{"id":2064,"date":"2010-12-13T00:00:00","date_gmt":"2010-12-13T08:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/the-stemness-of-cancer-cells\/"},"modified":"2010-12-13T00:00:00","modified_gmt":"2010-12-13T08:00:00","slug":"the-stemness-of-cancer-cells","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/the-stemness-of-cancer-cells\/","title":{"rendered":"\u764c\u7ec6\u80de\u7684\u5e72\u6027"},"content":{"rendered":"

\u62c9\u970d\u4e9a\uff0c\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u2014\u2014\u751f\u7269\u7814\u7a76\u6240\u7684\u8428\u5c14\u514b\u7814\u7a76\u6240\u548c\u9ad8\u7b49\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u4e4b\u95f4\u7684\u5bc6\u5207\u5408\u4f5c\u53d1\u73b0\uff0c\u957f\u671f\u4ee5\u6765\u88ab\u8ba4\u4e3a\u662f\u201c\u57fa\u56e0\u7ec4\u7684\u5b88\u62a4\u8005\u201d\u7684\u80bf\u7624\u6291\u5236\u57fa\u56e0 p53\uff0c\u53ef\u80fd\u4e0d\u4ec5\u4ec5\u80fd\u963b\u6b62\u81f4\u764c\u7a81\u53d8\u3002\u901a\u8fc7\u5145\u5f53\u201c\u57fa\u56e0\u7ec4\u91cd\u7f16\u7a0b\u7684\u5b88\u62a4\u8005\u201d\uff0c\u5b83\u8fd8\u53ef\u4ee5\u963b\u6b62\u5df2\u786e\u7acb\u7684\u764c\u7ec6\u80de\u6ed1\u5411\u66f4\u5177\u4fb5\u88ad\u6027\u3001\u7c7b\u4f3c\u5e72\u7ec6\u80de\u7684\u72b6\u6001\u3002\u201d\n<\/p>\n

\n\u65b0\u4f5c\u54c1\uff0c\u7531 \u6770\u5f17\u91cc\u00b7M\u00b7\u74e6\u5c14<\/a>, \uff0c\u535a\u58eb\uff0c\u4ee5\u53ca\u672c\u6770\u660e\u00b7\u65af\u6d3e\u514b\uff08Benjamin Spike\uff09\u535a\u58eb\uff0c\u5728\u7d22\u5c14\u514b\u7814\u7a76\u6240\uff1b\u963f\u8bfa\u5fb7\u00b7J\u00b7\u83b1\u6587\uff08Arnold J. Levine\uff09\u535a\u58eb\u548c\u6c34\u91ce\u82f1\u660e\uff08Hideaki Mizuno\uff09\u535a\u58eb\uff0c\u5728\u666e\u6797\u65af\u987f\u9ad8\u7b49\u7814\u7a76\u9662\uff0c\u5728\u672c\u5468\u5728\u7ebf\u7248\u7684 \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>, \u63ed\u793a\u4e86\u6b63\u5e38\u6210\u5e74\u7ec6\u80de\u4e2dp53\u7f3a\u5931\u7684\u91cd\u7f16\u7a0b\u6548\u7387\u63d0\u9ad8\u3001\u5e72\u7ec6\u80de\u56fa\u6709\u7684\u53ef\u5851\u6027\u548c\u81f4\u7624\u6027\u4ee5\u53ca\u6076\u6027\u80bf\u7624\u4e2dp53\u7a81\u53d8\u7684\u9ad8\u53d1\u7387\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u60ca\u4eba\u76f8\u4f3c\u4e4b\u5904\u3002.\n<\/p>\n

