{"id":24084,"date":"2019-09-09T10:16:57","date_gmt":"2019-09-09T17:16:57","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=24084"},"modified":"2024-01-30T14:51:31","modified_gmt":"2024-01-30T22:51:31","slug":"salk-scientists-develop-technique-to-reveal-epigenetic-features-of-cells-in-the-brain","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/salk-scientists-develop-technique-to-reveal-epigenetic-features-of-cells-in-the-brain\/","title":{"rendered":"\u7d22\u5c14\u514b\u79d1\u5b66\u5bb6\u5f00\u53d1\u51fa\u4e00\u79cd\u6280\u672f\uff0c\u53ef\u63ed\u793a\u5927\u8111\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u7279\u5f81"},"content":{"rendered":"

\u62c9\u970d\u4e9a\u2014\u5927\u8111\u7684\u524d\u989d\u53f6\u76ae\u5c42\uff0c\u5b83\u8d4b\u4e88\u6211\u4eec\u89e3\u51b3\u95ee\u9898\u548c\u63d0\u524d\u89c4\u5212\u7684\u80fd\u529b\uff0c\u5305\u542b\u6570\u5341\u4ebf\u4e2a\u7ec6\u80de\u3002\u4f46\u8981\u7406\u89e3\u8fd9\u4e2a\u5173\u952e\u533a\u57df\u4e2d\u7ec6\u80de\u7c7b\u578b\u7684\u5de8\u5927\u591a\u6837\u6027\uff0c\u6bcf\u79cd\u7ec6\u80de\u7c7b\u578b\u90fd\u5177\u6709\u72ec\u7279\u7684\u9057\u4f20\u548c\u5206\u5b50\u7279\u6027\uff0c\u4e00\u76f4\u662f\u4e00\u4e2a\u6311\u6218\u3002.<\/p>\n

\u79d1\u5b66\u5bb6\u4eec\u4e00\u76f4\u77e5\u9053\uff0c\u8fd9\u79cd\u591a\u6837\u6027\u5f88\u5927\u7a0b\u5ea6\u4e0a\u6e90\u4e8e\u8868\u89c2\u9057\u4f20\u5b66\uff08\u4f8b\u5982 DNA \u4e0a\u7684\u5316\u5b66\u6807\u7b7e\uff09\u4ee5\u53ca\u8868\u89c2\u9057\u4f20\u7279\u5f81\u5982\u4f55\u5728\u67d3\u8272\u4f53\u4e2d\u6298\u53e0\uff0c\u4ece\u800c\u5f71\u54cd\u57fa\u56e0\u7684\u8868\u8fbe\u3002.<\/p>\n

\"Human
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\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

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DNA\u5728\u7ec6\u80de\u6838\u5185\u88ab\u79f0\u4e3a\u67d3\u8272\u4f53\u7684\u7ed3\u6784\u4e2d\u7684\u5305\u88c5\u65b9\u5f0f\uff0c\u5bf9\u7ec6\u80de\u529f\u80fd\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002DNA\u6700\u7ec8\u5982\u4f55\u6298\u53e0\u53d6\u51b3\u4e8e\u54ea\u4e9bDNA\u90e8\u5206\u9700\u8981\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u53ca\u54ea\u4e9bDNA\u90e8\u5206\u9700\u8981\u6613\u4e8e\u88ab\u7ec6\u80de\u673a\u68b0\u8bbe\u5907\u8bbf\u95ee\u3002\u67d3\u8272\u4f53\u7684\u7ed3\u6784\u5c31\u50cf\u4e00\u79cd\u7ec6\u80de\u6307\u7eb9\uff1a\u5c3d\u7ba1\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u5177\u6709\u76f8\u540c\u7684DNA\u5e8f\u5217\uff0c\u4f46\u5b83\u4eec\u5177\u6709\u4e0d\u540c\u7684\u67d3\u8272\u4f53\u7ed3\u6784\u6765\u7ec4\u7ec7DNA\u3002.<\/p>\n

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\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

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\u4e3a\u4e86\u6d4b\u8bd5 sn-m3C-seq\uff0cEcker\u3001Dixon \u548c\u540c\u4e8b\u4eec\u5c06\u8be5\u65b9\u6cd5\u5e94\u7528\u4e8e 4200 \u591a\u4e2a\u6210\u5e74\u4eba\u8111\u524d\u989d\u53f6\u76ae\u5c42\u7ec6\u80de\u3002\u867d\u7136\u4ec5\u4f7f\u7528\u67d3\u8272\u4f53\u7ed3\u6784\u6570\u636e\u53ea\u80fd\u7c97\u7565\u5730\u533a\u5206\u795e\u7ecf\u5143\u548c\u975e\u795e\u7ecf\u5143\uff0c\u4f46\u7ed3\u5408\u8fd9\u4e9b\u65b9\u6cd5\u4f7f\u7814\u7a76\u4eba\u5458\u80fd\u591f\u8bc6\u522b\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684\u57fa\u56e0\u8c03\u63a7\u5143\u4ef6\uff0c\u7136\u540e\u8fdb\u4e00\u6b65\u7814\u7a76\u6bcf\u79cd\u7ec6\u80de\u7c7b\u578b\u4e2d\u5b58\u5728\u7684\u67d3\u8272\u4f53\u7ed3\u6784\u3002.<\/p>\n

\u6b64\u5916\uff0c\u7814\u7a76\u5c0f\u7ec4\u8fd8\u53d1\u73b0\u4e86\u8fd9\u4e24\u79cd\u8c03\u63a7\u6c34\u5e73\u4e4b\u95f4\u5b58\u5728\u5173\u8054\uff0c\u5e76\u8ba1\u5212\u672a\u6765\u5bf9\u6b64\u8fdb\u884c\u66f4\u6df1\u5165\u7684\u7814\u7a76\u3002\u65e2\u7136\u65b9\u6cd5\u5df2\u7ecf\u5efa\u7acb\uff0c\u4ed6\u4eec\u5e0c\u671b\u5f00\u59cb\u5c06\u5176\u5e94\u7528\u4e8e\u66f4\u591a\u7c7b\u578b\u7684\u5065\u5eb7\u548c\u75be\u75c5\u7ec4\u7ec7\u3002.<\/p>\n

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