{"id":23249,"date":"2019-06-21T00:00:38","date_gmt":"2019-06-21T07:00:38","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=23249"},"modified":"2019-12-09T13:42:28","modified_gmt":"2019-12-09T21:42:28","slug":"sugars-that-coat-proteins-are-a-possible-drug-target-for-pancreatitis","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/sugars-that-coat-proteins-are-a-possible-drug-target-for-pancreatitis\/","title":{"rendered":"Sugars that coat proteins are a possible drug target for pancreatitis"},"content":{"rendered":"<p>LA JOLLA\u2014Pancreatitis is an inflammation of the pancreas that accounts for 275,000 hospitalizations in the United States annually. Patients who suffer from\u00a0<a href=\"https:\/\/ghr.nlm.nih.gov\/condition\/hereditary-pancreatitis\" target=\"_blank\" rel=\"noopener\">hereditary pancreatitis<\/a>\u00a0have a 40 to 50 percent lifetime risk of developing pancreatic cancer.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-4K2NPnP-Ozk\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/4K2NPnP-Ozk?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>Salk Assistant Professor <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/dannielle-engle\/\">Dannielle Engle<\/a>, a former Cold Spring Harbor Laboratory (CSHL) Cancer Center postdoctoral fellow, studies the progression of pancreatitis to pancreatic cancer. She has focused on a potentially powerful biomarker, a chemical structure created by complex sugar molecules called CA19-9, since CA19-9 is elevated in patients with pancreatitis and pancreatic cancer. Now, Engle and her team provide the first evidence that CA19-9 actually causes the disease it was correlated with as a\u00a0biomarker, and\u00a0suggest that blocking this complex sugar structure could be used therapeutically to prevent the progression from pancreatitis to pancreatic cancer. Their findings were published in the journal\u00a0<em><a href=\"https:\/\/science.sciencemag.org\/content\/364\/6446\/1156\" rel=\"noopener\" target=\"_blank\">\u79d1\u5b66<\/a><\/em> on June 21, 2019.<\/p>\n<p>\u201cThis is one of those unique opportunities where prophylactic intervention of pancreatitis may lead to prevention of pancreatic cancer in at-risk patients,\u201d Engle said.<\/p>\n<figure id=\"attachment_23252\"  class=\"wp-caption alignright\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" class=\"img-responsive wp-image-23252 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-300x300.jpg\" alt=\"Salk Assistant Professor Dannielle Engle\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-200x200.jpg 200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption class=\"wp-caption-text\">Salk Assistant Professor Dannielle Engle<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767.jpg\">Click here<\/a> for a high-resolution image.<\/p>\n<p>Credit: Salk Institute<\/figcaption><\/figure>\n<p>In Cancer Center Director\u00a0David Tuveson\u2019s lab at CSHL, Engle investigated the\u00a0<a href=\"https:\/\/www.cshl.edu\/focusing-on-stroma-researchers-take-important-step-toward-understanding-why-pancreatic-cancer-is-so-difficult-to-treat\/\" target=\"_blank\" rel=\"noopener\">properties of pancreatic cancer<\/a>. She zeroed in on CA19-9, a complex sugar structure that coats many proteins but had not previously been ascribed with any\u00a0particular function. A single enzyme controls the final step in production of CA19-9 in humans, but this enzyme is missing in rodents. Engle generated mice that produced CA19-9, and surprisingly noted that the mice developed severe pancreatitis. Engle\u2019s findings position CA19-9 as an attractive therapeutic target for pancreatitis.<\/p>\n<p>In mice, CA19-9 recruits the immune system to repair injuries from pancreatitis. Engle found that during this recruitment process, CA19-9 can also induce a cascade of biochemical reactions propelled by the release of deleterious digestive enzymes from the pancreas. This cascade opens a transformational gateway for cancer to develop and Engle also demonstrated that CA19-9 can dramatically accelerate the growth of pancreatic tumors.<\/p>\n<p>\u201cPancreatitis is required for developing pancreatic cancer, and we might be able to prevent that transition in patients with pancreatitis by targeting CA19-9,\u201d posited Engle. \u201cBy targeting CA19-9 with antibodies in animal models, we were able to reduce the severity of pancreatitis and even prevent it from occurring.