{"id":2050,"date":"2010-10-03T00:00:00","date_gmt":"2010-10-03T07:00:00","guid":{"rendered":"https:\/\/vermont.salk.edu\/news-release\/ticking-of-a-cellular-clock-promotes-seismic-changes-in-the-chromatin-landscape-associated-with-aging\/"},"modified":"2010-10-03T00:00:00","modified_gmt":"2010-10-03T07:00:00","slug":"ticking-of-a-cellular-clock-promotes-seismic-changes-in-the-chromatin-landscape-associated-with-aging","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/ticking-of-a-cellular-clock-promotes-seismic-changes-in-the-chromatin-landscape-associated-with-aging\/","title":{"rendered":"\u7ec6\u80de\u65f6\u949f\u7684\u6ef4\u7b54\u58f0\u4fc3\u8fdb\u4e86\u4e0e\u8870\u8001\u76f8\u5173\u7684\u67d3\u8272\u8d28\u666f\u89c2\u7684\u5267\u70c8\u53d8\u5316"},"content":{"rendered":"

\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u62c9\u970d\u4e9a\u2014\u2014\u5c31\u50cf\u732b\u4e00\u6837\uff0c\u4eba\u7c7b\u7ec6\u80de\u4e5f\u6709\u6709\u9650\u7684\u751f\u547d\u2014\u2014\u4e00\u65e6\u5b83\u4eec\u5206\u88c2\u4e00\u5b9a\u7684\u6b21\u6570\uff08\u5e78\u8fd0\u7684\u662f\uff0c\u8d85\u8fc7\u4e5d\u6b21\uff09\uff0c\u5b83\u4eec\u5c31\u4f1a\u6539\u53d8\u5f62\u72b6\uff0c\u51cf\u7f13\u901f\u5ea6\uff0c\u6700\u7ec8\u505c\u6b62\u5206\u88c2\uff0c\u8fd9\u79cd\u73b0\u8c61\u88ab\u79f0\u4e3a\u201c\u7ec6\u80de\u8870\u8001\u201d\u3002.\n<\/p>\n

\n\u751f\u7269\u5b66\u5bb6\u77e5\u9053\uff0c\u7531\u67d3\u8272\u4f53\u672b\u7aef\u79f0\u4e3a\u7aef\u7c92\u7684\u7ed3\u6784\u7ec4\u6210\u7684\u7ec6\u80de\u65f6\u949f\u8bb0\u5f55\u4e86\u7ec6\u80de\u6d88\u8017\u4e86\u591a\u5c11\u201c\u751f\u547d\u201d\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u7814\u7a76\u4eba\u5458\u5c1a\u672a\u660e\u786e\u65f6\u949f\u7684\u6ef4\u7b54\u58f0\u5982\u4f55\u9884\u793a\u7740\u7ec6\u80de\u8870\u4ea1\u7684\u4e34\u8fd1\u3002.\n<\/p>\n

\"telomeres\"<\/p>\n

\u7ec6\u80de\u6bcf\u6b21\u5206\u88c2\u65f6\uff0c\u67d3\u8272\u4f53\u672b\u7aef\u7684\u4fdd\u62a4\u6027\u201c\u5e3d\u201d\uff08\u7ea2\u70b9\u548c\u7eff\u70b9\uff09\u90fd\u4f1a\u78e8\u635f\u5f97\u66f4\u5389\u5bb3\u3002\u968f\u7740\u7aef\u7c92\u78e8\u635f\uff0c\u5b83\u4eec\u7684 DNA \u5728\u5305\u88c5\u65b9\u5f0f\u4e0a\u4f1a\u53d1\u751f\u5de8\u5927\u53d8\u5316\u3002\u8fd9\u4e9b\u53d8\u5316\u5f88\u53ef\u80fd\u89e6\u53d1\u6211\u4eec\u6240\u8bf4\u7684\u201c\u8870\u8001\u201d\u3002.<\/p>\n

