\n
![\"Cord](\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/Belmontescience2_380.jpg\")
\n![\"Cord](\"https:\/\/www.salk.edu\/wp-content\/uploads\/2015\/03\/Belmontescience1_380.jpg\")
<\/p>\n
\u9876\u5c42\uff1a\u8fd9\u91cc\u7531 AFP \u548c FoxA2 \u6807\u8bb0\u8bc6\u522b\u51fa\u7684\u5185\u80da\u5c42\uff0c\u4f1a\u53d1\u80b2\u6210\u6d88\u5316\u9053\u3001\u80ba\u548c\u8180\u80f1\u3002.<\/p>\n
\u5e95\u90e8\uff1a\u4e2d\u80da\u5c42\uff0c\u5728\u6b64\u7531 ASM \u8bc6\u522b\uff0c\u5f62\u6210\u9aa8\u9abc\u3001\u808c\u8089\u3001\u7ed3\u7f14\u7ec4\u7ec7\u548c\u76ae\u80a4\u7684\u4e2d\u95f4\u5c42\u3002.<\/p>\n<\/div>\n
\u5168\u7403\u8303\u56f4\u5185\uff0c\u5df2\u7ecf\u50a8\u5b58\u4e86\u8d85\u8fc7 40 \u4e07\u4efd\u8110\u5e26\u8840\u5355\u4f4d\uff0c\u5e76\u9644\u5e26\u514d\u75ab\u5b66\u4fe1\u606f\u3002\u7531\u4e8e\u7ec6\u80de\u7684\u65e9\u671f\u6765\u6e90\uff0c\u8110\u5e26\u8840\u4e2d\u7684\u7ec6\u80de\u6240\u542b\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u6781\u5c11\uff0c\u5e76\u4e14\u5177\u6709\u65b0\u751f\u513f\u7ec6\u80de\u7684\u514d\u75ab\u4e0d\u6210\u719f\u6027\uff0c\u8fd9\u4f7f\u5f97 HLA \u4f9b\u8005-\u53d7\u8005\u914d\u578b\u4e0d\u4e00\u5b9a\u9700\u8981\u5b8c\u7f8e\u5339\u914d\uff0c\u540c\u65f6\u53c8\u4e0d\u4f1a\u6709\u53d1\u751f\u514d\u75ab\u6392\u65a5\u79fb\u690d\u7684\u98ce\u9669\u3002.<\/p>\n
\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\uff08HLA\uff09\u5206\u578b\u7528\u4e8e\u9aa8\u9ad3\u6216\u8110\u5e26\u8840\u79fb\u690d\u4e2d\u5339\u914d\u60a3\u8005\u548c\u6350\u8d60\u8005\u3002HLA\u662f\u4eba\u4f53\u5927\u591a\u6570\u7ec6\u80de\u4e0a\u53d1\u73b0\u7684\u7279\u6b8a\u8868\u9762\u6807\u5fd7\u7269\uff0c\u6709\u52a9\u4e8e\u514d\u75ab\u7cfb\u7edf\u533a\u5206\u201c\u81ea\u8eab\u201d\u548c\u201c\u975e\u81ea\u8eab\u201d\u3002Izpis\u00faa Belmonte\u8bf4\uff1a\u201c\u4ece\u5df2\u50a8\u5b58\u7684\u8110\u5e26\u8840\u5355\u4f4d\u4e2d\u9009\u62e9\u5e38\u89c1\u7684HLA\u5355\u500d\u4f53\u6765\u521b\u5efaiPS\u7ec6\u80de\uff0c\u5c06\u5927\u5927\u51cf\u5c11\u4e3a\u63d0\u4f9bHLA\u5339\u914d\u63d0\u4f9b\u6240\u9700\u7ec6\u80de\u7cfb\u7684\u6570\u76ee\uff0c\u4ece\u800c\u80fd\u8986\u76d6\u5927\u90e8\u5206\u4eba\u53e3\u3002\u201d.<\/p>\n
