{"id":2343,"date":"2008-03-04T00:00:00","date_gmt":"2008-03-04T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/"},"modified":"2008-03-04T00:00:00","modified_gmt":"2008-03-04T08:00:00","slug":"new-potential-drug-target-for-the-treatment-of-atherosclerosis","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/","title":{"rendered":"\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6cbb\u7597\u7684\u65b0\u6f5c\u5728\u836f\u7269\u9776\u70b9"},"content":{"rendered":"

\u52a0\u62c9\u8c37\uff0c\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u2014\u2014\u6839\u636e\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u548c\u54c8\u4f5b\u5927\u5b66\u516c\u5171\u536b\u751f\u5b66\u9662\u79d1\u5b66\u5bb6\u7684\u65b0\u7814\u7a76\uff0c\u4e00\u79cd\u4ee5\u63a7\u5236\u7ec6\u80de\u71c3\u70e7\u8102\u80aa\u7684\u80fd\u529b\u800c\u95fb\u540d\u7684\u6838\u53d7\u4f53\u86cb\u767d\uff0c\u5728\u52a8\u8109\u4e2d\u4e5f\u5177\u6709\u5f3a\u5927\u7684\u6297\u708e\u4f5c\u7528\uff0c\u53ef\u6291\u5236\u6613\u60a3\u6709\u5bb3\u6591\u5757\u7684\u5c0f\u9f20\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3002.<\/p>\n

\u4ed6\u4eec\u5728\u672c\u5468\u7684\u5728\u7ebf\u7248\u300a\u300b\u6742\u5fd7\u4e0a\u62a5\u9053\u4e86\u4ed6\u4eec\u7684\u53d1\u73b0 \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/i>, \u4e3a\u4e13\u95e8\u6cbb\u7597\u4ee3\u8c22\u7efc\u5408\u5f81\u76f8\u5173\u7684\u5e76\u53d1\u75c7\u63d0\u4f9b\u4e86\u4e00\u4e2a\u65b0\u7684\u3001\u5177\u4f53\u7684\u76ee\u6807\u3002. <\/p>\n

\u201c\u5fc3\u810f\u75c5\u5c31\u50cf\u4e00\u4e2a\u6ef4\u7b54\u4f5c\u54cd\u7684\u65f6\u949f\u2014\u2014\u5b83\u4f1a\u9010\u6e10\u53d1\u5c55\uff0c\u65e0\u60c5\u5730\u5411\u524d\u63a8\u8fdb\uff0c\u9ad8\u8102\u80aa\u996e\u98df\u3001\u708e\u75c7\u548c\u9ad8\u8840\u538b\u6df7\u5408\u5728\u4e00\u8d77\u4f1a\u52a0\u901f\u5b83\u7684\u8fdb\u7a0b\u3002\u6211\u4eec\u53d1\u73b0 PPAR delta \u80fd\u591f\u63d0\u4f9b\u4e00\u79cd\u57fa\u56e0\u6377\u5f84\uff0c\u7ed5\u8fc7\u8fd9\u4e9b\u533b\u7597\u969c\u788d\uff0c\u201d\u970d\u534e\u5fb7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\u8bf4\u3002 \u7f57\u7eb3\u5fb7\u00b7M\u00b7\u57c3\u6587\u65af<\/a>, \uff0c\u535a\u58eb\uff0c\u4ed6\u662f\u7d22\u5c14\u514b\u7814\u7a76\u6240\u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4\u7684\u6559\u6388\uff0c\u8be5\u7814\u7a76\u7531\u4ed6\u4e0e\u54c8\u4f5b\u5927\u5b66\u516c\u5171\u536b\u751f\u5b66\u9662\u9057\u4f20\u5b66\u4e0e\u590d\u6742\u75be\u75c5\u7cfb\u6559\u6388\u674e\u5fd7\u8c6a\u5171\u540c\u6307\u5bfc\u3002.<\/p>\n

<\/p>\n

PPAR delta \u53ef\u62b5\u6297\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3002\u5de6\uff1a\u6613\u60a3\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u5c0f\u9f20\u4e3b\u52a8\u8109\u74e3\u4e2d\u51fa\u73b0\u6591\u5757\u5806\u79ef\u3002\u53f3\uff1a\u6fc0\u6d3b PPAR delta \u53ef\u663e\u8457\u51cf\u5c0f\u4e3b\u52a8\u8109\u75c5\u53d8\u7684\u5927\u5c0f\u3002\u56fe\u7247\u7531\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u7684 Grant Barish \u535a\u58eb\u63d0\u4f9b\u3002.<\/p>\n<\/div>\n

