{"id":15781,"date":"2017-12-14T00:00:37","date_gmt":"2017-12-14T08:00:37","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=15781"},"modified":"2018-10-04T10:46:51","modified_gmt":"2018-10-04T17:46:51","slug":"revealing-best-kept-secrets-proteins","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/zh\/news-release\/revealing-best-kept-secrets-proteins\/","title":{"rendered":"\u63ed\u793a\u86cb\u767d\u8d28\u7684\u79d8\u5bc6"},"content":{"rendered":"

\u62c9\u970d\u4e9a\u2014\u5728\u7ec6\u80de\u7199\u7199\u6518\u6518\u7684\u73af\u5883\u4e2d\uff0c\u6570\u4ee5\u5343\u8ba1\u7684\u86cb\u767d\u8d28\u76f8\u4e92\u78b0\u649e\u3002\u5c3d\u7ba1\u4e00\u7247\u7e41\u5fd9\uff0c\u4f46\u6bcf\u79cd\u86cb\u767d\u8d28\u90fd\u80fd\u9009\u62e9\u6027\u5730\u4e0e\u5176\u6b63\u786e\u7684\u4f19\u4f34\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u8981\u5f52\u529f\u4e8e\u5176\u8868\u9762\u4e0a\u7279\u5b9a\u7684\u63a5\u89e6\u533a\u57df\uff0c\u5c3d\u7ba1\u7ecf\u8fc7\u6570\u5341\u5e74\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u548c\u529f\u80fd\u7814\u7a76\uff0c\u8fd9\u4e9b\u533a\u57df\u4ecd\u7136\u6bd4\u9884\u671f\u7684\u8981\u795e\u79d8\u5f97\u591a\u3002.<\/p>\n

\u73b0\u5728\uff0c\u7d22\u5c14\u514b\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u65b9\u6cd5\uff0c\u53ef\u4ee5\u7528\u4ee5\u53d1\u73b0\u86cb\u767d\u8d28\u4e0a\u54ea\u4e9b\u8868\u9762\u63a5\u89e6\u70b9\u5bf9\u4e8e\u8fd9\u4e9b\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u81f3\u5173\u91cd\u8981\u3002\u8fd9\u79cd\u65b0\u9896\u7684\u65b9\u6cd5\u8868\u660e\uff0c\u5373\u4f7f\u662f\u5df2\u7ecf\u88ab\u5145\u5206\u7814\u7a76\u8fc7\u7684\u86cb\u767d\u8d28\uff0c\u4e5f\u80fd\u63ed\u793a\u51fa\u5176\u5fc5\u4e0d\u53ef\u5c11\u7684\u65b0\u529f\u80fd\uff0c\u5e76\u5bf9\u6cbb\u7597\u6027\u836f\u7269\u7684\u5f00\u53d1\u5177\u6709\u91cd\u8981\u610f\u4e49\uff0c\u56e0\u4e3a\u836f\u7269\u7684\u5f00\u53d1\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u51b3\u4e8e\u836f\u7269\u4e0e\u7ec6\u80de\u9776\u70b9\u4e4b\u95f4\u7684\u7269\u7406\u76f8\u4e92\u4f5c\u7528\u3002\u8be5\u8bba\u6587\u51fa\u73b0\u5728\u4e86\u2026\u2026\u65e9\u671f\u5728\u7ebf\u7248\u672c\u4e2d\u3002 \u9057\u4f20\u5b66<\/em><\/a> \u5c06\u4e8e11\u6708\u4e0b\u65ec\u516c\u5e03\uff0c\u5e76\u5b9a\u4e8e\u8be5\u671f\u520a\u76841\u6708\u5370\u5237\u7248\u4e0a\u53d1\u8868\u3002.<\/p>\n

