{"id":56557,"date":"2026-04-22T02:00:40","date_gmt":"2026-04-22T09:00:40","guid":{"rendered":"https:\/\/www.salk.edu\/?post_type=disclosure&#038;p=56557"},"modified":"2026-04-22T09:23:21","modified_gmt":"2026-04-22T16:23:21","slug":"how-can-scientists-visualize-cellular-life-with-greater-precision","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/how-can-scientists-visualize-cellular-life-with-greater-precision\/","title":{"rendered":"How can scientists visualize cellular life with greater precision?"},"content":{"rendered":"<ul style=\"margin-bottom: 30px;\">\n<li style=\"list-style: none; padding-left: -20px !important; margin-left: -20px !important;\"><strong>Lo m\u00e1s destacado<\/strong><\/li>\n<li>Salk researchers collaborated with scientists at Albert Einstein College of Medicine to develop a new class of probes for imaging living cells<\/li>\n<li>The probes, called visible-spectrum antigen-stabilizable fluorescent nanobodies (VIS-Fbs), generate high-contrast images with minimal disruption to normal cellular activity<\/li>\n<li>The technology enables more precise investigation of complex biological processes, including cell signaling, development, and disease progression<\/li>\n<\/ul>\n<p>LA JOLLA\u2014Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and animals. Using these tools, researchers have watched viruses infect cells in real time, observed cellular trash collection, and tracked the signaling that spurs tumor growth.<\/p>\n<figure id=\"attachment_56559\"  class=\"wp-caption alignright\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"305\" class=\"img-responsive wp-image-56559 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-458x305.jpg\" alt=\"Axel Nimmerjahn helped develop a new technology for imaging cells, called visible-spectrum antigen-stabilizable fluorescent nanobodies, which provides a versatile platform for imaging and studying cellular processes in living systems.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-458x305.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-300x200.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-1024x683.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-768x512.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-18x12.jpg 18w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-147x98.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-585x390.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-553x369.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-750x500.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-767x511.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-945x630.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn.jpg 1500w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">Axel Nimmerjahn helped develop a new technology for imaging cells, called visible-spectrum antigen-stabilizable fluorescent nanobodies, which provides a versatile platform for imaging and studying cellular processes in living systems.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn.jpg\" target=\"_blank\" rel=\"noopener\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<br \/>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>Salk scientists and collaborators at Albert Einstein College of Medicine have advanced this visualization technology. The new technology, called visible-spectrum antigen-stabilizable fluorescent nanobodies (VIS-Fbs), was validated in multiple mammalian cell types and provides a powerful tool for a wide range of life science research applications.<\/p>\n<p>El estudio se public\u00f3 en <a href=\"https:\/\/www.nature.com\/articles\/s41592-026-03056-3\" target=\"_blank\" rel=\"noopener\"><em>Naturaleza M\u00e9todos<\/em><\/a> on April 22, 2026.<\/p>\n<p>\u201cThis work establishes a versatile platform for imaging proteins with high specificity and minimal background,\u201d says co-corresponding author <a href=\"https:\/\/www.salk.edu\/es\/scientist\/axel-nimmerjahn\/\" target=\"_blank\" rel=\"noopener\">Axel Nimmerjahn, doctor<\/a>, professor and Fran\u00e7oise Gilot-Salk Chair at Salk. \u201cIt opens new opportunities to study how molecular and cellular processes unfold in real time across diverse biological systems.\u201d<\/p>\n<h2 style=\"font-size: 20px; margin-top: 40px;\"><strong>How can current cellular imaging technology be optimized?<\/strong><\/h2>\n<p>The innovation began with tiny protein fragments called nanobodies, which can be engineered to bind specific protein targets in living cells. When fused to fluorescent proteins, these nanobody-based probes can reveal where target proteins are located and how they behave. However, conventional versions can still generate signal even when unbound, creating background fluorescence that can obscure fine details.<\/p>\n<figure id=\"attachment_56561\"  class=\"wp-caption alignleft\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"315\" class=\"img-responsive wp-image-56561 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-458x315.jpg\" alt=\"Mouse brain tissue showing inhibitory neurons labeled with a red fluorescent VIS-Fb that binds to the green calcium biosensor. Neurons are highlighted in blue.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-458x315.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-300x206.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-1024x704.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-768x528.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-18x12.jpg 18w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-147x101.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-585x402.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-553x380.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-750x516.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-767x528.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1-945x650.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1.jpg 1195w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">Mouse brain tissue showing inhibitory neurons labeled with a red fluorescent VIS-Fb that binds to the green calcium biosensor. Neurons are highlighted in blue.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-1.jpg\" target=\"_blank\" rel=\"noopener\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<br \/>Credit: Barykina et al., <em>Naturaleza M\u00e9todos<\/em><\/figcaption><\/figure>\n<p>The Salk and Einstein team designed a new type of probe that retains the targeting power of nanobodies while greatly reducing background fluorescence. VIS-Fbs become stable and fluorescent only when bound to their intended target. This binding-dependent (\u201con-demand\u201d) fluorescence reduces background noise by up to about a hundredfold, enabling much sharper visualization of protein location and dynamics.