\u201c\u5927\u591a\u6570\u4eba\u8ba4\u4e3a\u80c6\u56fa\u9187\u5728\u52a8\u8109\u7ca5\u6837\u786c\u5316\u4e2d\u8d77\u4e3b\u5bfc\u4f5c\u7528\u3002\u6211\u4eec\u7684\u7814\u7a76\u8868\u660e\uff0c\u9776\u5411\u75c5\u53d8\u90e8\u4f4d\u7684\u708e\u75c7\u4e0e\u6b64\u540c\u7b49\u91cd\u8981\uff0c\u201d\u674e\u8865\u5145\u9053\u3002. <\/p>\n

\u5c31\u50cf\u8102\u80aa\u4ee3\u8c22\u4e2d\u7684\u9634\u9633\u4e00\u6837\uff0cPPAR delta\u2014\u2014\u672c\u7814\u7a76\u7684\u91cd\u70b9\u2014\u2014\u53ca\u5176\u5bf9\u5e94\u7269 PPAR gamma \u63a7\u5236\u7740\u8102\u80aa\u7684\u50a8\u5b58\u548c\u71c3\u70e7\u3002PPAR gamma \u8d1f\u8d23\u5c06\u591a\u4f59\u7684\u8461\u8404\u7cd6\u50a8\u5b58\u4e3a\u8102\u80aa\u3002\u5f53 PPAR gamma \u88ab\u836f\u7269\u523a\u6fc0\u65f6\uff0c\u8eab\u4f53\u5bf9\u80f0\u5c9b\u7d20\u7684\u53cd\u5e94\u4f1a\u5f97\u5230\u6539\u5584\uff0c\u4ece\u800c\u964d\u4f4e\u5faa\u73af\u8461\u8404\u7cd6\u6c34\u5e73\u3002\u5b83\u7684\u540c\u80de\u57fa\u56e0\u5f00\u5173 PPAR delta \u63a7\u5236\u7740\u7ec6\u80de\u71c3\u70e7\u8102\u80aa\u7684\u80fd\u529b\u3002\u6fc0\u6d3b PPAR delta \u53ef\u4ee5\u63d0\u9ad8\u8102\u80aa\u7ec4\u7ec7\u548c\u808c\u8089\u71c3\u70e7\u8102\u80aa\u7684\u80fd\u529b\uff0c\u663e\u8457\u964d\u4f4e\u603b\u4f53\u91cd\uff0c\u589e\u52a0 HDL\uff08\u201c\u597d\u80c6\u56fa\u56fa\u9187\u201d\uff09\uff0c\u51cf\u5c11\u5faa\u73af\u7518\u6cb9\u4e09\u916f\uff0c\u5e76\u6539\u5584\u9ad8\u8840\u7cd6\u3002.<\/p>\n

\u201c\u5fc3\u8840\u7ba1\u75be\u75c5\u662f\u4ee3\u8c22\u7efc\u5408\u5f81\u60a3\u8005\u7684\u4e3b\u8981\u6b7b\u56e0\uff0c\u4ee3\u8c22\u7efc\u5408\u5f81\u662f\u4e00\u7cfb\u5217\u4e0e\u80a5\u80d6\u76f8\u5173\u7684\u75be\u75c5\uff0c\u5305\u62ec\u80f0\u5c9b\u7d20\u62b5\u6297\u3001\u9ad8\u8840\u538b\u548c\u8840\u8102\u5f02\u5e38\uff0c\u201d\u535a\u58eb\u540e\u7814\u7a76\u5458\u517c\u7b2c\u4e00\u4f5c\u8005 Grant D. Barish \u535a\u58eb\u8bf4\u9053\u3002\u201c\u7531\u4e8e PPAR delta \u5728\u8102\u80aa\u4ee3\u8c22\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\uff0c\u5e76\u4e14 PPAR delta \u836f\u7269\u53ef\u4ee5\u62b5\u6297\u80a5\u80d6\uff0c\u56e0\u6b64\u6211\u4eec\u60f3\u77e5\u9053\u6fc0\u6d3b PPAR delta \u662f\u5426\u80fd\u62b5\u6297\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3002\u201d <\/p>\n

\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff0c\u6216\u79f0\u201c\u52a8\u8109\u786c\u5316\u201d\uff0c\u662f\u4e00\u79cd\u6162\u6027\u75be\u75c5\uff0c\u5176\u4e2d\u9ad8\u80c6\u56fa\u9187\u6c34\u5e73\u4e0e\u708e\u75c7\u5171\u540c\u4f5c\u7528\uff0c\u5bfc\u81f4\u52a8\u8109\u5185\u58c1\u5f62\u6210\u8102\u80aa\u6c89\u79ef\uff0c\u79f0\u4e3a\u6591\u5757\u3002\u6700\u7ec8\uff0c\u8fd9\u4e9b\u6591\u5757\u4f1a\u9650\u5236\u8840\u6d41\uff0c\u5bfc\u81f4\u5fc3\u7ede\u75db\uff0c\u6216\u8005\u53ef\u80fd\u7834\u88c2\uff0c\u5bfc\u81f4\u5f62\u6210\u8840\u6813\uff0c\u5835\u585e\u52a8\u8109\uff0c\u5f15\u53d1\u5fc3\u810f\u75c5\u53d1\u4f5c\u6216\u4e2d\u98ce\u3002.<\/p>\n

