{"id":2144,"date":"2011-12-19T00:00:00","date_gmt":"2011-12-19T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/salk-discovery-may-lead-to-safer-treatments-for-asthma-allergies-and-arthritis\/"},"modified":"2023-12-08T20:12:30","modified_gmt":"2023-12-09T04:12:30","slug":"salk-discovery-may-lead-to-safer-treatments-for-asthma-allergies-and-arthritis","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/salk-discovery-may-lead-to-safer-treatments-for-asthma-allergies-and-arthritis\/","title":{"rendered":"\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u53d1\u73b0\u53ef\u80fd\u5e26\u6765\u66f4\u5b89\u5168\u7684\u54ee\u5598\u3001\u8fc7\u654f\u548c\u5173\u8282\u708e\u6cbb\u7597\u65b9\u6cd5"},"content":{"rendered":"<p>\u62c9\u970d\u4e9a\uff0c\u52a0\u5dde\u2014\u2014\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\u4e86\u4e00\u6761\u8fde\u63a5\u4eba\u4f53\u751f\u7269\u949f\u4e0e\u7cd6\u4ee3\u8c22\u7cfb\u7edf\u7684\u201c\u7f3a\u5931\u73af\u8282\u201d\uff0c\u8fd9\u4e00\u53d1\u73b0\u53ef\u80fd\u6709\u52a9\u4e8e\u907f\u514d\u7528\u4e8e\u6cbb\u7597\u54ee\u5598\u3001\u8fc7\u654f\u548c\u5173\u8282\u708e\u7684\u836f\u7269\u4ea7\u751f\u7684\u4e25\u91cd\u526f\u4f5c\u7528\u3002.\r\n<\/p><p>\r\n\u5728\u4e0a\u5468\u53d1\u8868\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d <em>\u81ea\u7136<\/em>, \u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u62a5\u544a\u79f0\uff0c\u4ed6\u4eec\u53d1\u73b0\u63a7\u5236\u8eab\u4f53\u751f\u7269\u8282\u5f8b\u7684\u86cb\u767d\u8d28\uff08\u73b0\u79f0\u4e3a\u9690\u8272\u7d20\uff09\u4e5f\u4f1a\u4e0e\u67d0\u4e9b\u6297\u708e\u836f\u7269\u9776\u5411\u7684\u4ee3\u8c22\u5f00\u5173\u76f8\u4e92\u4f5c\u7528\u3002.\r\n<\/p><p>\r\n\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5728\u7ed9\u836f\u65f6\u8003\u8651\u60a3\u8005\u7684\u751f\u7269\u8282\u5f8b\uff0c\u6216\u8005\u5f00\u53d1\u9776\u5411\u9690\u8272\u7d20\u7684\u65b0\u836f\u7269\uff0c\u53ef\u80fd\u53ef\u4ee5\u907f\u514d\u73b0\u6709\u836f\u7269\u7684\u526f\u4f5c\u7528\u3002.\r\n<\/p><p>\r\n\"\u6211\u4eec\u77e5\u9053\u6211\u4eec\u7684\u7761\u7720-\u89c9\u9192\u5468\u671f\u4e0e\u8eab\u4f53\u5982\u4f55\u5904\u7406\u8425\u517b\u7269\u8d28\u6709\u5173\uff0c\u4f46\u5176\u5728\u57fa\u56e0\u548c\u5206\u5b50\u5c42\u9762\u4e0a\u662f\u5982\u4f55\u53d1\u751f\u7684\uff0c\u8fd9\u66fe\u662f\u4e00\u4e2a\u8c1c\uff0c\" <a