\"From
\u4ece\u5de6\u8d77\uff1a\u7ea6\u7ff0\u00b7\u5362\u5bbe\u3001\u7ef4\u59ec\u00b7\u4f26\u5fb7\u5e03\u62c9\u5fb7\u548c\u8482\u59c6\u00b7\u56fe\u897f <\/p>\n

\u70b9\u51fb\u6b64\u5904<\/a> \u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf <\/p>\n

\u7248\u6743\uff1a\u8428\u514b\u7814\u7a76\u6240<\/figcaption><\/figure>\n

\u201c\u672c\u6587\u8bf4\u660e\u4e86\u8be5\u65b9\u6cd5\u7684\u5f3a\u5927\u4e4b\u5904\uff0c\u201d\u8d44\u6df1\u4f5c\u8005\u8bf4\u3002 \u7ef4\u59ec\u00b7\u4f26\u5fb7\u5e03\u62c9\u5fb7<\/a>, Ralph S. \u548c Becky O\u2019Conner \u8bb2\u5e2d\u6559\u6388\u3002\u201c\u5b83\u4e0d\u4ec5\u53ef\u4ee5\u8bc6\u522b\u86cb\u767d\u8d28\u5148\u524d\u672a\u77e5\u7684\u6d3b\u6027\uff0c\u8fd8\u53ef\u4ee5\u7cbe\u786e\u6307\u51fa\u86cb\u767d\u8d28\u8868\u9762\u4e0a\u6267\u884c\u8fd9\u4e9b\u65b0\u529f\u80fd\u7684\u6c28\u57fa\u9178\u3002\u201d<\/p>\n

\u6c28\u57fa\u9178\u662f\u86cb\u767d\u8d28\u7684\u57fa\u77f3\u3002\u5b83\u4eec\u7684\u7279\u5b9a\u7ebf\u6027\u6392\u5217\u51b3\u5b9a\u4e86\u86cb\u767d\u8d28\u7684\u8eab\u4efd\uff0c\u5b83\u4eec\u5728\u5176\u8868\u9762\u7684\u805a\u96c6\u5145\u5f53\u4e86\u63a5\u89e6\u70b9\uff0c\u8c03\u8282\u86cb\u767d\u8d28\u5982\u4f55\u4e0e\u5176\u4ed6\u86cb\u767d\u8d28\u548c\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u3002\u9686\u5fb7\u5e03\u62c9\u5fb7\u548c\u5979\u7684\u540c\u4e8b\u4eec\u6000\u7591\uff0c\u5c3d\u7ba1\u5728\u7834\u8bd1\u86cb\u767d\u8d28\u7684\u5965\u79d8\u65b9\u9762\u5df2\u7ecf\u5de5\u4f5c\u4e86\u51e0\u5341\u5e74\uff0c\u86cb\u767d\u8d28\u8868\u9762\u8fd9\u79cd\u8c03\u8282\u6027\u666f\u89c2\u7684\u8303\u56f4\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4ecd\u7136\u672a\u88ab\u63a2\u7d22\u3002\u5f88\u4e45\u4ee5\u524d\uff0c\u5979\u7684\u56e2\u961f\u5728\u9010\u4e00\u7b5b\u9009\u4e86 30 \u4e07\u4e2a\u7a81\u53d8\u9175\u6bcd\u7ec6\u80de\u65f6\uff0c\u610f\u5916\u5730\u53d1\u73b0\u4e86\u4e00\u4e2a\u8fd9\u6837\u7684\u8c03\u8282\u6027\u6c28\u57fa\u9178\u7c07\u3002\u5c3d\u7ba1\u8fd9\u9879\u5de5\u4f5c\u5728\u4e00\u4e2a\u65b0\u7684\u7aef\u7c92\u751f\u7269\u5b66\u7814\u7a76\u9886\u57df\u5f00\u8f9f\u4e86\u9053\u8def\uff0c\u4f46\u9686\u5fb7\u5e03\u62c9\u5fb7\u51b3\u5fc3\u627e\u5230\u4e00\u79cd\u66f4\u7a33\u5065\u7684\u65b9\u6cd5\uff0c\u80fd\u591f\u5feb\u901f\u63ed\u793a\u66f4\u591a\u8fd9\u4e9b\u672a\u88ab\u63a2\u7d22\u7684\u86cb\u767d\u8d28\u8868\u9762\u3002.<\/p>\n

