Salk

Uri Manor

Director

Biophotonics Core Facility

Uri Manor
Salk Institute for Biological Studies - Uri Manor
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Uri Manor

As Director of the Advanced Biophotonics Core Facility at the Salk Institute, Uri Manor’s primary focus is the integration and application of optical and charged particle detection technologies to study problems of critical biological significance. His current research focuses on developing deep learning-based computational approaches to increase the resolution, sensitivity and speed of the next generation of microscopes, as well as designing nanoprobes for high spatiotemporal resolution imaging of subcellular dynamics. Prior to joining Salk, Manor did his PhD thesis research work with Bechara Kachar (NIH), and his postdoctoral training with Jennifer Lippincott-Schwartz (NIH and Janelia Farms) using advanced quantitative imaging approaches, such as superresolution and live cell imaging, automated analysis and segmentation of microscopy data, and computational modeling of biophysical and biochemical dynamics in the cell. His main biological interests are organelle-organelle contacts and cytoskeletal dynamics, mitochondria, sensorineural hearing loss, and neurodegeneration.

Education

2005-2011 - Johns Hopkins University – Ph.D. in Cellular, Molecular, Developmental Biology and Biophysics
2002-2005 - Parks College of Engineering and Aviation - B.S. in Engineering Physics, Cum Laude

Awards & Honors

  • 2018 - Navapan Foundation Grant – Hearing Restoration Project Grant
  • 2018 - Salk Innovation Grant – Deep learning-based segmentation of root systems
  • 2017 - David F. and Margaret T. Grohne Family Foundation – Hearing Restoration Research Grant
  • 2016 - Salk Institute Innovation Award
  • 2015 - NIH Fellows Award for Research Excellence
  • 2015 - CRG-Centre for Genomic Regulation Travel Grant
  • 2012 - NIH Postdoctoral Fellowship
  • 2012 - BSF Prof. Rahamimoff Grant for Young Scientists
  • 2011 - NIH Fellows Award for Research Excellence
  • 2011 - NIH Graduate Student Research Excellence Award
  • 2010 - Full scholarship to the Woods Hole MBL Physiology course
  • 2007 - Full scholarship to the Woods Hole MBL Biology of the Inner Ear course
  • 2005 - NIH Graduate Fellowship

Recent Publications:

  1. Deep Learning-Based Point-Scanning Super-Resolution Imaging. Fang, Linjing; Monroe, Fred; Novak, Sammy Weiser; Kirk, Lyndsey; Schiavon, Cara R; Seungyoon, B Yu; Zhang, Tong; Wu, Melissa; Kastner, Kyle; Kubota, Yoshiyuki. bioRxiv 740548 2019.
  2. Regulation of the ER stress response by a mitochondrial microprotein. Chu, Qian; Martinez, Thomas F; Novak, Sammy Weiser; Donaldson, Cynthia J; Tan, Dan; Vaughan, Joan M; Chang, Tina; Diedrich, Jolene K; Andrade, Leo; Kim, Andrew. Nature Communications 10, (2019).
  3. Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption. Jesús E. Villanueva, Christopher Livelo, Adriana S. Trujillo, Sahaana Chandran, Brendon Woodworth, Leo Andrade, Hiep D. Le, Uri Manor, Satchidananda Panda & Girish C. Melkani. Nature Communications 10, Article number: 2700 (2019).
  4. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Yu Shi, Weina Gao, Nikki K Lytle, Peiwu Huang, Xiao Yuan, Amanda M Dann, Maya Ridinger-Saison, Kathleen E DelGiorno, Corina E Antal, Gaoyang Liang, Annette R Atkins, Galina Erikson, Huaiyu Sun, Jill Meisenhelder, Elena Terenziani, Gyunghwi Woo, Linjing Fang, Thom P Santisakultarm, Uri Manor, Ruilian Xu, Carlos R Becerra, Erkut Borazanci, Daniel D Von Hoff, Paul M Grandgenett, Michael A Hollingsworth, Mathias Leblanc, Sarah E Umetsu, Eric A Collisson, Miriam Scadeng, Andrew M Lowy, Timothy R Donahue, Tannishtha Reya, Michael Downes, Ronald M Evans, Geoffrey M Wahl, Tony Pawson, Ruijun Tian, Tony Hunter. Nature 569 (7754), 131.
  5. A novel role for Myosin-Va in mitochondrial fission. Jackeline S Araujo, Rui MP Silva-Junior, Tong Zhang, Cara R Schiavon, Qian Chu, Melissa Wu, Carmen LS Pontes, Anderson O Souza, Luciane C Alberici, Aline M Santos, Sadie Bartholomew Ingle, Alan Saghatelian, James Spudich, Uri Manor, Enilza Maria Espreafico. bioRxiv, 655803.
  6. Actin chromobody imaging reveals sub-organellar actin dynamics. Cara Schiavon, Tong Zhang, Bing Zhao, Leonardo Andrade, Melissa Wu, Tsung-Chang Sung, Yelena Dayn, Jasmine W Feng, Omar A Quintero, Robert Grosse, Uri Manor. bioRxiv, 639278.
  7. FanStore: Enabling Efficient and Scalable I/O for Distributed Deep Learning. Zhao Zhang, Lei Huang, Uri Manor, Linjing Fang, Gabriele Merlo, Craig Michoski, John Cazes, Niall Gaffney. arXiv preprint arXiv:1809.10799.
  8. In vivo ribbon mobility and turnover of ribeye at zebrafish hair cell synapses. Cole W Graydon, Uri Manor, Katie S Kindt. Scientific reports 7 (1), 7467.
  9. Actin Cytoskeleton-Mediated Constriction of Membrane Organelles via Endoplasmic Reticulum Scaffolding. Carol Lynn Curchoe, Uri Manor. ACS biomaterials science & engineering 3 (11), 2727-2732.
  10. Sonic hedgehog pathway activation increases mitochondrial abundance and activity in hippocampal neurons. Pamela J Yao, Uri Manor, Ronald S Petralia, Rebecca D Brose, Ryan TY Wu, Carolyn Ott, Ya-Xian Wang, Ari Charnoff, Jennifer Lippincott-Schwartz, Mark P Mattson. Molecular biology of the cell 28 (3), 387-395.
  11. Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus. Leonardo R Andrade, Felipe T Salles, M’hamed Grati, Uri Manor, Bechara Kachar. Journal of structural biology 194 (2), 139-146.
  12. Intravital imaging reveals ghost fibers as architectural units guiding myogenic progenitors during regeneration. Micah T Webster, Uri Manor, Jennifer Lippincott-Schwartz, Chen-Ming Fan. Cell stem cell 18 (2), 243-252.
  13. A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division. Uri Manor, Sadie Bartholomew, Gonen Golani, Eric Christenson, Michael Kozlov, Henry Higgs, James Spudich, Jennifer Lippincott-Schwartz. Elife 4, e08828.
  14. A biophysical model for the staircase geometry of stereocilia. Gilad Orly, Uri Manor, Nir S Gov. PloS one 10 (7), e0127926.
  15. Myosin 3A kinase activity is regulated by phosphorylation of the kinase domain activation loop. Omar A Quintero, William C Unrath, Stanley M Stevens, Uri Manor, Bechara Kachar, Christopher M Yengo. Journal of Biological Chemistry 288 (52), 37126-37137.
  16. Linking actin networks and cell membrane via a reaction-diffusion-elastic description of nonlinear filopodia initiation. Eyal Ben Isaac, Uri Manor, Bechara Kachar, Arik Yochelis, Nir S Gov. Physical Review E 88 (2), 022718.
  17. Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2. David N Furness, Stuart L Johnson, Uri Manor, Lukas Rüttiger, Arianna Tocchetti, Nina Offenhauser, Jennifer Olt, Richard J Goodyear, Sarath Vijayakumar, Yuhai Dai, Carole M Hackney, Christoph Franz, Pier Paolo Di Fiore, Sergio Masetto, Sherri M Jones, Marlies Knipper, Matthew C Holley, Guy P Richardson, Bechara Kachar, Walter Marcotti. Proceedings of the National Academy of Sciences 110 (34), 13898-13903.
  18. Competition and compensation: dissecting the biophysical and functional differences between the class 3 myosin paralogs, myosins 3a and 3b. Uri Manor, M'hamed Grati, Christopher M Yengo, Bechara Kachar, Nir S Gov. Bioarchitecture 2 (5), 171-174.
  19. Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Raymond C Merritt, Uri Manor, Felipe T Salles, M'hamed Grati, Andrea C Dose, William C Unrath, Omar A Quintero, Christopher M Yengo, Bechara Kachar. Current biology 22 (4), 320-325.
  20. Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8. Uri Manor, Andrea Disanza, M'Hamed Grati, Leonardo Andrade, Harrison Lin, Pier Paolo Di Fiore, Giorgio Scita, Bechara Kachar. Current Biology 21 (2), 167-172.
  21. Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles. Omar A Quintero, Judy E Moore, William C Unrath, Uri Manor, Felipe T Salles, M'hamed Grati, Bechara Kachar, Christopher M Yengo. Journal of Biological Chemistry 285 (46), 35770-35782.
  22. Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments. Raymond C Merritt, Uri Manor, Felipe T Salles, M'hamed Grati, Andrea C Dose, William C Unrath, Omar A Quintero, Christopher M Yengo, Bechara Kachar. Nature cell biology 11 (4), 443.
  23. Protein localization by actin treadmilling and molecular motors regulates stereocilia shape and treadmilling rate. Moshe Naoz, Uri Manor, Hirofumi Sakaguchi, Bechara Kachar, Nir S Gov. Biophysical journal 95 (12), 5706-5718.
  24. Dynamic length regulation of sensory stereocilia. Uri Manor, Bechara Kachar. Seminars in cell & developmental biology 19 (6), 502-510.
  25. Quantification of co-occurring reaction rates in deep subseafloor sediments. Guizhi Wang, Arthur J Spivack, Scott Rutherford, Uri Manor, Steven D’Hondt. Geochimica et Cosmochimica Acta 72 (14), 3479-3488.
  26. An Improved Numerical Model For Determining Chemical Reaction Rates. Uri Manor, Scott Rutherford. SURFO Technical Report No. 2004-01, 52.