{"id":2368,"date":"2012-04-08T00:00:00","date_gmt":"2012-04-08T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/sugar-production-switch-in-liver-may-offer-target-for-new-diabetes-therapies\/"},"modified":"2022-06-17T08:54:36","modified_gmt":"2022-06-17T15:54:36","slug":"sugar-production-switch-in-liver-may-offer-target-for-new-diabetes-therapies","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/sugar-production-switch-in-liver-may-offer-target-for-new-diabetes-therapies\/","title":{"rendered":"\u809d\u810f\u7cd6\u539f\u751f\u4ea7\u5f00\u5173\u6216\u53ef\u4e3a\u65b0\u7684\u7cd6\u5c3f\u75c5\u7597\u6cd5\u63d0\u4f9b\u9776\u70b9"},"content":{"rendered":"<p>\u52a0\u5dde\u62c9\u970d\u4e9a \u2014 \u5728\u5176\u6df1\u5165\u89e3\u7801\u4eba\u7c7b\u65b0\u9648\u4ee3\u8c22\u7684\u975e\u51e1\u63a2\u7d22\u4e2d\uff0c\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4e00\u5bf9\u8c03\u8282\u809d\u810f\u8461\u8404\u7cd6\u751f\u6210\u7684\u5206\u5b50\u2014\u2014\u8461\u8404\u7cd6\u662f\u4eba\u7c7b\u7ec6\u80de\u7684\u80fd\u91cf\u6765\u6e90\uff0c\u4e5f\u662f\u7cd6\u5c3f\u75c5\u7684\u5173\u952e\u56e0\u7d20\u3002.<\/p>\n<p>\n\u53d1\u8868\u4e8e4\u67088\u65e5\u7684\u4e00\u7bc7\u8bba\u6587 <em>\u81ea\u7136<\/em>, \u79d1\u5b66\u5bb6\u4eec\u8868\u793a\uff0c\u63a7\u5236\u8fd9\u4e24\u79cd\u5206\u5b50\u7684\u6d3b\u6027\u2014\u2014\u8fd9\u4e24\u79cd\u5206\u5b50\u534f\u540c\u4f5c\u7528\uff0c\u8c03\u8282\u8461\u8404\u7cd6\u7684\u4ea7\u751f\u2014\u2014\u6709\u53ef\u80fd\u4e3a\u964d\u4f4e\u8840\u7cd6\u3001\u6cbb\u7597\u80f0\u5c9b\u7d20\u62b5\u6297\u6027II\u578b\u7cd6\u5c3f\u75c5\u63d0\u4f9b\u65b0\u65b9\u6cd5\u3002\u4ed6\u4eec\u901a\u8fc7\u4e00\u79cd\u5b9e\u9a8c\u6280\u672f\u8bc1\u660e\uff0c\u5728\u60a3\u6709\u7cd6\u5c3f\u75c5\u7684\u5c0f\u9f20\u8eab\u4e0a\uff0c\u8fd9\u662f\u53ef\u884c\u7684\u3002.\n<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-u3QmJbB9lvk\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/u3QmJbB9lvk?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>\u201c\u5982\u679c\u60a8\u80fd\u63a7\u5236\u8fd9\u4e9b\u5f00\u5173\uff0c\u5c31\u80fd\u63a7\u5236\u8461\u8404\u7cd6\u7684\u751f\u6210\uff0c\u800c\u8fd9\u6b63\u662f2\u578b\u7cd6\u5c3f\u75c5\u95ee\u9898\u7684\u6838\u5fc3\u6240\u5728\u3002\u201d\u6559\u6388\u8bf4\u9053\u3002 <a href=\"\/zh\/faculty\/montminy.html\/\">\u9a6c\u514b\u00b7\u8499\u7279\u7c73\u5c3c<\/a>, \u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u9996\u5e2d <a href=\"\/zh\/faculty\/clayton_foundation_laboratories_for_peptide_biology.html\/\">\u514b\u83b1\u987f\u57fa\u91d1\u4f1a\u80bd\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4<\/a>.