{"id":21319,"date":"2019-01-07T12:54:06","date_gmt":"2019-01-07T20:54:06","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=21319"},"modified":"2024-01-30T15:01:30","modified_gmt":"2024-01-30T23:01:30","slug":"salk-team-reveals-clues-into-early-development-of-autism-spectrum-disorder","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/salk-team-reveals-clues-into-early-development-of-autism-spectrum-disorder\/","title":{"rendered":"\u7d22\u5c14\u514b\u7814\u7a76\u6240\u56e2\u961f\u63ed\u793a\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u65e9\u671f\u53d1\u80b2\u7684\u7ebf\u7d22"},"content":{"rendered":"<p>\u62c9\u970d\u4e9a\u2014\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u662f\u4e00\u79cd\u76f8\u5bf9\u5e38\u89c1\u7684\u53d1\u80b2\u969c\u788d\uff0c\u5f71\u54cd\u6c9f\u901a\u548c\u884c\u4e3a\uff0c\u5728\u7f8e\u56fd\u7ea6\u6709\u4e94\u5341\u4e5d\u5206\u4e4b\u4e00\u7684\u513f\u7ae5\u60a3\u6709\u6b64\u75c5\uff0c, <a href=\"https:\/\/www.cdc.gov\/ncbddd\/autism\/data.html\">\u6839\u636e\u7f8e\u56fd\u75be\u75c5\u63a7\u5236\u4e0e\u9884\u9632\u4e2d\u5fc3<\/a>. \u5c3d\u7ba1\u5b83\u5f88\u666e\u904d\uff0c\u4f46\u5176\u75c5\u56e0\u4ee5\u53ca\u6700\u4f73\u6cbb\u7597\u65b9\u6cd5\u4ecd\u4e0d\u6e05\u695a\u3002.<\/p>\n<p>\u8428\u514b\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u5c06\u6765\u81ea\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u60a3\u8005\u7684\u5e72\u7ec6\u80de\u4e0e\u6765\u81ea\u975eASD\u60a3\u8005\u7684\u5e72\u7ec6\u80de\u8fdb\u884c\u6bd4\u8f83\uff0c\u9996\u6b21\u53d1\u73b0\u4e86ASD\u6765\u6e90\u7ec6\u80de\u5728\u53d1\u80b2\u6a21\u5f0f\u548c\u901f\u5ea6\u4e0a\u7684\u53ef\u6d4b\u91cf\u5dee\u5f02\u3002.<\/p>\n<figure id=\"attachment_21322\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"458\" class=\"img-responsive wp-image-21322 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-458x458.jpg\" alt=\"This image shows a two-dimensional culture of subject-derived cortical neurons stained for neuronal markers MAP2 (red) and Tuj1 (green).\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-458x458.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-150x150.jpg 150w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-300x300.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-768x768.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-767x767.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-147x147.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-585x585.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-553x553.