{"id":56439,"date":"2026-04-08T08:00:15","date_gmt":"2026-04-08T15:00:15","guid":{"rendered":"https:\/\/www.salk.edu\/?post_type=disclosure&#038;p=56439"},"modified":"2026-04-08T11:39:01","modified_gmt":"2026-04-08T18:39:01","slug":"how-does-mitochondrial-dna-affect-your-health","status":"publish","type":"disclosure","link":"https:\/\/www.salk.edu\/es\/news-release\/how-does-mitochondrial-dna-affect-your-health\/","title":{"rendered":"\u00bfC\u00f3mo afecta el ADN mitocondrial tu salud?"},"content":{"rendered":"<ul style=\"margin-bottom: 30px;\">\n<li style=\"list-style: none; padding-left: -20px !important; margin-left: -20px !important;\"><strong>Lo m\u00e1s destacado<\/strong><\/li>\n<li>Cient\u00edficos de Salk han creado una plataforma para estudiar las mutaciones del ADN mitocondrial que conducen o contribuyen a enfermedades humanas.<\/li>\n<li>Generaron una biblioteca de 155 c\u00e9lulas mutantes de ADN mitocondrial, casi al nivel humano de diversidad de mutantes de ADN mitocondrial.<\/li>\n<li>La plataforma y la biblioteca acelerar\u00e1n la innovaci\u00f3n en el campo terap\u00e9utico de las enfermedades mitocondriales.<\/li>\n<\/ul>\n<p>LA JOLLA\u2014Algunos de tus compa\u00f1eros de vida m\u00e1s importantes son las mitocondrias que impulsan todas tus c\u00e9lulas. T\u00fa y estas peque\u00f1as centrales el\u00e9ctricas celulares se encuentran en una relaci\u00f3n evolutiva de 1.500 millones de a\u00f1os, pero las mitocondrias trajeron consigo algunas cargas. Las mitocondrias trajeron su propio ADN consigo cuando se unieron a las c\u00e9lulas m\u00e1s grandes y complejas hace tanto tiempo, y hoy ese ADN mitocondrial influye en la salud humana.<\/p>\n<p>Cient\u00edficos del Instituto Salk se preguntan cu\u00e1les son esas influencias, y su \u00faltimo estudio presenta una nueva plataforma biol\u00f3gica para estudiar el ADN mitocondrial en la fisiolog\u00eda, la adaptaci\u00f3n, los mecanismos de enfermedad y el desarrollo terap\u00e9utico. Ya han utilizado la plataforma para generar una biblioteca de 155 l\u00edneas celulares mutantes de ADN mitocondrial y revelar correlaciones entre el desarrollo de ratones y la funci\u00f3n mitocondrial. La plataforma, la biblioteca y los hallazgos acelerar\u00e1n el desarrollo terap\u00e9utico para trastornos mitocondriales, adem\u00e1s de ayudar a los cient\u00edficos a tratar la disfunci\u00f3n mitocondrial en otras enfermedades y afecciones como el c\u00e1ncer o el envejecimiento.<\/p>\n<p>El estudio se public\u00f3 en <a href=\"https:\/\/doi.org\/10.1073\/pnas.2535453123\" target=\"_blank\" rel=\"noopener\"><em>Actas de la Academia Nacional de Ciencias<\/em><\/a> el 10 de abril de 2026, y fue financiado tanto por becas de investigaci\u00f3n federales como por filantrop\u00eda privada.<\/p>\n<p>\u201cEl ADN mitocondrial acumula mutaciones a una alta velocidad, y se han identificado m\u00e1s de 260 mutaciones del ADN mitocondrial que causan enfermedades hereditarias en humanos\u201d, afirma el autor principal y co-correspondiente. <a href=\"https:\/\/www.salk.edu\/es\/scientist\/ronald-evans\/\" target=\"_blank\" rel=\"noopener\">Ronald Evans, PhD,<\/a> profesor y director del Laboratorio de Expresi\u00f3n G\u00e9nica y titular de la C\u00e1tedra March of Dimes en Biolog\u00eda Molecular y del Desarrollo en Salk. \u201cHasta ahora, la falta de modelos que representen esta diversidad ha limitado la comprensi\u00f3n mecanicista y el desarrollo de terapias. Nuestra nueva plataforma permitir\u00e1 a los cient\u00edficos investigar la variaci\u00f3n del ADN mitocondrial en la salud, la enfermedad y la evoluci\u00f3n, lo que posibilitar\u00e1 la innovaci\u00f3n terap\u00e9utica para los trastornos mitocondriales\u201d.\u201d<\/p>\n<figure id=\"attachment_56452\"  class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"945\" height=\"730\" class=\"img-responsive wp-image-56452 size-col-md-10\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-945x730.jpg\" alt=\"A playful representation of a mitochondrion moving into a larger cell, bringing with it the &quot;baggage&quot; of mutated mitochondrial DNA. Researchers at the Salk Institute developed a new platform for studying that mutated mitochondrial DNA, helping explain the ways it influences human health.