<\/p>\n<p>\u8499\u7279\u7c73\u5c3c\u8bf4\uff0c\u65b0\u836f\u7684\u9700\u6c42\u6b63\u5728\u52a0\u901f\uff0c\u56e0\u4e3a\u8fd1 2600 \u4e07\u7f8e\u56fd\u4eba\u60a3\u6709 II \u578b\u7cd6\u5c3f\u75c5\uff0c\u4f30\u8ba1\u6709 7900 \u4e07\u4eba\u6709\u60a3\u4e0a\u6b64\u75c5\u7684\u98ce\u9669\u3002\u7cd6\u5c3f\u75c5\u662f\u7f8e\u56fd\u7b2c\u516d\u5927\u6b7b\u56e0\uff0c\u6cbb\u7597\u8d39\u7528\u4f30\u8ba1\u6bcf\u5e74\u4e3a 1160 \u4ebf\u7f8e\u5143 $\u3002.<\/p>\n<p>\n\u8499\u7279\u7c73\u5c3c\u8868\u793a\uff0c\u4e3a\u4e86\u5f00\u53d1\u51fa\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u65b0\u6709\u6548\u7597\u6cd5\uff0c\u7814\u7a76\u4eba\u5458\u9700\u8981\u4e86\u89e3\u4eba\u7c7b\u65b0\u9648\u4ee3\u8c22\u80cc\u540e\u590d\u6742\u800c\u7cbe\u5bc6\u7684\u751f\u7269\u5b66\u539f\u7406\uff0c\u4ee5\u53ca\u5f53\u8fd9\u4e2a\u7cbe\u5bc6\u8c03\u63a7\u7684\u7cfb\u7edf\u5931\u8861\u65f6\u51fa\u73b0\u7684\u7d0a\u4e71\u3002.<\/p>\n<div class=\"imageCaption\"><img decoding=\"async\" alt=\"Marc Montminy and Yiguo Wang\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2012\/01\/553_montminy.jpg\"\/><\/p>\n<p>Marc R. Montminy \u6559\u6388\uff0c Clayton \u57fa\u91d1\u4f1a\u80bd\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4\u548c Yiguo Wang \u7814\u7a76\u5458\u3002.<\/p>\n<p>\u56fe\u7247\uff1a\u7531\u8428\u514b\u751f\u7269\u7814\u7a76\u6240\u63d0\u4f9b<\/p>\n<\/div>\n<p>\u767d\u5929\uff0c\u4eba\u7c7b\u71c3\u70e7\u4ece\u98df\u7269\u4e2d\u83b7\u53d6\u7684\u8461\u8404\u7cd6\u3002\u8fd9\u662f\u4e3a\u6d88\u8017\u80fd\u91cf\u7684\u808c\u8089\u548c\u5176\u4ed6\u8eab\u4f53\u90e8\u4f4d\u63d0\u4f9b\u71c3\u6599\u3002\u665a\u4e0a\u7761\u89c9\u65f6\uff0c\u6211\u4eec\u4f1a\u8f6c\u800c\u5229\u7528\u50a8\u5b58\u7684\u8102\u80aa\u4f5c\u4e3a\u4e00\u79cd\u975e\u5e38\u53ef\u9760\u4f46\u91ca\u653e\u7f13\u6162\u7684\u80fd\u91cf\u6765\u6e90\u3002\u4f46\u662f\u8eab\u4f53\u7684\u67d0\u4e9b\u90e8\u5206\uff0c\u5c24\u5176\u662f\u5927\u8111\uff0c\u5373\u4f7f\u5728\u6211\u4eec\u7981\u98df\u65f6\uff0c\u4e5f\u9700\u8981\u8461\u8404\u7cd6\u4f5c\u4e3a\u80fd\u91cf\u6765\u6e90\u3002. <\/p>\n<p>\n\u80f0\u5c9b\u7ec6\u80de\u63a7\u5236\u7740\u80fd\u91cf\u5e73\u8861\u7684\u4e24\u4e2a\u65b9\u9762\u3002\u5b83\u4eec\u4f4d\u4e8e\u80f0\u817a\u4e2d\uff0c\u4ea7\u751f\u80f0\u9ad8\u8840\u7cd6\u7d20\uff0c\u4e00\u79cd\u5728\u7981\u98df\u671f\u95f4\u91ca\u653e\u7684\u6fc0\u7d20\uff0c\u7528\u4e8e\u544a\u8bc9\u809d\u810f\u5236\u9020\u8461\u8404\u7cd6\u4f9b\u5927\u8111\u4f7f\u7528\u3002\u5f53\u6211\u4eec\u8fdb\u98df\u65f6\uff0c\u8fd9\u4e2a\u8fc7\u7a0b\u4f1a\u9006\u8f6c\uff0c\u80f0\u5c9b\u7ec6\u80de\u4f1a\u91ca\u653e\u80f0\u5c9b\u7d20\uff0c\u544a\u8bc9\u809d\u810f\u505c\u6b62\u5236\u9020\u8461\u8404\u7cd6\u3002.