Previous Page  11 / 48 Next Page
Information
Show Menu
Previous Page 11 / 48 Next Page
Page Background

Similar to the dozens of Sherpas who guide hikers up treacherous

Himalayan mountains to reach a summit, the nervous system relies

on elaborate timing and location of guidance cues for neuronal axons—

threadlike projections—to successfully reach their destinations in the body.

Professor Samuel Pfaff, first author Dario Bonanomi and collaborators

discovered how neurons listen for directions and simultaneously filter out

inappropriate instructions to navigate tricky cellular environments.

LIKE MOUNTAINEERS,

NERVES NEED EXPERT

GUIDANCE TO FIND

THEIR WAY

Motor neurons (green) exit the spinal cord

(red) and enter the periphery of the body to

connect with muscles.

Motor neurons (white arrow) without the

guidance of p190 are trapped within the

spinal cord.

“These results

provide mechanistic

insight into the

unimagined

complexity

that cells use to

communicate with

one another.”

SAMUEL PFAFF

NEURON

03/2019

9

INSIDE SALK

FALL 2019

WWW.SALK.EDU

NEUROSCIENCE