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-945x730.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-300x232.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-1024x791.jpg 1024w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-768x593.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-16x12.jpg 16w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-147x114.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-458x354.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-585x452.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-553x427.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-750x580.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration-767x593.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration.jpg 1500w\" sizes=\"auto, (max-width: 945px) 100vw, 945px\" \/><\/a><figcaption class=\"wp-caption-text\">Una representaci\u00f3n juguetona de una mitocondria movi\u00e9ndose hacia una c\u00e9lula m\u00e1s grande, trayendo consigo el \u201cequipaje\u201d de ADN mitocondrial mutado. Investigadores del Instituto Salk desarrollaron una nueva plataforma para estudiar ese ADN mitocondrial mutado, ayudando a explicar las formas en que influye en la salud humana.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-illustration.jpg\" target=\"_blank\" rel=\"noopener\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<br \/>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<h2 style=\"font-size: 20px; margin-top: 40px;\"><strong>\u00bfQu\u00e9 son los trastornos mitocondriales?<\/strong><\/h2>\n<p>El ADN mitocondrial cumple la funci\u00f3n extremadamente importante de crear las prote\u00ednas necesarias para la producci\u00f3n de energ\u00eda, pero tambi\u00e9n tiene una tasa de mutaci\u00f3n especialmente alta, y esas mutaciones pueden acumularse gracias a mecanismos de reparaci\u00f3n ineficientes. Dado que las mitocondrias son partes esenciales de todas las c\u00e9lulas, su disfunci\u00f3n puede provocar disfunci\u00f3n en todo el cuerpo, con un impacto especialmente devastador en \u00f3rganos de alta energ\u00eda como el cerebro y el coraz\u00f3n. Sin suficiente energ\u00eda en sus c\u00e9lulas, pueden comenzar a manifestarse s\u00edntomas como migra\u00f1as, debilidad muscular y p\u00e9rdida de audici\u00f3n o vista.<\/p>\n<p>El impacto cr\u00f3nico y amplio de la disfunci\u00f3n mitocondrial hace que sea especialmente importante estudiarla. Intentar precisar el resultado de mutaciones espec\u00edficas del ADN mitocondrial fue un proceso lento y arduo durante muchos a\u00f1os. Los investigadores creaban modelos de rat\u00f3n uno por uno con diferentes mutaciones del ADN mitocondrial, y un solo modelo a veces tomaba a\u00f1os. Este fue un problema que el cient\u00edfico del personal de Salk, Weiwei Fan, doctorado, not\u00f3 al principio de su carrera cient\u00edfica y que se propuso resolver como estudiante de doctorado.<\/p>\n<p>\u201cEste nuevo trabajo se basa en una plataforma original que gener\u00e9 durante mi doctorado\u201d, dice Fan, primer autor y coautor correspondiente del estudio. \u201cEsa plataforma era ineficiente: tomaba mucho tiempo generar un solo mutante de ADN mitocondrial. Con algunas mejoras y modificaciones tecnol\u00f3gicas, esta nueva plataforma es mucho m\u00e1s eficiente y puede crear docenas de mutantes con mucha mayor facilidad\u201d.\u201d<\/p>\n<h2 style=\"font-size: 20px; margin-top: 40px;\"><strong>\u00bfQu\u00e9 nos ense\u00f1an los modelos biol\u00f3gicos?<\/strong><\/h2>\n<p>El nuevo modelo de Salk es una plataforma escalable basada en c\u00e9lulas madre que crea ratones con mutaciones en su ADN mitocondrial. Una vez que uno de estos ratones est\u00e1 establecido, los investigadores pueden investigar los s\u00edntomas espec\u00edficos de su mutaci\u00f3n particular del ADN mitocondrial y los mecanismos por los cuales surgen esos s\u00edntomas, informaci\u00f3n que puede ser utilizada para dise\u00f1ar terapias dirigidas en el futuro.