\u73b0\u5165\u7ea6\u7ff0\u00b7\u5362\u5bbe\uff0c\u4ed6\u662f\u4f26\u5fb7\u5e03\u62c9\u5fb7\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u751f\uff0c\u672c\u79d1\u65f6\u5c31\u5f00\u59cb\u4e0e\u5979\u5171\u4e8b\u3002.<\/p>\n

\u201c\u6211\u7684\u4efb\u52a1\u662f\u627e\u51fa\u5982\u4f55\u53ea\u7b5b\u900930\u4e2a\u7a81\u53d8\u9175\u6bcd\u7ec6\u80de\uff0c\u800c\u4e0d\u662f30\u4e07\u4e2a\uff0c\u6765\u53d1\u73b0\u86cb\u767d\u8d28\u7684\u65b0\u6d3b\u6027\uff0c\u201d\u8be5\u8bba\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005Lubin\u8bf4\u9053\u3002\u53e6\u4e00\u4f4d\u5171\u540c\u7b2c\u4e00\u4f5c\u8005Timothy Tucey\u66fe\u662fLundblad\u5c0f\u7ec4\u7684\u535a\u58eb\u540e\u7814\u7a76\u5458\uff0c\u73b0\u5c31\u804c\u4e8e\u83ab\u7eb3\u4ec0\u5927\u5b66\u3002.<\/p>\n

\u4ed6\u4eec\u4e00\u8d77\u8f6c\u5411\u4e86\u4e00\u79cd\u540d\u4e3a Est1 \u7684\u86cb\u767d\u8d28\uff0c\u8fd9\u662f Lundblad \u5728 1989 \u5e74\u4f5c\u4e3a\u535a\u58eb\u540e\u7814\u7a76\u5458\u5728\u9175\u6bcd\u4e2d\u53d1\u73b0\u7684\u3002Est1 \u662f\u7aef\u7c92\u9176\uff08\u4e00\u79cd\u9176\uff09\u7684\u4e00\u4e2a\u4e9a\u57fa\uff0c\u7aef\u7c92\u9176\u53ef\u4ee5\u9632\u6b62\u67d3\u8272\u4f53\u672b\u7aef\u7684\u4fdd\u62a4\u6027\u5e3d\uff08\u79f0\u4e3a\u7aef\u7c92\uff09\u53d8\u5f97\u592a\u77ed\u3002\u4f5c\u4e3a\u7b2c\u4e00\u4e2a\u88ab\u53d1\u73b0\u7684\u7aef\u7c92\u9176\u4e9a\u57fa\uff0cEst1 \u5df2\u7ecf\u88ab\u8bb8\u591a\u7814\u7a76\u5c0f\u7ec4\u8fdb\u884c\u4e86\u6df1\u5165\u7814\u7a76\u3002.<\/p>\n

