{"id":23249,"date":"2019-06-21T00:00:38","date_gmt":"2019-06-21T07:00:38","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=23249"},"modified":"2019-12-09T13:42:28","modified_gmt":"2019-12-09T21:42:28","slug":"sugars-that-coat-proteins-are-a-possible-drug-target-for-pancreatitis","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/sugars-that-coat-proteins-are-a-possible-drug-target-for-pancreatitis\/","title":{"rendered":"\u7cd6\u57fa\u5316\u86cb\u767d\u662f\u80f0\u817a\u708e\u7684\u4e00\u79cd\u6f5c\u5728\u836f\u7269\u9776\u70b9"},"content":{"rendered":"<p>\u62c9\u970d\u4e9a\u2014\u80f0\u817a\u708e\u662f\u80f0\u817a\u7684\u708e\u75c7\uff0c\u5728\u7f8e\u56fd\u6bcf\u5e74\u5bfc\u81f4 275,000 \u4eba\u4f4f\u9662\u3002\u60a3\u6709\u00a0<a href=\"https:\/\/ghr.nlm.nih.gov\/condition\/hereditary-pancreatitis\" target=\"_blank\" rel=\"noopener\">\u9057\u4f20\u6027\u80f0\u817a\u708e<\/a>\u00a0\u60a3\u80f0\u817a\u764c\u7684\u7ec8\u751f\u98ce\u9669\u4e3a40%\u81f350%\u3002.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-4K2NPnP-Ozk\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/4K2NPnP-Ozk?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>\u7d22\u5c14\u514b\u52a9\u7406\u6559\u6388 <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/dannielle-engle\/\">\u4e39\u59ae\u5c14\u00b7\u6069\u683c\u5c14<\/a>, \uff0c\u4e00\u4f4d\u524d\u51b7\u6cc9\u6e2f\u5b9e\u9a8c\u5ba4\uff08CSHL\uff09\u764c\u75c7\u4e2d\u5fc3\u535a\u58eb\u540e\u7814\u7a76\u5458\uff0c\u7814\u7a76\u80f0\u817a\u708e\u5411\u80f0\u817a\u764c\u7684\u8fdb\u5c55\u3002\u5979\u4e00\u76f4\u4e13\u6ce8\u4e8e\u4e00\u79cd\u53ef\u80fd\u5177\u6709\u5f3a\u5927\u6f5c\u529b\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4e00\u79cd\u7531\u79f0\u4e3aCA19-9\u7684\u590d\u6742\u7cd6\u5206\u5b50\u4ea7\u751f\u7684\u5316\u5b66\u7ed3\u6784\uff0c\u56e0\u4e3aCA19-9\u5728\u80f0\u817a\u708e\u548c\u80f0\u817a\u764c\u60a3\u8005\u4e2d\u5347\u9ad8\u3002\u73b0\u5728\uff0cEngle\u548c\u5979\u7684\u56e2\u961f\u63d0\u4f9b\u4e86\u7b2c\u4e00\u4e2a\u8bc1\u636e\uff0c\u8868\u660eCA19-9\u5b9e\u9645\u4e0a\u5bfc\u81f4\u4e86\u4e0e\u5176\u4f5c\u4e3a\u751f\u7269\u6807\u5fd7\u7269\u76f8\u5173\u7684\u75be\u75c5\uff0c\u5e76\u63d0\u51fa\u963b\u65ad\u8fd9\u79cd\u590d\u6742\u7cd6\u7ed3\u6784\u53ef\u80fd\u5728\u6cbb\u7597\u4e0a\u7528\u4e8e\u9884\u9632\u80f0\u817a\u708e\u5411\u80f0\u817a\u764c\u7684\u8fdb\u5c55\u3002\u4ed6\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728\u671f\u520a\u300a\u300b\u4e0a\u3002\u00a0<em><a href=\"https:\/\/science.sciencemag.org\/content\/364\/6446\/1156\" rel=\"noopener\" target=\"_blank\">\u79d1\u5b66<\/a><\/em> 2019\u5e746\u670821\u65e5\u3002.