{"id":21807,"date":"2019-02-19T00:00:43","date_gmt":"2019-02-19T08:00:43","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=21807"},"modified":"2019-07-22T13:47:30","modified_gmt":"2019-07-22T20:47:30","slug":"putting-the-brakes-on-aging","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/putting-the-brakes-on-aging\/","title":{"rendered":"\u7ed9\u8870\u8001\u8e29\u5239\u8f66"},"content":{"rendered":"<p>\u62c9\u970d\u4e9a\u2014\u8870\u8001\u662f\u5305\u62ec\u5fc3\u810f\u75c5\u3001\u764c\u75c7\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5728\u5185\u7684\u591a\u79cd\u4f7f\u4eba\u8870\u5f31\u7684\u75be\u75c5\u7684\u4e3b\u8981\u5371\u9669\u56e0\u7d20\uff0c\u4ec5\u4e3e\u51e0\u4f8b\u3002\u8fd9\u4f7f\u5f97\u6297\u8870\u8001\u7597\u6cd5\u7684\u9700\u6c42\u66f4\u52a0\u8feb\u5207\u3002\u73b0\u5728\uff0c\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u7684\u57fa\u56e0\u7597\u6cd5\uff0c\u4ee5\u5e2e\u52a9\u51cf\u7f13\u8870\u8001\u8fc7\u7a0b\u3002.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-12zTbeGddY4\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/12zTbeGddY4?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>\u8be5\u53d1\u73b0\u4e8e2019\u5e742\u670818\u65e5\u53d1\u8868\u5728\u8be5\u671f\u520a\u4e0a <a href=\"https:\/\/doi.org\/10.1038\/s41591-019-0343-4\" target=\"_blank\" rel=\"noopener\"><em>\u81ea\u7136\u533b\u5b66<\/em><\/a>, \u4ecb\u7ecd\u4e00\u79cd\u65b0\u9896\u7684 CRISPR\/Cas9 \u57fa\u56e0\u7ec4\u7f16\u8f91\u7597\u6cd5\uff0c\u8be5\u7597\u6cd5\u53ef\u6291\u5236\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u4e2d\u89c2\u5bdf\u5230\u7684\u52a0\u901f\u8870\u8001\u73b0\u8c61\u3002\u65e9\u8870\u75c7\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u9057\u4f20\u6027\u75be\u75c5\uff0c\u4e5f\u4f1a\u5f71\u54cd\u4eba\u7c7b\u3002\u8fd9\u79cd\u6cbb\u7597\u65b9\u6cd5\u4e3a\u4e86\u89e3\u52a0\u901f\u8870\u8001\u7684\u5206\u5b50\u901a\u8def\u4ee5\u53ca\u5982\u4f55\u901a\u8fc7\u57fa\u56e0\u7597\u6cd5\u51cf\u5c11\u6bd2\u6027\u86cb\u767d\u63d0\u4f9b\u4e86\u91cd\u8981\u89c1\u89e3\u3002.<\/p>\n<p>\u201c\u8870\u8001\u662f\u4e00\u4e2a\u590d\u6742\u7684\u8fc7\u7a0b\uff0c\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\u7ec6\u80de\u5f00\u59cb\u5931\u53bb\u529f\u80fd\uff0c\u56e0\u6b64\u5bfb\u627e\u6709\u6548\u7684\u65b9\u6cd5\u6765\u7814\u7a76\u8870\u8001\u7684\u5206\u5b50\u9a71\u52a8\u56e0\u7d20\u5bf9\u6211\u4eec\u6765\u8bf4\u81f3\u5173\u91cd\u8981\uff0c\u201d <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/juan-carlos-izpisua-belmonte\/\">\u80e1\u5b89\u00b7\u5361\u6d1b\u65af\u00b7\u4f0a\u5179\u76ae\u82cf\u4e9a\u00b7\u8d1d\u5c14\u8499\u7279<\/a>, \u7d22\u5c14\u514b\u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4\u6559\u6388\u3001\u8be5\u8bba\u6587\u7684\u8d44\u6df1\u4f5c\u8005\u3002\u201c\u65e9\u8870\u75c7\u662f\u7814\u7a76\u8870\u8001\u7684\u7406\u60f3\u6a21\u578b\uff0c\u56e0\u4e3a\u5b83\u80fd\u8ba9\u6211\u4eec\u5feb\u901f\u5236\u5b9a\u5e72\u9884\u63aa\u65bd\u3001\u8fdb\u884c\u6539\u8fdb\u5e76\u518d\u6b21\u8fdb\u884c\u6d4b\u8bd5\u3002\u201d<\/p>\n<figure id=\"attachment_21810\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"222\" class=\"img-responsive wp-image-21810 size-medium\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-progeria-mouse-300x222.png\" alt=\"This image shows two mice of the same age with progeria. The larger and healthier mouse on the left received the gene therapy, while the mouse on the right did not.