\u201cCannabis is one of the most extraordinary plants on Earth. Despite its global importance as a source of medicine, food, seed oil, and fiber for at least the last 10,000 years, it remains one of the least developed major crops of modern times, largely due to a century of legal restrictions,\u201d says Todd Michael<\/a>, senior author of the study and research professor at Salk. \u201cOur team constructed the most complete genetic map, or pangenome, of the plant to date by analyzing nearly 200 diverse cannabis genomes, showing that we are just starting to see the full potential of this amazing plant. Those same legal restrictions spurred an underground breeding revolution, revealing cannabis\u2019s power as a chemical factory. With this new genomic blueprint, we can now apply modern breeding to unlock novel compounds and traits across agriculture, medicine, and biotechnology.\u201d<\/p>\n <\/p>\n Background: Cannabis as a chemical powerhouse<\/strong><\/p>\n Cannabis sativa<\/em>, also known as hemp, is a flowering plant native to Asia. Cannabis has many unique features that have made it a prominent crop over the course of human history, like its ability to produce strong fibers for textiles or its medicinal qualities stemming from its being one of the few plants to make high quantities of cannabinoids. Innovators today suggest that cannabis oil could rival canola or soybean with the right breeding, or that cannabis derivatives could even be used as a sustainable alternative to jet fuel.<\/p>\n Cannabis is a chemical powerhouse. It can produce more than 30% by dry weight as terpenes and cannabinoids, small chemicals that the plant makes to protect against predators, yet humans leverage for mood-altering purposes. Terpenes create the exquisite aromas that attract us to fruits and flowers, while cannabinoids interact with the human body to provide many therapeutic properties. One cannabinoid, the non-psychedelic cannabidiol (CBD), expanded the public\u2019s view of cannabis when the \u201cCharlotte\u2019s Web\u201d strain was used to treat epileptic seizures. CBD, tetrahydrocannabinol (THC), and more than 100 other poorly studied cannabinoids have been used to treat a variety of ailments, including pain, arthritis, nausea, asthma, depression, and anxiety.<\/p>\n Importantly, the impact this selective breeding has had on cannabis\u2019s genomic diversity has remained a mystery. Solving this mystery has proven difficult since cannabis has a complicated genome. First, cannabis is among the less than 5% of plants to have distinct female and male sexes on separate plants. Second, cannabis genomes contain many transposable elements, which are repetitive stretches of DNA that can \u201cjump\u201d around the genome and are thus difficult to track.<\/p>\n <\/p>\n Key discoveries: New, and surprisingly diverse, genetic patterns<\/strong><\/p>\n Scientists use a technology called sequencing to determine the patterns of nucleic acids, which connect across DNA\u2019s double helix to form base pairs, along DNA strands. Traditional short-read sequencing methods chop up the DNA to investigate it piece by piece, just a few hundred base pairs at a time. Newer long-read sequencing techniques can capture thousands <\/em>of base pairs at once.<\/p>\n \u201cThere are limits to what you can discover with short-read sequencing technologies, since those short genetic excerpts are impossible to stitch together in any meaningful way when looking at complex regions of the genome, especially repetitive DNA sequences,\u201d says co-first author Lillian Padgitt-Cobb, a postdoctoral researcher in Michael\u2019s lab. \u201cWe\u2019re among the first to harness this long-read technology at scale in the pangenome context, and with that comes all these insights into structural variation and gene ordering that can inform end-game decisions about breeding favorable traits into cannabis plants.\u201d<\/p>\n The study isn\u2019t the first to use long-read sequencing\u2014in fact, Michael himself was the first researcher to generate a chromosome-level genome of cannabis using long-read sequencing back in 2018, which revealed complex genetic architecture where cannabinoids are synthesized, and explained the breeding history behind anti-epileptic Charlotte\u2019s Web. Where this new study stands apart is its completeness. It contains the most genomes yet, and is the first to include sex chromosomes and, relatedly, the first to have haplotype resolution.<\/p>\n Cannabis is a diploid <\/em>plant. This means that, like humans, it contains two sets of chromosomes, one set inherited from a male plant and the other from a female plant. While most genomes published to date have only been able to decode one chromosome, also known as haplotype resolution, the team resolved both<\/em> sets of cannabis chromosomes. By looking at both chromosome sets, the researchers revealed an unprecedented amount of genetic variation\u2014possibly up to 20 times that of humans.<\/p>\n \u201cWith this haplotype resolution,\u201d Padgitt-Cobb explains, \u201cwe can look at what was inherited from just one of the parent plants and start to understand the breeding and background of that plant.