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-750x750.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-945x945.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-400x400.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP-200x200.jpg 200w, https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP.jpg 1024w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><figcaption class=\"wp-caption-text\">\u8be5\u56fe\u50cf\u663e\u793a\u4e86\u7528\u795e\u7ecf\u5143\u6807\u8bb0\u7269 MAP2\uff08\u7ea2\u8272\uff09\u548c Tuj1\uff08\u7eff\u8272\uff09\u67d3\u8272\u7684\u53d7\u4f53\u6e90\u6027\u76ae\u5c42\u795e\u7ecf\u5143\u7684\u4e8c\u7ef4\u57f9\u517b\u7269\u3002.<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2019\/01\/Hues6NPC-N_8weeks_Tuj1.-MAP2_MIP.jpg\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<\/p>\n<p>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u8fd9\u4efd\u7814\u7a76\u53d1\u73b0\u4e8e2019\u5e741\u67087\u65e5\u53d1\u8868\u5728\u300a <em><a href=\"https:\/\/www.nature.com\/articles\/s41593-018-0295-x\" target=\"_blank\" rel=\"noopener\">\u81ea\u7136-\u795e\u7ecf\u79d1\u5b66<\/a>,<\/em> \u53ef\u80fd\u6709\u52a9\u4e8e\u5f00\u53d1\u65e9\u671f\u8bca\u65ad\u5b64\u72ec\u75c7\u7684\u65b9\u6cd5\uff0c\u4ece\u800c\u5728\u6709\u671b\u8fdb\u884c\u9884\u9632\u6027\u5e72\u9884\u7684\u9636\u6bb5\u8fdb\u884c\u5e72\u9884\u3002.<\/p>\n<p>\u201c\u5c3d\u7ba1\u6211\u4eec\u7684\u7814\u7a76\u4ec5\u5728\u4f53\u5916\u57f9\u517b\u7684\u7ec6\u80de\u4e2d\u8fdb\u884c\uff0c\u4f46\u5b83\u53ef\u80fd\u6709\u52a9\u4e8e\u6211\u4eec\u7406\u89e3\u57fa\u56e0\u8868\u8fbe\u7684\u65e9\u671f\u53d8\u5316\u5982\u4f55\u5bfc\u81f4\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u4e2a\u4f53\u5927\u8111\u53d1\u80b2\u7684\u6539\u53d8\uff0c\u201d\u7d22\u5c14\u514b\u7814\u7a76\u6240\u6559\u6388\u8bf4\u9053\u3002 <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/rusty-gage\/\">\u9c81\u65af\u8482\u00b7\u76d6\u5947<\/a>, \uff0c\u8be5\u7814\u7a76\u7684\u8d44\u6df1\u4f5c\u8005\u517c\u7814\u7a76\u6240\u6240\u957f\u3002\u201c\u6211\u4eec\u5e0c\u671b\u8fd9\u9879\u5de5\u4f5c\u80fd\u4e3a\u7814\u7a76\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u548c\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u5f00\u8f9f\u65b0\u9014\u5f84\u3002\u201d<\/p>\n<p>\u4e3a\u4e86\u8fdb\u884c\u8fd9\u9879\u7814\u7a76\uff0c\u7814\u7a76\u4eba\u5458\u4ece\u516b\u540d\u60a3\u6709\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u7684\u4eba\u548c\u4e94\u540d\u672a\u60a3 ASD \u7684\u4eba\u8eab\u4e0a\u63d0\u53d6\u76ae\u80a4\u7ec6\u80de\uff0c\u5e76\u5c06\u5b83\u4eec\u8f6c\u5316\u4e3a\u591a\u80fd\u5e72\u7ec6\u80de\u2014\u2014\u5177\u6709\u53d1\u80b2\u6210\u4efb\u4f55\u7ec6\u80de\u7c7b\u578b\u7684\u80fd\u529b\u7684\u7ec6\u80de\u3002\u7136\u540e\uff0c\u4ed6\u4eec\u901a\u8fc7\u66b4\u9732\u4e8e\u67d0\u4e9b\u5316\u5b66\u56e0\u7d20\uff0c\u8bf1\u5bfc\u8fd9\u4e9b\u5e72\u7ec6\u80de\u53d1\u80b2\u6210\u795e\u7ecf\u5143\u3002.