\u81ea\u4ece\u9996\u4e2a\u4f53\u7ec6\u80de\u88ab\u8f6c\u5316\u6210\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPS\u7ec6\u80de\uff09\u4ee5\u6765\uff0c\u5b83\u4eec\u4f5c\u4e3a\u4e00\u79cd\u4e0e\u80da\u80ce\u5e72\u7ec6\u80de\u65e0\u4e89\u8bae\u7684\u66ff\u4ee3\u54c1\uff0c\u4ee5\u53ca\u4f5c\u4e3a\u60a3\u8005\u7279\u5f02\u6027\u5e72\u7ec6\u80de\u7684\u6f5c\u5728\u6765\u6e90\uff0c\u4e00\u76f4\u5907\u53d7\u77a9\u76ee\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u5c06\u60a3\u8005\u7684\u7ec6\u80de\u201c\u8fd4\u8001\u8fd8\u7ae5\u201d\u4e0d\u4ec5\u6210\u672c\u9ad8\u6602\uff0c\u800c\u4e14\u5f53\u9700\u8981\u7acb\u523b\u7528\u8fd9\u4e9b\u7ec6\u80de\u6765\u4fee\u590d\u53d7\u4f24\u7684\u810a\u9ad3\u6216\u6cbb\u7597\u6025\u6027\u75be\u75c5\u65f6\uff0c\u8fc7\u7a0b\u53ef\u80fd\u5f88\u56f0\u96be\uff0c\u5f53\u8870\u8001\u6216\u6162\u6027\u75be\u75c5\u7684\u5f71\u54cd\u5bf9\u4f53\u7ec6\u80de\u5e93\u9020\u6210\u4e86\u4e0d\u53ef\u9006\u7684\u635f\u5bb3\u65f6\uff0c\u8fd9\u751a\u81f3\u662f\u5b8c\u5168\u4e0d\u53ef\u80fd\u7684\u3002.<\/p>\n
\u201c\u60a3\u8005\u7279\u5f02\u6027iPS\u7ec6\u80de\u7cfb\u5728\u7406\u8bba\u4e0a\u88ab\u8ba4\u4e3a\u662f\u518d\u751f\u7ec4\u7ec7\u7684\u7406\u60f3\u4e34\u5e8a\u9009\u62e9\uff0c\u4f46\u4ece\u5b9e\u9645\u548c\u6210\u672c\u6548\u76ca\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u8fd9\u79cd\u65b9\u6cd5\u53ef\u80fd\u5e76\u4e0d\u53ef\u884c\uff0c\u201dIzpis\u00faa Belmonte \u8868\u793a\u3002\u4ed6\u5e0c\u671b\u201c\u5927\u89c4\u6a21\u751f\u4ea7\u548c\u50a8\u5b58\u8110\u5e26\u8840\u6765\u6e90\u7684iPS\u7ec6\u80de\u7cfb\uff0c\u5e76\u5efa\u7acb\u4e00\u4e2a\u516c\u5171\u53ef\u7528\u7684\u7f51\u7edc\uff0c\u53ef\u80fd\u6210\u4e3a\u672a\u6765\u4e34\u5e8a\u5e94\u7528\u7684 viable \u66ff\u4ee3\u65b9\u6848\u3002\u201d<\/p>\n
\u8003\u8651\u5230\u8fd9\u4e00\u70b9\uff0cBelmonte \u548c\u4ed6\u7684\u540c\u4e8b\u4eec\u7740\u624b\u5c06\u4ece\u8110\u5e26\u8840\u4e2d\u5206\u79bb\u51fa\u7684\u9020\u8840\u5e72\u7ec6\u80de\u8f6c\u5316\u4e3a iPS \u7ec6\u80de\u3002\u4ed6\u4eec\u4e0d\u4ec5\u4ec5\u4f7f\u7528\u4e86\u56db\u79cd\u6700\u5e38\u7528\u7684\u56e0\u5b50\u4e2d\u7684\u4e24\u79cd\u2014\u2014OCT4 \u548c SOX2\u2014\u2014\u5c31\u6210\u529f\u5730\u5c06\u5b83\u4eec\u8f6c\u5316\u4e86\uff0c\u800c\u4e14\u6240\u9700\u65f6\u95f4\u6bd4\u4e4b\u524d\u53d1\u5e03\u7684\u4efb\u4f55\u5176\u4ed6\u65b9\u6cd5\u90fd\u8981\u77ed\u3002\u65e0\u8bba\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u7684\u662f\u65b0\u9c9c\u91c7\u96c6\u7684\u8110\u5e26\u8840\u8fd8\u662f\u5148\u524d\u51b7\u51bb\u7684\u6837\u672c\uff0c\u4ea7\u751f\u7684 iPS \u7ec6\u80de\u90fd\u4e0e\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u65e0\u5f02\u3002.<\/p>\n