href=\"\/zh\/faculty\/evans.html\/\">\u7f57\u7eb3\u5fb7\u00b7M\u00b7\u57c3\u6587\u65af<\/a>, \u7d22\u5c14\u514b\u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4\u7684\u6559\u6388\uff0c\u4e5f\u662f\u8be5\u7814\u7a76\u56e2\u961f\u7684\u9886\u5bfc\u8005\u3002\"\u73b0\u5728\u6211\u4eec\u5df2\u7ecf\u627e\u5230\u4e86\u8fd9\u4e24\u4e2a\u91cd\u8981\u7cfb\u7edf\u4e4b\u95f4\u7684\u8054\u7cfb\uff0c\u8fd9\u53ef\u4ee5\u4f5c\u4e3a\u5176\u4ed6\u7ec6\u80de\u8fc7\u7a0b\u5982\u4f55\u8054\u7cfb\u7684\u6a21\u5f0f\uff0c\u5e76\u53ef\u80fd\u4e3a\u66f4\u597d\u7684\u7597\u6cd5\u5e26\u6765\u5e0c\u671b\u3002\"\r\n<\/p><div class=\"imageCaption\"><img decoding=\"async\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2011\/01\/533-EvansNature12.19.jpg\" alt=\"Linking Metabolic Disease to the Circadian Clock\" width=\"300\">\r\n<p>\u56fe\u7247\uff1a\u7531\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u63d0\u4f9b \r\n<\/p><\/div><p>\r\n\u7cd6\u76ae\u8d28\u6fc0\u7d20\u662f\u4f53\u5185\u5929\u7136\u5b58\u5728\u7684\u7c7b\u56fa\u9187\u6fc0\u7d20\uff0c\u6709\u52a9\u4e8e\u63a7\u5236\u4e00\u4e2a\u4eba\u8840\u6db2\u4e2d\u7684\u7cd6\u5206\u542b\u91cf\uff0c\u4ece\u800c\u4f7f\u8425\u517b\u6c34\u5e73\u5728\u65e9\u6668\u5347\u9ad8\u4ee5\u63d0\u4f9b\u65e5\u5e38\u6d3b\u52a8\u6240\u9700\u7684\u80fd\u91cf\uff0c\u5e76\u5728\u591c\u95f4\u518d\u6b21\u4e0b\u964d\u3002\u5b83\u4eec\u901a\u8fc7\u4e0e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53d7\u4f53\uff081985\u5e74\u7531\u57c3\u6587\u65af\u9996\u6b21\u53d1\u73b0\u7684\u7ec6\u80de\u6838\u5916\u90e8\u5206\u5206\u5b50\u5f00\u5173\uff09\u76f8\u4e92\u4f5c\u7528\uff0c\u5728\u7ec6\u80de\u5185\u53d1\u6325\u4f5c\u7528\u3002.\r\n<\/p><p>\r\n\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5728\u8c03\u8282\u708e\u75c7\u65b9\u9762\u4e5f\u8d77\u7740\u4f5c\u7528\uff0c\u5e76\u88ab\u7528\u4f5c\u6297\u708e\u836f\uff0c\u6cbb\u7597\u514d\u75ab\u7cfb\u7edf\u8fc7\u5ea6\u6d3b\u8dc3\u5f15\u8d77\u7684\u75be\u75c5\uff0c\u5982\u8fc7\u654f\u3001\u54ee\u5598\u548c\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3002\u5b83\u4eec\u8fd8\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u60a3\u8005\u7684\u708e\u75c7\u3002.\r\n<\/p><p>\r\n\u7136\u800c\uff0c\u7531\u4e8e\u5b83\u4eec\u5728\u7cd6\u4ee3\u8c22\u4e2d\u7684\u4f5c\u7528\uff0c\u8fd9\u4e9b\u7c7b\u56fa\u9187\u4f1a\u6270\u4e71\u4eba\u4f53\u7684\u6b63\u5e38\u4ee3\u8c22\uff0c\u4ece\u800c\u5bfc\u81f4\u5371\u9669\u7684\u526f\u4f5c\u7528\uff0c\u5305\u62ec\u8840\u7cd6\u8fc7\u9ad8\u3001\u80f0\u5c9b\u7d20\u62b5\u6297\u548c\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u3002.