{"id":20826,"date":"2018-11-09T10:46:42","date_gmt":"2018-11-09T18:46:42","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&#038;p=20826"},"modified":"2018-11-12T09:19:26","modified_gmt":"2018-11-12T17:19:26","slug":"salk-awarded-19-2-million-by-the-american-heart-association-allen-initiative-to-study-alzheimers-and-aging-in-the-brain","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/salk-awarded-19-2-million-by-the-american-heart-association-allen-initiative-to-study-alzheimers-and-aging-in-the-brain\/","title":{"rendered":"Salk awarded $19.2 million by the American Heart Association-Allen Initiative to study Alzheimer&#8217;s and aging in the brain"},"content":{"rendered":"<p>LA JOLLA\u2014A team of Salk Institute researchers led by President <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/rusty-gage\/\">\u9c81\u65af\u8482\u00b7\u76d6\u5947<\/a> has been awarded $19.2 million over eight years by the American Heart Association-Allen Initiative in Brain Health and Cognitive Impairment to investigate mechanisms underlying Alzheimer&#8217;s disease and aging-related cognitive decline and uncover new therapies. This bold venture will comprehensively analyze interactions between five areas key to brain health: proteins, genes, metabolism, inflammation and epigenetics.<\/p>\n<div class=\"row\" style=\"\"><div class=\"col-md-12 col-md-push-0\"><div class=\"video-anchor\" id=\"video-igPDz1r2H-k\"><\/div><div class=\"embed-responsive embed-responsive-16by9\"> <iframe class=\"embed-responsive-item\" src=\"\/\/www.youtube.com\/embed\/igPDz1r2H-k?rel=0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe><\/div><!-- .embed-responsive --><\/div><!-- .col-md-*size --><\/div><!-- .\/row -->\n<p>&#8220;At the Salk Institute, we have devised a completely new way of approaching Alzheimer&#8217;s and aging research,&#8221; says Gage, a world-renowned researcher in neuroscience and genetics who holds the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease. &#8220;With the generous support of The Paul G. Allen Frontiers Group, the American Heart Association and other philanthropic donors to this initiative, we believe we can make significant progress in the diagnosis and treatment of Alzheimer\u2019s and other age-related cognitive diseases.&#8221;<\/p>\n<figure id=\"attachment_20828\"  class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"260\" class=\"img-responsive wp-image-20828 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-300x260.jpg\" alt=\"\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-300x260.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-768x665.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-1024x887.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-147x127.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-458x397.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-585x507.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-553x479.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-750x649.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-767x664.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-945x818.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-1250x1082.jpg 1250w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract-400x346.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract.jpg 1387w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-caption-text\">This image represents how the Salk research effort will comprehensively analyze interactions between five areas key to brain health: proteins, genes, metabolism, inflammation and epigenetics. The Salk team aims to study how failure in any one of these systems can cause a domino-like crash that results in devastating brain disorders like Alzheimer\u2019s.<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Graphical-abstract.jpg\">Click here<\/a> for a high-resolution image.<\/p>\n<p>Credit: Salk Institute<\/figcaption><\/figure>\n<p>An aging-related disorder that results in severe memory loss, Alzheimer\u2019s disease represents a global health crisis with estimates suggesting that <a href=\"https:\/\/www.who.int\/mental_health\/publications\/dementia_report_2012\/en\/\">130 million people will be affected by 2050<\/a>. To date, there are no therapies to effectively treat the disease.<\/p>\n<p>To respond to this critical need, Gage will be leading a multidisciplinary team of 10 Salk scientists, all luminaries in their respective fields across metabolism, immunology and inflammation, genetics and epigenetics, and protein analysis. The all-star interdisciplinary group believes that Alzheimer\u2019s and other age-related brain disorders are triggered not by a single event, but by a failure of complex, interdependent biological systems in our body that start to break down as we age. Failure in any one of these systems can cause a domino-like crash that results in devastating brain disorders like Alzheimer\u2019s. By studying the networks that keep our brains healthy, the team aims to reveal new targets for therapeutic research and biomarkers of early stage cognitive decline.<\/p>\n<p>&#8220;The fact that numerous clinical trials over the past several decades have not yielded effective therapies points to the complex nature of neurodegeneration,&#8221; says Professor <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/susan-kaech\/\">Susan Kaech<\/a>, director of Salk\u2019s NOMIS Center for Immunobiology and Pathogenesis, holder of the NOMIS Chair, and a member of the project&#8217;s leadership team. &#8220;We are grateful for this support, which will help us learn more about the role of inflammation in Alzheimer\u2019s and how it affects other cellular processes associated with this disease.\u00a0We are hopeful this work will lead to the breakthroughs humanity so desperately needs.\u201d<\/p>\n<figure id=\"attachment_20829\"  class=\"wp-caption alignleft\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Organoid-Neural-blood.