\u201c\u7528\u4e8e\u91cd\u7f16\u7a0b\u7684\u8110\u5e26\u8840\u7ec6\u80de\u7fa4\u8868\u8fbe\u7684\u91cd\u7f16\u7a0b\/\u5e72\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u9ad8\u4e8e\u5176\u4ed6\u6210\u4f53\u4f53\u7ec6\u80de\uff0c\u8fd9\u53ef\u80fd\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u8110\u5e26\u8840\u7ec6\u80de\u53ef\u4ee5\u7528\u66f4\u5c11\u7684\u56e0\u5b50\u548c\u66f4\u5c11\u7684\u65f6\u95f4\u8fdb\u884c\u91cd\u7f16\u7a0b\uff0c\u201dIzpis\u00faa Belmonte \u8bf4\u3002\u201c\u8fd9\u51e0\u4e4e\u5c31\u50cf\u5b83\u4eec\u5df2\u7ecf\u8d70\u5230\u4e86\u4e00\u534a\u3002\u201d<\/p>\n
\u6b64\u5916\uff0c\u8110\u5e26\u8840\u6765\u6e90\u7684iPS\u7ec6\u80de\uff0c\u7b80\u79f0CBiPS\u7ec6\u80de\uff0c\u901a\u8fc7\u4e86\u6240\u6709\u6807\u51c6\u7684\u8bf1\u5bfc\u591a\u80fd\u6027\u6d4b\u8bd5\uff1a\u5b83\u4eec\u5f62\u6210\u4e86\u79f0\u4e3a\u7578\u80ce\u7624\u7684\u5e72\u7ec6\u80de\u80bf\u7624\uff0c\u5e76\u5206\u5316\u6210\u4e86\u4e09\u79cd\u80da\u80ce\u7ec4\u7ec7\u5c42\u7cfb\u7684\u884d\u751f\u7269\uff0c\u5305\u62ec\u6709\u89c4\u5f8b\u640f\u52a8\u7684 the cardiomyocytes \u548c\u4ea7\u751f\u591a\u5df4\u80fa\u7684 the neurons\u3002.<\/p>\n
Izpis\u00faa Belmonte\u7684\u4e0b\u4e00\u4e2a\u76ee\u6807\u662f\u5229\u7528\u5bf9\u4eba\u4f53\u4e34\u5e8a\u5e94\u7528\u88ab\u8ba4\u4e3a\u5b89\u5168\u7684\u65b9\u6cd5\uff0c\u8bf4\u670d\u8110\u5e26\u8840\u7ec6\u80de\u9006\u8f6c\u65f6\u95f4\u3002\u5236\u9020iPS\u7ec6\u80de\u7684\u539f\u59cb\u65b9\u6848\u2014\u2014\u5305\u62ecBelmonte\u53ca\u5176\u56e2\u961f\u4f7f\u7528\u7684\u65b9\u6848\u2014\u2014\u4f9d\u8d56\u4e8e\u5c06\u5916\u6765\u201c\u91cd\u7f16\u7a0b\u201d\u57fa\u56e0\u6574\u5408\u5230\u5bbf\u4e3b\u7ec6\u80de\u57fa\u56e0\u7ec4\u4e2d\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u4e0e\u7a81\u53d8\u548ciPS\u7ec6\u80de\u79fb\u690d\u540e\u60a3\u764c\u75c7\u7684\u98ce\u9669\u76f8\u5173\uff0c\u4ece\u800c\u9650\u5236\u4e86\u5b83\u4eec\u7684\u6cbb\u7597\u4ef7\u503c\u3002.<\/p>\n
\u4f46\u7814\u7a76\u4eba\u5458\u6b63\u52aa\u529b\u5f00\u53d1\u66ff\u4ee3\u65b9\u6cd5\uff0c\u8ba9\u4ed6\u4eec\u53ef\u4ee5\u5728\u4e0d\u7559\u4e0b\u4efb\u4f55\u9057\u4f20\u75d5\u8ff9\u7684\u60c5\u51b5\u4e0b\u91cd\u7f16\u7a0b\u7ec6\u80de\uff0c\u4f8b\u5982\u7b80\u5355\u5730\u5c06\u5206\u5316\u7ec6\u80de\u66b4\u9732\u5728\u5c0f\u5206\u5b50\u4e0b\u3002\u201c\u51e0\u9879\u7814\u7a76\u5df2\u7ecf\u8868\u660e\u8fd9\u53ef\u80fd\u662f\u53ef\u80fd\u7684\uff0c\u201dIzpis\u00faa