\u201d<\/p>\n<p>A pending patent application filed by CSHL covering use of CA19-9 antibodies for the treatment and prevention of pancreatitis has been exclusively licensed to\u00a0BioNTech, a German-based biotech company.<\/p>\n<p>This research was funded by the Lustgarten Foundation, Pancreatic Cancer UK, National Institutes of Health (NIH), and Cold Spring Harbor Laboratory Association.<\/p>\n<p><em>Press release materials courtesy of Cold Spring Harbor Laboratory.<\/em><\/p>\n<p><strong>About Cold Spring Harbor Laboratory:<\/strong><\/p>\n<p>Founded in 1890, Cold Spring Harbor Laboratory has shaped contemporary biomedical research and education with programs in cancer, neuroscience, plant biology and quantitative biology. Home to eight Nobel Prize winners, the private, not-for-profit Laboratory employs 1,100 people including 600 scientists, students and technicians. The Meetings &amp; Courses Program annually hosts more than 12,000 scientists. The Laboratory\u2019s education arm also includes an academic publishing house, a graduate school and the DNA Learning Center with programs for middle and high school students and teachers. For more information, visit\u00a0<a href=\"https:\/\/www.cshl.edu\/\" target=\"_blank\" rel=\"noopener\">www.cshl.edu<\/a>.<\/p>\n<p><strong>About the Salk Institute for Biological Studies:<\/strong><\/p>\n<p>Every cure has a starting point. The Salk Institute embodies Jonas Salk\u2019s mission to dare to make dreams into reality. Its internationally renowned and award-winning scientists explore the very foundations of life, seeking new understandings in neuroscience, genetics, immunology, plant biology and more. The Institute is an independent nonprofit organization and architectural landmark: small by choice, intimate by nature and fearless in the face of any challenge. Be it cancer or Alzheimer\u2019s, aging or diabetes, Salk is where cures begin. Learn more at: salk.edu.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[345],"disease-research":[46,172],"class_list":["post-23249","disclosure","type-disclosure","status-publish","hentry","faculty-dannielle-engle","disease-research-cancer-biology","disease-research-pancreatic-cancer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sugars that coat proteins are a possible drug target for pancreatitis - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/sugars-that-coat-proteins-are-a-possible-drug-target-for-pancreatitis\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sugars that coat proteins are a possible drug target for pancreatitis - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Pancreatitis is an inflammation of the pancreas that accounts for 275,000 hospitalizations in the United States annually. 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Engle, Herve\u0301 Tiriac, Keith D. Rivera, Arnaud Pommier, Sean Whalen, Tobiloba E. Oni, Brinda Alagesan, Eun Jung Lee, Melissa A. Yao, Matthew S. Lucito, Benjamin Spielman, Brandon Da Silva, Christina Schoepfer, Kevin Wright, Brianna Creighton, Lauren Afinowicz, Kenneth Yu, Robert Gru\u0308tzmann, Daniela Aust, Phyllis A. Gimotty, Katherine S. Pollard, Ralph H. Hruban, Michael G. Goggins, Christian Pilarsky, Youngkyu Park, Darryl J. Pappin, Michael A. Hollingsworth, David A. Tuveson","doi":"","paper_title":"The Glycan CA19-9 Promotes Pancreatitis and Pancreatic Cancer in Mice","subhead":"","home_photo":"","listing_photo":"","legacy_boilerplate":[],"hide_boilerplate":["Hide"],"disable_date":false,"listing_excerpt":"","descriptive_blurb":"","has_journal_cover":false,"og_image_override":false,"gallery":false},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/23249","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":9,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/23249\/revisions"}],"predecessor-version":[{"id":25040,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/23249\/revisions\/25040"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/media?parent=23249"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/faculty?post=23249"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disease-research?post=23249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}