uff0c \u90a3\u4e2a \u585e\u7f2a\u5c14\u00b7\u74e6\u514b\u65af\u66fc\u764c\u75c7\u7814\u7a76\u6240<\/a>, \uff0c \u90a3\u4e2a \u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u4e54\u6069\u677e\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3<\/a>, \uff0c\u548c \u76ca\u666e\u68ee\/\u751f\u7269\u6d4b\u91cf<\/a>.\n<\/p>\n


\n\u5173\u4e8e\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\uff1a<\/strong>
\n\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u662f\u4e16\u754c\u9876\u5c16\u7684\u57fa\u7840\u7814\u7a76\u673a\u6784\u4e4b\u4e00\uff0c\u5176\u56fd\u9645\u77e5\u540d\u7684\u6559\u804c\u4eba\u5458\u5728\u4e00\u4e2a\u72ec\u7279\u3001\u534f\u4f5c\u548c\u5bcc\u6709\u521b\u9020\u6027\u7684\u73af\u5883\u4e2d\uff0c\u6df1\u5165\u63a2\u7a76\u751f\u547d\u79d1\u5b66\u7684\u57fa\u672c\u95ee\u9898\u3002\u7d22\u5c14\u514b\u79d1\u5b66\u5bb6\u4eec\u81f4\u529b\u4e8e\u53d1\u73b0\u548c\u6307\u5bfc\u672a\u6765\u51e0\u4ee3\u7814\u7a76\u4eba\u5458\uff0c\u901a\u8fc7\u7814\u7a76\u795e\u7ecf\u79d1\u5b66\u3001\u9057\u4f20\u5b66\u3001\u7ec6\u80de\u548c\u690d\u7269\u751f\u7269\u5b66\u4ee5\u53ca\u76f8\u5173\u5b66\u79d1\uff0c\u5728\u764c\u75c7\u3001\u8870\u8001\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c7\u3001\u7cd6\u5c3f\u75c5\u548c\u4f20\u67d3\u75c5\u7684\u8ba4\u8bc6\u65b9\u9762\u505a\u51fa\u4e86\u5f00\u521b\u6027\u7684\u8d21\u732e\u3002.\n<\/p>\n

\n\u5b66\u9662\u53d6\u5f97\u4e86\u8bb8\u591a\u6210\u5c31\uff0c\u83b7\u5f97\u4e86\u5305\u62ec\u8bfa\u8d1d\u5c14\u5956\u548c\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\u5728\u5185\u7684\u65e0\u6570\u8363\u8a89\u3002\u8be5\u7814\u7a76\u6240\u7531\u810a\u9ad3\u7070\u8d28\u708e\u75ab\u82d7\u5148\u9a71 Jonas Salk \u535a\u58eb\u4e8e 1960 \u5e74\u521b\u7acb\uff0c\u662f\u4e00\u5bb6\u72ec\u7acb\u7684\u975e\u8425\u5229\u7ec4\u7ec7\u548c\u5efa\u7b51\u5730\u6807\u3002.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[91],"disease-research":[],"class_list":["post-2425","disclosure","type-disclosure","status-publish","hentry","faculty-ronald-evans"],"acf":[],"yoast_head":"\nSalk scientists find potential therapeutic target for Cushing's disease - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/salk-scientists-find-potential-therapeutic-target-for-cushings-disease\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk scientists find potential therapeutic target for Cushing's disease - 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