\n\u56fe\u7247\uff1a\u7531\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240Jan Karlseder\u535a\u58eb\u63d0\u4f9b\n<\/p>\n<\/div>\n

\n\u53d1\u8868\u4e8e2010\u5e7410\u67083\u65e5\u300a \u81ea\u7136\u7ed3\u6784\u4e0e\u5206\u5b50\u751f\u7269\u5b66<\/em>, \u4e00\u4e2a\u7531\u2026\u9886\u5bfc\u7684\u56e2\u961f \u626c\u00b7\u5361\u5c14\u585e\u5fb7<\/a>, \u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\u7684\u751f\u7269\u5b66\u535a\u58eb\u62a5\u544a\u8bf4\uff0c\u968f\u7740\u7ec6\u80de\u8870\u8001\u548c\u7aef\u7c92\u78e8\u635f\uff0c\u5b83\u4eec\u7684 DNA \u5728\u5305\u88c5\u65b9\u5f0f\u4e0a\u4f1a\u53d1\u751f\u5de8\u5927\u53d8\u5316\u3002\u8fd9\u4e9b\u53d8\u5316\u5f88\u53ef\u80fd\u4f1a\u5f15\u53d1\u6211\u4eec\u6240\u8bf4\u7684\u201c\u8870\u8001\u201d\u3002.\n<\/p>\n

\n\u201c\u5728\u6b64\u9879\u7814\u7a76\u4e4b\u524d\uff0c\u6211\u4eec\u77e5\u9053\u7aef\u7c92\u968f\u7740\u7ec6\u80de\u5206\u88c2\u800c\u8d8a\u6765\u8d8a\u77ed\uff0c\u5f53\u5b83\u4eec\u8fbe\u5230\u4e34\u754c\u957f\u5ea6\u65f6\uff0c\u7ec6\u80de\u5c31\u4f1a\u505c\u6b62\u5206\u88c2\u6216\u6b7b\u4ea1\uff0c\u201d\u5206\u5b50\u4e0e\u7ec6\u80de\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4\u526f\u6559\u6388 Karlseder \u8bf4\u3002\u201c\u4e00\u5b9a\u6709\u4ec0\u4e48\u4e1c\u897f\u80fd\u5c06\u67d3\u8272\u4f53\u672b\u7aef\u7684\u5c40\u90e8\u4fe1\u53f7\u8f6c\u5316\u4e3a\u6574\u4e2a\u7ec6\u80de\u6838\u90fd\u80fd\u611f\u53d7\u5230\u7684\u5de8\u5927\u4fe1\u53f7\u3002\u4f46\u5728\u8fd9\u4e24\u8005\u4e4b\u95f4\u5b58\u5728\u4e00\u4e2a\u5de8\u5927\u7684\u9e3f\u6c9f\u3002\u201d\n<\/p>\n

\nKarlseder\u548c\u535a\u58eb\u540eRoddy O\u2019Sullivan\u535a\u58eb\u901a\u8fc7\u6bd4\u8f83\u5e74\u8f7b\u7ec6\u80de\uff08\u5206\u88c230\u6b21\u7684\u7ec6\u80de\uff09\u548c\u201c\u4e2d\u665a\u5e74\u201d\u7ec6\u80de\uff08\u5206\u88c275\u6b21\u5e76\u6ed1\u5411\u8870\u8001\uff0c\u8870\u8001\u53d1\u751f\u572885\u6b21\u5206\u88c2\u65f6\uff09\u4e2d\u79f0\u4e3a\u7ec4\u86cb\u767d\u7684\u86cb\u767d\u8d28\u6c34\u5e73\uff0c\u5f00\u59cb\u7f29\u5c0f\u8fd9\u4e00\u5dee\u8ddd\u3002\u7ec4\u86cb\u767d\u7ed3\u5408\u7ebf\u6027DNA\u94fe\uff0c\u5e76\u5c06\u5176\u538b\u7f29\u6210\u6838\u590d\u5408\u7269\uff0c\u7edf\u79f0\u4e3a\u67d3\u8272\u8d28\u3002.\n<\/p>\n