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-progeria-mouse-300x222.png 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-progeria-mouse-147x109.png 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-progeria-mouse.png 394w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-caption-text\">\u8fd9\u5f20\u56fe\u7247\u663e\u793a\u4e86\u4e24\u53ea\u60a3\u6709\u65e9\u8870\u75c7\u7684\u540c\u9f84\u5c0f\u9f20\u3002\u5de6\u8fb9\u8f83\u5927\u3001\u8f83\u5065\u5eb7\u7684\u5c0f\u9f20\u63a5\u53d7\u4e86\u57fa\u56e0\u6cbb\u7597\uff0c\u800c\u53f3\u8fb9\u7684\u5c0f\u9f20\u5219\u6ca1\u6709\u3002.<\/p>\n<p>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u65e9\u53d1\u4e14\u8fdb\u5c55\u8fc5\u901f\u7684\u65e9\u8870\u75c7\u662f\u7531 LMNA \u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u4e00\u7ec4\u9000\u884c\u6027\u75be\u75c5\u4e2d\u6700\u4e25\u91cd\u7684\u4e00\u79cd\u3002\u60a3\u6709\u65e9\u8870\u75c7\u7684\u5c0f\u9f20\u548c\u4eba\u7c7b\u90fd\u8868\u73b0\u51fa\u8bb8\u591a\u8870\u8001\u8ff9\u8c61\uff0c\u5305\u62ec DNA \u635f\u4f24\u3001\u5fc3\u810f\u529f\u80fd\u969c\u788d\u548c\u5bff\u547d\u663e\u8457\u7f29\u77ed\u3002LMNA \u57fa\u56e0\u901a\u5e38\u5728\u7ec6\u80de\u5185\u4ea7\u751f\u4e24\u79cd\u76f8\u4f3c\u7684\u86cb\u767d\u8d28\uff1alamin A \u548c lamin C\u3002\u65e9\u8870\u75c7\u5c06 lamin A \u7684\u751f\u4ea7\u8f6c\u53d8\u4e3a progerin\u3002Progerin \u662f lamin A \u7684\u4e00\u79cd\u7f29\u77ed\u7684\u3001\u6709\u6bd2\u7684\u5f62\u5f0f\uff0c\u5b83\u4f1a\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u79ef\u7d2f\uff0c\u5e76\u5728\u65e9\u8870\u75c7\u60a3\u8005\u4e2d\u52a0\u91cd\u3002.<\/p>\n<p>\u201c\u6211\u4eec\u7684\u76ee\u6807\u662f\u51cf\u8f7b LMNA \u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u6bd2\u6027\uff0c\u8be5\u7a81\u53d8\u4f1a\u5bfc\u81f4\u7ec6\u80de\u5185\u65e9\u8870\u86cb\u767d\u7684\u79ef\u7d2f\uff0c\u201d\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3001Izpisua Belmonte \u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u5458 Hsin-Kai Liao \u8bf4\u9053\u3002\u201c\u6211\u4eec\u8ba4\u4e3a\uff0c\u901a\u8fc7 CRISPR\/Cas9 \u5b9a\u5411\u7834\u574f\u5c42\u7c98\u86cb\u767d A \u548c\u65e9\u8870\u86cb\u767d\uff0c\u53ef\u4ee5\u6cbb\u7597\u65e9\u8870\u75c7\u3002\u201d<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u5229\u7528CRISPR\/Cas9\u7cfb\u7edf\u5c06\u57fa\u56e0\u7597\u6cd5\u9012\u9001\u5230\u8868\u8fbeCas9\u7684\u539f\u53d1\u6027\u65e9\u8870\u5c0f\u9f20\u6a21\u578b\u7ec6\u80de\u4e2d\u3002\u6ce8\u5c04\u4e86\u542b\u6709\u4e24\u79cd\u5408\u6210\u5411\u5bfcRNA\u548c\u4e00\u4e2a\u62a5\u544a\u57fa\u56e0\u7684\u817a\u76f8\u5173\u75c5\u6bd2\uff08AAV\uff09\u3002\u5411\u5bfcRNA\u5c06Cas9\u86cb\u767d\u5f15\u5bfc\u81f3DNA\u4e0a\u7684\u7279\u5b9a\u4f4d\u7f6e\uff0c\u4f7f\u5176\u80fd\u591f\u8fdb\u884c\u5207\u5272\uff0c\u4ece\u800c\u4f7fLamin A\u548c\u65e9\u8870\u86cb\u767d\u5931\u6548\uff0c\u540c\u65f6\u4e0d\u7834\u574fLamin C\u3002\u62a5\u544a\u57fa\u56e0\u6709\u52a9\u4e8e\u7814\u7a76\u4eba\u5458\u8ffd\u8e2a\u88abAAV\u611f\u67d3\u7684\u7ec4\u7ec7\u3002.