\r\n<\/p><p>\r\n\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u53ef\u80fd\u901a\u8fc7\u53d1\u73b0\u9690\u8272\u7d20 1 \u548c 2 \u7684\u65b0\u529f\u80fd\uff0c\u627e\u5230\u4e86\u4e00\u79cd\u7ed5\u8fc7\u8fd9\u4e9b\u526f\u4f5c\u7528\u7684\u65b9\u6cd5\uff0c\u8fd9\u4e24\u79cd\u86cb\u767d\u8d28\u5148\u524d\u56e0\u5176\u5728\u751f\u7269\u949f\u4e2d\u7684\u529f\u80fd\u800c\u95fb\u540d\u3002.\r\n<\/p><p>\r\n\u9690\u8272\u86cb\u767d\u5145\u5f53\u5239\u8f66\uff0c\u51cf\u7f13\u65f6\u949f\u7684\u6d3b\u52a8\uff0c\u5411\u6211\u4eec\u7684\u751f\u7269\u7cfb\u7edf\u53d1\u51fa\u4fe1\u53f7\uff0c\u6307\u793a\u5b83\u4eec\u5728\u6bcf\u5929\u665a\u4e0a\u9010\u6e10\u505c\u6ede\u3002\u65e9\u6668\uff0c\u5b83\u4eec\u505c\u6b62\u6291\u5236\u65f6\u949f\u7684\u6d3b\u52a8\uff0c\u5e2e\u52a9\u6211\u4eec\u7684\u751f\u7406\u673a\u80fd\u4e3a\u5373\u5c06\u5230\u6765\u7684\u4e00\u5929\u505a\u597d\u51c6\u5907\u3002.\r\n<\/p><p>\r\n\u5728\u4ed6\u4eec\u5bf9\u5c0f\u9f20\u7ec6\u80de\u8fdb\u884c\u7684\u6700\u65b0\u7814\u7a76\u4e2d\uff0c\u57c3\u6587\u65af\u53ca\u5176\u540c\u4e8b\u60ca\u4eba\u5730\u53d1\u73b0\uff0c\u9690\u82b1\u8272\u7d20\u8fd8\u4e0e\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\uff0c\u5e2e\u52a9\u8c03\u8282\u8eab\u4f53\u50a8\u5b58\u548c\u4f7f\u7528\u7cd6\u5206\u7684\u65b9\u5f0f\u3002.\r\n<\/p><p>\r\n\"\u6211\u4eec\u53d1\u73b0\uff0c\u9690\u8272\u7d20\u4e0d\u4ec5\u5bf9\u663c\u591c\u8282\u5f8b\u949f\u7684\u529f\u80fd\u81f3\u5173\u91cd\u8981\uff0c\u5b83\u4eec\u8fd8\u80fd\u8c03\u8282\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7684\u4f5c\u7528\uff0c\u56e0\u6b64\u662f\u663c\u591c\u8282\u5f8b\u949f\u5982\u4f55\u4e0e\u6211\u4eec\u65e5\u5e38\u7684\u8425\u517b\u4ee3\u8c22\u76f8\u4e92\u4f5c\u7528\u7684\u6838\u5fc3\uff0c\"\u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u52a9\u7406\u6559\u6388\u3001\u7d22\u5c14\u514b\u7814\u7a76\u6240\u57c3\u6587\u5b9e\u9a8c\u5ba4\u524d\u535a\u58eb\u540e\u7814\u7a76\u5458 Katja A. Lamia \u8bf4\u3002.\r\n<\/p><p>\r\n\u5c0f\u9f20\u7ec6\u80de\u7684\u529f\u80fd\u4e0e\u4eba\u7c7b\u7ec6\u80de\u975e\u5e38\u76f8\u4f3c\uff0c\u56e0\u6b64\u8fd9\u4e9b\u53d1\u73b0\u53ef\u80fd\u5bf9\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u764c\u75c7\u7684\u6cbb\u7597\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u79d1\u5b66\u5bb6\u4eec\u8868\u793a\uff0c\u901a\u8fc7\u8003\u8651\u9690\u8272\u7d20\u6c34\u5e73\u7684\u6bcf\u65e5\u5347\u964d\uff0c\u533b\u751f\u6216\u8bb8\u80fd\u591f\u66f4\u597d\u5730\u638c\u63e1\u7cd6\u76ae\u8d28\u6fc0\u7d20\u836f\u7269\u7684\u7ed9\u836f\u65f6\u95f4\uff0c\u4ee5\u907f\u514d\u4e0e\u7cd6\u4ee3\u8c22\u76f8\u5173\u7684\u67d0\u4e9b\u526f\u4f5c\u7528\u3002.