{"id":21162,"date":"2018-12-14T09:21:31","date_gmt":"2018-12-14T17:21:31","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=21162"},"modified":"2023-12-08T09:31:54","modified_gmt":"2023-12-08T17:31:54","slug":"to-repair-dna-damage-plants-need-good-contractors","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/to-repair-dna-damage-plants-need-good-contractors\/","title":{"rendered":"\u8981\u4fee\u590d DNA 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id=\"attachment_20196\"  class=\"wp-caption alignright\"><img decoding=\"async\" class=\"img-responsive wp-image-20196 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/12\/Law-Web-750x750-300x300.jpg\" alt=\"Julie Law\" \/><figcaption class=\"wp-caption-text\">\u6731\u8389\u00b7\u52b3<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/12\/Law-Web-750x750.jpg\" target=\"_blank\" rel=\"noopener\">\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf<\/p>\n<p>\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n<p>\u73b0\u5728\uff0c\u8428\u5c14\u514b\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u62a5\u544a\u4e86\u54ea\u4e9b\u57fa\u56e0\u4f1a\u5f00\u542f\u6216\u5173\u95ed\uff0c\u4ee5\u53ca\u5b83\u4eec\u7684\u987a\u5e8f\uff0c\u4ee5\u534f\u8c03\u7ec6\u80de\u5728DNA\u635f\u4f24\u540e\u4fdd\u62a4\u548c\u4fee\u590d\u57fa\u56e0\u7ec4\u6240\u9700\u7684\u8fc7\u7a0b\u3002\u8fd9\u9879\u7814\u7a76\u53d1\u8868\u5728\u300a\u671f\u520a\u300b\u4e0a <em><a href=\"https:\/\/www.pnas.org\/content\/early\/2018\/12\/11\/1810582115\" target=\"_blank\" rel=\"noopener\">\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/a><\/em> 2018\u5e7410\u670810\u65e5\u5f53\u5468\u7684\u300a\u81ea\u7136\u300b\u6742\u5fd7\u63ed\u793a\u4e86\u63a7\u5236\u590d\u6742\u751f\u7269\u8fc7\u7a0b\u7684\u9057\u4f20\u673a\u5236\uff0c\u8be5\u673a\u5236\u5bf9\u4e8e\u7406\u89e3\u690d\u7269\u4e43\u81f3\u6240\u6709\u751f\u7269\u4f53\u5982\u4f55\u5e94\u5bf9DNA\u635f\u4f24\u4ee5\u786e\u4fdd\u957f\u671f\u5065\u5eb7\u548c\u6d3b\u529b\u5177\u6709\u5e7f\u6cdb\u610f\u4e49\u3002.<\/p>\n<p>\u201c\u5c31\u50cf\u6709\u7ed3\u6784\u635f\u4f24\u7684\u5efa\u7b51\u7269\u53ef\u80fd\u4e0d\u5b89\u5168\u4e00\u6837\uff0c\u7ec6\u80de\u4e2d\u672a\u88ab\u53d1\u73b0\u6216\u672a\u7ecf\u4fee\u590d\u7684 DNA \u635f\u4f24\u4e5f\u53ef\u80fd\u5f88\u5371\u9669\uff0c\u201d\u52a9\u7406\u6559\u6388\u8bf4 <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/julie-law\/\">\u6731\u8389\u00b7\u52b3<\/a>, \u3002 \u8be5\u8bba\u6587\u7684\u901a\u8baf\u4f5c\u8005\u8bf4\u3002\u201c\u7136\u800c\uff0cDNA\u635f\u4f24\u68c0\u6d4b\u540e\u53d1\u751f\u7684\u4e8b\u4ef6\u7684\u65f6\u95f4\u548c\u6574\u4f53\u534f\u8c03\u4ecd\u7136\u77e5\u4e4b\u751a\u5c11\u3002SOG1\u662f\u50cf\u4e2a\u5fae\u89c2\u7ba1\u7406\u8005\u4e00\u6837\uff0c\u76f4\u63a5\u6307\u6d3e\u6bcf\u4e2a\u5206\u5305\u5546\u5b8c\u6210\u4efb\u52a1\uff0c\u8fd8\u662f\u626e\u6f14\u4e00\u79cd\u66f4\u4e0d\u5e72\u6d89\u7684\u89d2\u8272\uff1f\u672c\u8bba\u6587\u4f7f\u6211\u4eec\u79bb\u7406\u89e3DNA\u635f\u4f24\u7684\u53cd\u5e94\u5982\u4f55\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u8fdb\u884c\u534f\u8c03\u4ee5\u7ef4\u6301\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u66f4\u8fd1\u4e86\u4e00\u6b65\u3002\u201d<\/p>\n<p>\u4e3a\u4e86\u66f4\u597d\u5730\u7406\u89e3DNA\u635f\u4f24\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u57fa\u56e0\u8c03\u63a7\u7684\u52a8\u6001\u53d8\u5316\uff0c\u5e76\u786e\u5b9aSOG1\u5728\u8be5\u53cd\u5e94\u4e2d\u7684\u76f4\u63a5\u4f5c\u7528\uff0cLaw\u53ca\u5176\u56e2\u961f\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217\u5b9e\u9a8c\uff0c\u5176\u4e2d <em>\u62df\u5357\u82a5<\/em>, \u4e00\u79cd\u5e38\u7528\u4e8e\u9057\u4f20\u5b66\u7814\u7a76\u7684\u6742\u8349\u3002\u4ed6\u4eec\u79cd\u690d\u4e86\u4e24\u7ec4 <em>\u62df\u5357\u82a5<\/em> \u5e7c\u82d7\uff1a\u4e00\u7ec4\u662f\u6b63\u5e38\u7684\uff1b\u53e6\u4e00\u7ec4\u542b\u6709 SOG1 \u57fa\u56e0\u7684\u7a81\u53d8\u7248\u672c\uff0c\u4f7f\u5176\u65e0\u6cd5\u6b63\u5e38\u5de5\u4f5c\u3002.<\/p>\n<figure id=\"attachment_20196\"  class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"img-responsive wp-image-20196 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/12\/Law-PNAS-graphical-abstract-300x300.png\" alt=\"Julie Law\" \/><figcaption class=\"wp-caption-text\">\u8be5\u56fe\u50cf\u8bf4\u660e\u4e86\u690d\u7269\u5982\u4f55\u54cd\u5e94 DNA \u635f\u4f24\uff08\u4f8b\u5982\u4f3d\u9a6c\u8f90\u5c04\uff09\uff0c\u5728 24 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\u4e2a\u57fa\u56e0\u7684\u8868\u8fbe\u56e0 DNA \u635f\u4f24\u800c\u4e0a\u8c03\u6216\u4e0b\u8c03\uff0c\u5176\u4e2d\u51e0\u4e4e\u6240\u6709\u90fd\u4f9d\u8d56\u4e8e SOG1 \u7684\u5b58\u5728\u3002\u7136\u800c\uff0c\u4ed6\u4eec\u53d1\u73b0\u53ea\u6709\u7ea6 200 \u4e2a\u57fa\u56e0\u2014\u2014\u6216\u7ea6 8%\u2014\u2014\u76f4\u63a5\u88ab SOG1 \u6fc0\u6d3b\uff0c\u8fd9\u63ed\u793a\u4e86\u4e00\u4e2a\u590d\u6742\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u7684\u7b2c\u4e00\u4e2a\u5c42\u9762\uff0c\u5e76\u8868\u660e SOG1 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\u635f\u4f24\u53cd\u5e94\u7684\u7279\u5b9a\u57fa\u56e0\u7f51\u7edc\u548c\u5b50\u7f51\u7edc\uff0c\u4ee5\u53ca\u5b83\u4eec\u7684\u53d1\u751f\u65f6\u95f4\uff0c\u800c\u8fd9\u4e9b\u5728\u6b64\u4e4b\u524d\u4ece\u672a\u88ab\u7814\u7a76\u8fc7\uff0c\u201d\u52b3\u8bf4\u3002.