Belmonte\u8bf4\u3002\u201c\u5982\u679c\u6211\u4eec\u80fd\u8bc1\u660e\u5b83\u4eec\u4e5f\u9002\u7528\u4e8e\u8110\u5e26\u8840\u7ec6\u80de\uff0c\u8fd9\u65e0\u7591\u662fiPS\u7ec6\u80de\u4e34\u5e8a\u5e94\u7528\u7684\u4e00\u5927\u8fdb\u6b65\u3002\u6211\u4eec\u81f3\u5c11\u5e94\u5728\u8fd1\u671f\u5c06\u91cd\u70b9\u653e\u5728\u8fd9\u79cd\u7279\u5b9a\u7684\u7ec6\u80de\u6765\u6e90\u2014\u2014CBiPS\u7ec6\u80de\u4e0a\u3002\u201d<\/p>\n
\u53c2\u4e0e\u672c\u9879\u5de5\u4f5c\u7684\u7814\u7a76\u4eba\u5458\u5305\u62ec\u6765\u81ea\u897f\u73ed\u7259\u5df4\u585e\u7f57\u90a3\u518d\u751f\u533b\u5b66\u4e2d\u5fc3\u7684 Alessandra Giorgeti\u3001Nuria Montserrat\u3001Trond Aasen\u3001Federico Gonzalez\u3001Ignacio Rodriguez-Piz\u00e0\u3001Rita Vassena\u3001Angel Raya\u3001St\u00e9phani\u00e9 Boue\u3001Maria Jose Barrero\u3001Bego\u00f1a Aran Corbella \u548c Anna Veiga\uff0c\u4ee5\u53ca\u6765\u81ea\u897f\u73ed\u7259\u5df4\u585e\u7f57\u90a3 Vall d\u2019Hebron \u6851\u683c\u4e0e\u7ec4\u7ec7\u94f6\u884c\u7684 Marta Torrabadella\u3002.<\/p>\n
\u672c\u7814\u7a76\u90e8\u5206\u5f97\u5230\u4e86\u6559\u80b2\u548c\u79d1\u5b66\u90e8\u3001\u536b\u751f\u7814\u7a76\u57fa\u91d1\u3001TERCEL\u3001Cellex\u57fa\u91d1\u4f1a\u4ee5\u53caG. Harold and Leila Y. Mathers\u6148\u5584\u57fa\u91d1\u4f1a\u7684\u652f\u6301\u3002.<\/p>\n
\u5173\u4e8e\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240\uff1a <\/strong>\u7d22\u5c14\u514b\u751f\u7269\u5b66\u7814\u7a76\u6240\u662f\u4e16\u754c\u9876\u5c16\u7684\u57fa\u7840\u7814\u7a76\u673a\u6784\u4e4b\u4e00\uff0c\u5176\u56fd\u9645\u77e5\u540d\u7684\u6559\u804c\u5458\u5de5\u5728\u4e00\u4e2a\u72ec\u7279\u7684\u3001\u534f\u4f5c\u548c\u5bcc\u6709\u521b\u9020\u6027\u7684\u73af\u5883\u4e2d\uff0c\u81f4\u529b\u4e8e\u63a2\u7d22\u751f\u547d\u79d1\u5b66\u7684\u57fa\u672c\u95ee\u9898\u3002\u7d22\u5c14\u514b\u79d1\u5b66\u5bb6\u4eec\u65e2\u4e13\u6ce8\u4e8e\u79d1\u5b66\u53d1\u73b0\uff0c\u4e5f\u81f4\u529b\u4e8e\u57f9\u517b\u4e0b\u4e00\u4ee3\u7814\u7a76\u4eba\u5458\uff0c\u901a\u8fc7\u7814\u7a76\u795e\u7ecf\u79d1\u5b66\u3001\u9057\u4f20\u5b66\u3001\u7ec6\u80de\u751f\u7269\u5b66\u548c\u690d\u7269\u751f\u7269\u5b66\u53ca\u76f8\u5173\u5b66\u79d1\uff0c\u4e3a\u6211\u4eec\u7406\u89e3\u764c\u75c7\u3001\u8870\u8001\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u7cd6\u5c3f\u75c5\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u505a\u51fa\u4e86\u5f00\u521b\u6027\u8d21\u732e\u3002.