<\/p>\n<p>\u901a\u8fc7\u5229\u7528\u5e72\u7ec6\u80de\u5728\u4e0d\u540c\u53d1\u80b2\u9636\u6bb5\u7684\u5206\u5b50\u201c\u5feb\u7167\u201d\uff0c\u8be5\u56e2\u961f\u80fd\u591f\u8ffd\u8e2a\u5e72\u7ec6\u80de\u53d1\u80b2\u6210\u795e\u7ecf\u5143\u65f6\u6309\u7279\u5b9a\u987a\u5e8f\u5f00\u542f\u7684\u57fa\u56e0\u7a0b\u5e8f\u3002\u8fd9\u63ed\u793a\u4e86\u6765\u81ea\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u60a3\u8005\u7684\u7ec6\u80de\u7684\u5173\u952e\u5dee\u5f02\u3002\u4f8b\u5982\uff0c\u7d22\u5c14\u514b\u56e2\u961f\u89c2\u5bdf\u5230\uff0c\u4e0e\u795e\u7ecf\u5e72\u7ec6\u80de\u9636\u6bb5\u76f8\u5173\u7684\u57fa\u56e0\u7a0b\u5e8f\u5728\u81ea\u95ed\u75c7\u60a3\u8005\u7684\u7ec6\u80de\u4e2d\u6bd4\u5728\u975e\u81ea\u95ed\u75c7\u60a3\u8005\u7684\u7ec6\u80de\u4e2d\u66f4\u65e9\u5f00\u542f\u3002\u8fd9\u4e2a\u57fa\u56e0\u7a0b\u5e8f\u5305\u542b\u4e86\u8bb8\u591a\u4e0e\u60a3\u81ea\u95ed\u75c7\u98ce\u9669\u589e\u52a0\u76f8\u5173\u7684\u57fa\u56e0\u3002\u6b64\u5916\uff0c\u6700\u7ec8\u7531\u81ea\u95ed\u75c7\u60a3\u8005\u53d1\u80b2\u800c\u6765\u7684\u795e\u7ecf\u5143\u6bd4\u5bf9\u7167\u7ec4\u7684\u795e\u7ecf\u5143\u751f\u957f\u66f4\u5feb\uff0c\u6811\u7a81\u4e5f\u66f4\u590d\u6742\u3002.<\/p>\n<p>\u201c\u76ee\u524d\u63a8\u6d4b\uff0c\u65e9\u671f\u5927\u8111\u53d1\u80b2\u5f02\u5e38\u4f1a\u5bfc\u81f4\u81ea\u95ed\u75c7\uff0c\u4f46\u4ece\u6b63\u5e38\u53d1\u80b2\u7684\u5927\u8111\u5230\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u7684\u8bca\u65ad\u4e4b\u95f4\u7684\u8fc7\u6e21\u662f\u6a21\u7cca\u7684\uff0c\u201d\u7b2c\u4e00\u4f5c\u8005\u3001Gage\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u540e\u7814\u7a76\u5458Simon Schafer\u8bf4\u3002\u201c\u8be5\u9886\u57df\u7684\u4e00\u4e2a\u4e3b\u8981\u6311\u6218\u662f\u786e\u5b9a\u5173\u952e\u7684\u53d1\u80b2\u671f\u53ca\u5176\u76f8\u5173\u7684\u7ec6\u80de\u72b6\u6001\u3002\u8fd9\u9879\u7814\u7a76\u53ef\u80fd\u4e3a\u53d1\u73b0ASD\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u7684\u5171\u540c\u75c5\u7406\u7279\u5f81\u63d0\u4f9b\u57fa\u7840\u3002\u201d<\/p>\n<p>\u201c\u8fd9\u9879\u53d1\u73b0\u975e\u5e38\u4ee4\u4eba\u5174\u594b\uff0c\u5b83\u9f13\u52b1\u6211\u4eec\u8fdb\u4e00\u6b65\u5b8c\u