<\/p>\n<p>\u9664\u4e86\u4e3a\u901a\u8fc7\u7ef4\u6301\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u6765\u6539\u5584\u4f5c\u7269\u5065\u5eb7\u63d0\u4f9b\u7b56\u7565\u6027\u4fe1\u606f\u5916\uff0c\u8fd9\u9879\u5de5\u4f5c\u8fd8\u53ef\u80fd\u4e3a\u5176\u4ed6\u751f\u7269\u4f53\u4e2d DNA \u635f\u4f24\u53cd\u5e94\u7684\u4fdd\u5b88\u65b9\u9762\u63d0\u4f9b\u542f\u793a\uff0c\u56e0\u4e3a SOG1 \u4e0e\u52a8\u7269\u4e2d\u5177\u6709\u76f8\u4f3c\u201c\u603b\u5305\u5546\u201d\u529f\u80fd\u7684\u57fa\u56e0 p53 \u57fa\u56e0\u6709\u8bb8\u591a\u76f8\u4f3c\u4e4b\u5904\uff0cp53 \u662f\u4e00\u79cd\u4ee5\u5176\u5728\u5bf9\u6297 DNA \u635f\u4f24\u4ee5\u9884\u9632\u764c\u75c7\u65b9\u9762\u7684\u4f5c\u7528\u800c\u95fb\u540d\u7684\u80bf\u7624\u6291\u5236\u57fa\u56e0\u3002.<\/p>\n<p>\u63a5\u4e0b\u6765\uff0c\u8be5\u5b9e\u9a8c\u5ba4\u8ba1\u5212\u6839\u636e\u65b0\u7684DNA\u635f\u4f24\u53cd\u5e94\u76f8\u5173\u56e0\u5b50\u7684\u8868\u8fbe\u8c31\uff0c\u7814\u7a76\u5b83\u4eec\u7684\u4f5c\u7528\uff0c\u5e76\u7ee7\u7eed\u63a2\u7d22\u53d7SOG1\u76f4\u63a5\u6216\u95f4\u63a5\u63a7\u5236\u7684\u57fa\u56e0\u7f51\u7edc\u3002.<\/p>\n<p>\u8bba\u6587\u7684\u8054\u5408\u4f5c\u8005\u8fd8\u5305\u62ec\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684Clara Bourbousse\u548cNeeraja Vegesna\u3002.<\/p>\n<p>\u8fd9\u9879\u5de5\u4f5c\u5f97\u5230\u4e86\u4e3d\u5854\u00b7\u827e\u4f26\u57fa\u91d1\u4f1a\u3001\u8d6b\u65af\u7279\u57fa\u91d1\u4f1a\u3001\u51ef\u745f\u7433\u5a1c\u57fa\u91d1\u4f1a\u5956\u5b66\u91d1\u3001\u6770\u897f\u548c\u51ef\u8389\u00b7\u83f2\u5229\u666e\u65af\u57fa\u91d1\u4f1a\u3001\u683c\u4f26\u533b\u5b66\u7814\u7a76\u6240\u57fa\u91d1\u4f1a\u3001\u67e5\u666e\u66fc\u57fa\u91d1\u4f1a\u4ee5\u53ca\u6d77\u59c6\u65af\u5229\u6148\u5584\u4fe1\u6258\u57fa\u91d1\u7684\u8d44\u52a9\u3002.<\/p>","protected":false},"featured_media":21166,"template":"","faculty":[94],"disease-research":[125,451],"class_list":["post-21162","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-julie-law","disease-research-plant-biology","disease-research-plant-genomics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>To repair DNA damage, plants need good contractors - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/to-repair-dna-damage-plants-need-good-contractors\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"To repair DNA damage, plants need good contractors - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014When a building is damaged, a general contractor often oversees various subcontractors\u2014framers, electricians, plumbers and drywall hangers\u2014to ensure repairs are done in the correct order and on time.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/zh\/news-release\/to-repair-dna-damage-plants-need-good-contractors\/\" \/>\n<meta property=\"og:site_name\" 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