\u5f53\u7814\u7a76\u4eba\u5458\u7ed9\u4e00\u79cd\u6613\u60a3\u5178\u578b\u6591\u5757\u7684\u57fa\u56e0\u6539\u9020\u5c0f\u9f20\uff08\u5c24\u5176\u662f\u5728\u9ad8\u8102\u996e\u98df\u4e0b\uff09\u5582\u98df\u4e00\u79cd\u80fd\u5f00\u542fPPAR delta\u7684\u5b9e\u9a8c\u6027\u836f\u7269\u65f6\uff0c\u5c0f\u9f20\u7684\u6591\u5757\u6570\u91cf\u51cf\u5c11\u4e8625-30%\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u8868\u660e\uff0cPPAR delta\u4e0d\u4ec5\u80fd\u63d0\u9ad8HDL\u6c34\u5e73\uff0c\u8fd8\u80fd\u6291\u5236\u52a8\u8109\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u663e\u8457\u51cf\u7f13\u75c5\u53d8\u8fdb\u5c55\u3002.<\/p>\n

Barish \u548c Evans \u8fd8\u4e3a\u4e00\u9879\u76f8\u5173\u7814\u7a76\u505a\u51fa\u4e86\u8d21\u732e\uff0c\u8be5\u7814\u7a76\u7531\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u9886\u5bfc\uff0c\u5e76\u53d1\u8868\u5728\u540c\u4e00\u671f\u300a\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u300b\u4e0a\u3002UCLA \u7684\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86\u4e00\u4e2a\u4e0d\u540c\u7684\u9f20\u6807\u6a21\u578b\u6765\u6a21\u62df\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u53d1\u5c55\uff0c\u68c0\u6d4b\u5230\u4e86\u4e00\u79cd\u66f4\u4e3a\u660e\u663e\u7684\u6297\u708e\u4f5c\u7528\uff0c\u5c06\u4e3b\u52a8\u8109\u75c5\u53d8\u7684\u6570\u91cf\u51cf\u5c11\u4e86\u9ad8\u8fbe 70%\u3002.<\/p>\n

\u5c3d\u7ba1\u53d7\u8fc7\u4e34\u5e8a\u57f9\u8bad\u7684\u5185\u5206\u6ccc\u4e13\u5bb6Barish\u8b66\u544a\u8bf4\uff0c\u4ece\u8001\u9f20\u63a8\u65ad\u5230\u4eba\u7c7b\u56fa\u6709\u5730\u5145\u6ee1\u590d\u6742\u6027\uff0c\u4f46\u4ed6\u8ba4\u4e3a\u6fc0\u6d3bPPAR delta\u7684\u836f\u7269\u6709\u53ef\u80fd\u9884\u9632\u80a5\u80d6\u3001\u80f0\u5c9b\u7d20\u62b5\u6297\u53ca\u5176\u76f8\u5173\u7684\u0639iovascular\u98ce\u9669\u3002.<\/p>\n

\u201c\u4efb\u4f55\u53e3\u670d\u6d3b\u6027\u5316\u5408\u7269\u90fd\u80fd\u5ef6\u7f13\u5fc3\u810f\u75c5\u8fdb\u5c55\u7684\u53d1\u73b0\u662f\u7f55\u89c1\u7684\uff0c\u8003\u8651\u5230\u95ee\u9898\u7684\u4e25\u91cd\u6027\uff0c\u6211\u4eec\u5e0c\u671b\u80fd\u8fc5\u901f\u5c06\u8fd9\u9879\u5de5\u4f5c\u63a8\u5411\u4e34\u5e8a\uff0c\u201d\u57c3\u6587\u65af\u8bf4\u3002. <\/p>\n

\u53c2\u4e0e\u8be5\u7814\u7a76\u7684 \u0936\u094b\u0927\u0915\u0930\u094d\u0924\u093e \u5305\u62ec\u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u540e\u7814\u7a76\u5458 Annette R. Atkins\u3001Michael Downes\u3001Ling-Wa Chong\u3001Mike Nelson\u3001Yuhua Zou \u548c Peter Olson \u535a\u58eb\uff0c\u4ee5\u53ca\u97e9\u56fd\u9996\u5c14\u56fd\u7acb\u5927\u5b66\u7684 Hoosang Hwang \u548c Heonjoong Kang \u535a\u58eb\uff0c\u8fd8\u6709\u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u514d\u75ab\u5b66\u548c\u8840\u7ba1\u751f\u7269\u5b66\u7cfb\u7684\u6559\u6388 Linda Curtiss \u535a\u58eb\u3002.<\/p>\n

