Amandine Chaix

Staff Scientist

Regulatory Biology Laboratory

Salk Institute for Biological Studies - Amandine Chaix

Amandine Chaix


The overarching goal of my research is to explore the dynamic relationship between nutrition and the circadian clock in health and disease in order to develop new therapeutic strategies to increase healthspan and well being across lifespan in humans. In particular, I study the role of the circadian clock in the integration of nutritional and temporal cues to maintain cardiometabolic homeostasis. My work has shown that restricting eating to a regular daily schedule (time restricted feeding) can prevent and reverse diet-induced obesity and associated metabolic diseases in mice. Furthermore, imposed feeding/fasting rhythms can override otherwise compromised rhythms in clock deficient mice by restoring metabolic oscillations and inducing a rhythmic coherent activation of nutrient-sensing pathways and physiological cellular stress responses to maintain cellular homeostasis. Moving forward I want to (i) determine the mechanisms of circadian clock function underlying TRF-mediated health benefits, (ii) describe the effects of TRF on age-related metabolic and cognitive decline, (iii) test TRF as a beneficial lifestyle intervention in humans.

Education

Postdoctoral fellow, The Salk Institute, CA.
PhD in Biology, Aix-Marseille II University, Marseille, France
MSc in Immunology, Aix-Marseille II University, Marseille, France
BSc in Cellular Biology and Physiology, Paris VI University and ENS Cachan, Paris, France

Awards & Honors

  • 2019-2024 National Institute of Aging (NIA), R01
  • 2018-2021 American Heart Association (AHA), Career Development Award
  • 2019 Nutrition 2019, SSIB 2019, EBRS 2019, Muscle clocks and Diabetes Invited Speaker
  • 2019 Salk Women & Science Travel Grant, Salk Institute
  • 2017 Selected short talk, Cell symposium on Metabolic disease therapies, CA
  • 2017 Poster Award, Metabolism in action meeting, Denmark
  • 2016 Salk Women & Science Research Award, Salk Institute
  • 2016 Selected short talk, Keystone symposium Metabolism, Transcription and Disease, UT
  • 2014 People’s Choice Award, Salk Institute Science Retreat
  • 2014 Society for Research on Biological Rhythms (SRBR) Research Merit Award
  • 2012-2016 American Diabetes Association (ADA), Mentor-Based Postdoctoral Fellowship
  • 2010-2011 French Society of Haematology (FSH), PhD-to-postdoc Transition Fellowship
  • 2009-2010 French Association for Cancer Research (ARC) Predoctoral Fellowship
  • 2006-2009 French Ministry of Education and Research Dual Research & Teaching Predoctoral Fellowship

Selected Publications

- For full list please click here
https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/

  1. Chaix A, Manoogian ENC, Melkani GC, Panda S. Time restricted eating for the prevention and management of chronic metabolic diseases. Annual Review of Nutrition, In press.
  2. Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. Cell Rep. 2019 Jan 2;26(1):192-208.
  3. Chaix A, Lin T, Le HD, Chang MW, Panda S. Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock. Cell Metab, 2019 Feb 5;29(2):303-319.
  4. Zarrinpar A*, Chaix A*, Xu ZZ, Chang MW, Marotz CA, Saghatelian A, Knight R, Panda S. * co-authors. Antibiotic induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat Commun, 2018, 9(1):2872.
  5. Chaix A, Zarrinpar A, Panda S. The circadian coordination of cell biology. J Cell Biol, 2016, 215(1):15-25.
  6. Chaix A, Panda S. Ketone Bodies Signal Opportunistic Food-Seeking Activity. Trends Endocrinol Metab, 2016, 27(6):350-2.
  7. Zarrinpar A, Chaix A, Panda S. Daily Eating Patterns and Their Impact on Health and Disease. Trends Endocrinol Metab, 2016, 27(2):69-83.
  8. Chaix A and Zarrinpar A. The effects of time-restricted feeding on lipid metabolism and adiposity. Adipocyte, 2015, 4(4):319-24.
  9. Mingueneau M, Chaix A, Scotti N, Chaix J, Reynders A, Hammond C, Thimonier J. A multidisciplinary guided practical on type I diabetes engaging students in inquiry-based learning. Adv Physiol Educ, 2015, 39(4):383-91.
  10. Mingueneau M, Chaix A, Scotti N, Chaix J, Reynders A, Hammond C, Thimonier J. Hands-on experiments on glycemia regulation and type 1 diabetes. Adv Physiol Educ, 2015, 39(3):232-9.
  11. Chaix A, Zarrinpar A, Miu P, Panda S. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metabolism, 2014, 20(6):991-1005.
  12. Zarrinpar A, Chaix A, Yooseph S, Panda S. Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell Metabolism, 2014, 20(6):1006-17.
  13. Chaix A, Arcangelli ML, Lopez S, Voisset E, Yang Y, Vita M, Letard S, Audebert S, Finetti P, Birnbaum D, Bertucci F, Aurrand-Lions M, Dubreuil P, De Sepulveda P. KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570. Oncogene. 2014, 33(7):872-81.
  14. Plikus MV, Vollmers C, De la Cruz D, Chaix A, Ramos R, Panda S, Chuong CM. Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling. Proc Natl Acad Sci U S A., 2013, 110(23):E2106-15.
  15. Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JA, Ellisman MH, Panda S. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metabolism, 2012, 15(6):848-60.
  16. Fournier G, Cabaud O, Josselin E, Chaix A, Adélaïde J, Isnardon D, Restouin A, Castellano R, Dubreuil P, Chaffanet M, Birnbaum D, Lopez M. Loss of AF6/Afadin, a marker of poor outcome in breast cancer, induces cell migration and tumor growth. Oncogene, 2011 Sep 8;30(36):3862-74.
  17. Chaix A, Lopez S, Voisset E, Gros L, Dubreuil P, De Sepulveda P. Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. J Biol Chem, 2011, 286(8):5956-66.
  18. Yang Y, Létard S, Borge L, Chaix A, Hanssens K, Lopez S, Vita M, Finetti P, Birnbaum D, Bertucci F, Gomez S, De Sepulveda P and Dubreuil P. Pediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations. Blood, 2010, 116(7):1114-23.
  19. Voisset E, Lopez S, Chaix A, Vita M, George C, Dubreuil P, De Sepulveda P. FES kinase participates in KIT-ligand induced chemotaxis. Biochem and Biophys Res Commun., 2010, 393(1):174–8.
  20. Voisset E, Lopez S, Chaix A, Georges C, Hanssens K, Prébet T, Dubreuil P, De Sepulveda P. FES kinases are required for oncogenic FLT3 signaling. Leukemia, 2010, 24(4):721-8.
  21. Simon C, Dondi E, Chaix A, de Sepulveda P, Kubiseski TJ, Varin-Blank N, Velazquez L. Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells. Blood, 2008, 112(10).
  22. Gironella M, Seux M, Xie MJ, Cano C, Tomasini R, Gommeaux J, Garcia S, Nowak J, Yeung ML, Jeang KT, Chaix A, Fazli L, Motoo Y, Wang Q, Rocchi P, Russo A, Gleave M, Dagorn JC, Iovanna JL, Carrier A, Pébusque MJ, Dusetti NJ. Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. PNAS, 2007, 104(41).