\n\u201c\u5206\u5316\u4e0d\u826f\u7684\u5916\u89c2\u3001\u7ec6\u80de\u548c\u9057\u4f20\u5f02\u8d28\u6027\u662f\u8bb8\u591a\u4fb5\u88ad\u6027\u548c\u81f4\u547d\u6027\u764c\u75c7\u7684\u4f17\u6240\u5468\u77e5\u6807\u5fd7\uff0c\u201d\u7d22\u5c14\u514b\u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4\u6559\u6388 Wahl \u89e3\u91ca\u8bf4\uff0c\u201c\u6700\u8fd1\u6709\u4eba\u63d0\u51fa\uff0c\u8fd9\u4e9b\u7279\u6027\u6e90\u4e8e\u7c7b\u4f3c\u5e72\u7ec6\u80de\u7684\u764c\u7ec6\u80de\u7684\u5b58\u5728\u3002\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cp53 \u7a81\u53d8\u53ef\u80fd\u4f7f\u80bf\u7624\u5185\u7684\u7ec6\u80de\u901a\u8fc7\u83b7\u5f97\u7c7b\u4f3c\u5e72\u7ec6\u80de\u7684\u2018\u7a0b\u5e8f\u2019\u6765'\u9006\u8f6c\u65f6\u95f4\u201d\u3002\u201d\n<\/p>\n

\"Model<\/p>\n

\u6291\u764c\u57fa\u56e0p53\u53ef\u963b\u6b62\u5df2\u5f62\u6210\u7684\u764c\u7ec6\u80de\u6ed1\u5411\u66f4\u5177\u4fb5\u88ad\u6027\u7684\u3001\u7c7b\u5e72\u7ec6\u80de\u7684\u72b6\u6001\u3002.<\/p>\n

\u63d2\u56fe\uff1a\u7531\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u7684 Benjamin Spike \u535a\u58eb\u63d0\u4f9b\u3002.<\/p>\n<\/div>\n

\n\u764c\u7ec6\u80de\u9700\u8981\u83b7\u5f97\u4e00\u4e9b\u5e72\u7ec6\u80de\u7684\u7279\u5f81\u624d\u80fd\u5728\u4e0d\u65ad\u53d8\u5316\u7684\u73af\u5883\u4e2d\u751f\u5b58\u548c\u9002\u5e94\u3002\u8fd9\u4e9b\u7279\u5f81\u5305\u62ec\u6c38\u751f\u3001\u81ea\u6211\u66f4\u65b0\u80fd\u529b\u4ee5\u53ca\u4ea7\u751f\u5206\u5316\u6210\u5176\u4ed6\u7ec6\u80de\u7c7b\u578b\u7684\u7956\u7ec6\u80de\u7684\u80fd\u529b\u3002\u201c\u6bcf\u4e2a\u80bf\u7624\u90fd\u4ee3\u8868\u7740\u764c\u7ec6\u80de\u591a\u6837\u5316\u7684\u96c6\u5408\uff0c\u201d\u6c83\u52d2\u8bf4\uff0c\u201c\u95ee\u9898\u662f\u5982\u4f55\u6700\u597d\u5730\u89e3\u91ca\u8fd9\u79cd\u5f02\u8d28\u6027\u662f\u5982\u4f55\u4ea7\u751f\u7684\u3002\u201d\n<\/p>\n

\n\u8fc7\u53bb\uff0c\u764c\u75c7\u7684\u7ec6\u80de\u591a\u6837\u6027\u4e3b\u8981\u5f52\u56e0\u4e8e\u57fa\u56e0\u4e0d\u7a33\u5b9a\u6027\uff0c\u800c\u591a\u5e74\u524dWahl\u53ca\u5176\u56e2\u961f\u5df2\u8868\u660e\uff0c\u5f53p53\u5931\u6d3b\u65f6\u5c31\u4f1a\u53d1\u751f\u8fd9\u79cd\u60c5\u51b5\u3002\u4e3b\u6d41\u7406\u8bba\u8ba4\u4e3a\uff0c\u968f\u7740\u80bf\u7624\u7ec6\u80de\u7fa4\u4f53\u7684\u6269\u5f20\uff0c\u5355\u4e2a\u7ec6\u80de\u4f1a\u968f\u673a\u53d1\u751f\u7a81\u53d8\uff0c\u5176\u5206\u5b50\u8eab\u4efd\u5f00\u59cb\u53d1\u751f\u5206\u5316\u3002\u5230\u764c\u75c7\u88ab\u68c0\u6d4b\u51fa\u6765\u65f6\uff0c\u6784\u6210\u80bf\u7624\u7684\u6570\u767e\u4e07\u4e2a\u7ec6\u80de\u5f7c\u6b64\u4e4b\u95f4\u7684\u5dee\u5f02\u5df2\u7ecf\u975e\u5e38\u5927\u4e86\u3002.\n<\/p>\n