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"276\" class=\"img-responsive wp-image-20829 size-pr-300\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Organoid-Neural-blood-300x276.jpg\" alt=\"This illustration shows a blood vessel traversing neurons and support cells called glia in a brain organoid, as recently described in research from the Gage lab. Improved 3D models of brain function can better approximate both health and diseases such as Alzheimer's.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Organoid-Neural-blood-300x276.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Organoid-Neural-blood-147x135.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Organoid-Neural-blood-458x422.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Organoid-Neural-blood-585x538.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Organoid-Neural-blood-553x509.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Organoid-Neural-blood-400x368.jpg 400w, https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Organoid-Neural-blood.jpg 641w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption class=\"wp-caption-text\">This illustration shows a blood vessel traversing neurons and support cells called glia in a brain organoid, as recently described in research from the <a href=\"https:\/\/gage.salk.edu\/\">Gage lab<\/a>. Improved 3D models of brain function can better approximate both health and diseases such as Alzheimer&#8217;s.<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2018\/11\/Organoid-Neural-blood.jpg\">Click here<\/a> for a high-resolution image.<\/p>\n<p>Credit: Salk Institute<\/figcaption><\/figure>\n<p>To accomplish this, Salk research teams are developing cutting-edge methods to study aging and diseased neurons and other brain cells through cell cultures, brain organoids and a new primate model of cognitive aging. In addition to these technological advances, the team will use sophisticated machine-learning algorithms that can integrate diverse datasets, allowing scientists to identify the cell types and biological pathways most critical for brain aging.<\/p>\n<p>&#8220;Age is the greatest risk factor for a diversity of devastating diseases including Alzheimer&#8217;s, heart disease and cancer,&#8221; says Professor <a href=\"https:\/\/www.salk.edu\/zh\/scientist\/jan-karlseder\/\">Jan Karlseder<\/a>, a member of the project&#8217;s leadership team who directs the Glenn Center for Biology of Aging Research and holds the Donald and Darlene Shiley Chair. &#8220;Since the effects of aging are themselves comprehensive, taking a systems approach seems promising. We very much appreciate the generosity of The Paul G. Allen Frontiers Group and American Heart Association in supporting this research to advance our understanding of aging.\u201d<\/p>\n<p>\u201cThe innovative approaches that have come about through this initiative are a clear testament to Allen Institute founder Paul G. Allen\u2019s legacy in science,\u201d said <a href=\"https:\/\/alleninstitute.org\/about\/team\/staff-profiles\/allan-jones\/\">Allan Jones<\/a>, PhD, President and Chief Executive Officer of the Allen Institute. \u201cPaul inspired all of us every day to tackle hard problems that require systematic, comprehensive approaches to solve, and these new research teams are a perfect example of that way of thinking about mysteries in science and human health.\u201d<\/p>\n<p>The Salk investigators on the grant are:<\/p>\n<p><a href=\"https:\/\/www.salk.edu\/zh\/scientist\/nicola-allen\/\">Nicola Allen<\/a>, assistant professor<br \/>\n<a href=\"https:\/\/www.salk.edu\/zh\/scientist\/joseph-ecker\/\">\u7ea6\u745f\u592b\u00b7\u57c3\u514b\u5c14<\/a>, professor<br \/>\n<a href=\"https:\/\/www.salk.edu\/zh\/scientist\/rusty-gage\/\">\u9c81\u65af\u8482\u00b7\u76d6\u5947<\/a>, professor<br \/>\n<a href=\"https:\/\/www.salk.edu\/zh\/scientist\/martin-hetzer\/\">Martin Hetzer<\/a>, professor<br \/>\n<a href=\"https:\/\/www.salk.edu\/zh\/scientist\/susan-kaech\/\">Susan Kaech<\/a>, professor<br \/>\n<a href=\"https:\/\/www.salk.edu\/zh\/scientist\/jan-karlseder\/\">Jan Karlseder<\/a>, professor<br \/>\n<a href=\"https:\/\/www.salk.edu\/zh\/scientist\/saket-navlakha\/\">Saket Navlakha<\/a>, assistant professor<br \/>\n<a href=\"https:\/\/www.salk.edu\/zh\/scientist\/john-reynolds\/\">John Reynolds<\/a>, professor<br \/>\n<a href=\"https:\/\/www.salk.edu\/zh\/scientist\/gerald-shadel\/\">Gerald Shadel<\/a>, professor<br \/>\n<a href=\"https:\/\/www.salk.edu\/zh\/scientist\/reuben-shaw\/\">\u9c81\u672c-\u8096<\/a>, professor<\/p>","protected":false},"featured_media":20859,"template":"","faculty":[308,69,107,42,86,81,45,76,101,311],"disease-research":[127,146],"class_list":["post-20826","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-gerald-shadel","faculty-jan-karlseder","faculty-john-reynolds","faculty-joseph-ecker","faculty-martin-hetzer","faculty-nicola-allen","faculty-reuben-shaw","faculty-rusty-gage","faculty-saket-navlakha","faculty-susan-kaech","disease-research-alzheimers-disease","disease-research-aging-and-regenerative-medicine"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Salk awarded $19.2 million by the American Heart Association-Allen Initiative to study Alzheimer&#039;s and aging in the brain - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/salk-awarded-19-2-million-by-the-american-heart-association-allen-initiative-to-study-alzheimers-and-aging-in-the-brain\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk awarded $19.2 million by the American Heart Association-Allen Initiative to study Alzheimer&#039;s and aging in the brain - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014A team of Salk Institute researchers led by President Rusty Gage has been awarded $19.2 million over eight years by the American Heart Association-Allen Initiative in Brain Health and Cognitive Impairment to investigate mechanisms underlying Alzheimer&#8217;s disease and aging-related cognitive decline and uncover new therapies. 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