\nKarlseder \u548c O\u2019Sullivan \u53d1\u73b0\uff0c\u8870\u8001\u7ec6\u80de\u4ea7\u751f\u7684\u7ec4\u86cb\u767d\u6bd4\u5e74\u8f7b\u7ec6\u80de\u5c11\u3002\u201c\u6211\u4eec\u60ca\u8bb6\u5730\u53d1\u73b0\uff0c\u7ec4\u86cb\u767d\u6c34\u5e73\u4f1a\u968f\u7740\u7ec6\u80de\u7684\u8870\u8001\u800c\u4e0b\u964d\uff0c\u201d\u8be5\u7814\u7a76\u7684\u9996\u5e2d\u4f5c\u8005 O\u2019Sullivan \u8868\u793a\u3002\u201c\u8fd9\u4e9b\u86cb\u767d\u8d28\u5728\u6574\u4e2a\u57fa\u56e0\u7ec4\u4e2d\u90fd\u662f\u5fc5\u9700\u7684\uff0c\u56e0\u6b64 \u4efb\u4f55<\/em> \u201d\u8be5\u751f\u4ea7\u7ebf\u53d1\u751f\u7684\u4efb\u4f55\u6270\u52a8\u90fd\u4f1a\u5f71\u54cd\u6574\u4e2a\u57fa\u56e0\u7ec4\u7684\u7a33\u5b9a\u6027\u3002\u201d\n<\/p>\n

\n\u7136\u540e\uff0c\u8be5\u56e2\u961f\u5bf9\u5e74\u8f7b\u7ec6\u80de\u548c\u8870\u8001\u7ec6\u80de\u4e2d\u7684\u7ec4\u86cb\u767d\u8fdb\u884c\u4e86\u8be6\u5c3d\u7684\u201c\u5ef6\u65f6\u201d\u6bd4\u8f83\uff0c\u8bc1\u5b9e\u4e86\u5728\u7ec6\u80de\u5206\u88c2\u8fc7\u7a0b\u4e2d\uff0c\u7ec4\u86cb\u767d\u7684\u4e30\u5ea6\u548c\u591a\u6837\u6027\u5728\u6bcf\u4e00\u6b65\u90fd\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002.\n<\/p>\n

\n\u5965\u6c99\u5229\u6587\u79f0\u5e74\u8f7b\u7ec6\u80de\u8868\u73b0\u51fa\u7684\u201c\u9ed8\u8ba4\u201d\u7ec4\u86cb\u767d\u6a21\u5f0f\u4e3a\u201c\u5feb\u4e50\u3001\u5065\u5eb7\u7684\u67d3\u8272\u8d28\u201d\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u4ed6\u8bf4\uff0c\u8870\u8001\u7ec6\u80de\u5728\u51c6\u5907\u7ec6\u80de\u5206\u88c2\u590d\u5236\u67d3\u8272\u4f53\u65f6\u4f3c\u4e4e\u4f1a\u7ecf\u5386\u538b\u529b\uff0c\u5e76\u4e14\u5728\u5206\u88c2\u5b8c\u6210\u540e\u96be\u4ee5\u6062\u590d\u201c\u5065\u5eb7\u7684\u201d\u67d3\u8272\u8d28\u6a21\u5f0f\u3002.\n<\/p>\n