<\/p>\n<p>\u6cbb\u7597\u4ea4\u4ed8\u4e24\u4e2a\u6708\u540e\uff0c\u5c0f\u9f20\u8eab\u4f53\u66f4\u52a0\u5f3a\u58ee\u3001\u66f4\u52a0\u6d3b\u8dc3\uff0c\u5fc3\u8840\u7ba1\u5065\u5eb7\u72b6\u51b5\u5f97\u5230\u6539\u5584\u3002\u5b83\u4eec\u7684\u4e3b\u8981\u52a8\u8109\u8840\u7ba1\u9000\u5316\u51cf\u5c11\uff0c\u5e76\u4e14\u5fc3\u52a8\u8fc7\u7f13\uff08\u5fc3\u7387\u5f02\u5e38\u7f13\u6162\uff09\u7684\u53d1\u4f5c\u88ab\u5ef6\u8fdf\u2014\u2014\u8fd9\u662f\u65e9\u8870\u75c7\u548c\u8001\u5e74\u671f\u5e38\u89c1\u7684\u4e24\u4e2a\u95ee\u9898\u3002\u603b\u4f53\u800c\u8a00\uff0c\u7ecf\u8fc7\u6cbb\u7597\u7684\u65e9\u8870\u5c0f\u9f20\u7684\u6d3b\u52a8\u6c34\u5e73\u4e0e\u6b63\u5e38\u5c0f\u9f20\u76f8\u4f3c\uff0c\u5bff\u547d\u5ef6\u957f\u4e86\u7ea6 25%\u3002.<\/p>\n<figure id=\"attachment_21809\"  class=\"wp-caption alignleft\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"305\" class=\"img-responsive wp-image-21809 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-458x305.jpg\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-458x305.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-300x200.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-768x512.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-1024x683.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-147x98.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-585x390.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-553x369.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-750x500.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-767x511.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-945x630.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-1250x833.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500-400x267.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500.jpg 1500w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">\u4ece\u5de6\uff08\u524d\u6392\uff09\u96f7\u5a1c\u00b7\u57c3\u5c14\u5357\u5fb7\u65af-\u8d1d\u5c3c\u7279\u65af\uff0c\u5ed6\u4fe1\u51ef\uff1b\uff08\u540e\u6392\uff09\u666e\u62c9\u8fea\u666e\u00b7\u96f7\u8fea\uff0c\u5c71\u672c\u771f\u5b50\uff0c\u80e1\u5b89\u00b7\u5361\u6d1b\u65af\u00b7\u4f0a\u5179\u76ae\u82cf\u4e9a\u00b7\u8d1d\u5c14\u8499\u7279<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/02\/Belmonte-PR-1500.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<\/p>\n<p>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u201c\u4e00\u65e6\u6211\u4eec\u63d0\u9ad8\u4e86\u75c5\u6bd2\u611f\u67d3\u591a\u79cd\u7ec4\u7ec7\u7684\u6548\u7387\uff0c\u6211\u4eec\u5c31\u6709\u4fe1\u5fc3\u80fd\u591f\u8fdb\u4e00\u6b65\u5ef6\u957f\u5bff\u547d\uff0c\u201dIzpisua Belmonte\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u540e\u7814\u7a76\u5458\u3001\u8be5\u8bba\u6587\u7684\u4f5c\u8005\u4e4b\u4e00Pradeep Reddy\u8868\u793a\u3002.