Deaths from colorectal cancer in
people under 55 are increasing. A
new study led by Professor Ronald
Evans, with first author Ting Fu and
collaborators, suggests that high-fat
diets fuel colorectal cancer growth
by upsetting the balance of bile acids
in the intestine and triggering a
hormonal signal that lets cancerous
cells thrive. The findings could
explain why colorectal cancer is
being seen in younger people growing
up at a time when high-fat diets are
Advanced pancreatic cancer is often symptomless, leading to
late diagnosis after metastases have spread throughout the body.
Additionally, tumor cells are encased in a protective shield, a
microenvironment conferring resistance to many cancer drugs.
Professor Tony Hunter, first author Yu Shi and an international team
of collaborators uncovered the role of a signaling protein, LIF, that
may be a useful biomarker to help diagnose pancreatic cancer more
quickly and efficiently than current screenings methods.
LIF (green), expressed mainly in activated
pancreatic stellate cells, is shown along
with immune cells (purple) and cancer
cells (yellow) in pancreatic cancer tissue.
Colon cancer growth, as measured by the
number of dividing cells shown in green, is
dramatically increased when the FXR-regulated
gene network is disrupted by specific bile acids
or a high-fat diet.
NEW STUDY TARGETS
ACHILLES’ HEEL OF
6 INSIDE SALK
FALL 2019WWW.SALK.EDU www.salk.edu/hunter201908