{"id":2357,"date":"2008-06-25T00:00:00","date_gmt":"2008-06-25T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/salk-institute-partners-with-the-foundation-for-prader-willi-research-to-study-extreme-obesity-related-genetic-disorder\/"},"modified":"2008-06-25T00:00:00","modified_gmt":"2008-06-25T07:00:00","slug":"salk-institute-partners-with-the-foundation-for-prader-willi-research-to-study-extreme-obesity-related-genetic-disorder","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/salk-institute-partners-with-the-foundation-for-prader-willi-research-to-study-extreme-obesity-related-genetic-disorder\/","title":{"rendered":"Salk Institute partners with the Foundation for Prader-Willi Research to study extreme obesity-related genetic disorder"},"content":{"rendered":"<p>La Jolla, CA \u2013 The <a href=\"https:\/\/www.salk.edu\/zh\/\">Salk Institute for Biological  Studies<\/a> and the <a href=\"http:\/\/www.fpwr.org\" title=\"Foundation for Prader-Willi Research\" target=\"_blank\">Foundation for Prader-Willi  Research<\/a> (FPWR) today announced a partnership that will forge new research  to study a rare genetic disorder that thwarts appetite regulation and leads to  extreme obesity.<\/p>\n<p>FPWR&#8217;s initial $50,000 grant will fund a collaborative  effort between three Salk Institute laboratories to study <a href=\"http:\/\/www.fpwr.org\/aboutPWS\" title=\"Prader-Willi syndrome\" target=\"_blank\">Prader-Willi  syndrome<\/a> (PWS), a disorder that occurs in approximately one out of every 15,000 births  regardless of gender or race. Individuals with PWS lack the normal hunger and satiety cues, and  constantly crave food. Without continual supervision, those with Prader-Willi  eat excessively and risk becoming extremely obese. Scientists believe it is  caused by the loss of active genetic material on chromosome 15. The research  performed by the Salk investigators will focus on understanding why appetite is  not properly regulated in PWS.<\/p>\n<p>Dr. <a href=\"\/zh\/faculty\/vale\/\">Wylie Vale<\/a>, a  professor and head of the Clayton  Foundation Laboratories for Peptide Biology who will lead the study, is an authority on brain hormones regulating stress, growth  and appetite. His field of expertise is complemented by collaboration with Salk  researchers Dr. <a href=\"\/zh\/faculty\/sawchenko.html\/\">Paul  Sawchenko<\/a>, head of the Laboratory of Neuronal Structure and Function, who  studies cells in the brain responsible for essential bodily functions such as  eating and drinking; and Dr. <a href=\"\/zh\/faculty\/montminy.html\/\">Marc Montminy<\/a>,  also a professor in the Clayton Foundation Laboratories for Peptide  Biology and an expert in the molecular regulation of  energy balance and metabolism.<\/p>\n<p>&#8220;We are hopeful that research on an animal model of this genetic  disorder will lead to a better understanding and means of controlling appetite  in patients with <a href=\"http:\/\/www.fpwr.org\/aboutPWS\" title=\"Prader-Willi syndrome\" target=\"_blank\">Prader-Willi syndrome<\/a>,&#8221; said Vale. &#8220;We also  hope the studies will reveal lessons for unraveling the complex roles of  neuropeptides in regulating body weight in the general population.&#8221;<br \/>\nDr. Theresa Strong, chair of the FPWR Scientific Advisory Board said:  &#8220;This highly accomplished group of investigators brings years of experience in  appetite regulation and metabolism, neuroanatomy and pharmacology. We are  thrilled to have them applying their expertise to understanding Prader-Willi  syndrome.&#8221;<\/p>\n<h3>About the FPWR:<\/h3>\n<p>\"(\u300a\u4e16\u754c\u4eba\u6743\u5ba3\u8a00\u300b) <a href=\"http:\/\/www.fpwr.org\" title=\"Foundation for Prader-Willi Research\" target=\"_blank\">Foundation for Prader-Willi  Research<\/a> is a nonprofit organization whose mission is to eliminate the  challenges of Prader-Willi syndrome through the advancement of research. <\/p>\n<h3>About the Salk Institute:<\/h3>\n<p>\"(\u300a\u4e16\u754c\u4eba\u6743\u5ba3\u8a00\u300b) <a href=\"https:\/\/www.salk.edu\/zh\/\">Salk Institute for Biological  Studies<\/a> in La Jolla, California, is an independent nonprofit organization  dedicated to fundamental discoveries in the life sciences, the improvement of  human health and the training of future generations of researchers. Jonas Salk,  M.D., whose polio vaccine all but eradicated the crippling disease  poliomyelitis in 1955, opened the Institute in 1965 with a gift of land from  the City of San Diego and the financial support of the March of Dimes.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[100,112],"disease-research":[],"class_list":["post-2357","disclosure","type-disclosure","status-publish","hentry","faculty-marc-montminy","faculty-paul-sawchenko"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Salk Institute partners with the Foundation for Prader-Willi Research to study extreme obesity-related genetic disorder - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/salk-institute-partners-with-the-foundation-for-prader-willi-research-to-study-extreme-obesity-related-genetic-disorder\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk Institute partners with the Foundation for Prader-Willi Research to study extreme obesity-related genetic disorder - 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