\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u62c9\u970d\u4e9a\u7684\u7d22\u5c14\u514b\u751f\u7269\u5b66\u7814\u7a76\u6240\uff08Salk Institute for Biological Studies\uff09\u662f\u4e00\u4e2a\u72ec\u7acb\u7684\u975e\u8425\u5229\u7ec4\u7ec7\uff0c\u81f4\u529b\u4e8e\u5728\u751f\u547d\u79d1\u5b66\u9886\u57df\u505a\u51fa\u57fa\u7840\u6027\u53d1\u73b0\uff0c\u6539\u5584\u4eba\u7c7b\u5065\u5eb7\uff0c\u5e76\u57f9\u517b\u672a\u6765\u7684\u7814\u7a76\u4eba\u5458\u3002\u5176\u810a\u9ad3\u7070\u8d28\u708e\u75ab\u82d7\u51e0\u4e4e\u6839\u9664\u4e861955\u5e74\u4ee4\u4eba\u8870\u5f31\u7684\u810a\u9ad3\u7070\u8d28\u708e\u75be\u75c5\u7684\u4e54\u7eb3\u65af\u00b7\u7d22\u5c14\u514b\u533b\u5b66\u535a\u58eb\u4e8e1965\u5e74\u521b\u7acb\u4e86\u8be5\u7814\u7a76\u6240\uff0c\u5f97\u5230\u4e86\u5723\u5730\u4e9a\u54e5\u5e02\u8d60\u9001\u7684\u571f\u5730\u4ee5\u53ca\u201cMarch of Dimes\u201d\u7ec4\u7ec7\u7684\u8d22\u653f\u652f\u6301\u3002.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[91],"disease-research":[],"class_list":["post-2343","disclosure","type-disclosure","status-publish","hentry","faculty-ronald-evans"],"acf":[],"yoast_head":"\nNew potential drug target for the treatment of atherosclerosis - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New potential drug target for the treatment of atherosclerosis - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"La Jolla, CA \u2013 A nuclear receptor protein, known for controlling the ability of cells to burn fat, also exerts powerful anti-inflammatory effects in arteries, suppressing atherosclerosis in mice prone to developing the harmful plaques, according to new research by scientists at the Salk Institute for Biological Studies and the Harvard School of Public Health.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/zh\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\\\/\",\"name\":\"New potential drug target for the treatment of atherosclerosis - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\\\/#primaryimage\"},\"thumbnailUrl\":\"..https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/caption_20080304.jpg\",\"datePublished\":\"2008-03-04T08:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\\\/#breadcrumb\"},\"inLanguage\":\"zh-CN\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-CN\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\\\/#primaryimage\",\"url\":\"..https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/caption_20080304.jpg\",\"contentUrl\":\"..https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/caption_20080304.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"New potential drug target for the treatment of atherosclerosis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-CN\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-CN\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New potential drug target for the treatment of atherosclerosis - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/zh\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/","og_locale":"zh_CN","og_type":"article","og_title":"New potential drug target for the treatment of atherosclerosis - Salk Institute for Biological Studies","og_description":"La Jolla, CA \u2013 A nuclear receptor protein, known for controlling the ability of cells to burn fat, also exerts powerful anti-inflammatory effects in arteries, suppressing atherosclerosis in mice prone to developing the harmful plaques, according to new research by scientists at the Salk Institute for Biological Studies and the Harvard School of Public Health.","og_url":"https:\/\/www.salk.edu\/zh\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/","og_site_name":"Salk Institute for Biological Studies","og_image":[{"width":628,"height":329,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/","url":"https:\/\/www.salk.edu\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/","name":"New potential drug target for the treatment of atherosclerosis - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/#primaryimage"},"thumbnailUrl":"..https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/caption_20080304.jpg","datePublished":"2008-03-04T08:00:00+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/#breadcrumb"},"inLanguage":"zh-CN","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/"]}]},{"@type":"ImageObject","inLanguage":"zh-CN","@id":"https:\/\/www.salk.edu\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/#primaryimage","url":"..https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/caption_20080304.jpg","contentUrl":"..https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/caption_20080304.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/new-potential-drug-target-for-the-treatment-of-atherosclerosis\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"New potential drug target for the treatment of atherosclerosis"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240","description":"\u79d1\u5b66\u7684\u529b\u91cf","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-CN"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"zh-CN","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"paper_url":"","journal_title":"","paper_author_list":"","paper_title":"","subhead":"NULL","home_photo":"","listing_photo":"","line_2":"NULL","line_1":"New potential drug target for the treatment of atherosclerosis"},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/2343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":0,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/2343\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/media?parent=2343"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/faculty?post=2343"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disease-research?post=2343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}