\u201d<\/p>\n The team\u2019s study collected genomes from 144 different cannabis plants from around the world to assemble 193 total genomes\u2014181 of which had never been catalogued before. The genome total is greater than the plant total owing to that haplotype resolution, since each plant that had both chromosome sets investigated produced two genome assemblies. Collectively, these many genomes make up the pangenome, which was analyzed to understand the full extent of genetic diversity within the cannabis species.<\/p>\n The high quality of the collected genomes allowed the researchers to resolve previously unseen genetic patterns, including the architecture of genes responsible for cannabinoid synthesis, and, by incorporating sex chromosomes, a first look at cannabis Y chromosomes.<\/p>\n Their first discovery was that there is unexpected diversity within the species. Across the pangenome, 23% of genes were found in every genome, 55% were nearly<\/em> universal (seen in 95%\u201399% of genomes), 21% were in between 5% and 94% of genomes, and less than 1% were entirely unique. Some of the most universal genes were those that produce cannabinoids.<\/p>\n While cannabinoid genes were consistent across genomes, genes related to fatty acid metabolism, growth, and defense were not. These variable genes are an untapped breeding pool, and their selective breeding could also make cannabis more robust in the field or improve the nutritional content of hemp oil to make it a competitor among existing seed oils. Notably, the research team discovered that structural variation in the fatty acid biosynthetic pathway contributes to the production of tetrahydrocannabivarin (THCV), a rare varin-type cannabinoid gaining attention for its non-psychoactive, energizing effects.<\/p>\n Looking more closely at cannabinoid genes across the pangenome, the researchers concluded that two genes, THCAS and CBDAS, are likely under strong selective pressure from human-directed breeding for THC and CBD content. Importantly, they found that cannabinoid genes are located in transposable elements. Selectively breeding for genes inside these \u201cjumping\u201d transposable elements has, in turn, created immense diversity among cannabis plants.<\/p>\n <\/p>\n Looking ahead: Optimizing plants for health and industry<\/strong><\/p>\n The researchers also identified interesting targets for agricultural optimization. First, by looking at the differences between European and Asian genomes, they concluded there is likely an ancient cannabis relative somewhere in Asia waiting to be discovered. This wild relative will have novel genetic adaptations related to its unique environmental history, making it a wealth of information for breeding cannabis plants that are more resilient crops.<\/p>\n Finally, the novel insight into sex chromosomes revealed that there are genes only <\/em>present in \u201cfather\u201d plants that can be used to breed better-performing offspring. Modern marijuana breeding leverages \u201cfeminization,\u201d where farmers induce a female plant to make male flowers\u2014entirely bypassing the Y chromosome. These new findings suggest that breeding programs may be missing valuable genetic diversity and trait potential encoded in those bypassed male genomes. Incorporating true male plants into breeding strategies could unlock overlooked genetic gains and expand opportunities for crop improvement.<\/p>\n \u201cOver the last 10 years, breeders have already done a decent job of getting yields up and making cannabis an economically viable crop,\u201d says co-first author Ryan Lynch, a postdoctoral researcher in Michael\u2019s lab. \u201cOnce there\u2019s market interest there, paired with these new insights into cannabis genomes that can guide breeding efforts, I can see hemp and hemp oils really booming in both human health and industry applications.\u201d<\/p>\n In the short term, the team hopes the pangenome will serve as a dynamic resource for researchers around the world to build upon and use to inform cultivation strategies, helping to realize the untapped potential of cannabis as a valuable multi-use crop grown for fiber, seed oil, and medicine.<\/p>\n <\/p>\n More about this paper<\/strong><\/p>\n Other authors include Nolan Hartwick, Nicholas Allsing, Anthony Aylward, Allen Mamerto, Justine Kitony, Kelly Colt, Emily Murray, Tiffany Duong, Heidi Chen of Salk; Andrea Garfinkel, Aaron Trippe, and Seth Crawford of Oregon CBD; Brian Knaus and Kelly Vining of Oregon State University; and Philip Bentz, Sarah Carey, and Alex Harkess of the HudsonAlpha Institute for Biotechnology.<\/p>\n The work was supported by the Tang genomics fund, National Science Foundation (NSF-IOS PRFB 2209290, IOS-PGRP CAREER 2236530), Bill and Melinda Gates Foundation (INV-040541), and US Department of Agriculture (USDA NIFA 2022-67012-38987, USDA NIFA 2023-67013-39620).<\/p>","protected":false},"featured_media":53478,"template":"","faculty":[365],"disease-research":[125,451],"class_list":["post-53469","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-todd-michael","disease-research-plant-biology","disease-research-plant-genomics"],"acf":[],"yoast_head":"\n![\"The](\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/05\/250528-pr-michael-cannabis-458x305.jpg\")
<\/a>
Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n![\"From](\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/05\/250528-pr-michael-authors-458x306.jpg\")
<\/a>
Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.
Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\n
![Haga clic aqu\u00ed<\/a> para obtener una imagen en alta resoluci\u00f3n.Cr\u00e9dito: Instituto Salk<\/figcaption><\/figure>\nThe team\u2019s study collected genomes from 144 different cannabis plants from around the world to assemble 193 total genomes\u2014181 of which had never been catalogued before. The genome total is greater than the plant total owing to that haplotype resolution, since each plant that had both chromosome sets investigated produced two genome assemblies. Collectively, these many genomes make up the pangenome, which was analyzed to understand the full extent of genetic diversity within the cannabis species.<\/p>\nThe high quality of the collected genomes allowed the researchers to resolve previously unseen genetic patterns, including the architecture of genes responsible for cannabinoid synthesis, and, by incorporating sex chromosomes, a first look at cannabis Y chromosomes.<\/p>\nTheir first discovery was that there is unexpected diversity within the species. Across the pangenome, 23% of genes were found in every genome, 55% were nearly<\/em> universal (seen in 95%\u201399% of genomes), 21% were in between 5% and 94% of genomes, and less than 1% were entirely unique. Some of the most universal genes were those that produce cannabinoids.<\/p>\nWhile cannabinoid genes were consistent across genomes, genes related to fatty acid metabolism, growth, and defense were not. These variable genes are an untapped breeding pool, and their selective breeding could also make cannabis more robust in the field or improve the nutritional content of hemp oil to make it a competitor among existing seed oils. Notably, the research team discovered that structural variation in the fatty acid biosynthetic pathway contributes to the production of tetrahydrocannabivarin (THCV), a rare varin-type cannabinoid gaining attention for its non-psychoactive, energizing effects.<\/p>\nLooking more closely at cannabinoid genes across the pangenome, the researchers concluded that two genes, THCAS and CBDAS, are likely under strong selective pressure from human-directed breeding for THC and CBD content. Importantly, they found that cannabinoid genes are located in transposable elements. Selectively breeding for genes inside these \u201cjumping\u201d transposable elements has, in turn, created immense diversity among cannabis plants.<\/p>\n <\/p>\nLooking ahead: Optimizing plants for health and industry<\/strong><\/p>\nThe researchers also identified interesting targets for agricultural optimization. First, by looking at the differences between European and Asian genomes, they concluded there is likely an ancient cannabis relative somewhere in Asia waiting to be discovered. This wild relative will have novel genetic adaptations related to its unique environmental history, making it a wealth of information for breeding cannabis plants that are more resilient crops.<\/p>\nFinally, the novel insight into sex chromosomes revealed that there are genes only <\/em>present in \u201cfather\u201d plants that can be used to breed better-performing offspring. Modern marijuana breeding leverages \u201cfeminization,\u201d where farmers induce a female plant to make male flowers\u2014entirely bypassing the Y chromosome. These new findings suggest that breeding programs may be missing valuable genetic diversity and trait potential encoded in those bypassed male genomes. Incorporating true male plants into breeding strategies could unlock overlooked genetic gains and expand opportunities for crop improvement.<\/p>\n\u201cOver the last 10 years, breeders have already done a decent job of getting yields up and making cannabis an economically viable crop,\u201d says co-first author Ryan Lynch, a postdoctoral researcher in Michael\u2019s lab. \u201cOnce there\u2019s market interest there, paired with these new insights into cannabis genomes that can guide breeding efforts, I can see hemp and hemp oils really booming in both human health and industry applications.