<\/p>\n<p>\u56e0\u6b64\uff0c\u80f0\u9ad8\u8840\u7cd6\u7d20\u548c\u80f0\u5c9b\u7d20\u662f\u65e8\u5728\u5c06\u8840\u7cd6\u7ef4\u6301\u5728\u7a33\u5b9a\u6c34\u5e73\u7684\u53cd\u9988\u7cfb\u7edf\u7684\u4e00\u90e8\u5206\u3002.\n<\/p>\n<p>\u8499\u7279\u7c73\u5c3c\uff08Montminy\uff09\u7684\u5b9e\u9a8c\u5ba4\u591a\u5e74\u6765\u4e00\u76f4\u4e13\u6ce8\u4e8e\u63a7\u5236\u809d\u810f\u8461\u8404\u7cd6\u4ea7\u751f\u7684\u4e2d\u67a2\u5f00\u5173\uff0c\u4ee5\u53ca\u63a7\u5236\u80f0\u817a\u8461\u8404\u7cd6\u4f20\u611f\u548c\u80f0\u5c9b\u7d20\u4ea7\u751f\u7684\u5f00\u5173\u3002\u4ed6\u7684\u4e3b\u8981\u53d1\u73b0\u4e4b\u4e00\u662f\uff0c\u5347\u7cd6\u7d20\uff08\u4e00\u79cd\u9965\u997f\u6fc0\u7d20\uff09\u4f1a\u6fc0\u6d3b\u4e00\u4e2a\u57fa\u56e0\u5f00\u5173\uff08CRTC2\uff09\uff0c\u4ece\u800c\u63d0\u9ad8\u8840\u6db2\u4e2d\u8461\u8404\u7cd6\u7684\u4ea7\u751f\u3002\u53cd\u8fc7\u6765\uff0c\u5f53\u8840\u6db2\u4e2d\u80f0\u5c9b\u7d20\u589e\u52a0\u65f6\uff0cCRTC2 \u7684\u6d3b\u6027\u53d7\u5230\u6291\u5236\uff0c\u809d\u810f\u4ea7\u751f\u7684\u8461\u8404\u7cd6\u5c31\u4f1a\u51cf\u5c11\u3002.<\/p>\n<p>\u201c\u4f46\u5728\u80f0\u5c9b\u7d20\u62b5\u6297\u7684II\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\uff0cCRTC2\u5f00\u5173\u7684\u5f00\u542f\u8fc7\u4e8e\u5f3a\u70c8\uff0c\u56e0\u4e3a\u80f0\u5c9b\u7d20\u4fe1\u53f7\u672a\u80fd\u6709\u6548\u4f20\u9012\uff0c\u201dMontminy\u8bf4\u3002\u201c\u7ed3\u679c\u662f\uff0c\u809d\u810f\u4ea7\u751f\u8fc7\u591a\u7684\u8461\u8404\u7cd6\uff0c\u5bfc\u81f4\u8840\u6db2\u4e2d\u7684\u8461\u8404\u7cd6\u6c34\u5e73\u8fc7\u9ad8\u3002\u572810\u523020\u5e74\u7684\u65f6\u95f4\u91cc\uff0c\u8fd9\u79cd\u5f02\u5e38\u5347\u9ad8\u7684\u8461\u8404\u7cd6\u4f1a\u5bfc\u81f4\u6162\u6027\u5e76\u53d1\u75c7\uff0c\u5305\u62ec\u5fc3\u810f\u75c5\u3001\u5931\u660e\u548c\u80be\u529f\u80fd\u8870\u7aed\u3002\u201d<\/p>\n<p>\u65b0\u7684\u7814\u7a76\u53d1\u73b0 <em>\u81ea\u7136<\/em> 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\u57fa\u91d1\u4f1a\u3001Clayton \u533b\u5b66\u7814\u7a76\u6240\u57fa\u91d1\u4f1a\u4ee5\u53ca Leona M. \u548c Harry B. 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