\n\u957f\u671f\u4ee5\u6765\uff0c\u4e00\u76f4\u6709\u4e00\u79cd\u89c2\u70b9\u8ba4\u4e3a\uff0c\u5728\u80bf\u7624\u7684\u53d1\u751f\u548c\u53d1\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u5b8c\u5168\u5206\u5316\u548c\u7279\u5316\u7684\u7ec6\u80de\u53ef\u80fd\u4f1a\u53d1\u751f\u53bb\u5206\u5316\uff0c\u5c3d\u7ba1\u5176\u5b9e\u73b0\u65b9\u5f0f\u5c1a\u4e0d\u6e05\u695a\u3002\u6700\u7ec8\uff0c\u8be5\u7406\u8bba\u88ab\u73b0\u4eca\u6d41\u884c\u7684\u764c\u75c7\u5e72\u7ec6\u80de\u7406\u8bba\u6240\u53d6\u4ee3\u3002\u764c\u75c7\u5e72\u7ec6\u80de\u7406\u8bba\u8ba4\u4e3a\uff0c\u764c\u75c7\u5e72\u7ec6\u80de\u2014\u2014\u5373\u80fd\u591f\u589e\u6b96\u80bf\u7624\u5e76\u53ef\u80fd\u6765\u6e90\u4e8e\u6b63\u5e38\u5e72\u7ec6\u80de\u6216\u65e9\u671f\u7956\u7ec6\u80de\u7684\u7ec6\u80de\u2014\u2014\u4e0e\u5927\u90e8\u5206\u764c\u7ec6\u80de\u4e0d\u540c\uff0c\u5b83\u4eec\u80fd\u591f\u81ea\u6211\u66f4\u65b0\u5e76\u4ea7\u751f\u975e\u5e72\u7ec6\u80de\uff0c\u5c31\u50cf\u6b63\u5e38\u7684\u5e72\u7ec6\u80de\u4e00\u6837\u3002.\n<\/p>\n

\n\u201c\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u7c7b\u4f3c\u4e8e\u5e72\u7ec6\u80de\u7684\u764c\u7ec6\u80de\u4e0d\u5fc5\u662f\u539f\u59cb\u80bf\u7624\u7684\u4e00\u90e8\u5206\uff0c\u800c\u53ef\u80fd\u5728\u80bf\u7624\u53d1\u5c55\u7684\u540e\u671f\u9636\u6bb5\u51fa\u73b0\uff0cp53 \u7684\u4e22\u5931\u4fc3\u8fdb\u4e86\u8fd9\u4e00\u70b9\uff0c\u201d\u535a\u58eb\u540e\u7814\u7a76\u5458\u3001\u5171\u540c\u7b2c\u4e00\u4f5c\u8005 Benjamin T. Spike \u535a\u58eb\u8bf4\u3002\u201c\u89c2\u5bdf\u5230\u7684\u80bf\u7624\u5f02\u8d28\u6027\u53ef\u80fd\u662f\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u6027\u589e\u957f\u7684\u7ec4\u5408 \u548c<\/em> \u4e0e\u83b7\u5f97\u5e72\u7ec6\u80de\u6837\u8868\u578b\u76f8\u5173\u7684\u8868\u89c2\u9057\u4f20\u4e0d\u7a33\u5b9a\u6027\u3002\u201d\n<\/p>\n

