{"id":19660,"date":"2018-09-13T15:08:27","date_gmt":"2018-09-13T22:08:27","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=19660"},"modified":"2024-01-30T15:08:00","modified_gmt":"2024-01-30T23:08:00","slug":"research-in-yeast-leads-to-serendipitous-finding-about-a-central-nervous-system-disorder","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/research-in-yeast-leads-to-serendipitous-finding-about-a-central-nervous-system-disorder\/","title":{"rendered":"\u9175\u6bcd\u7814\u7a76\u5e26\u6765\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u610f\u5916\u53d1\u73b0"},"content":{"rendered":"

\u52a0\u62c9\u4e54\u62c9\u2014\u2014\u7814\u7a76\u751f\u7269\u5b66\u7684\u57fa\u672c\u65b9\u9762\u6709\u65f6\u4f1a\u5e26\u6765\u4e0e\u4eba\u7c7b\u75be\u75c5\u76f4\u63a5\u76f8\u5173\u7684\u610f\u5916\u53d1\u73b0\u3002\u5728\u6700\u65b0\u7684\u79d1\u5b66\u5947\u9047\u4f8b\u5b50\u4e2d\uff0c\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u9762\u5305\u9175\u6bcd\u4e2d\u7684\u4e00\u4e2a\u91cd\u8981\u8d28\u91cf\u63a7\u5236\u673a\u5236\u4e0e\u513f\u7ae5\u7684\u4e00\u79cd\u4f7f\u4eba\u8870\u5f31\u7684\u75be\u75c5\u2014\u2014\u9ad3\u9798\u751f\u6210\u4f4e\u4e0b\u767d\u8d28\u8425\u517b\u4e0d\u826f\u75c7\u2014\u2014\u5bc6\u5207\u76f8\u5173\u3002.<\/p>\n

\"\"
\u9175\u6bcd\u7ec6\u80de\u901a\u8fc7\u51fa\u82bd\u8fdb\u884c\u5206\u88c2\u7684\u827a\u672f\u5bb6\u6e32\u67d3\u56fe\u3002.<\/p>\n

\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<\/p>\n

\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e749\u67087\u65e5\u53d1\u8868\u5728\u8be5\u6742\u5fd7\u4e0a eLife<\/a>, <\/em>\u53ef\u80fd\u4e3a\u8fd9\u79cd\u7f55\u89c1\u75c5\u3001\u591a\u53d1\u6027\u786c\u5316\u75c7\u4ee5\u53ca\u5176\u4ed6\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u6cd5\u63d0\u4f9b\u6307\u793a\u3002.<\/p>\n

\u201c\u6211\u4eec\u80fd\u6709\u8fd9\u4e2a\u53d1\u73b0\u5b8c\u5168\u662f\u5de7\u5408\uff0c\u201d\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\u7684\u7d22\u5c14\u514b\u6559\u6388\u8bf4\u9053 \u6258\u5c3c\u00b7\u4ea8\u7279<\/a>, \uff0c\u8be5\u8bba\u6587\u7684\u901a\u8baf\u4f5c\u8005\u3002\u201c\u6211\u4eec\u5f53\u521d\u600e\u4e48\u4e5f\u60f3\u4e0d\u5230\uff0c\u8fd9\u79cd\u9175\u6bcd\u86cb\u767d\u4f1a\u4ee5\u8fd9\u79cd\u65b9\u5f0f\u5728\u4eba\u7c7b\u75be\u75c5\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u201d<\/p>\n

\u9762\u5bf9\u764c\u75c7\u6216\u5176\u4ed6\u75be\u75c5\u5f15\u8d77\u7684\u57fa\u56e0\u635f\u4f24\uff0c\u7ec6\u80de\u4f1a\u52a8\u5458\u5206\u5b50\u8fc7\u7a0b\uff0c\u5c31\u50cf\u542f\u52a8\u7ef4\u4fee\u56e2\u961f\u4e00\u6837\u3002\u5728\u8fc7\u53bb\u5341\u5e74\u5de6\u53f3\u7684\u65f6\u95f4\u91cc\uff0c\u4ea8\u7279\u5b9e\u9a8c\u5ba4\u7684\u4e00\u4e2a\u91cd\u70b9\u4e00\u76f4\u662f\u7814\u7a76\u901a\u8fc7\u4e00\u79cd\u79f0\u4e3a\u201c\u82cf\u83ab\u5316\u201d\u7684\u8fc7\u7a0b\u6765\u8c03\u8282\u8fd9\u4e9b\u4fee\u590d\u7a0b\u5e8f\u7684\u67d0\u4e9b\u86cb\u767d\u8d28\u3002SUMO \u6dfb\u52a0\u5230\u86cb\u767d\u8d28\u4e0a\uff0c\u6216\u8005\u8bf4\u82cf\u83ab\u5316\uff0c\u5145\u5f53\u4e00\u79cd\u8d28\u91cf\u63a7\u5236\u673a\u5236\uff0c\u5411\u7ec6\u80de\u53d1\u51fa\u4fe1\u53f7\uff0c\u8868\u660e\u8be5\u86cb\u767d\u8d28\u5e94\u8be5\u88ab\u6e05\u9664\u3002.<\/p>\n