\u201d<\/p>\nIn the short term, the team hopes the pangenome will serve as a dynamic resource for researchers around the world to build upon and use to inform cultivation strategies, helping to realize the untapped potential of cannabis as a valuable multi-use crop grown for fiber, seed oil, and medicine.<\/p>\n <\/p>\nMore about this paper<\/strong><\/p>\nOther authors include Nolan Hartwick, Nicholas Allsing, Anthony Aylward, Allen Mamerto, Justine Kitony, Kelly Colt, Emily Murray, Tiffany Duong, Heidi Chen of Salk; Andrea Garfinkel, Aaron Trippe, and Seth Crawford of Oregon CBD; Brian Knaus and Kelly Vining of Oregon State University; and Philip Bentz, Sarah Carey, and Alex Harkess of the HudsonAlpha Institute for Biotechnology.<\/p>\nThe work was supported by the Tang genomics fund, National Science Foundation (NSF-IOS PRFB 2209290, IOS-PGRP CAREER 2236530), Bill and Melinda Gates Foundation (INV-040541), and US Department of Agriculture (USDA NIFA 2022-67012-38987, USDA NIFA 2023-67013-39620).<\/p>","protected":false},"featured_media":53478,"template":"","faculty":[365],"disease-research":[125,451],"class_list":["post-53469","disclosure","type-disclosure","status-publish","has-post-thumbnail","hentry","faculty-todd-michael","disease-research-plant-biology","disease-research-plant-genomics"],"acf":[],"yoast_head":"\nCannabis pangenome reveals potential for medicinal and industrial use - Salk Institute for Biological Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.salk.edu\/es\/news-release\/cannabis-pangenome-reveals-potential-for-medicinal-and-industrial-use\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cannabis pangenome reveals potential for medicinal and industrial use - Salk Institute for Biological Studies\" \/>\n<meta property=\"og:description\" content=\"LA JOLLA\u2014Cannabis has been a globally important crop for millennia. 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Lynch, Lillian K. Padgitt-Cobb, Andrea R. Garfinkel, Brian J. Knaus, Nolan T. Hartwick, Nicholas Allsing, Anthony Aylward, Philip C. Bentz, Sarah B. Carey, Allen Mamerto, Justine K. Kitony, Kelly Colt, Emily R. Murray, Tiffany Duong, Heidi I. Chen, Aaron Trippe, Alex Harkess, Seth Crawford, Kelly Vining, Todd P. Michael","doi":"10.1038\/s41586-025-09065-0","paper_title":"Domesticated cannabinoid synthases amid a wild mosaic cannabis pangenome","subhead":"Collaborative, multi-year research effort produces most comprehensive genetic archive of cannabis plant to date","home_photo":"","listing_photo":"","legacy_boilerplate":[],"hide_boilerplate":[],"disable_date":false,"listing_excerpt":"","descriptive_blurb":"","has_journal_cover":false,"og_image_override":false},"_links":{"self":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/53469","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure"}],"about":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/types\/disclosure"}],"version-history":[{"count":10,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/53469\/revisions"}],"predecessor-version":[{"id":53509,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disclosure\/53469\/revisions\/53509"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media\/53478"}],"wp:attachment":[{"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/media?parent=53469"}],"wp:term":[{"taxonomy":"faculty","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/faculty?post=53469"},{"taxonomy":"disease-research","embeddable":true,"href":"https:\/\/www.salk.edu\/es\/wp-json\/wp\/v2\/disease-research?post=53469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}](\"https:\/\/www.salk.edu\/wp-content\/uploads\/2025\/05\/250528-pr-michael-authors.jpg\"){kind=link}