\u7d22\u5c14\u514b\u56e2\u961f\u7684\u65b9\u6cd5\u662f\u5411\u9175\u6bcd\u7ec6\u80de\u4e2d\u5f15\u5165\u4e00\u7ec4\u5c11\u91cf\u4f46\u7ecf\u8fc7\u5b9a\u5236\u7684\u7a81\u53d8\uff0c\u4ee5\u9009\u62e9\u6027\u5730\u7834\u574f\u7ec6\u80de Est1 \u86cb\u767d\u4e0a\u7684\u8868\u9762\u63a5\u89e6\u3002\u7136\u540e\uff0c\u8be5\u56e2\u961f\u5206\u6790\u7ec6\u80de\uff0c\u89c2\u5bdf\u5404\u79cd\u7a81\u53d8\u662f\u5426\u4ee5\u53ca\u6709\u4f55\u5f71\u54cd\u3002\u7279\u5b9a\u7a81\u53d8\u5f15\u8d77\u7684\u5f02\u5e38\u5c06\u8868\u660e\u672a\u7a81\u53d8\u7248\u672c\u7684\u4f5c\u7528\u3002\u4e3a\u6b64\uff0c\u4ed6\u4eec\u4f7f\u7528\u4e86\u4e00\u79cd\u9057\u4f20\u5b66\u6280\u5de7\uff0c\u5c06\u6bcf\u79cd\u7a81\u53d8\u86cb\u767d\u6ce8\u5165\u7ec6\u80de\uff0c\u5e76\u5bfb\u627e\u80fd\u591f\u5e72\u6270\u7ec6\u80de\u529f\u80fd\u7684\u7f55\u89c1\u7a81\u53d8\u86cb\u767d\uff0c\u56e0\u4e3a\u4ed6\u4eec\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4f1a\u4f18\u5148\u9776\u5411\u86cb\u767d\u8d28\u8868\u9762\u3002.<\/p>\n

\u9686\u5fb7\u5e03\u62c9\u5fb7\u7684\u56e2\u961f\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\u53d1\u73b0\u4e86 Est1 \u7684\u56db\u79cd\u529f\u80fd\u3002\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u901a\u8fc7\u5bf9 Est1 \u8868\u9762\u6c28\u57fa\u9178\u8fdb\u884c\u7a81\u53d8\u5bfc\u81f4\u8fd9\u56db\u79cd\u529f\u80fd\u53d7\u635f\uff0c\u4f1a\u4ea7\u751f\u7aef\u7c92\u4e25\u91cd\u7f29\u77ed\u7684\u7ec6\u80de\uff0c\u8fd9\u8868\u660e Est1 \u4e0e\u7aef\u7c92\u9176\u590d\u5408\u7269\u7684\u63a5\u89e6\u5728\u5176\u4e2d\u53d1\u6325\u7740\u7279\u5b9a\u7684\u4f5c\u7528\u3002.<\/p>\n

\u201c\u8fd9\u79cd\u6280\u672f\u8ba9\u6211\u4eec\u611f\u5230\u5174\u594b\u7684\u662f\uff0c\u5b83\u53ef\u4ee5\u5e94\u7528\u4e8e\u591a\u79cd\u86cb\u767d\u8d28\uff0c\u201d\u4f26\u5fb7\u5e03\u62c9\u5fb7\u8bf4\u3002\u201c\u7279\u522b\u662f\uff0c\u8bb8\u591a\u6cbb\u7597\u836f\u7269\u4f9d\u8d56\u4e8e\u80fd\u591f\u63a5\u89e6\u86cb\u767d\u8d28\u8868\u9762\u7684\u4e00\u4e2a\u975e\u5e38\u7279\u5b9a\u7684\u4f4d\u7f6e\uff0c\u6211\u4eec\u6000\u7591\u8fd9\u79cd\u65b9\u6cd5\u53ef\u4ee5\u63ed\u793a\u8fd9\u4e00\u70b9\u3002\u201d<\/p>\n

\u5229\u7528\u8fd9\u79cd\u65b9\u6cd5\uff0c\u5979\u7684\u56e2\u961f\u5df2\u7ecf\u53d1\u73b0\u4e86\u4e00\u7ec4\u8c03\u63a7\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u7684\u86cb\u767d\u8d28\u7684\u65b0\u529f\u80fd\uff0c\u5e76\u4e14\u5df2\u7ecf\u7533\u8bf7\u4e86\u4e3a\u836f\u7269\u9776\u70b9\u7814\u7a76\u63d0\u4f9b\u8d44\u91d1\u7684\u8d44\u52a9\u3002.<\/p>\n