\u5728\u5f53\u524d\u7684\u7814\u7a76\u4e2d\uff0c\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u7814\u7a76\u5458\u3001\u8be5\u8bba\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u90d1\u738b\uff08Zheng Wang\uff09\u5728\u9175\u6bcd\u4e2d\u5efa\u7acb\u4e86\u4e00\u4e2a\u57fa\u56e0\u7b5b\u9009\u6d4b\u8bd5\uff0c\u4ee5\u786e\u5b9a\u54ea\u4e9b\u86cb\u767d\u8d28\u4f9d\u8d56\u4e8eSUMO\u5316\u624d\u80fd\u6b63\u5e38\u53d1\u6325\u529f\u80fd\u3002\u4ed6\u4ece\u4e2d\u53d1\u73b0\u4e86\u86cb\u767d\u8d28\u590d\u5408\u7269RNA\u805a\u5408\u9176III\uff08RNA polymerase III\uff09\u7684\u51e0\u4e2a\u4e9a\u57fa\u2014\u2014\u8be5\u590d\u5408\u7269\u5728\u5c06DNA\u590d\u5236\u6210RNA\u7684\u8fc7\u7a0b\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u2014\u2014\u5b83\u4eec\u53d7\u5230\u4e86\u5f71\u54cd\u3002\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u5f53Pol III\u53d1\u751f\u7a81\u53d8\u65f6\uff0c\u7ec6\u80de\u5c31\u4f1a\u505c\u6b62\u751f\u957f\uff0c\u56e0\u4e3a\u7a81\u53d8\u7684Pol III\u65e0\u6cd5\u5236\u9020\u8db3\u591f\u7684\u8f6c\u79fbRNA\uff08\u7ec6\u80de\u5408\u6210\u86cb\u767d\u8d28\u6240\u9700\u7684\u5c0fRNA\uff09\u3002\u7136\u800c\uff0c\u901a\u8fc7\u964d\u4f4e\u9175\u6bcd\u7ec6\u80de\u4e2d\u7684SUMO\u5316\u6c34\u5e73\u53ef\u4ee5\u4fee\u590d\u8fd9\u4e00\u7f3a\u9677\u3002.<\/p>\n

\"Tony
\u6258\u5c3c\u00b7\u4ea8\u7279<\/p>\n

\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\u3002.<\/p>\n

\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

\u4e0e\u6b64\u540c\u65f6\uff0c\u5728\u4ea8\u7279\u5b9e\u9a8c\u5ba4\u8fdb\u884c Pol III \u7814\u7a76\u7684\u540c\u65f6\uff0c\u5176\u4ed6\u7814\u7a76\u4f4e\u9ad3\u9798\u5316\u767d\u8d28\u8425\u517b\u4e0d\u826f\uff08\u4e00\u79cd\u4ee5\u795e\u7ecf\u7ec6\u80de\u5468\u56f4\u4fdd\u62a4\u6027\u7edd\u7f18\u5c42\uff08\u9ad3\u9798\uff09\u4e27\u5931\u4e3a\u7279\u5f81\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff09\u7684\u5c0f\u7ec4\u53d1\u73b0\uff0c\u8fd9\u79cd\u60c5\u51b5\u662f\u7531 Pol III \u7684\u7a81\u53d8\u5f15\u8d77\u7684\u3002\u5c3d\u7ba1 Pol III \u5df2\u77e5\u5bf9\u7ec6\u80de\u751f\u957f\u8c03\u63a7\u5f88\u91cd\u8981\uff0c\u4f46\u8fd9\u5374\u662f\u7b2c\u4e00\u6b21\u6709\u5177\u4f53\u75be\u75c5\u4e0e Pol III \u7f3a\u9677\u8054\u7cfb\u8d77\u6765\u3002.<\/p>\n