\n\u4ece\u4eba\u7c7b\u53d7\u8bd5\u8005\uff08\u4e00\u540d9\u5c81\u4e0e\u4e00\u540d92\u5c81\uff09\u4f53\u5185\u63d0\u53d6\u7ec6\u80de\uff0c\u5bf9\u5176\u7ec4\u86cb\u767d\u6a21\u5f0f\u8fdb\u884c\u6bd4\u8f83\uff0c\u5176\u7ed3\u679c\u4e0e\u7ec6\u80de\u7cfb\u4e2d\u89c2\u5bdf\u5230\u7684\u7ec4\u86cb\u767d\u8d8b\u52bf\u60ca\u4eba\u5730\u76f8\u4f3c\u3002\u201c\u8fd9\u4e9b\u5173\u952e\u5b9e\u9a8c\u8868\u660e\uff0c\u6211\u4eec\u5728\u5b9e\u9a8c\u5ba4\u57f9\u517b\u7684\u7ec6\u80de\u4e2d\u6240\u89c2\u5bdf\u5230\u7684\u73b0\u8c61\u5b9e\u9645\u4e0a\u662f\u4f1a\u53d1\u751f\u7684\uff0c\u5e76\u4e14\u4e0e\u4eba\u7fa4\u7684\u8870\u8001\u6709\u5173\uff0c\u201d Karlseder\u8bf4\u9053\u3002.\n<\/p>\n

\n\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\uff0c\u5982\u764c\u75c7\u7684\u53d1\u751f\uff0c\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u5f52\u56e0\u4e8e DNA \u6216\u9057\u4f20\u635f\u4f24\u3002\u4f46\u8fd9\u9879\u7814\u7a76\u8868\u660e\uff0c\u8870\u8001\u672c\u8eab\u662f\u65e0\u9650\u590d\u6742\u7684\uff1a\u7aef\u7c92\u9010\u6e10\u7f29\u77ed\u4f1a\u901a\u8fc7\u6539\u53d8\u57fa\u56e0\u4e0e\u7ec4\u86cb\u767d\u7f20\u7ed5\u7684\u65b9\u5f0f\u6765\u52a0\u901f\u67d3\u8272\u4f53\u8870\u8001\uff0c\u8fd9\u5c31\u662f\u6240\u8c13\u7684\u201c\u8868\u89c2\u9057\u4f20\u201d\u53d8\u5316\u3002DNA \u4e0e\u7ec4\u86cb\u767d\u7684\u76f8\u4e92\u4f5c\u7528\u5bf9\u57fa\u56e0\u662f\u5426\u8868\u8fbe\u6709\u7740\u5de8\u5927\u7684\u5f71\u54cd\u2014\u2014\u56e0\u6b64\uff0c\u8868\u89c2\u57fa\u56e0\u7ec4\u666f\u89c2\u4e0e\u75be\u75c5\u72b6\u6001\u7684\u5173\u7cfb\u76ee\u524d\u5907\u53d7\u5173\u6ce8\u3002.\n<\/p>\n

\n\u5728\u5176\u4e2d\u4e00\u4e2a\u56e2\u961f\u5bf9\u5916\u8c8c\u8fdb\u884c\u8001\u5316\u7ec6\u80de\u4fee\u590d\u7684\u6551\u63f4\u5b9e\u9a8c\u4e2d\uff0c\u8bc1\u5b9e\u4e86\u7aef\u7c92\u7f29\u77ed\u53d1\u51fa\u7684\u4fe1\u53f7\u4f1a\u9a71\u52a8\u8868\u89c2\u9057\u4f20\u5b66\u6539\u53d8\u3002\u5f53\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u8001\u5316\u7ec6\u80de\u4ee5\u8868\u8fbe\u7aef\u7c92\u9176\uff08\u4e00\u79cd\u4fee\u590d\u548c\u5ef6\u957f\u77ed\u5c0f\u7aef\u7c92\u7684\u9176\uff09\u65f6\uff0c\u8fd9\u4e9b\u590d\u539f\u7684\u7ec6\u80de\u663e\u793a\u51fa\u8ba9\u4eba\u60f3\u8d77\u201c\u5feb\u4e50\u3001\u5065\u5eb7\u7684\u67d3\u8272\u8d28\u201d\u7684\u7ec4\u86cb\u767d\u6c34\u5e73\uff0c\u4ee5\u53ca\u90e8\u5206\u6062\u590d\u5230\u5e74\u8f7b\u7684\u67d3\u8272\u8d28\u7279\u5f81\u3002.\n<\/p>\n