5584\u6211\u4eec\u7684\u65b9\u6cd5\u6846\u67b6\uff0c\u4ee5\u5e2e\u52a9\u6211\u4eec\u52a0\u6df1\u5bf9\u75c7\u72b6\u51fa\u73b0\u524d\u65e9\u671f\u7ec6\u80de\u751f\u7269\u5b66\u4e8b\u4ef6\u7684\u7406\u89e3\uff0c\u201d\u76d6\u5947\u8865\u5145\u9053\u3002\u76d6\u5947\u8fd8\u62c5\u4efb\u4e86\u5173\u4e8e\u8870\u8001\u76f8\u5173\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7814\u7a76\u7684Vi\u548cJohn Adler\u4e3b\u5e2d\u3002\u201c\u7814\u7a76\u7cfb\u7edf\u52a8\u529b\u5b66\u53ef\u4ee5\u6700\u5927\u5316\u6211\u4eec\u6355\u6349\u76f8\u5173\u673a\u5236\u6027\u75be\u75c5\u72b6\u6001\u7684\u673a\u4f1a\u3002\u201d<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u672c\u7814\u7a76\u4e2d\u7684\u5b9e\u9a8c\u5c06\u6709\u52a9\u4e8e\u4e3a\u7814\u7a76\u6d89\u53ca\u81ea\u95ed\u75c7\u6613\u611f\u6027\u548c\u8fdb\u5c55\u7684\u673a\u5236\u63d0\u4f9b\u66f4\u5177\u6d3b\u529b\u7684\u9014\u5f84\u3002.<\/p>\n<p>\u4ed6\u4eec\u63a5\u4e0b\u6765\u7684\u8ba1\u5212\u662f\u4e13\u6ce8\u4e8e\u521b\u5efa\u5927\u8111\u7c7b\u5668\u5b98\uff0c\u8fd9\u662f\u5b9e\u9a8c\u5ba4\u4e2d\u5927\u8111\u53d1\u80b2\u7684\u4e09\u7ef4\u6a21\u578b\uff0c\u4f7f\u79d1\u5b66\u5bb6\u80fd\u591f\u7814\u7a76\u4e0d\u540c\u7c7b\u578b\u8111\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002.<\/p>\n<p>\u201c\u76ee\u524d\u7684\u8bca\u65ad\u65b9\u6cd5\u5927\u591a\u662f\u4e3b\u89c2\u7684\uff0c\u5e76\u4e14\u662f\u5728\u5e7c\u513f\u51fa\u73b0\u884c\u4e3a\u5f02\u5e38\u540e\u8fdb\u884c\u7684\uff0c\u201dSchafer \u8bf4\u3002\u201c\u6211\u4eec\u5e0c\u671b\u8fd9\u4e9b\u7814\u7a76\u80fd\u591f\u4e3a\u5f00\u53d1\u65b0\u7684\u8bca\u65ad\u65b9\u6cd5\u63d0\u4f9b\u4e00\u4e2a\u6846\u67b6\uff0c\u5728\u513f\u7ae5\u53d1\u80b2\u65e9\u671f\u2014\u2014\u5728\u884c\u4e3a\u75c7\u72b6\u51fa\u73b0\u5f88\u4e45\u4e4b\u524d\u2014\u2014\u8fdb\u884c\u8bca\u65ad\uff0c\u4ece\u800c\u5bf9\u6cbb\u7597\u548c\u5e72\u9884\u4ea7\u751f\u6700\u5927\u7684\u5f71\u54cd\u3002\u201d<\/p>\n<p>\u8be5\u8bba\u6587\u7684\u5176\u4ed6\u7814\u7a76\u4eba\u5458\u5305\u62ec\uff1aSalk\u7814\u7a76\u6240\u7684Apua C. M. Paquola\u3001Shani Stern\u3001Monique Pena\u3001Thomas J. M. Kuret\u3001Marvin Liyanage\u3001Abed AlFatah Mansour\u3001Baptiste N. Jaeger\u3001Maria C. Marchetto\u548cJerome Mertens\uff1b\u52a0\u62ff\u5927\u9b41\u5317\u514b\u5e02\u62c9\u74e6\u5c14\u5927\u5b66\u7684David Gosselin\uff1b\u5fb7\u56fd\u5f17\u83b1\u5821\u5927\u5b66\u7684Ku Manching\uff1b\u4ee5\u53ca\u52a0\u5dde\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\u7684Christopher K. 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