{"id":7978,"date":"2015-11-19T14:24:46","date_gmt":"2015-11-19T22:24:46","guid":{"rendered":"https:\/\/vermont.salk.edu\/?post_type=disclosure&p=7978"},"modified":"2024-01-30T15:49:44","modified_gmt":"2024-01-30T23:49:44","slug":"salk-scientists-make-serotonin-transmitting-neurons-dish","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-make-serotonin-transmitting-neurons-dish\/","title":{"rendered":"Salk scientists make serotonin-transmitting neurons in a dish"},"content":{"rendered":"

LA JOLLA\u2014Scientists at the Salk Institute have taken human skin cells and turned them into neurons that signal to one another using serotonin, a brain chemical that is crucial to our mental well-being.<\/p>\n

Although serotonin neurons comprise only a small fraction of the brain\u2019s cells, these neurons are tied to debilitating disorders such as major depression, schizophrenia and autism. Depression is commonly treated using selective serotonin reuptake inhibitors, which heighten serotonin signaling in the small gaps between neighboring neurons.<\/p>\n

Described October 27, 2015 in Molecular Psychiatry<\/a><\/em>, the method gives researchers a new lens with which to study serotonin\u2019s mechanisms and how they may go awry in mental illness.<\/p>\n

\"Scientists
Scientists have created serotonin-signaling neurons from human skin cells <\/p>\n

Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n. <\/p>\n

Image: Krishna Vadodaria\/Salk Institute<\/figcaption><\/figure>\n

\u201cWe can finally start asking questions about cells from people affected by depression and other disorders,\u201d says Salk Professor Rusty Gage<\/a>, the study\u2019s senior investigator.<\/p>\n

Scientists have long been producing specialized types of human cells for study in culture dishes. For nearly a decade, for example, it has been possible to transform the cells of specific tissues, converting them into pluripotent stem cells (iPS) and, in turn, prompting them to develop into other types of cells, including neurons. Although more recent methods have turned skin cells directly into neurons, those neurons use a different brain chemical, glutamate.<\/p>\n

In the new study, the Salk team isolated the minority population of serotonin neurons that were differentiated from stem cells and asked what unique genes were activated in these cells. The researchers then found a cocktail of six gene-activating proteins that worked to direct differentiation to serotonergic neurons directly from human fibroblasts.<\/p>\n

\u201cWhen I looked into the microscope and saw serotonin positive neurons, it was really exciting and the moment when I said, \u2018Wow, we\u2019ve got serotonergic neurons!\u2019\u201d says the study\u2019s lead author Krishna Vadodaria, a research associate in the Gage laboratory. \u201cWhile these neurons may not be identical to the brain\u2019s serotonergic neurons, the iSNs have functional properties of neurons, produce serotonin and respond to antidepressants in the dish, which will help us more accurately study serotonergic neurotransmission in neuropsychiatric disorders.\u201d<\/p>\n

Other authors on the study include Jerome Mertens, Apua Paquola, Cedric Bardy, Xinyi Li, Roberto Jappelli, Lianna Fung, Carol Marchetto, Michael Hamm and Mark Gorris, all of the Salk Institute; and Philipp Koch of the University of Bonn<\/a> in Germany.<\/p>\n

This study was supported by the Swiss National Science Foundation<\/a> (SNSF), the
\nGlenn Center for Aging Research, the FP7 Marie Curie, Lynn and Edward Streim, the Robert and Mary Jane Engman Foundation, the JPB Foundation<\/a>, y el Fundaci\u00f3n Ben\u00e9fica Leona M. y Harry B. Helmsley<\/a>.<\/p>","protected":false},"featured_media":0,"template":"","faculty":[76],"disease-research":[124],"class_list":["post-7978","disclosure","type-disclosure","status-publish","hentry","faculty-rusty-gage","disease-research-neuroscience-and-neurological-disorders"],"acf":[],"yoast_head":"\nSalk scientists make serotonin-transmitting neurons in a dish - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-make-serotonin-transmitting-neurons-dish\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salk scientists make serotonin-transmitting neurons in a dish - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Scientists at the Salk Institute have taken human skin cells and turned them into neurons that signal to one another using serotonin, a brain chemical that is crucial to our mental well-being.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/salk-scientists-make-serotonin-transmitting-neurons-dish\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-30T23:49:44+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.salk.edu\/wp-content\/uploads\/2015\/11\/20151119-gage-serotonin1-458x458.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-make-serotonin-transmitting-neurons-dish\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/salk-scientists-make-serotonin-transmitting-neurons-dish\\\/\",\"name\":\"Salk scientists make serotonin-transmitting neurons in a dish - 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