\n\u5c0f\u5fc3\uff0c\u4ee5\u514d\u4f60\u7684\u79ef\u84c4\u6253\u6c34\u6f02\uff0c\u6295\u5165\u5230\u90a3\u4e9b\u5ef6\u957f\u7aef\u7c92\u7684\u65b9\u6848\u4e2d\u3002\u5361\u5c14\u585e\u5fb7\u8bf4\uff1a\u201c\u5ef6\u957f\u7aef\u7c92\u7684\u53e6\u4e00\u9762\u662f\uff0c\u5b83\u80fd\u4f7f\u7ec6\u80de\u5728\u66f4\u957f\u7684\u65f6\u95f4\u5185\u751f\u957f\uff0c\u5e76\u53ef\u80fd\u4ea7\u751f\u6240\u8c13\u7684\u201c\u6c38\u751f\u2019\u7ec6\u80de\u3002\u201d\u201d\u8fd9\u4f1a\u8ba9\u4f60\u79bb\u764c\u7ec6\u80de\u7684\u53d1\u5c55\u66f4\u8fd1\u4e00\u6b65\u3002\u201c\n<\/p>\n

\n\u5230\u76ee\u524d\u4e3a\u6b62\uff0cKarlseder\u5b9e\u9a8c\u5ba4\u4e3b\u8981\u5173\u6ce8\u7aef\u7c92\u548cDNA\u4fee\u590d\u673a\u5236\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u8fd9\u7bc7\u8bba\u6587\u73b0\u5728\u5c06\u4ed6\u4eec\u5f15\u5165\u4e86\u8868\u89c2\u9057\u4f20\u5b66\u9886\u57df\u3002\u201c\u6211\u4eec\u5c06\u7ee7\u7eed\u7814\u7a76\u4e0d\u540c\u5e74\u9f84\u6bb5\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u53d8\u5316\uff0c\u201dKarlseder\u8bf4\u3002\u201c\u6211\u4eec\u73b0\u5728\u60f3\u786e\u5b9a\u7ec4\u86cb\u767d\u7684\u53d8\u5316\u662f\u5426\u9075\u5faa\u4e00\u4e2a\u7ebf\u6027\u8fc7\u7a0b\uff0c\u6216\u8005\u5b83\u4eec\u662f\u5426\u5728\u6211\u4eec\u8870\u8001\u65f6\u5f00\u59cb\u51fa\u73b0\u3002\u201d\n<\/p>\n

\n\u53c2\u4e0e\u8fd9\u9879\u5de5\u4f5c\u7684\u8fd8\u6709\u54c8\u4f5b-\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u5e03\u7f57\u5fb7\u7814\u7a76\u6240\u548c\u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u7684\u65af\u56fe\u5c14\u7279\u00b7\u65bd\u8d56\u4f2f\u535a\u58eb\uff08Stuart Schreiber, Ph.D.\uff09\u4ee5\u53ca\u4ed6\u7684\u535a\u58eb\u540e\u7814\u7a76\u5458\u65af\u7279\u51e1\u00b7\u5e93\u6bd4\u5207\u514b\u535a\u58eb\uff08Stefan Kubicek, Ph.D.\uff09\u3002.\n<\/p>\n

\n\u8fd9\u9879\u7814\u7a76\u7531\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u3001\u4e54\u6cbb\u00b7E\u00b7\u4f11\u4f0a\u7279\u533b\u5b66\u7814\u7a76\u57fa\u91d1\u4f1a\u3001\u6069\u65af\u7279\u00b7\u8c22\u6797\u7814\u7a76\u57fa\u91d1\u4f1a\u548c\u6b27\u76df\u8d44\u52a9\u3002.\n<\/p>\n

\u5173\u4e8e\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\uff1a<\/strong>
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