Cancers in the Crosshairs
The evolution of cancer research has always relied on the progression of technology, and now, more
than ever, Salk scientists benefit from a critical mass of cutting-edge research technologies. Verma’s
virus-based gene delivery systems and mouse models are just one example.
Discovery RoundupInduced pluripotent stem cells reveal differences between humans and great apes
It's now also possible to compare iPSCs from humans to those of our closest living relatives—great apes. Recently, scientists working in the lab of Fred Gage, who holds the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease, took chimpanzee and bonobo skin cells and for the first time turned them into iPSCs.
Salk scientists identify factors that trigger ALT-ernative cancer cell growth
Recently, scientists in the laboratory of Jan Karlseder, holder of the Donald and Darlene Shiley Chair, reported in Nature Structural and Molecular Biology the first experimental induction of an ALT telomere-building program in human cells.
Discovery RoundupMissing molecule in chemical production line discovered
Noel and his group used bioinformatics to find all organisms with the IPK enzyme, suspecting that these would all also have the decarboxylase they were looking for, and the approach worked. In an unusual type of bacteria that live in hot springs, he and his colleagues pinpointed a decarboxylase that works in conjunction with IPK. First it removes carbon, and then IPK adds a phosphate—the process, reversing the last two steps of the classic mevalonate pathway, still ends in IPP.
Connecting the dots between genes and human behavior
Williams syndrome is caused by the deletion of one of the two usual copies of approximately 25 genes from chromosome 7, resulting in mental impairment; nearly everyone with the condition is missing these same genes. The condition affects approximately 1 in 10,000 people around the world, including an estimated 20,000 to 30,000 in the United States.
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