\nWahl \u548c\u4ed6\u7684\u56e2\u961f\u5728\u4e0e\u7d22\u5c14\u514b\u7814\u7a76\u6240\u57fa\u56e0\u8868\u8fbe\u5b9e\u9a8c\u5ba4\u7684\u6559\u6388 Juan-Carlos Izpis\u00faa Belmonte \u535a\u58eb\u7684\u4e00\u6b21\u5408\u4f5c\u7814\u7a76\u4e2d\uff0c\u9996\u6b21\u8003\u8651\u4e86 p53 \u9664\u4e86\u4f5c\u4e3a\u201c\u57fa\u56e0\u7ec4\u5b88\u62a4\u8005\u201d\u4e4b\u5916\u662f\u5426\u8fd8\u6709\u5176\u4ed6\u529f\u80fd\uff0c\u8be5\u7814\u7a76\u63ed\u793a\u4e86\u8fd9\u79cd\u80bf\u7624\u6291\u5236\u56e0\u5b50\u4e5f\u5bf9\u4f53\u7ec6\u80de\u91cd\u7f16\u7a0b\u6784\u6210\u969c\u788d\u3002.\n<\/p>\n

\n\u4e3a\u4e86\u786e\u5b9ap53\u5931\u6d3b\u662f\u5426\u5141\u8bb8\u7c7b\u4f3c\u5e72\u7ec6\u80de\u7684\u80bf\u7624\u7ec6\u80de\u7684\u51fa\u73b0\uff0cSpike\u548cMizuno\u4ed4\u7ec6\u68c0\u67e5\u4e86\u6570\u767e\u4efd\u5bab\u9888\u548c\u80ba\u90e8\u80bf\u7624\u7684\u6863\u6848\u57fa\u56e0\u8868\u8fbe\u8c31\uff0c\u5bfb\u627e\u7c7b\u4f3c\u5e72\u7ec6\u80de\u7684\u7279\u5f81\uff0c\u5e76\u5c06\u5b83\u4eec\u4e0e\u5176p53\u72b6\u6001\u76f8\u5173\u8054\u3002.\n<\/p>\n

\n\u201c\u6211\u4eec\u53d1\u73b0\uff0c\u7ecf\u8fc7\u786e\u8ba4\u7684 p53 \u7a81\u53d8\u6216\u660e\u663e\u7684 p53 \u5931\u6d3b\u7684\u80bf\u7624\uff0c\u4e0e\u5178\u578b\u7684\u5e72\u7ec6\u80de\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u4e4b\u95f4\u5b58\u5728\u5bc6\u5207\u7684\u76f8\u5173\u6027\uff0c\u201dSpike \u89e3\u91ca\u9053\u3002\u201c\u8fd9\u5c06\u5f71\u54cd\u6211\u4eec\u5bf9 p53 \u7684\u770b\u6cd5\uff0c\u56e0\u4e3a\u5b83\u7684\u7f3a\u5931\u4f3c\u4e4e\u5e26\u6765\u4e86\u6bd4\u6d88\u9664\u80bf\u7624\u53d1\u751f\u8fc7\u7a0b\u4e2d\u76f4\u63a5\u7684\u7ec6\u80de\u6b7b\u4ea1\u548c\u589e\u6b96\u969c\u788d\u66f4\u6df1\u8fdc\u7684\u5f71\u54cd\u3002\u201d\n<\/p>\n

\n\u6c83\u5c13\u5e0c\u671b\u901a\u8fc7\u66f4\u6df1\u5165\u5730\u4e86\u89e3\u764c\u7ec6\u80de\u8f6c\u53d8\u4e3a\u66f4\u5177\u5e72\u7ec6\u80de\u6837\u72b6\u6001\u7684\u8fc7\u7a0b\uff0c\u80fd\u591f\u53d1\u73b0\u65b0\u7684\u6cbb\u7597\u5e72\u9884\u9776\u70b9\u3002\u201c\u66f4\u5177\u5e72\u7ec6\u80de\u6837\u7684\u80bf\u7624\u4f3c\u4e4e\u66f4\u5177\u4fb5\u88ad\u6027\uff0c\u4f46\u5b83\u4eec\u53ef\u80fd\u4ecd\u6709\u5206\u5316\u6210\u4fb5\u88ad\u6027\u8f83\u4f4e\u7684\u7ec6\u80de\u7c7b\u578b\u7684\u6b8b\u4f59\u80fd\u529b\uff0c\u201d\u4ed6\u8bf4\u3002\u201c\u5982\u679c\u6211\u4eec\u80fd\u591f\u5229\u7528\u8fd9\u79cd\u6f5c\u529b\uff0c\u6216\u8bb8\u5c31\u80fd\u8feb\u4f7f\u8fd9\u4e9b\u7ec6\u80de\u5206\u5316\uff0c\u53d8\u5f97\u4e0d\u90a3\u4e48\u5371\u9669\uff0c\u8fd9\u662f\u4e00\u4e2a\u9700\u8981\u6211\u4eec\u8ba4\u771f\u91cd\u65b0\u8003\u8651\u7684\u65e7\u89c2\u5ff5\u3002\u201d\n<\/p>\n