\r\n<\/p><p>\r\n\u8fd9\u9879\u53d1\u73b0\u4e5f\u5e26\u6765\u4e86\u5f00\u53d1\u65b0\u578b\u6297\u708e\u836f\u7269\u7684\u53ef\u80fd\u6027\uff0c\u8fd9\u4e9b\u836f\u7269\u53ef\u4ee5\u901a\u8fc7\u9776\u5411\u9690\u82b1\u8272\u7d20\u800c\u4e0d\u662f\u76f4\u63a5\u9776\u5411\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5f00\u5173\u6765\u907f\u514d\u4e00\u4e9b\u526f\u4f5c\u7528\u3002.\r\n<\/p>\r\n<p>\r\n\u66f4\u5e7f\u6cdb\u5730\u8bf4\uff0c\u57c3\u6587\u65af\u8bf4\uff0c\u8fd9\u9879\u7814\u7a76\u53ef\u80fd\u6709\u52a9\u4e8e\u89e3\u91ca\u7761\u7720\u4e0e\u6211\u4eec\u4f53\u5185\u8425\u517b\u7269\u8d28\u4ee3\u8c22\u4e4b\u95f4\u7684\u8054\u7cfb\uff0c\u5305\u62ec\u4e3a\u4ec0\u4e48\u4ece\u4e8b\u9700\u8981\u4e0a\u591c\u73ed\u6216\u5de5\u4f5c\u65f6\u95f4\u4e0d\u89c4\u5f8b\u7684\u4eba\u60a3\u80a5\u80d6\u75c7\u548c\u7cd6\u5c3f\u75c5\u7684\u98ce\u9669\u66f4\u9ad8\u3002.\r\n<\/p><p>\r\n\"\u6270\u4e71\u6b63\u5e38\u7684\u663c\u591c\u6d3b\u52a8\u5468\u671f\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4eba\u4f53\u7684\u751f\u7269\u949f\u65e0\u6cd5\u4e0e\u5176\u65e5\u5e38\u7684\u8425\u517b\u4ee3\u8c22\u6a21\u5f0f\u6b63\u786e\u540c\u6b65\uff0c\"\u57c3\u6587\u65af\u8bf4\u3002\"\u7ed3\u679c\uff0c\u8eab\u4f53\u53ef\u80fd\u65e0\u6cd5\u6b63\u5e38\u50a8\u5b58\u548c\u5904\u7406\u7cd6\u5206\uff0c\u4ece\u800c\u5bfc\u81f4\u4ee3\u8c22\u6027\u75be\u75c5\u3002\"\r\n<\/p><p>\r\n\u8fd9\u9879\u7814\u7a76\u7531\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u3001\u683c\u4f26\u533b\u5b66\u7814\u7a76\u57fa\u91d1\u4f1a\u3001\u8389\u6602\u5a1c\u00b7M\u00b7\u54c8\u91cc\u00b7B\u00b7\u8d6b\u5c14\u59c6\u65af\u5229\u6148\u5584\u4fe1\u6258\u57fa\u91d1\u4ee5\u53ca\u751f\u547d\u79d1\u5b66\u7814\u7a76\u57fa\u91d1\u4f1a\u8d44\u52a9\u3002.<\/p>\r\n<p><strong>\u5173\u4e8e\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\uff1a<\/strong><br \/>\r\n\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u662f\u4e16\u754c\u9876\u5c16\u7684\u57fa\u7840\u7814\u7a76\u673a\u6784\u4e4b\u4e00\uff0c\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u62c9\u970d\u4e9a\u3002\u8be5\u7814\u7a76\u6240\u62e5\u6709\u56fd\u9645\u77e5\u540d\u7684\u6559\u804c\u5458\u5de5\uff0c\u5728\u4e00\u4e2a\u72ec\u7279\u3001\u534f\u4f5c\u548c\u5bcc\u6709\u521b\u610f\u7684\u73af\u5883\u4e2d\uff0c\u63a2\u7d22\u751f\u547d\u79d1\u5b66\u7684\u57fa\