<\/p>\n<p>\u201c\u6069\u683c\u5c14\u8bf4\uff1a\u201d\u8fd9\u662f\u4e3a\u6570\u4e0d\u591a\u7684\u72ec\u7279\u673a\u4f1a\u4e4b\u4e00\uff0c\u901a\u8fc7\u9884\u9632\u6027\u5e72\u9884\u80f0\u817a\u708e\uff0c\u53ef\u80fd\u9884\u9632\u9ad8\u98ce\u9669\u60a3\u8005\u7684\u80f0\u817a\u764c\u3002\u201d.<\/p>\n<figure id=\"attachment_23252\"  class=\"wp-caption alignright\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" class=\"img-responsive wp-image-23252 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-300x300.jpg\" alt=\"Salk Assistant Professor Dannielle Engle\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-200x200.jpg 200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption class=\"wp-caption-text\">\u7d22\u5c14\u514b\u7814\u7a76\u6240\u52a9\u7406\u6559\u6388 Dannielle Engle<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<\/p>\n<p>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u5728\u51b7\u6cc9\u6e2f\u5b9e\u9a8c\u5ba4\uff08CSHL\uff09\u764c\u75c7\u4e2d\u5fc3\u4e3b\u4efbDavid Tuveson\u7684\u5b9e\u9a8c\u5ba4\u91cc\uff0cEngle\u7814\u7a76\u4e86\u00a0<a href=\"https:\/\/www.cshl.edu\/focusing-on-stroma-researchers-take-important-step-toward-understanding-why-pancreatic-cancer-is-so-difficult-to-treat\/\" target=\"_blank\" rel=\"noopener\">\u80f0\u817a\u764c\u7684\u7279\u6027<\/a>. \u5979\u5c06\u6ce8\u610f\u529b\u96c6\u4e2d\u5728\u4e86CA19-9\u4e0a\uff0c\u8fd9\u662f\u4e00\u79cd\u8986\u76d6\u5728\u8bb8\u591a\u86cb\u767d\u8d28\u4e0a\u7684\u590d\u6742\u7cd6\u7ed3\u6784\uff0c\u4f46\u6b64\u524d\u5e76\u672a\u53d1\u73b0\u5176\u5177\u6709\u4efb\u4f55\u7279\u5b9a\u529f\u80fd\u3002\u4e00\u79cd\u9176\u63a7\u5236\u7740CA19-9\u5728\u4eba\u4f53\u5185\u7684\u6700\u7ec8\u751f\u6210\u6b65\u9aa4\uff0c\u4f46\u5728\u556e\u9f7f\u7c7b\u52a8\u7269\u4f53\u5185\u5374\u7f3a\u5931\u8fd9\u79cd\u9176\u3002Engle\u57f9\u80b2\u51fa\u4e86\u80fd\u591f\u4ea7\u751fCA19-9\u7684\u5c0f\u9f20\uff0c\u5e76\u60ca\u5947\u5730\u53d1\u73b0\u8fd9\u4e9b\u5c0f\u9f20\u60a3\u4e0a\u4e86\u4e25\u91cd\u7684\u80f0\u817a\u708e\u3002Engle\u7684\u7814\u7a76\u7ed3\u679c\u5c06CA19-9\u5b9a\u4f4d\u4e3a\u80f0\u817a\u708e\u7684\u4e00\u4e2a\u6709\u5438\u5f15\u529b\u7684\u6cbb\u7597\u9776\u70b9\u3002.<\/p>\n<p>\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cCA19-9 \u4f1a\u52df\u96c6\u514d\u75ab\u7cfb\u7edf\u6765\u4fee\u590d\u80f0\u817a\u708e\u9020\u6210\u7684\u635f\u4f24\u3002Engle \u7814\u7a76\u53d1\u73b0\uff0c\u5728\u52df\u96c6\u8fc7\u7a0b\u4e2d\uff0cCA19-9 \u8fd8\u80fd\u5f15\u53d1\u4e00\u7cfb\u5217\u751f\u5316\u53cd\u5e94\uff0c\u5176\u52a8\u529b\u6765\u6e90\u4e8e\u80f0\u817a\u5206\u6ccc\u7684\u6709\u5bb3\u6d88\u5316\u9176\u3002\u8fd9\u4e00\u7cfb\u5217\u53cd\u5e94\u4e3a\u764c\u75c7\u7684\u53d1\u751f\u6253\u5f00\u4e86\u8f6c\u5316\u4e4b\u95e8\uff0cEngle \u8fd8\u8bc1\u660e CA19-9 \u80fd\u663e\u8457\u52a0\u901f\u80f0\u817a\u80bf\u7624\u7684\u751f\u957f\u3002.