\n\u8fd9\u79cd\u7d27\u5bc6\u7684\u5408\u4f5c\u5173\u7cfb\u4f53\u73b0\u5728\u5171\u540c\u7f72\u540d\u7684\u7b2c\u4e00\u4f5c\u8005\uff0c\u5373Spike\u548cMizuno\u3002Mizuno\u73b0\u5c31\u804c\u4e8e\u65e5\u672c\u9570\u4ed3\u7684Chugai Pharmaceutical Co. Ltd.\u516c\u53f8\u3002.\n<\/p>\n

\n\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u5de5\u4f5c\u83b7\u5f97\u4e86\u4e73\u817a\u764c\u7814\u7a76\u57fa\u91d1\u4f1a\u3001G. Harold and Leila Y. Mathers Charitable Foundation\u3001\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u4ee5\u53ca Ruth L. Kirschstein \u56fd\u5bb6\u79d1\u7814\u670d\u52a1\u5956\u7684\u8d44\u52a9\u3002. <\/p>\n


\n\u5173\u4e8e\u8428\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240<\/strong>
\n\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u662f\u4e16\u754c\u9876\u5c16\u7684\u57fa\u7840\u7814\u7a76\u673a\u6784\u4e4b\u4e00\uff0c\u5176\u56fd\u9645\u77e5\u540d\u7684\u6559\u804c\u4eba\u5458\u5728\u4e00\u4e2a\u72ec\u7279\u3001\u534f\u4f5c\u548c\u5bcc\u6709\u521b\u9020\u6027\u7684\u73af\u5883\u4e2d\uff0c\u6df1\u5165\u63a2\u7a76\u751f\u547d\u79d1\u5b66\u7684\u57fa\u672c\u95ee\u9898\u3002\u7d22\u5c14\u514b\u79d1\u5b66\u5bb6\u4eec\u81f4\u529b\u4e8e\u53d1\u73b0\u548c\u6307\u5bfc\u672a\u6765\u51e0\u4ee3\u7814\u7a76\u4eba\u5458\uff0c\u901a\u8fc7\u7814\u7a76\u795e\u7ecf\u79d1\u5b66\u3001\u9057\u4f20\u5b66\u3001\u7ec6\u80de\u548c\u690d\u7269\u751f\u7269\u5b66\u4ee5\u53ca\u76f8\u5173\u5b66\u79d1\uff0c\u5728\u764c\u75c7\u3001\u8870\u8001\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c7\u3001\u7cd6\u5c3f\u75c5\u548c\u4f20\u67d3\u75c5\u7684\u8ba4\u8bc6\u65b9\u9762\u505a\u51fa\u4e86\u5f00\u521b\u6027\u7684\u8d21\u732e\u3002.<\/p>\n

\n\u5b66\u9662\u53d6\u5f97\u4e86\u8bb8\u591a\u6210\u5c31\uff0c\u83b7\u5f97\u4e86\u5305\u62ec\u8bfa\u8d1d\u5c14\u5956\u548c\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\u5728\u5185\u7684\u65e0\u6570\u8363\u8a89\u3002\u8be5\u7814\u7a76\u6240\u7531\u810a\u9ad3\u7070\u8d28\u708e\u75ab\u82d7\u5148\u9a71 Jonas Salk \u535a\u58eb\u4e8e 1960 \u5e74\u521b\u7acb\uff0c\u662f\u4e00\u5bb6\u72ec\u7acb\u7684\u975e\u8425\u5229\u7ec4\u7ec7\u548c\u5efa\u7b51\u5730\u6807\u3002.\n<\/p>\n