\u8fd9\u9879\u5de5\u4f5c\u7531\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u3001\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u57fa\u91d1\u4f1a\u3001\u7f57\u65af\u5e0c\u5c14\u65af\u57fa\u91d1\u4f1a\u548c\u683c\u4f26\u8870\u8001\u7814\u7a76\u4e2d\u5fc3\u8d44\u52a9\u3002.<\/p>","protected":false},"featured_media":15784,"template":"","faculty":[98],"disease-research":[146,331],"class_list":["post-15781","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-vicki-lundblad","disease-research-aging-and-regenerative-medicine","disease-research-protein-interactions"],"acf":[],"yoast_head":"\nRevealing the best-kept secrets of proteins - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/zh\/news-release\/revealing-best-kept-secrets-proteins\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Revealing the best-kept secrets of proteins - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014In the bustling setting of the cell, proteins encounter each other by the thousands. Despite the hubbub, each one manages to selectively interact with just the right partners, thanks to specific contact regions on its surface that are still far more mysterious than might be expected, given decades of research into protein structure and function.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/zh\/news-release\/revealing-best-kept-secrets-proteins\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2018-10-04T17:46:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/12\/John_Lubin_Victoria_Lundblad_Timothy_Tucey767x767.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"767\" \/>\n\t<meta property=\"og:image:height\" content=\"767\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/revealing-best-kept-secrets-proteins\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/revealing-best-kept-secrets-proteins\\\/\",\"name\":\"Revealing the best-kept secrets of proteins - Salk Institute for Biological Studies\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/revealing-best-kept-secrets-proteins\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/revealing-best-kept-secrets-proteins\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2017\\\/12\\\/John_Lubin_Victoria_Lundblad_Timothy_Tucey767x767.jpg\",\"datePublished\":\"2017-12-14T08:00:37+00:00\",\"dateModified\":\"2018-10-04T17:46:51+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/revealing-best-kept-secrets-proteins\\\/#breadcrumb\"},\"inLanguage\":\"zh-CN\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/revealing-best-kept-secrets-proteins\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-CN\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/revealing-best-kept-secrets-proteins\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2017\\\/12\\\/John_Lubin_Victoria_Lundblad_Timothy_Tucey767x767.jpg\",\"contentUrl\":\"https:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2017\\\/12\\\/John_Lubin_Victoria_Lundblad_Timothy_Tucey767x767.jpg\",\"width\":767,\"height\":767},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/revealing-best-kept-secrets-proteins\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.salk.edu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Revealing the best-kept secrets of proteins\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#website\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"name\":\"Salk Institute for Biological Studies\",\"description\":\"The Power of Science\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.salk.edu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-CN\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#organization\",\"name\":\"Salk Institute for Biological Studies\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-CN\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"contentUrl\":\"http:\\\/\\\/www.salk.edu\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/salk_logo_696.jpg\",\"width\":696,\"height\":696,\"caption\":\"Salk Institute for Biological Studies\"},\"image\":{\"@id\":\"https:\\\/\\\/www.salk.edu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Revealing the best-kept secrets of proteins - Salk Institute for Biological Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.salk.edu\/zh\/news-release\/revealing-best-kept-secrets-proteins\/","og_locale":"zh_CN","og_type":"article","og_title":"Revealing the best-kept secrets of proteins - Salk Institute for Biological Studies","og_description":"LA JOLLA\u2014In the bustling setting of the cell, proteins encounter each other by the thousands. Despite the hubbub, each one manages to selectively interact with just the right partners, thanks to specific contact regions on its surface that are still far more mysterious than might be expected, given decades of research into protein structure and function.","og_url":"https:\/\/www.salk.edu\/zh\/news-release\/revealing-best-kept-secrets-proteins\/","og_site_name":"Salk Institute for Biological Studies","article_modified_time":"2018-10-04T17:46:51+00:00","og_image":[{"width":767,"height":767,"url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/12\/John_Lubin_Victoria_Lundblad_Timothy_Tucey767x767.