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PRESIDENT’S LETTER

Dear Friends,

Recently, we honored the 100th anniversary of the birth of the late Francis Crick,

who spent the second chapter of his scientific life at the Salk Institute. As you will no

doubt recall, Crick, who was born on June 8, 1916, shared the Nobel Prize in Physiology

or Medicine with James Watson and Maurice Wilkins for describing the double-helical

structure of DNA. Crick later joined the Salk Institute and turned his attention to

understanding the brain, another monumental challenge. Their discovery provided

access to the operating manual for all living things including our human bodies. Even

now, more than 60 years later, the workings of DNA continue to puzzle and surprise

scientists.

In this issue of

Inside Salk

, we take a look at the epigenome, a layer of information that

coats the genome and modifies its functions, often altering the way cells implement

DNA’s instructions. Scientists are finding that the epigenome plays critical roles in

health and disease and that it can change in surprising ways throughout a person’s

lifetime; it can even be passed down to the next generation. This is a tantalizing frontier

for science.

Another exciting frontier explored in this issue’s Observations interview with Salk

professor Ye Zheng is immune system research—and the possibility that our immune

systemmight be leveraged to fight a much broader range of diseases than previously

thought possible. Zheng and other Salk scientists are at the cutting edge of exploring

how to mobilize the immune system to fight cancers, metabolic disorders and even

prevent neurodegenerative diseases such as Alzheimer’s.

On a somber note, we also honor in this issue the lives of John Codey and Conrad Prebys,

visionary supporters of scientific research and great friends to the Salk Institute, both

of whom recently passed away. As a trustee of the Helmsley Charitable Trust, Codey,

along with his fellow trustees and the staff of the Trust, made extraordinary gifts to

support Salk science over the past decade, including $42 million to launch the Institute’s

Helmsley Center for Genomic Medicine. Prebys gave $25 million to Salk’s unrestricted

endowment, which funds basic research. In honor of that gift, the single largest to the

Institute’s endowment, the Salk Institute auditoriumwas named the Conrad T. Prebys

Auditorium. Codey’s and Prebys’ ardent enthusiasm for Salk and the power of science to

change lives led to numerous discoveries, some of them currently being tested in clinical

trials. They are highlighted here in the Discoveries section.

Sincerely,

Elizabeth Blackburn

President, Salk Institute

Irwin M. Jacobs Presidential Chair

“ Scientists are finding that

the epigenome plays

critical roles in health

and disease.”