<\/p>\n<p>La plataforma comienza con una prote\u00edna, llamada ADN polimerasa mitocondrial, que genera ADN mitocondrial mutado aleatoriamente. Ese ADN mitocondrial mutado se transfiere luego a c\u00e9lulas madre, que pueden integrarse con embriones de rat\u00f3n para crear ratones para estudio.<\/p>\n<p>Usando esta plataforma, el equipo de Salk gener\u00f3 una biblioteca de 155 l\u00edneas celulares con mutaciones en el ADN mitocondrial, cada una con su propio impacto distintivo en el rendimiento mitocondrial. Luego utilizaron esa biblioteca para validar que las c\u00e9lulas pod\u00edan usarse para generar ratones con mutaciones individuales en el ADN mitocondrial. Estos ratones les permitieron encontrar una fuerte correlaci\u00f3n entre la funci\u00f3n mitocondrial y el desarrollo embrionario temprano, lo que sugiere que se requiere un nivel energ\u00e9tico de base para el desarrollo normal.<\/p>\n<h2 style=\"font-size: 20px; margin-top: 40px;\"><strong>\u00bfC\u00f3mo cambia este nuevo recurso el tratamiento de los trastornos mitocondriales? <\/strong><\/h2>\n<figure id=\"attachment_56442\"  class=\"wp-caption alignright\"><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"583\" class=\"img-responsive wp-image-56442 size-col-md-5\" src=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-458x583.jpg\" alt=\"Weiwei Fan (left) and Ronald Evans (right) developed a new platform for studying mitochondrial DNA mutations that lights the way to new therapeutics for mitochondrial diseases and mitochondrial dysfunction in conditions and diseases like aging and cancer.\" srcset=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-458x583.jpg 458w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-236x300.jpg 236w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-805x1024.jpg 805w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-768x977.jpg 768w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-1207x1536.jpg 1207w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-9x12.jpg 9w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-147x187.jpg 147w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-300x382.jpg 300w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-585x745.jpg 585w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-553x704.jpg 553w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-750x955.jpg 750w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-767x976.jpg 767w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors-945x1203.jpg 945w, https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors.jpg 1500w\" sizes=\"auto, (max-width: 458px) 100vw, 458px\" \/><\/a><figcaption class=\"wp-caption-text\">Weiwei Fan (izquierda) y Ronald Evans (derecha) desarrollaron una nueva plataforma para estudiar mutaciones en el ADN mitocondrial que abre el camino a nuevas terapias para enfermedades mitocondriales y disfunci\u00f3n mitocondrial en condiciones y enfermedades como el envejecimiento y el c\u00e1ncer.<br \/><a href=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-fan-authors.jpg\" target=\"_blank\" rel=\"noopener\">Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.<br \/>Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n<p>\u201cNuestra biblioteca es un hito importante y es muy diversa, con una escala de diversidad similar a la diversidad de mutaciones causantes de enfermedades humanas conocidas, alrededor de 260\u201d, dice Fan. \u201cY con esta colecci\u00f3n de c\u00e9lulas mutantes, no solo podemos observar mutaciones hereditarias, sino tambi\u00e9n aquellas que ocurren en funci\u00f3n de otros factores estresantes como se\u00f1ales ambientales o envejecimiento\u201d.