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.salk.edu\/news-release\/revealing-best-kept-secrets-proteins\/","url":"https:\/\/www.salk.edu\/news-release\/revealing-best-kept-secrets-proteins\/","name":"Revealing the best-kept secrets of proteins - Salk Institute for Biological Studies","isPartOf":{"@id":"https:\/\/www.salk.edu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.salk.edu\/news-release\/revealing-best-kept-secrets-proteins\/#primaryimage"},"image":{"@id":"https:\/\/www.salk.edu\/news-release\/revealing-best-kept-secrets-proteins\/#primaryimage"},"thumbnailUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/12\/John_Lubin_Victoria_Lundblad_Timothy_Tucey767x767.jpg","datePublished":"2017-12-14T08:00:37+00:00","dateModified":"2018-10-04T17:46:51+00:00","breadcrumb":{"@id":"https:\/\/www.salk.edu\/news-release\/revealing-best-kept-secrets-proteins\/#breadcrumb"},"inLanguage":"zh-CN","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.salk.edu\/news-release\/revealing-best-kept-secrets-proteins\/"]}]},{"@type":"ImageObject","inLanguage":"zh-CN","@id":"https:\/\/www.salk.edu\/news-release\/revealing-best-kept-secrets-proteins\/#primaryimage","url":"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/12\/John_Lubin_Victoria_Lundblad_Timothy_Tucey767x767.jpg","contentUrl":"https:\/\/www.salk.edu\/wp-content\/uploads\/2017\/12\/John_Lubin_Victoria_Lundblad_Timothy_Tucey767x767.jpg","width":767,"height":767},{"@type":"BreadcrumbList","@id":"https:\/\/www.salk.edu\/news-release\/revealing-best-kept-secrets-proteins\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.salk.edu\/"},{"@type":"ListItem","position":2,"name":"Revealing the best-kept secrets of proteins"}]},{"@type":"WebSite","@id":"https:\/\/www.salk.edu\/#website","url":"https:\/\/www.salk.edu\/","name":"\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240","description":"\u79d1\u5b66\u7684\u529b\u91cf","publisher":{"@id":"https:\/\/www.salk.edu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.salk.edu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-CN"},{"@type":"Organization","@id":"https:\/\/www.salk.edu\/#organization","name":"\u7d22\u5c14\u514b\u751f\u7269\u7814\u7a76\u6240","url":"https:\/\/www.salk.edu\/","logo":{"@type":"ImageObject","inLanguage":"zh-CN","@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/","url":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","contentUrl":"http:\/\/www.salk.edu\/wp-content\/uploads\/2023\/03\/salk_logo_696.jpg","width":696,"height":696,"caption":"Salk Institute for Biological Studies"},"image":{"@id":"https:\/\/www.salk.edu\/#\/schema\/logo\/image\/"}}]}},"ACF":{"gallery":false,"paper_url":"http:\/\/www.genetics.org\/content\/early\/2017\/11\/29\/genetics.117.300145","journal_title":"Genetics","paper_author_list":"Johnathan W. Lubin, Timothy M. Tucey and Victoria Lundblad","paper_title":"Using separation-of-function mutagenesis to define the full spectrum of activities performed by the EST1 telomerase subunit in vivo","subhead":"Salk scientists develop new approach to identify important undiscovered functions of proteins","home_photo":"","listing_photo":"","legacy_boilerplate":[],"hide_boilerplate":[],"disable_date":false,"listing_excerpt":"","descriptive_blurb":"","has_journal_cover":false},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/15781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":5,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/15781\/revisions"}],"predecessor-version":[{"id":15790,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disclosure\/15781\/revisions\/15790"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/media\/15784"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/media?parent=15781"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/faculty?post=15781"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/zh\/wp-json\/wp\/v2\/disease-research?post=15781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}