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The medicinal powers of aspirin,

digitalis and the anti-malarial

artemisinin come fromplants. Members

of the lab of Professor David Schubert,

including senior author PamelaMaher

and first authorWolfgang Fisher,

discovered a potent neuroprotective and

anti-inflammatory chemical in a shrub

native to California that may lead to a

treatment for Alzheimer’s disease.

Native California

medicinal plant may

hold promise for treating

Alzheimer’s

REDOX

BIOLOGY

02/2019

NATURE

MEDICINE

02/2019

Professor Juan Carlos Izpisua

Belmonte, co-first author Hsin-Kai

Liao and colleagues developed a novel

CRISPR/Cas9 genome-editing therapy

that can suppress the accelerated aging

observed inmice with Hutchinson-

Gilford progeria syndrome, a rare

genetic disorder that also afflicts

humans. The treatment provides

insight into the molecular pathways

involved in accelerated aging, as well

as how gene therapy can be used to

reduce toxic proteins.

Putting the brakes

on aging

Vice President, Chief Science Officer and

Professor Martin Hetzer, first author

Rafael Arrojo e Drigo and colleagues

discovered that the mouse brain, liver

and pancreas contain populations of

cells and proteins with extremely long

life spans—some as old as the organism

itself. The team’s methods could be

applied to nearly any tissue in the body

to provide valuable information about

the lifelong function of nondividing

cells and how cells lose control over the

quality of proteins and cell structures

during aging.

How old are your organs?

To scientists’ surprise,

organs are a mix of young and

old cells

CELL

METABOLISM

06/2019

5

INSIDE SALK

FALL 2019

WWW.SALK.EDU www.salk.edu/belmonte201908

WATCH

www.salk.edu/hetzer201908

WATCH