\u7531\u4e8e\u795e\u7ecf\u5468\u56f4\u7684\u9ad3\u9798\u7edd\u7f18\u5c42\u4e27\u5931\uff0c\u4f4e\u9ad3\u9798\u5316\u767d\u8d28\u8425\u517b\u4e0d\u826f\u75c7\u60a3\u8005\u4f1a\u51fa\u73b0\u53d1\u80b2\u8fdf\u7f13\u3001\u667a\u529b\u969c\u788d\u548c\u8fd0\u52a8\u529f\u80fd\u53d7\u635f\u3002\u76ee\u524d\u5c1a\u65e0\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u4ea8\u7279\u5b9e\u9a8c\u5ba4\u7684\u65b0\u53d1\u73b0\u8868\u660e\uff0c\u9650\u5236\u8fd9\u4e9b\u7a81\u53d8\u5f71\u54cd\u7684\u4e00\u79cd\u65b9\u6cd5\u53ef\u80fd\u662f\u90e8\u5206\u6291\u5236SUMO\u5316\uff0c\u8fdb\u800c\u963b\u65ad\u7a81\u53d8\u7684Pol III\u7684\u4f5c\u7528\u3002.<\/p>\n

\u8fd9\u9879\u7814\u7a76\u8fd8\u6709\u5f88\u957f\u7684\u8def\u8981\u8d70\uff1aSUMO\u5316\u5bf9\u8bb8\u591a\u5176\u4ed6\u529f\u80fd\u4e5f\u5f88\u91cd\u8981\uff0c\u56e0\u6b64\u5728\u6240\u6709\u7ec6\u80de\u4e2d\u6291\u5236\u5b83\u5e76\u975e\u4e00\u79cd\u6709\u6548\u7684\u65b9\u6cd5\u3002\u6b64\u5916\uff0c\u5c3d\u7ba1\u65b0\u53d1\u73b0\u90e8\u5206\u89e3\u91ca\u4e86\u57fa\u56e0\u7a81\u53d8\u5bfc\u81f4\u7684\u9ad3\u9798\u8131\u5931\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u4ecd\u7136\u4e0d\u77e5\u9053\u4e3a\u4ec0\u4e48\u8fd9\u4e9bPol III\u7a81\u53d8\u4f1a\u7279\u522b\u5f71\u54cd\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u2014\u2014\u8fd9\u4e9b\u7ec6\u80de\u8d1f\u8d23\u5728\u795e\u7ecf\u8f74\u7a81\u5468\u56f4\u5f62\u6210\u9ad3\u9798\u3002.<\/p>\n

\u4ea8\u7279\u5b9e\u9a8c\u5ba4\u76ee\u524d\u6b63\u5728\u5408\u4f5c\u7814\u7a76\u5177\u6709\u7a81\u53d8 Pol III \u7684\u5c0f\u9f20\u6a21\u578b\uff0c\u4ee5\u8c03\u67e5\u8fd9\u4e9b\u7a81\u53d8\u5bf9\u80da\u80ce\u53d1\u80b2\u7684\u5f71\u54cd\u3002\u4ed6\u7684\u56e2\u961f\u8fd8\u8ba1\u5212\u5728\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de (iPSCs) \u4ee5\u53ca\u5176\u4ed6\u7c7b\u578b\u7684\u7ec6\u80de\uff08\u5305\u62ec\u764c\u7ec6\u80de\uff09\u4e2d\u7814\u7a76\u7c7b\u4f3c\u7684 Pol III \u7a81\u53d8\uff0c\u4ee5\u671f\u66f4\u6df1\u5165\u5730\u4e86\u89e3 Pol III \u7f3a\u9677\u7684\u6f5c\u5728\u673a\u5236\u3002.<\/p>\n

\u8bba\u6587\u7684\u5176\u4ed6\u7814\u7a76\u4eba\u5458\u5305\u62ec\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u51ef\u745f\u7433\u00b7\u5434\uff08Catherine Wu\uff09\u548c\u4e9a\u4f26\u00b7\u963f\u65af\u5170\u5c3c\u5b89\uff08Aaron Aslanian\uff09\uff0c\u4ee5\u53ca\u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u7684\u7ea6\u7ff0\u00b7R\u00b7\u8036\u8328\u4e09\u4e16\uff08John R. Yates III\uff09\u3002.<\/p>\n

\u8fd9\u9879\u5de5\u4f5c\u5f97\u5230\u4e86\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662 8P41GM103533-17\u3001CA080100\u30015P41RR011823-17 \u548c CA082683 \u8d44\u52a9\u3002.<\/p>","protected":false},"featured_media":19666,"template":"","faculty":[72],"disease-research":[124],"class_list":["post-19660","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-tony-hunter","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nResearch in yeast leads to serendipitous finding about a central nervous system disorder - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/research-in-yeast-leads-to-serendipitous-finding-about-a-central-nervous-system-disorder\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research in yeast leads to serendipitous finding about a central nervous system disorder - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Studying the fundamental aspects of biology can sometimes lead to unexpected findings that directly relate to human disease. 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