<\/p>\n<p>In addition, the researchers developed multiple versions of this new probe that fluoresce across nearly the entire visible spectrum, from blue to far red. With this many color options, multiple cellular targets can be tracked simultaneously. Certain VIS-Fb variants can also be switched \u201con\u201d and \u201coff\u201d with light, making it possible to follow protein behavior over time with high spatial and temporal precision. The researchers also established a modular design framework, enabling rapid adaptation of VIS-Fb probes to different targets and functional readouts.<\/p>\n<h2 style=\"font-size: 20px; margin-top: 40px;\"><strong>What do scientists study with light probes?<\/strong><\/h2>\n<figure id=\"attachment_56564\"  class=\"wp-caption alignright\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"315\" class=\"img-responsive wp-image-56564 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-458x315.jpg\" alt=\"Mouse brain tissue showing astrocytes labeled with a red fluorescent VIS-Fb that binds to the green calcium biosensor. Astrocytes are highlighted in purple, while neurons are shown in blue, illustrating cell-type-specific labeling.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-458x315.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-300x206.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-1024x704.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-768x528.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-18x12.jpg 18w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-147x101.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-585x402.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-553x380.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-750x516.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-767x527.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2-945x650.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2.jpg 1431w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">Mouse brain tissue showing astrocytes labeled with a red fluorescent VIS-Fb that binds to the green calcium biosensor. Astrocytes are highlighted in purple, while neurons are shown in blue, illustrating cell-type-specific labeling.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-microscopy-2.jpg\" target=\"_blank\" rel=\"noopener\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<br \/>Credit: Barykina et al., <em>Naturaleza M\u00e9todos<\/em><\/figcaption><\/figure>\n<p>The new technology will allow scientists to gain more accurate, timely insight into cellular activity\u2014even in complex environments like living brain tissue. The researchers demonstrated VIS-Fbs\u2019 capabilities across a range of living models.<\/p>\n<p>In mouse models, VIS-Fb probes enabled selective labeling and ratiometric imaging of calcium activity in neurons and astrocytes during behavior. In zebrafish, the technology allowed real-time tracking of dynamic changes during early development and in response to drugs that alter signaling pathways.<\/p>\n<p>\u201cOur results show that this imaging platform offers a much clearer and more precise view of how proteins behave inside living systems,\u201d says co-corresponding author of the study Vladislav Verkhusha, PhD, professor and co-director of the Gruss Lipper Biophotonics Center at Albert Einstein College of Medicine. \u201cIt opens the door to studying complex biological processes, such as cell signaling, development, and disease progression, in new ways.\u201d<\/p>\n<h2 style=\"font-size: 20px; margin-top: 40px;\"><strong>Otros autores y financiaci\u00f3n<\/strong><\/h2>\n<p>Other authors include Erin Carey of Salk; Natalia Barykina, Juliana Mendon\u00e7a-Gomes, and Sofia de Oliveira of the Albert Einstein College of Medicine; and Olena Oliinyk of the University of Helsinki.<\/p>\n<p>This study was funded by the National Institutes of Health (GM122567, NS123719, GM147416), Jane and Aatos Erkko Foundation, Research Council of Finland, Finland Cancer Foundation, Chan Zuckerberg Initiative Foundation, NOMIS Foundation (Salk\u2019s Neuroimmunology Initiative), and Edwards-Yeckel Research Foundation.<\/p>","protected":false},"featured_media":56569,"template":"","faculty":[89],"disease-research":[449,332],"class_list":["post-56557","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-axel-nimmerjahn","disease-research-biochemistry-and-biophysics","disease-research-computational-biology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How can scientists visualize cellular life with greater precision? - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/how-can-scientists-visualize-cellular-life-with-greater-precision\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How can scientists visualize cellular life with greater precision? - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"Highlights Salk researchers collaborated with scientists at Albert Einstein College of Medicine to develop a new class of probes for imaging living cells The probes, called visible-spectrum antigen-stabilizable fluorescent nanobodies (VIS-Fbs), generate high-contrast images with minimal disruption to normal cellular activity The technology enables more precise investigation of complex biological processes, including cell signaling, development, and disease progression LA JOLLA\u2014Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and animals. Using these tools, researchers have watched viruses infect cells in real time, observed cellular trash collection, and tracked the signaling that spurs tumor growth.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/how-can-scientists-visualize-cellular-life-with-greater-precision\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-22T16:23:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260422-pr-nimmerjahn-homepage.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"767\" \/>\n\t<meta property=\"og:image:height\" content=\"767\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/how-can-scientists-visualize-cellular-life-with-greater-precision\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/how-can-scientists-visualize-cellular-life-with-greater-precision\\\/\",\"name\":\"How can scientists visualize cellular life with greater precision? 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