Similar to the dozens of Sherpas who guide hikers up treacherous
Himalayan mountains to reach a summit, the nervous system relies
on elaborate timing and location of guidance cues for neuronal axons—
threadlike projections—to successfully reach their destinations in the body.
Professor Samuel Pfaff, first author Dario Bonanomi and collaborators
discovered how neurons listen for directions and simultaneously filter out
inappropriate instructions to navigate tricky cellular environments.
NERVES NEED EXPERT
GUIDANCE TO FIND
Motor neurons (green) exit the spinal cord
(red) and enter the periphery of the body to
connect with muscles.
Motor neurons (white arrow) without the
guidance of p190 are trapped within the
insight into the
that cells use to