<\/p>\n\u5b66\u9662\u53d6\u5f97\u4e86\u8bb8\u591a\u6210\u5c31\uff0c\u83b7\u5f97\u4e86\u5305\u62ec\u8bfa\u8d1d\u5c14\u5956\u548c\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\u5728\u5185\u7684\u65e0\u6570\u8363\u8a89\u3002\u8be5\u7814\u7a76\u6240\u7531\u810a\u9ad3\u7070\u8d28\u708e\u75ab\u82d7\u5148\u9a71 Jonas Salk \u535a\u58eb\u4e8e 1960 \u5e74\u521b\u7acb\uff0c\u662f\u4e00\u5bb6\u72ec\u7acb\u7684\u975e\u8425\u5229\u7ec4\u7ec7\u548c\u5efa\u7b51\u5730\u6807\u3002.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[85],"disease-research":[],"class_list":["post-1997","disclosure","type-disclosure","status-publish","hentry","faculty-juan-carlos-izpisua-belmonte"],"acf":[],"yoast_head":"\n
Umbilical cord blood as a readily available source for off-the-shelf, patient-specific stem cells - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/umbilical-cord-blood-as-a-readily-available-source-for-off-the-shelf-patient-specific-stem-cells\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Umbilical cord blood as a readily available source for off-the-shelf, patient-specific stem cells - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA, CA\u2014Umbilical cord blood cells can successfully be reprogrammed to function like embryonic stem cells, setting the basis for the creation of a comprehensive bank of tissue-matched, cord blood-derived induced pluripotent stem (iPS) cells for off-the-shelf applications, report researchers at the Salk Institute for Biological Studies and the Center for Regenerative Medicine in Barcelona, Spain.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/zh\/news-release\/umbilical-cord-blood-as-a-readily-available-source-for-off-the-shelf-patient-specific-stem-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2018-09-19T22:13:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk-institute-preview-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"628\" \/>\n\t<meta property=\"og:image:height\" content=\"329\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/umbilical-cord-blood-as-a-readily-available-source-for-off-the-shelf-patient-specific-stem-cells\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/umbilical-cord-blood-as-a-readily-available-source-for-off-the-shelf-patient-specific-stem-cells\\\/\",\"name\":\"Umbilical cord blood as a readily available source for off-the-shelf, patient-specific stem cells - 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