\u7d22\u5c14\u514b\u7814\u7a76\u6240\u4e3a\u57fa\u7840\u7814\u7a76\u9886\u57df\u7684\u5353\u8d8a\u79d1\u5b66\u6210\u5c31\u800c\u81ea\u8c6a\u5730\u5e86\u795d\u4e86\u4e94\u5341\u5468\u5e74\u3002.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[90],"disease-research":[],"class_list":["post-2064","disclosure","type-disclosure","status-publish","hentry","faculty-geoffrey-wahl"],"acf":[],"yoast_head":"\nThe stemness of cancer cells - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/the-stemness-of-cancer-cells\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The stemness of cancer cells - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA, CA\u2014A close collaboration between researchers at the Salk Institute for Biological Studies and the Institute for Advanced Study found that the tumor suppressor p53, long thought of as the “Guardian of the Genome,” may do more than thwart cancer-causing mutations. It may also prevent established cancer cells from sliding toward a more aggressive, stem-like state by serving as a “Guardian against Genome Reprogramming.”\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/zh\/news-release\/the-stemness-of-cancer-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/the-stemness-of-cancer-cells\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/the-stemness-of-cancer-cells\\\/\",\"name\":\"The stemness of cancer cells - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/the-stemness-of-cancer-cells\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/the-stemness-of-cancer-cells\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/455_wahl.jpg\",\"datePublished\":\"2010-12-13T08:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/the-stemness-of-cancer-cells\\\/#breadcrumb\"},\"inLanguage\":\"zh-CN\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/the-stemness-of-cancer-cells\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-CN\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/the-stemness-of-cancer-cells\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/455_wahl.jpg\",\"contentUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2015\\\/03\\\/455_wahl.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/the-stemness-of-cancer-cells\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The stemness of cancer cells\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-CN\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-CN\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The stemness of cancer cells - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/zh\/news-release\/the-stemness-of-cancer-cells\/","og_locale":"zh_CN","og_type":"article","og_title":"The stemness of cancer cells - Salk Institute for Biological Studies","og_description":"LA JOLLA, CA\u2014A close collaboration between researchers at the Salk Institute for Biological Studies and the Institute for Advanced Study found that the tumor suppressor p53, long thought of as the “Guardian of the Genome,” may do more than thwart cancer-causing mutations. It may also prevent established cancer cells from sliding toward a more aggressive, stem-like state by serving as a “Guardian against Genome Reprogramming.”","og_url":"https:\/\/www.salk.edu\/zh\/news-release\/the-stemness-of-cancer-cells\/","og_site_name":"Salk Institute for Biological Studies","og_image":[{"width":628,"height":329,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/the-stemness-of-cancer-cells\/","url":"https:\/\/www.salk.edu\/news-release\/the-stemness-of-cancer-cells\/","name":"The stemness of cancer cells - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/the-stemness-of-cancer-cells\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/the-stemness-of-cancer-cells\/#primaryimage"},"thumbnailUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/455_wahl.jpg","datePublished":"2010-12-13T08:00:00+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/the-stemness-of-cancer-cells\/#breadcrumb"},"inLanguage":"zh-CN","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/the-stemness-of-cancer-cells\/"]}]},{"@type":"ImageObject","inLanguage":"zh-CN","@id":"https:\/\/www.salk.edu\/news-release\/the-stemness-of-cancer-cells\/#primaryimage","url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/455_wahl.jpg","contentUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/455_wahl.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/the-stemness-of-cancer-cells\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"The stemness of cancer cells"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240","description":"\u79d1\u5b66\u7684\u529b\u91cf","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-CN"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"zh-CN","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"paper_url":"","journal_title":"","paper_author_list":"","paper_title":"","subhead":"","home_photo":"455_WahlSpikeHeadshot.jpg","listing_photo":"","line_2":"","line_1":"The stemness of cancer cells"},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/2064","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":0,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/2064\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/media?parent=2064"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/faculty?post=2064"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disease-research?post=2064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}