u672c\u95ee\u9898\u3002\u7d22\u5c14\u514b\u7684\u7814\u7a76\u4eba\u5458\u4e13\u6ce8\u4e8e\u79d1\u5b66\u53d1\u73b0\u548c\u57f9\u517b\u4e0b\u4e00\u4ee3\u7814\u7a76\u4eba\u5458\uff0c\u901a\u8fc7\u5bf9\u795e\u7ecf\u79d1\u5b66\u3001\u9057\u4f20\u5b66\u3001\u7ec6\u80de\u548c\u690d\u7269\u751f\u7269\u5b66\u4ee5\u53ca\u76f8\u5173\u5b66\u79d1\u7684\u7814\u7a76\uff0c\u5728\u764c\u75c7\u3001\u8870\u8001\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u7cd6\u5c3f\u75c5\u548c\u4f20\u67d3\u75c5\u7b49\u9886\u57df\u53d6\u5f97\u4e86\u5f00\u521b\u6027\u7684\u8d21\u732e\uff0c\u6781\u5927\u5730\u589e\u8fdb\u4e86\u6211\u4eec\u5bf9\u8fd9\u4e9b\u75be\u75c5\u7684\u7406\u89e3\u3002.\r\n<\/p><p>\r\n\u5b66\u9662\u53d6\u5f97\u4e86\u8bb8\u591a\u6210\u5c31\uff0c\u83b7\u5f97\u4e86\u5305\u62ec\u8bfa\u8d1d\u5c14\u5956\u548c\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\u5728\u5185\u7684\u65e0\u6570\u8363\u8a89\u3002\u8be5\u7814\u7a76\u6240\u7531\u810a\u9ad3\u7070\u8d28\u708e\u75ab\u82d7\u5148\u9a71 Jonas Salk \u535a\u58eb\u4e8e 1960 \u5e74\u521b\u7acb\uff0c\u662f\u4e00\u5bb6\u72ec\u7acb\u7684\u975e\u8425\u5229\u7ec4\u7ec7\u548c\u5efa\u7b51\u5730\u6807\u3002.<\/p>\r\n<p><strong>\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff1a<\/strong><br \/>\r\n<em>\u81ea\u7136<\/em><br \/>\r\n\u4f5c\u8005\uff1aKatja A. Lamia, Stephanie J. Papp, Ruth T. Yu, Grant D. Barish, N. Henriette Uhlenhaut, Johan W. Jonker, Michael Downes, Ronald M. Evans<br \/>\r\n<a href=\"http:\/\/www.nature.com\/nature\/journal\/vaop\/ncurrent\/full\/nature10700.html\">\u9690\u8272\u4f53\u4ecb\u5bfc\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53d7\u4f53\u7684\u8282\u5f8b\u6027\u6291\u5236<\/a><\/p>","protected":false},"featured_media":0,"template":"","faculty":[],"disease-research":[453,454,122,123,124],"class_list":["post-2144","disclosure","type-disclosure","status-publish","hentry","disease-research-allergies","disease-research-asthma","disease-research-immune-system-biology","disease-research-metabolism-and-diabetes","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Salk discovery may lead to safer treatments for asthma, allergies and arthritis - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/salk-discovery-may-lead-to-safer-treatments-for-asthma-allergies-and-arthritis\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk discovery may lead to safer treatments for asthma, allergies and arthritis - 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