<\/p>\n<p>\u201c\u80f0\u817a\u708e\u662f\u7f79\u60a3\u80f0\u817a\u764c\u7684\u5fc5\u8981\u6761\u4ef6\uff0c\u6211\u4eec\u6216\u8bb8\u53ef\u4ee5\u901a\u8fc7\u9776\u5411 CA19-9 \u6765\u9884\u9632\u80f0\u817a\u708e\u60a3\u8005\u7684\u764c\u53d8\uff0c\u201dEngle \u8bf4\u9053\u3002\u201c\u901a\u8fc7\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u7528\u6297\u4f53\u9776\u5411 CA19-9\uff0c\u6211\u4eec\u80fd\u591f\u51cf\u8f7b\u80f0\u817a\u708e\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u751a\u81f3\u53ef\u4ee5\u9884\u9632\u5176\u53d1\u751f\u3002\u201d<\/p>\n<p>\u51b7\u6cc9\u6e2f\u5b9e\u9a8c\u5ba4\uff08CSHL\uff09\u4e00\u9879\u5173\u4e8e\u4f7f\u7528 CA19-9 \u6297\u4f53\u6cbb\u7597\u548c\u9884\u9632\u80f0\u817a\u708e\u7684\u5f85\u6279\u4e13\u5229\u7533\u8bf7\uff0c\u5df2\u7ecf\u72ec\u5bb6\u6388\u6743\u7ed9\u4e86\u5fb7\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8 BioNTech\u3002.<\/p>\n<p>\u672c\u7814\u7a76\u7531Lustgarten\u57fa\u91d1\u4f1a\u3001\u6cdb\u764c\u82f1\u56fd\u3001\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662(NIH)\u4ee5\u53ca\u51b7\u6cc9\u6e2f\u5b9e\u9a8c\u5ba4\u534f\u4f1a\u8d44\u52a9\u3002.<\/p>\n<p><em>\u65b0\u95fb\u8d44\u6599\u7531\u51b7\u6cc9\u6e2f\u5b9e\u9a8c\u5ba4\u63d0\u4f9b\u3002.<\/em><\/p>\n<p><strong>\u5173\u4e8e\u51b7\u6cc9\u6e2f\u5b9e\u9a8c\u5ba4\uff1a<\/strong><\/p>\n<p>\u79d1\u5fb7\u6d77\u6587\u5b9e\u9a8c\u5ba4\u6210\u7acb\u4e8e1890\u5e74\uff0c\u901a\u8fc7\u764c\u75c7\u3001\u795e\u7ecf\u79d1\u5b66\u3001\u690d\u7269\u751f\u7269\u5b66\u548c\u5b9a\u91cf\u751f\u7269\u5b66\u7b49\u65b9\u9762\u7684\u7814\u7a76\u9879\u76ee\uff0c\u5851\u9020\u4e86\u5f53\u4ee3\u7684\u751f\u7269\u533b\u5b66\u7814\u7a76\u548c\u6559\u80b2\u3002\u8be5\u79c1\u4eba\u975e\u8425\u5229\u6027\u5b9e\u9a8c\u5ba4\u62e5\u6709\u516b\u4f4d\u8bfa\u8d1d\u5c14\u5956\u5f97\u4e3b\uff0c\u5171\u67091100\u540d\u5458\u5de5\uff0c\u5176\u4e2d\u5305\u62ec600\u540d\u79d1\u5b66\u5bb6\u3001\u5b66\u751f\u548c\u6280\u672f\u4eba\u5458\u3002\u4f1a\u8bae\u4e0e\u8bfe\u7a0b\u9879\u76ee\u6bcf\u5e74\u63a5\u5f8512000\u591a\u540d\u79d1\u5b66\u5bb6\u3002\u5b9e\u9a8c\u5ba4\u7684\u6559\u80b2\u90e8\u95e8\u8fd8\u62e5\u6709\u4e00\u5bb6\u5b66\u672f\u51fa\u7248\u793e\u3001\u4e00\u6240\u7814\u7a76\u751f\u9662\u4ee5\u53ca\u4e00\u4e2a\u9762\u5411\u521d\u9ad8\u4e2d\u751f\u548c\u6559\u5e08\u7684DNA\u5b66\u4e60\u4e2d\u5fc3\u3002\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u00a0<a href=\"https:\/\/www.cshl.edu\/\" target=\"_blank\" rel=\"noopener\">www.cshl.edu<\/a>.