\u201d<\/p>\n<p>La nueva plataforma y biblioteca est\u00e1n abriendo el mundo del ADN mitocondrial. Con la capacidad de generar mutantes de ADN mitocondrial m\u00e1s r\u00e1pidamente, el desarrollo terap\u00e9utico para enfermedades y disfunciones mitocondriales tambi\u00e9n llegar\u00e1 m\u00e1s r\u00e1pido. Los modelos de rat\u00f3n ya son un gran avance para el campo, pero los investigadores tambi\u00e9n est\u00e1n ansiosos por pasar a modelos humanos en un contexto m\u00e1s relevante para los humanos.<\/p>\n<p>\u201cLa mayor\u00eda de las enfermedades humanas vienen con o causan disfunci\u00f3n mitocondrial\u201d, dice Evans. \u201cEl progreso en este campo ha sido limitado, pero esta nueva plataforma va a impulsar mucha investigaci\u00f3n importante que apunta a enfoques terap\u00e9uticos para combatir las enfermedades mitocondriales, as\u00ed como enfermedades o condiciones asociadas con la disfunci\u00f3n mitocondrial como el c\u00e1ncer o el envejecimiento\u201d.\u201d<\/p>\n<h2 style=\"font-size: 20px; margin-top: 40px;\"><strong>Otros autores y financiaci\u00f3n<\/strong><\/h2>\n<p>Otros autores incluyen a Lillian Crossley, Hunter Robbins, Mingxiao He, Yang Dai, Morgan Truitt, Annette Atkins y Michael Downes de Salk, y Tae Gyu Oh de Salk y la Universidad de Oklahoma.<\/p>\n<p>El trabajo fue apoyado por los National Institutes of Health (P01HL147835, DK057978, DK120515, 1R21OD030076, CCSG P30CA23100, CCSG P30 CA014195, CCSG P30 CA014195, P30 AG068635), el Departamento de la Marina, la Oficina de Investigaci\u00f3n Naval (N00014-16-1-3159), la Fundaci\u00f3n Larry L. Hillblom, Inc. (2021-D-001-NET), la Wu Tsai Human Performance Alliance, la Fundaci\u00f3n Henry L. Guenther y la Fundaci\u00f3n Waitt.<\/p>","protected":false},"featured_media":56462,"template":"","faculty":[91],"disease-research":[123,176],"class_list":["post-56439","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-ronald-evans","disease-research-metabolism-and-diabetes","disease-research-mitochondrial-disease"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How does mitochondrial DNA affect your health? - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/how-does-mitochondrial-dna-affect-your-health\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How does mitochondrial DNA affect your health? - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"Highlights Salk scientists have created a platform to study mitochondrial DNA mutations that lead or contribute to human disease They generated a library of 155 mitochondrial DNA mutant cells, nearly the human level of mitochondrial DNA mutant diversity The platform and library will accelerate innovation in the mitochondrial disease therapeutic space LA JOLLA\u2014Some of your most important life partners are the mitochondria that power all your cells. You and these little cellular powerhouses are in a 1.5-billion-year-old evolutionary relationship\u2014but mitochondria brought some baggage. Mitochondria brought their own DNA with them when they joined with the bigger, more complex cells so long ago, and today that mitochondrial DNA influences human health.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.salk.edu\/es\/news-release\/how-does-mitochondrial-dna-affect-your-health\/\" \/>\n<meta property=\"og:site_name\" content=\"Salk Institute for Biological Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-08T18:39:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.salk.edu\/wp-content\/uploads\/2026\/04\/260410-pr-evans-homeage.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"767\" \/>\n\t<meta property=\"og:image:height\" content=\"767\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/how-does-mitochondrial-dna-affect-your-health\\\/\",\"url\":\"https:\\\/\\\/www.salk.edu\\\/news-release\\\/how-does-mitochondrial-dna-affect-your-health\\\/\",\"name\":\"How does mitochondrial DNA affect your health? 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You and these little cellular powerhouses are in a 1.5-billion-year-old evolutionary relationship\u2014but mitochondria brought some baggage. 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