{"id":17923,"date":"2018-05-10T14:08:09","date_gmt":"2018-05-10T21:08:09","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=17923"},"modified":"2024-01-30T15:14:07","modified_gmt":"2024-01-30T23:14:07","slug":"boosting-the-effects-of-vitamin-d-to-tackle-diabetes","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/boosting-the-effects-of-vitamin-d-to-tackle-diabetes\/","title":{"rendered":"Boosting the effects of Vitamin D to tackle diabetes"},"content":{"rendered":"

LA JOLLA\u2014More than 27 million people in the United States are living with\u00a0type 2 diabetes<\/a>, according to the Centers for Disease Control and Prevention. As the population ages and a growing percentage of people become overweight or obese, that number is expected to increase.<\/p>\n

\"Enhanced
Enhanced activation of vitamin D curbs type 2 diabetes progression in animal models. Left: damaged insulin positive B cells (red) in a diabetic mouse pancreas. Right: B cells (red) were protected in a diabetic mouse pancreas treated with a combination of a vitamin D activator and BRD9 inhibitor.<\/p>\n

Click here<\/a> for a high-resolution image.<\/p>\n

Credit: Salk Institute<\/figcaption><\/figure>\n

In a paper published May 10, 2018, in Cell<\/em>, researchers from the Salk Institute report a potential new approach for treating diabetes by protecting beta cells\u2014the cells in the pancreas that produce, store and release the hormone insulin. When beta cells become dysfunctional, the body can\u2019t make insulin to control blood sugar (glucose) and levels of glucose can rise to dangerous\u2014even fatal\u2014levels.<\/p>\n

The investigators accomplished their goal by using an unexpected source: vitamin D. Vitamin D in cells and mouse models proved beneficial in treating damaged beta cells. It also provided new insights about gene regulation that could be applied to developing treatments for other diseases, including cancer.<\/p>\n

\u201cWe know that diabetes is a disease caused by inflammation,\u201d explains senior author \u7f57\u7eb3\u5fb7\u00b7\u57c3\u6587\u65af<\/a>, a Howard Hughes Medical Institute investigator and holder of Salk\u2019s March of Dimes Chair in Molecular and Developmental Biology. \u201cIn this study, we identified the vitamin D receptor as an important modulator of both inflammation and beta cell survival.\u201d<\/p>\n

Using beta cells created from embryonic stem cells, the investigators were able to identify a compound, iBRD9, that appeared to enhance the activation of the vitamin D receptor when it was combined with vitamin D to improve the survival of beta cells. The team accomplished this by conducting a screening test to look for compounds that improved the survival of beta cells in a dish. They then tested the combination in a mouse model of diabetes and showed that it could bring glucose back to normal levels in the animals.<\/p>\n

\u201cThis study started out by looking at the role of vitamin D in beta cells,\u201d says Zong Wei, a research associate in Salk\u2019s Gene Expression Laboratory and the study\u2019s first author. \u201cEpidemiological studies in patients have suggested a correlation between high vitamin D concentrations in the blood and a lower risk of diabetes, but the underlying mechanism was not well understood. It\u2019s been hard to protect beta cells with the vitamin alone. We now have some ideas about how we might be able to take advantage of this connection.\u201d<\/p>\n

\"From
From left: (front row) Nanhai He, Gabriela Estepa, Ron Evans and Ruth Yu; (back row) Eiji Yoshihara, Michael Downes, Weiwei Fan and Zong Wei.<\/p>\n

Click here<\/a> for a high-resolution image.<\/p>\n

Credit: Salk Institute<\/figcaption><\/figure>\n

The underlying process has to do with transcription\u2014the way that genes are translated into proteins. Combining the new compound with vitamin D allowed certain protective genes to be expressed at much higher levels than they are in diseased cells.<\/p>\n

\u201cActivating the vitamin D receptor can trigger the anti-inflammatory function of genes to help cells survive under stressed conditions,\u201d says Michael Downes, a Salk senior staff scientist and co\u2013corresponding author. \u201cBy using a screening system that we developed in the lab, we\u2019ve been able to identify an important piece of that puzzle that allows for super-activation of the Vitamin D pathway.\u201d<\/p>\n

The discovery\u2019s implications can have far-reaching implications: It identifies a basic mechanism that can be translated into drugging many different targets in the clinic.<\/p>\n

\u201cIn this study, we looked at diabetes, but because this is an important receptor it could potentially be universal for any treatments where you need to boost the effect of vitamin D,\u201d adds Ruth Yu, a Salk staff researcher and one of the study\u2019s authors. \u201cFor example, we are especially interested in looking at it in pancreatic cancer, which is a disease that our lab already studies.\u201d<\/p>\n

The investigators say that, although the new compound did not appear to cause any side effects in the mice, further testing is needed before clinical trials can begin.<\/p>\n

The paper\u2019s other authors were Eiji Yoshihara, Nanhai He, Nasun Hah, Weiwei Fan, Antonio Pinto, Timothy Huddy, Yuhao Wang, Brittany Ross, Gabriela Estepa, Yang Dai, Ning Ding, Mara Sherman, Sungsoon Fang, Xuan Zhao and Annette Atkins of Salk; and Christopher Liddle of the Westmead Institute for Medical Research and Sydney Medical School in Sydney, Australia.<\/p>\n

This work was funded by the National Institutes of Health and its National Institute of Environmental Health Sciences, the Glenn Foundation for Medical Research, the Leona M. and Harry B. Helmsley Charitable Trust, Ipsen\/Biomeasure, the California Institute for Regenerative Medicine, the Ellison Medical Foundation, and a gift from Steven and Lisa Altman.<\/p>","protected":false},"featured_media":17929,"template":"","faculty":[91],"disease-research":[165],"class_list":["post-17923","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-ronald-evans","disease-research-diabetes-type-2"],"acf":[],"yoast_head":"\nBoosting the effects of Vitamin D to tackle diabetes - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/boosting-the-effects-of-vitamin-d-to-tackle-diabetes\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Boosting the effects of Vitamin D to tackle diabetes - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014More than 27 million people in the United States are living with\u00a0type 2 diabetes, according to the Centers for Disease Control and Prevention. 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