<\/p>\n<p>\u603b\u800c\u8a00\u4e4b\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u4f7f\u7528 CRISPR\/Cas9 \u7cfb\u7edf\u9776\u5411 Lmna \u548c\u65e9\u8870\u86cb\u767d\u53ef\u4ee5\u663e\u8457\u6539\u5584\u65e9\u8870\u5c0f\u9f20\u7684\u751f\u7406\u5065\u5eb7\u548c\u5bff\u547d\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e3a\u79d1\u5b66\u5bb6\u5982\u4f55\u6700\u7ec8\u9776\u5411\u4eba\u7c7b\u8870\u8001\u7684\u5206\u5b50\u9a71\u52a8\u56e0\u7d20\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u65b0\u8ba4\u8bc6\u3002.<\/p>\n<p>\u672a\u6765\u7684\u52aa\u529b\u5c06\u4fa7\u91cd\u4e8e\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u5e76\u5c06\u5176\u5b8c\u5584\u4ee5\u4f9b\u4eba\u7c7b\u4f7f\u7528\u3002\u76ee\u524d\uff0c\u5c1a\u65e0\u6cbb\u6108\u65e9\u8870\u75c7\u7684\u65b9\u6cd5\uff0c\u56e0\u6b64\u91c7\u53d6\u5bf9\u75c7\u6cbb\u7597\uff0c\u5e76\u5728\u51fa\u73b0\u5e76\u53d1\u75c7\u65f6\u8fdb\u884c\u5904\u7406\u3002.<\/p>\n<p>\u201c\u8fd9\u662f\u9996\u6b21\u5c06\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u5e94\u7528\u4e8e\u6cbb\u7597\u65e9\u8870\u75c7\uff0c\u201dRoger Guillemin\u8bb2\u5e2d\u6559\u6388Izpisua Belmonte\u8bf4\u9053\u3002\u201c\u5b83\u8fd8\u9700\u8981\u4e00\u4e9b\u5b8c\u5584\uff0c\u4f46\u4e0e\u5176\u4ed6\u73b0\u6709\u7597\u6cd5\u76f8\u6bd4\uff0c\u5176\u8d1f\u9762\u5f71\u54cd\u8981\u5c11\u5f97\u591a\u3002\u8fd9\u662f\u65e9\u8870\u75c7\u6cbb\u7597\u7684\u4e00\u4e2a\u6fc0\u52a8\u4eba\u5fc3\u7684\u8fdb\u6b65\u3002\u201d<\/p>\n<p>\u5176\u4ed6\u4f5c\u8005\u5305\u62ecErgin Beyret\u3001Mako Yamamoto\u3001Reyna Hernandez-Benitez\u3001Yunpeng Fu\u548cGalina Erikson\u3002 <a href=\"https:\/\/www.salk.edu\/zh\/\">\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240<\/a>.<\/p>\n<p>\u8be5\u9879\u5de5\u4f5c\u7531Catharina\u57fa\u91d1\u4f1a\u3001\u808c\u840e\u7f29\u75c7\u534f\u4f1a\u3001NIH-NCI CCSG: P30 014195\u3001Helmsley\u4fe1\u6258\u57fa\u91d1\u3001\u65e9\u8870\u75c7\u7814\u7a76\u57fa\u91d1\u4f1a\u3001\u7a46\u5c14\u897f\u4e9a\u5929\u4e3b\u6559\u5723\u5b89\u4e1c\u5c3c\u5965\u5927\u5b66\uff08UCAM\uff09\u3001Pedro Guillen\u57fa\u91d1\u4f1a\u3001G. Harold and Leila Y. Mathers\u6148\u5584\u57fa\u91d1\u4f1a\u3001Glenn\u57fa\u91d1\u4f1a\u548cMoxie\u57fa\u91d1\u4f1a\u8d44\u52a9\u3002.<\/p>","protected":false},"featured_media":21809,"template":"","faculty":[85],"disease-research":[146],"class_list":["post-21807","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-juan-carlos-izpisua-belmonte","disease-research-aging-and-regenerative-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Putting the brakes on aging - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/putting-the-brakes-on-aging\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Putting the brakes on aging - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer\u2019s disease, to name a few. 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