New technologies for investigation of neuronal structure and function have expanded the range of experimental questions that can be posed and have vastly increased the quality of acquired data. Hand-in-hand with these improvements has come a dramatic increase in the quantity of data, as well as the complexity of many post-acquisition data analyses. To serve these needs, the Advanced Computing Core provides central hardware for mass data storage, high-speed computation, as well as personnel to assist in custom software and hardware development.
Recent advances in molecular and genetic technologies allow the identification and manipulation of the activity of specific neuron types within complex neuronal structures and networks. For these tools to be exploited by systems neurobiologists, including those studying perception in behaving models, novel reagents tailored to specific experimental aims must be constructed. Although the methods used to generate these reagents are common, the expertise is not typically found within systems neuroscience labs. This core is aimed at providing such resources in the form of technical assistance and supplies so that custom-built reagents can be generated.
Models of visual function are a fundamental component of the vision research conducted at the Salk Institute. This core supports personnel and facilities for operation of the Institute’s animal facilities. This support optimizes our systems for monitoring and documenting the health status of our models, enhances our ability to remain in compliance with standards for the care and use of laboratory animals promoted and enforced by the U.S. Department of Agriculture, the National Institutes of Health and the International Association for Assessment and Accreditation of Laboratory Animal Care, and ensures that we continue to offer the highest quality of care possible to animals involved in vision research.
Many studies carried out in the laboratories of the Center for the Neurobiology of Vision require special purpose hardware built to meet the needs of individual experiments. The design and construction of these and other specialized pieces of equipment requires highly trained machinists. This core supports the requisite staff machinists and provides materials to fabricate necessary equipment.