<\/p>\n<p><strong>\u5173\u4e8e\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\uff1a<\/strong><\/p>\n<p>\u6bcf\u4e00\u4e2a\u6cbb\u6108\u90fd\u6709\u4e00\u4e2a\u8d77\u70b9\u3002\u201c\u8428\u5c14\u514b\u7814\u7a76\u6240\u201d\u4f53\u73b0\u4e86\u4e54\u7eb3\u65af\u00b7\u7d22\u5c14\u514b\u7684\u4f7f\u547d\u2014\u2014\u6562\u4e8e\u5c06\u68a6\u60f3\u53d8\u4e3a\u73b0\u5b9e\u3002\u5176\u4eab\u8a89\u56fd\u9645\u5e76\u5c61\u83b7\u6b8a\u8363\u7684\u79d1\u5b66\u5bb6\u4eec\u63a2\u7d22\u751f\u547d\u7684\u6839\u57fa\uff0c\u5728\u795e\u7ecf\u79d1\u5b66\u3001\u9057\u4f20\u5b66\u3001\u514d\u75ab\u5b66\u3001\u690d\u7269\u751f\u7269\u5b66\u7b49\u9886\u57df\u5bfb\u6c42\u65b0\u7684\u8ba4\u8bc6\u3002\u8be5\u7814\u7a76\u6240\u662f\u4e00\u4e2a\u72ec\u7acb\u7684\u975e\u8425\u5229\u7ec4\u7ec7\uff0c\u4e5f\u662f\u4e00\u5ea7\u6807\u5fd7\u6027\u7684\u5efa\u7b51\uff1a\u6709\u610f\u8bc6\u5730\u9009\u62e9\u5c0f\u578b\u5316\uff0c\u5176\u672c\u8d28\u662f\u4eb2\u5bc6\u7684\uff0c\u5e76\u4e14\u65e0\u6240\u754f\u60e7\u5730\u9762\u5bf9\u4efb\u4f55\u6311\u6218\u3002\u65e0\u8bba\u662f\u764c\u75c7\u8fd8\u662f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff0c\u8870\u8001\u8fd8\u662f\u7cd6\u5c3f\u75c5\uff0c\u201c\u7d22\u5c14\u514b\u201d\u90fd\u662f\u6cbb\u6108\u7684\u8d77\u70b9\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\uff1asalk.edu\u3002.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[345],"disease-research":[46,172],"class_list":["post-23249","disclosure","type-disclosure","status-publish","hentry","faculty-dannielle-engle","disease-research-cancer-biology","disease-research-pancreatic-cancer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sugars that coat proteins are a possible drug target for pancreatitis - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/sugars-that-coat-proteins-are-a-possible-drug-target-for-pancreatitis\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sugars that coat proteins are a possible drug target for pancreatitis - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Pancreatitis is an inflammation of the pancreas that accounts for 275,000 hospitalizations in the United States annually. Patients who suffer from\u00a0hereditary pancreatitis\u00a0have a 40 to 50 percent lifetime risk of developing pancreatic cancer.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/zh\/news-release\/sugars-that-coat-proteins-are-a-possible-drug-target-for-pancreatitis\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2019-12-09T21:42:28+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.salk.edu\/wp-content\/uploads\/2019\/06\/Dannielle-Engle-767-300x300.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/sugars-that-coat-proteins-are-a-possible-drug-target-for-pancreatitis\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/sugars-that-coat-proteins-are-a-possible-drug-target-for-pancreatitis\\\/\",\"name\":\"Sugars that coat proteins are a possible drug target for pancreatitis - 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