Salk

Uri Manor

Director

Biophotonics Core Facility

Uri Manor
Salk Institute for Biological Studies - Uri Manor
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Uri Manor

As Director of the Advanced Biophotonics Core Facility at the Salk Institute, Uri Manor’s primary focus is the integration and application of optical and charged particle detection technologies to study problems of critical biological significance. His current research focuses on developing deep learning-based computational approaches to increase the resolution, sensitivity and speed of the next generation of microscopes, as well as designing nanoprobes for high spatiotemporal resolution imaging of subcellular dynamics. Prior to joining Salk, Manor did his PhD thesis research work with Bechara Kachar (NIH), and his postdoctoral training with Jennifer Lippincott-Schwartz (NIH and Janelia Farms) using advanced quantitative imaging approaches, such as superresolution and live cell imaging, automated analysis and segmentation of microscopy data, and computational modeling of biophysical and biochemical dynamics in the cell. His main biological interests are organelle-organelle contacts and cytoskeletal dynamics, mitochondria, sensorineural hearing loss, and neurodegeneration.

Education

2005-2011 - Johns Hopkins University – Ph.D. in Cellular, Molecular, Developmental Biology and Biophysics
2002-2005 - Parks College of Engineering and Aviation - B.S. in Engineering Physics, Cum Laude

Awards & Honors

  • 2018 - Navapan Foundation Grant – Hearing Restoration Project Grant
  • 2018 - Salk Innovation Grant – Deep learning-based segmentation of root systems
  • 2017 - David F. and Margaret T. Grohne Family Foundation – Hearing Restoration Research Grant
  • 2016 - Salk Institute Innovation Award
  • 2015 - NIH Fellows Award for Research Excellence
  • 2015 - CRG-Centre for Genomic Regulation Travel Grant
  • 2012 - NIH Postdoctoral Fellowship
  • 2012 - BSF Prof. Rahamimoff Grant for Young Scientists
  • 2011 - NIH Fellows Award for Research Excellence
  • 2011 - NIH Graduate Student Research Excellence Award
  • 2010 - Full scholarship to the Woods Hole MBL Physiology course
  • 2007 - Full scholarship to the Woods Hole MBL Biology of the Inner Ear course
  • 2005 - NIH Graduate Fellowship

Recent Publications:

  1. Organelle–Organelle Contacts: Origins and Functions. Manor, Uri; The Liver: Biology and Pathobiology 151-159 2020
  2. Tuft cell formation reflects epithelial plasticity in pancreatic injury; implications for modeling human pancreatitis. DelGiorno, Kathleen E; Naeem, Razia F; Fang, H Linjing; Chung, Chi-Yeh; Ramos, Cynthia; Luhtala, Natalie; O'connor, Carolyn; Hunter, Tony; Manor, Uri; Wahl, Geoffrey M; Frontiers in Physiology 11 88 2020
  3. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Shi, Yu; Gao, Weina; Lytle, Nikki K; Huang, Peiwu; Yuan, Xiao; Dann, Amanda M; Ridinger-Saison, Maya; DelGiorno, Kathleen E; Antal, Corina E; Liang, Gaoyang; Nature 569 7754 131-135 2019
  4. Actin chromobody imaging reveals sub-organellar actin dynamics. Schiavon, Cara R; Zhang, Tong; Zhao, Bing; Andrade, Leonardo; Wu, Melissa; Sung, Tsung-Chang; Dayn, Yelena; Feng, Jasmine W; Quintero, Omar A; Grosse, Robert; bioRxiv 639278 2019
  5. A novel role for Myosin-Va in mitochondrial fission. Araujo, Jackeline S; Silva-Junior, Rui MP; Zhang, Tong; Schiavon, Cara R; Chu, Qian; Wu, Melissa; Pontes, Carmen LS; Souza, Anderson O; Alberici, Luciane C; Santos, Aline M; bioRxiv 655803 2019
  6. Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption. Villanueva, Jesús E; Livelo, Christopher; Trujillo, Adriana S; Chandran, Sahaana; Woodworth, Brendon; Andrade, Leo; Le, Hiep D; Manor, Uri; Panda, Satchidananda; Melkani, Girish C; Nature Communications 10 1 1-17 2019
  7. Auxin-induced nanoclustering of membrane signaling complexes underlies cell polarity establishment in Arabidopsis. Pan, Xue; Liu, Jianfeng; Senay-Aras, Betul; Lin, Wenwei; Zheng, Shuan; Zhang, Tong; Manor, Uri; Chen, Weitao; Yang, Zhenbiao; bioRxiv 734665 2019
  8. Deep learning-based point-scanning super-resolution imaging. Fang, Linjing; Monroe, Fred; Novak, Sammy Weiser; Kirk, Lyndsey; Schiavon, Cara R; Seungyoon, B Yu; Zhang, Tong; Wu, Melissa; Kastner, Kyle; Kubota, Yoshiyuki; bioRxiv 740548 2019
  9. Regulation of the ER stress response by a mitochondrial microprotein. Chu, Qian; Martinez, Thomas F; Novak, Sammy Weiser; Donaldson, Cynthia J; Tan, Dan; Vaughan, Joan M; Chang, Tina; Diedrich, Jolene K; Andrade, Leo; Kim, Andrew; Nature Communications 10 1 1-13 2019
  10. Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import. Badgley, Michael A; Kremer, Daniel; Maurer, H Carlo; DelGiorno, Kathleen E; Lee, Ho-Joon; Purohit, Vinee; Sagalovskiy, Irina; Ma, Alice; Kapillian, Jonathan; Firl, Christina EM; bioRxiv 827972 2019
  11. Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling. DelGiorno, Kathleen E; Chung, Chi-Yeh; Maurer, H Carlo; Novak, Sammy Weiser; Giraddi, Rajshekhar R; Wang, Dezhen; Naeem, Razia F; Fang, Linjing; Andrade, Leonardo R; Lytle, Nikki K; bioRxiv 2019
  12. Fanstore: Enabling efficient and scalable i/o for distributed deep learning. Zhang, Zhao; Huang, Lei; Manor, Uri; Fang, Linjing; Merlo, Gabriele; Michoski, Craig; Cazes, John; Gaffney, Niall; arXiv preprint arXiv:1809.10799 2018
  13. Sonic hedgehog pathway activation increases mitochondrial abundance and activity in hippocampal neurons. Yao, Pamela J; Manor, Uri; Petralia, Ronald S; Brose, Rebecca D; Wu, Ryan TY; Ott, Carolyn; Wang, Ya-Xian; Charnoff, Ari; Lippincott-Schwartz, Jennifer; Mattson, Mark P; Molecular Biology of the Cell 28 3 387-395 2017
  14. Actin Cytoskeleton-Mediated Constriction of Membrane Organelles via Endoplasmic Reticulum Scaffolding. Curchoe, Carol Lynn; Manor, Uri; ACS Biomaterials Science & Engineering 3 11 2727-2732 2017
  15. In vivo ribbon mobility and turnover of ribeye at zebrafish hair cell synapses. Graydon, Cole W; Manor, Uri; Kindt, Katie S; Scientific Reports 7 1 1-8 2017
  16. Intravital imaging reveals ghost fibers as architectural units guiding myogenic progenitors during regeneration. Webster, Micah T; Manor, Uri; Lippincott-Schwartz, Jennifer; Fan, Chen-Ming; Cell Stem Cell 18 2 243-252 2016
  17. Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus. Andrade, Leonardo R; Salles, Felipe T; Grati, M'hamed; Manor, Uri; Kachar, Bechara; Journal of Structural Biology 194 2 139-146 2016
  18. A biophysical model for the staircase geometry of stereocilia. Orly, Gilad; Manor, Uri; Gov, Nir S; PloS One 10 7 2015
  19. A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division. Manor, Uri; Bartholomew, Sadie; Golani, Gonen; Christenson, Eric; Kozlov, Michael; Higgs, Henry; Spudich, James; Lippincott-Schwartz, Jennifer; Elife 4 e08828 2015
  20. Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2. Furness, David N; Johnson, Stuart L; Manor, Uri; Rüttiger, Lukas; Tocchetti, Arianna; Offenhauser, Nina; Olt, Jennifer; Goodyear, Richard J; Vijayakumar, Sarath; Dai, Yuhai; Proceedings of the National Academy of Sciences 110 34 13898-13903 2013
  21. Linking actin networks and cell membrane via a reaction-diffusion-elastic description of nonlinear filopodia initiation. Isaac, Eyal Ben; Manor, Uri; Kachar, Bechara; Yochelis, Arik; Gov, Nir S; Physical Review E 88 2 22718 2013
  22. Myosin 3A kinase activity is regulated by phosphorylation of the kinase domain activation loop. Quintero, Omar A; Unrath, William C; Stevens, Stanley M; Manor, Uri; Kachar, Bechara; Yengo, Christopher M; Journal of Biological Chemistry 288 52 37126-37137 2013
  23. Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Merritt, Raymond C; Manor, Uri; Salles, Felipe T; Grati, M'hamed; Dose, Andrea C; Unrath, William C; Quintero, Omar A; Yengo, Christopher M; Kachar, Bechara; Current Biology 22 4 320-325 2012
  24. Competition and compensation: dissecting the biophysical and functional differences between the class 3 myosin paralogs, myosins 3a and 3b. Manor, Uri; Grati, M'hamed; Yengo, Christopher M; Kachar, Bechara; Gov, Nir S; Bioarchitecture 2 5 171-174 2012
  25. Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8. Manor, Uri; Disanza, Andrea; Grati, M'Hamed; Andrade, Leonardo; Lin, Harrison; Di Fiore, Pier Paolo; Scita, Giorgio; Kachar, Bechara; Current Biology 21 2 167-172 2011
  26. Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles. Quintero, Omar A; Moore, Judy E; Unrath, William C; Manor, Uri; Salles, Felipe T; Grati, M'hamed; Kachar, Bechara; Yengo, Christopher M; Journal of Biological Chemistry 285 46 35770-35782 2010
  27. Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments. Salles, Felipe T; Merritt, Raymond C; Manor, Uri; Dougherty, Gerard W; Sousa, Aurea D; Moore, Judy E; Yengo, Christopher M; Dosé, Andréa C; Kachar, Bechara; Nature Cell Biology 11 4 443-450 2009
  28. Dynamic length regulation of sensory stereocilia. Manor, Uri; Kachar, Bechara; Seminars in Cell & Developmental Biology 19 6 502-510 2008
  29. Protein localization by actin treadmilling and molecular motors regulates stereocilia shape and treadmilling rate. Naoz, Moshe; Manor, Uri; Sakaguchi, Hirofumi; Kachar, Bechara; Gov, Nir S; Biophysical Journal 95 12 5706-5718 2008
  30. Quantification of co-occurring reaction rates in deep subseafloor sediments. Wang, Guizhi; Spivack, Arthur J; Rutherford, Scott; Manor, Uri; D'Hondt, Steven; Geochimica et Cosmochimica Acta 72 14 3479-3488 2008